Adam19 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adam19
Entrez Gene ID	303068
Full Name	ADAM metallopeptidase domain 19
Synonyms	Sox30
General protein information	Preferred Names ADAM metallopeptidase domain 19 Names disintegrin and metalloproteinase domain-containing protein 19 SRY-box containing gene 30 a disintegrin and metallopeptidase domain 19 (meltrin beta) a disintegrin and metalloproteinase domain 19 (meltrin beta) meltrin beta
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q21
Summary	membrane-bound metalloprotease-disintegrin similar to meltrin beta; may be involved in neural crest, muscle and skeletal developmental morphogenesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001160228.1	NP_001153700.1	disintegrin and metalloproteinase domain-containing protein 19 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ADAM19	XP_001137856.1
Homo sapiens (human)	ADAM19	NP_150377.1
	ADAM19	XP_001105246.2
Mus musculus (house mouse)	Adam19	NP_033746.1
Rattus norvegicus (Norway rat)	Adam19	NP_001153700.1
Gallus gallus (chicken)	ADAM19	NP_001182051.1
Danio rerio (zebrafish)	LOC571252	XP_699915.6
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003498	XP_309659.5
Bos taurus (cattle)	ADAM19	NP_001068943.2
Drosophila melanogaster (fruit fly)	Meltrin	NP_001027575.1
Xenopus tropicalis (tropical clawed frog)	adam19	NP_001035105.1
Canis lupus familiaris (dog)	ADAM19	XP_005619308.1

Gene Ontology
Bibliography

Related articles in PubMed

Canonical transforming growth factor-? signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29.
Ramdas V, McBride M, Denby L, Baker AH
The American journal of pathology183(6)1885-1896(2013 Dec)

Dynamic change of Adamalysin 19 (ADAM19) in human placentas and its effects on cell invasion and adhesion in human trophoblastic cells.
Zhao M, Qiu W, Li Y, Sang QA, Wang Y
Science in China. Series C, Life sciences52(8)710-8(2009 Aug)

ADAMs: key components in EGFR signalling and development.
Blobel CP
Nature reviews. Molecular cell biology6(1)32-43(2005 Jan)

Essential roles of Meltrin beta (ADAM19) in heart development.
Kurohara K, Komatsu K, Kurisaki T, Masuda A, Irie N, Asano M, Sudo K, Nabeshima Y, Iwakura Y, Sehara-Fujisawa A
Developmental biology267(1)14-28(2004 Mar)

Essential role for ADAM19 in cardiovascular morphogenesis.
Zhou HM, Weskamp G, Chesneau V, Sahin U, Vortkamp A, Horiuchi K, Chiusaroli R, Hahn R, Wilkes D, Fisher P, Baron R, Manova K, Basson CT, Hempstead B, Blobel CP
Molecular and cellular biology24(1)96-104(2004 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TGF-beta stimulation of renal cells results in a significant up-regulation of Adams 10, 17, 12, and 19
Title: Canonical transforming growth factor-? signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29.

The following Adam19 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adam19 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04609	NM_001160228.1 Latest version!	Rattus norvegicus ADAM metallopeptidase domain 19 (Adam19), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adam19 ( NM_001160228.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001153700.1 Rattus norvegicus ADAM metallopeptidase domain 19 (Adam19), mRNA.

