The following Mbtps2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mbtps2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa09160 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001035007.1 | |
| Accession Version | NM_001035007.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1560bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-18 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | membrane-bound transcription factor site-2 protease | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07038108.1, AABR07038109.1 and AABR07038110.1. On Oct 22, 2005 this sequence version replaced XM_228964.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGATTCCGG TGTCGCTGGT GGTGGTGGTG GTGGGTGGTT GGACTGCCGT CTACCTGGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001030179.1 |
| CDS | 93..1652 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001035007.1 |
1 | ATGATTCCGG TGTCGCTGGT GGTGGTGGTG GTGGGTGGTT GGACTGCCGT CTACCTGGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa39737 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006256944.3 | |
| Accession Version | XM_006256944.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1323bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | membrane-bound transcription factor site-2 protease isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005120.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006256944.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGTGTTTG GTGTGATTGC CATGTTCAGC TCTTTTTTTC TCCTTGGAAA AACACTGATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006257006.1 |
| CDS | 101..1423 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006256944.3 |
1 | ATGGTGTTTG GTGTGATTGC CATGTTCAGC TCTTTTTTTC TCCTTGGAAA AACACTGATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
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IFAP syndrome is caused by deficiency in MBTPS2, an intramembrane zinc metalloprotease essential for cholesterol homeostasis and ER stress response. |
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. |