Price & Availability↑

CloneID	ORa04609
Clone ID Related Accession (Same CDS sequence)	NM_001160228.1
Accession Version	NM_001160228.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2763bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	disintegrin and metalloproteinase domain-containing protein 19 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07029502.1, AABR07029504.1 and AABR07029505.1. On or before May 17, 2009 this sequence version replaced XM_220328.4, XM_001069002.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCCGGGC GCGCGGGCGT CGCCCGGTTC TGCTTGCTGG CTCTCGCTCT GCAGCTACAG 
TGGCCGCTGG CGGCATGCGA ACCGGAATGG ACCACAAGAG GAAGCAAAGA AGACAGCCCT 
CCACTACAAC ATGAACTCAT AATACCTCAG TGGAGGACTT CAGAAAGCCC CAGGGGAGGA 
AAGCATCCAC TCACGGCAGA GCTCAGGGTC ATGGCTGAAG GGCGAGAGCT GATCCTGGAC 
CTGGAGAAGA ACGAGCACCT TTTTGCTCCA GCCTACACAG AGACCTGCTA CACCGCAAGT 
GGCAATCCTC AGACCACCAC GCTGAAATCT GAGGATCACT GCTTTTACCA CGGGACTGTG 
AGGAAAGTGG ATGAGTCCAG CGTCACTCTC AGCACCTGCC GGGGAATTAG AGGACTGATT 
ATAGTGAGAA GTAACCTCAG CTACATCATC GAGCCCGTCC CTAACAGCGA CAACCAACAC 
CGTATTTACA GATCCGAACA TCTCAAGCTG CCCCCGGGGA ACTGTGGGTT CGAGCACTCC 
AGGCCCACCT CTAAGGACTG GACCCTTCAG TTTACACATC AGACCAAAAA GCAACCTCGC 
AGAATGAAAC GGGAAGATTT ACACTCTATG AAGTACGTGG AGCTTTATCT GGTGGCTGAT 
TACGCAGAGT TTCAGAAGAA CCGGCATGAC CAGGATGCCA CCAAACACAA GCTCATGGAG 
ATTGCCAACT ATGTTGATAA GTTTTACCGC TCCCTGAGCA TCCGGATTGC GCTTGTCGGC 
TTGGAGGTGT GGACACACGG GGATAAGTGT GAAGTCTCAG AGAATCCGTA CTCTACCCTC 
TGGTCCTTTC TCAGTTGGAG GCGCAAGCTG CTCACCCAGA AGAGCCATGA CAATGCCCAG 
CTAATCACGG GCAGGTCCTT CCAAGGCACC ACCATTGGCC TGGCCCCCCT CATGGCCATG 
TGTTCTGTGT ACCAGTCCGG AGGAGTTAGC ATGGACCACT CCGAGAATGC CATCGGTGTA 
GCCTCCACCG TGGCCCACGA GATTGGCCAC AACTTTGGCA TGAGCCATGA TTCTGCACAC 
TGCTGTTCTA CCAGCGCAGC CGATGGTGGG TGCATCATGG CTGCTGCTAC GGGGCACCCT 
TTCCCCAAAG TGTTCAGTTC GTGCAACAGG AAGGAGCTGG ACAGGTATCT GCAGTCAGGA 
GGTGGGATGT GTCTCTCCAA CATGCCAGAT ACGAGGACTC TGTATGGAGG CCGGAGGTGT 
GGCAATGGGT ACCTGGAAGA CGGTGAAGAA TGTGACTGCG GAGAAGAGGA CGAATGTAAG 
AACCCTTGCT GCAATGCCTC CAACTGCACT CTGAAGGAAG GGGCCGAGTG TGCCCATGGC 
TCCTGCTGCC ACCAGTGTAA GCTGGTGGCT CCTGGAACCC AGTGTCGTGA GCAGGTGCGG 
CAGTGTGATC TCCCCGAGTT CTGCACGGGC AAGTCCCCCC ACTGCCCCAC CAACTATTAC 
CAGATGGATG GCACCCCCTG CGAGGGTGGC CAGGCCTACT GCTACAATGG CATGTGCCTC 
ACTTATCAGG AGCAGTGCCA GCAGCTGTGG GGACCTGGAG CCAGGCCTGC TCTTGATCTT 
TGCTTCGAGA GGGTGAATGC TGCTGGTGAC ACCTATGGTA ACTGCGGCAA AGGCTTGAAT 
GGCAAATACA GGAAGTGCAG CCCCAGGGAT GCCAAGTGTG GGAAGATCCA GTGTCAGAGC 
ACCCAGGCCA GGCCCCTGGA ATCCAACGCA GTATCTATTG ACACCACCAT TACCTTGAAC 
GGGAGGCGGA TCCACTGTCG GGGCACCCAT GTCTACCGGG GTCCTGAGGA GGAAGAAGGG 
GAGGGTGACA TGCTGGACCC AGGGCTGGTG ATGACCGGGA CCAAGTGTGG CCACAACCAT 
ATTTGCTTCG AGGGGCAATG CAGGAACACC TCCTTCTTTG AGACGGAAGG CTGTGGGAAA 
AAGTGCAATG GTCATGGGGT CTGCAACAAC AACAAGAACT GTCATTGCTT CCCTGGCTGG 
GCTCCACCTT TCTGTAACAC CCCAGGAGAT GGCGGCAGCA TTGACAGTGG GCCTTTGCCC 
CCTAAGAGTG CGGGTCCTGT GATTGCTGGG GTGTTTTCTG CCCTCTTCGT GTTGGCAGTC 
CTGGTGCTAT TGTGTCATTG CTACAGACAG AGCCACAAAC TGGGCAAGCC CTCAGCTCTC 
CCTTTTAAGC TGCGGCAACA GTTCAGTTGT CCCTTCAGGG TGTCTCAGAA TGGTGGAACT 
GGCCACGCCA ACCCAACTTT CAAGTTGCAG ACACCCCAGG GCAAGCGAAA GGTGACTAAC 
ACCCCTGAAA CTCTCCGGAA GCCCTCCCAC CCTCCTCCCC GGCCCCCTCC GGACTACCTA 
CGAGTTGAAT CCCATCCTGC ACCACTGCCA GCACATCTGA ACAGGGCTGC TGGGAGCTCA 
CCAGAAGCTG GAGCTCAGAT AGAAAGAAAG GAATCAGCCA GAAGACCTCC CCCAAGCCGG 
CCCATGCCCC CTGCACCGAA CTGCCTACTG TCCCAGGATT TCTCCAGGCC TCGACCACCT 
CAGAAGGCAC TCCCAGCGAA TCCTGTGCCG GGCCAAAGGA CTGTTCCCAG GCCAGGAGGC 
ACCTCCCTGT TTCATCCCCC TACTACTGGT CCTCAGCCTC CCAGGCCTCC AGCAGTGTCT 
GTTCCAAAGC TTCCTGAGTA CCGATCACAG AGGATTGGAG GGATAACCAG CTCCAAGATC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001153700.1
CDS	92..2854
Translation	MPGRAGVARFCLLALALQLQWPLAACEPEWTTRGSKEDSPPLQHELIIPQWRTSESPRGGKHPLTAELRVMAEGRELILDLEKNEHLFAPAYTETCYTASGNPQTTTLKSEDHCFYHGTVRKVDESSVTLSTCRGIRGLIIVRSNLSYIIEPVPNSDNQHRIYRSEHLKLPPGNCGFEHSRPTSKDWTLQFTHQTKKQPRRMKREDLHSMKYVELYLVADYAEFQKNRHDQDATKHKLMEIANYVDKFYRSLSIRIALVGLEVWTHGDKCEVSENPYSTLWSFLSWRRKLLTQKSHDNAQLITGRSFQGTTIGLAPLMAMCSVYQSGGVSMDHSENAIGVASTVAHEIGHNFGMSHDSAHCCSTSAADGGCIMAAATGHPFPKVFSSCNRKELDRYLQSGGGMCLSNMPDTRTLYGGRRCGNGYLEDGEECDCGEEDECKNPCCNASNCTLKEGAECAHGSCCHQCKLVAPGTQCREQVRQCDLPEFCTGKSPHCPTNYYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPALDLCFERVNAAGDTYGNCGKGLNGKYRKCSPRDAKCGKIQCQSTQARPLESNAVSIDTTITLNGRRIHCRGTHVYRGPEEEEGEGDMLDPGLVMTGTKCGHNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNKNCHCFPGWAPPFCNTPGDGGSIDSGPLPPKSAGPVIAGVFSALFVLAVLVLLCHCYRQSHKLGKPSALPFKLRQQFSCPFRVSQNGGTGHANPTFKLQTPQGKRKVTNTPETLRKPSHPPPRPPPDYLRVESHPAPLPAHLNRAAGSSPEAGAQIERKESARRPPPSRPMPPAPNCLLSQDFSRPRPPQKALPANPVPGQRTVPRPGGTSLFHPPTTGPQPPRPPAVSVPKLPEYRSQRIGGITSSKI

Target ORF information:

RefSeq Version	NM_001160228.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus ADAM metallopeptidase domain 19 (Adam19), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001160228.1

ORF Insert Sequence:

ATGCCCGGGC GCGCGGGCGT CGCCCGGTTC TGCTTGCTGG CTCTCGCTCT GCAGCTACAG 
TGGCCGCTGG CGGCATGCGA ACCGGAATGG ACCACAAGAG GAAGCAAAGA AGACAGCCCT 
CCACTACAAC ATGAACTCAT AATACCTCAG TGGAGGACTT CAGAAAGCCC CAGGGGAGGA 
AAGCATCCAC TCACGGCAGA GCTCAGGGTC ATGGCTGAAG GGCGAGAGCT GATCCTGGAC 
CTGGAGAAGA ACGAGCACCT TTTTGCTCCA GCCTACACAG AGACCTGCTA CACCGCAAGT 
GGCAATCCTC AGACCACCAC GCTGAAATCT GAGGATCACT GCTTTTACCA CGGGACTGTG 
AGGAAAGTGG ATGAGTCCAG CGTCACTCTC AGCACCTGCC GGGGAATTAG AGGACTGATT 
ATAGTGAGAA GTAACCTCAG CTACATCATC GAGCCCGTCC CTAACAGCGA CAACCAACAC 
CGTATTTACA GATCCGAACA TCTCAAGCTG CCCCCGGGGA ACTGTGGGTT CGAGCACTCC 
AGGCCCACCT CTAAGGACTG GACCCTTCAG TTTACACATC AGACCAAAAA GCAACCTCGC 
AGAATGAAAC GGGAAGATTT ACACTCTATG AAGTACGTGG AGCTTTATCT GGTGGCTGAT 
TACGCAGAGT TTCAGAAGAA CCGGCATGAC CAGGATGCCA CCAAACACAA GCTCATGGAG 
ATTGCCAACT ATGTTGATAA GTTTTACCGC TCCCTGAGCA TCCGGATTGC GCTTGTCGGC 
TTGGAGGTGT GGACACACGG GGATAAGTGT GAAGTCTCAG AGAATCCGTA CTCTACCCTC 
TGGTCCTTTC TCAGTTGGAG GCGCAAGCTG CTCACCCAGA AGAGCCATGA CAATGCCCAG 
CTAATCACGG GCAGGTCCTT CCAAGGCACC ACCATTGGCC TGGCCCCCCT CATGGCCATG 
TGTTCTGTGT ACCAGTCCGG AGGAGTTAGC ATGGACCACT CCGAGAATGC CATCGGTGTA 
GCCTCCACCG TGGCCCACGA GATTGGCCAC AACTTTGGCA TGAGCCATGA TTCTGCACAC 
TGCTGTTCTA CCAGCGCAGC CGATGGTGGG TGCATCATGG CTGCTGCTAC GGGGCACCCT 
TTCCCCAAAG TGTTCAGTTC GTGCAACAGG AAGGAGCTGG ACAGGTATCT GCAGTCAGGA 
GGTGGGATGT GTCTCTCCAA CATGCCAGAT ACGAGGACTC TGTATGGAGG CCGGAGGTGT 
GGCAATGGGT ACCTGGAAGA CGGTGAAGAA TGTGACTGCG GAGAAGAGGA CGAATGTAAG 
AACCCTTGCT GCAATGCCTC CAACTGCACT CTGAAGGAAG GGGCCGAGTG TGCCCATGGC 
TCCTGCTGCC ACCAGTGTAA GCTGGTGGCT CCTGGAACCC AGTGTCGTGA GCAGGTGCGG 
CAGTGTGATC TCCCCGAGTT CTGCACGGGC AAGTCCCCCC ACTGCCCCAC CAACTATTAC 
CAGATGGATG GCACCCCCTG CGAGGGTGGC CAGGCCTACT GCTACAATGG CATGTGCCTC 
ACTTATCAGG AGCAGTGCCA GCAGCTGTGG GGACCTGGAG CCAGGCCTGC TCTTGATCTT 
TGCTTCGAGA GGGTGAATGC TGCTGGTGAC ACCTATGGTA ACTGCGGCAA AGGCTTGAAT 
GGCAAATACA GGAAGTGCAG CCCCAGGGAT GCCAAGTGTG GGAAGATCCA GTGTCAGAGC 
ACCCAGGCCA GGCCCCTGGA ATCCAACGCA GTATCTATTG ACACCACCAT TACCTTGAAC 
GGGAGGCGGA TCCACTGTCG GGGCACCCAT GTCTACCGGG GTCCTGAGGA GGAAGAAGGG 
GAGGGTGACA TGCTGGACCC AGGGCTGGTG ATGACCGGGA CCAAGTGTGG CCACAACCAT 
ATTTGCTTCG AGGGGCAATG CAGGAACACC TCCTTCTTTG AGACGGAAGG CTGTGGGAAA 
AAGTGCAATG GTCATGGGGT CTGCAACAAC AACAAGAACT GTCATTGCTT CCCTGGCTGG 
GCTCCACCTT TCTGTAACAC CCCAGGAGAT GGCGGCAGCA TTGACAGTGG GCCTTTGCCC 
CCTAAGAGTG CGGGTCCTGT GATTGCTGGG GTGTTTTCTG CCCTCTTCGT GTTGGCAGTC 
CTGGTGCTAT TGTGTCATTG CTACAGACAG AGCCACAAAC TGGGCAAGCC CTCAGCTCTC 
CCTTTTAAGC TGCGGCAACA GTTCAGTTGT CCCTTCAGGG TGTCTCAGAA TGGTGGAACT 
GGCCACGCCA ACCCAACTTT CAAGTTGCAG ACACCCCAGG GCAAGCGAAA GGTGACTAAC 
ACCCCTGAAA CTCTCCGGAA GCCCTCCCAC CCTCCTCCCC GGCCCCCTCC GGACTACCTA 
CGAGTTGAAT CCCATCCTGC ACCACTGCCA GCACATCTGA ACAGGGCTGC TGGGAGCTCA 
CCAGAAGCTG GAGCTCAGAT AGAAAGAAAG GAATCAGCCA GAAGACCTCC CCCAAGCCGG 
CCCATGCCCC CTGCACCGAA CTGCCTACTG TCCCAGGATT TCTCCAGGCC TCGACCACCT 
CAGAAGGCAC TCCCAGCGAA TCCTGTGCCG GGCCAAAGGA CTGTTCCCAG GCCAGGAGGC 
ACCTCCCTGT TTCATCCCCC TACTACTGGT CCTCAGCCTC CCAGGCCTCC AGCAGTGTCT 
GTTCCAAAGC TTCCTGAGTA CCGATCACAG AGGATTGGAG GGATAACCAG CTCCAAGATC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Canonical transforming growth factor-? signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29.
The American journal of pathology183(6)1885-1896(2013 Dec)
Ramdas V,McBride M,Denby L,Baker AH

Dynamic change of Adamalysin 19 (ADAM19) in human placentas and its effects on cell invasion and adhesion in human trophoblastic cells.
Science in China. Series C, Life sciences52(8)710-8(2009 Aug)
Zhao M,Qiu W,Li Y,Sang QA,Wang Y

ADAMs: key components in EGFR signalling and development.
Nature reviews. Molecular cell biology6(1)32-43(2005 Jan)
Blobel CP

Essential roles of Meltrin beta (ADAM19) in heart development.
Developmental biology267(1)14-28(2004 Mar)
Kurohara K,Komatsu K,Kurisaki T,Masuda A,Irie N,Asano M,Sudo K,Nabeshima Y,Iwakura Y,Sehara-Fujisawa A

Essential role for ADAM19 in cardiovascular morphogenesis.
Molecular and cellular biology24(1)96-104(2004 Jan)
Zhou HM,Weskamp G,Chesneau V,Sahin U,Vortkamp A,Horiuchi K,Chiusaroli R,Hahn R,Wilkes D,Fisher P,Baron R,Manova K,Basson CT,Hempstead B,Blobel CP

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Adam19 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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