Efhc1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Efhc1
Entrez Gene ID	301295
Full Name	EF-hand domain containing 1
General protein information	Preferred Names EF-hand domain containing 1 Names EF-hand domain-containing protein 1 EF-hand domain (C-terminal) containing 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q13

mRNA and Protein(s)

mRNA	Protein	Name
NM_001122947.2	NP_001116419.2	EF-hand domain-containing protein 1

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	EFHC1	XP_420047.2
Rattus norvegicus (Norway rat)	Efhc1	NP_001116419.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003805	XP_310360.7
Homo sapiens (human)	EFHC1	NP_060570.2
Pan troglodytes (chimpanzee)	EFHC1	XP_001152433.1
	EFHC1	XP_001107470.1
Canis lupus familiaris (dog)	EFHC1	XP_005627529.1
Mus musculus (house mouse)	Efhc1	NP_082250.1
Danio rerio (zebrafish)	efhc1	NP_957261.1
Bos taurus (cattle)	EFHC1	NP_001179173.1
Xenopus tropicalis (tropical clawed frog)	efhc1	NP_001008106.1

Gene Ontology
Bibliography

Related articles in PubMed

Microtubule-associated defects caused by EFHC1 mutations in juvenile myoclonic epilepsy.
Raju PK, Satishchandra P, Nayak S, Iyer V, Sinha S, Anand A
Human mutation38(7)816-826(2017 Jul)

Mutations of EFHC1, linked to juvenile myoclonic epilepsy, disrupt radial and tangential migrations during brain development.
de Nijs L, Wolkoff N, Coumans B, Delgado-Escueta AV, Grisar T, Lakaye B
Human molecular genetics21(23)5106-17(2012 Dec)

EFHC1 interacts with microtubules to regulate cell division and cortical development.
de Nijs L, L?on C, Nguyen L, Loturco JJ, Delgado-Escueta AV, Grisar T, Lakaye B
Nature neuroscience12(10)1266-74(2009 Oct)

Expression profile and distribution of Efhc1 gene transcript during rodent brain development.
Conte FF, Ribeiro PA, Marchesini RB, Pascoal VD, Silva JM, Oliveira AR, Gilioli R, Sbragia L, Bittencourt JC, Lopes-Cendes I
Journal of molecular neuroscience : MN39(1-2)69-77(2009 Sep)

The mouse ortholog of EFHC1 implicated in juvenile myoclonic epilepsy is an axonemal protein widely conserved among organisms with motile cilia and flagella.
Ikeda T, Ikeda K, Enomoto M, Park MK, Hirono M, Kamiya R
FEBS letters579(3)819-22(2005 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

EFHC1 is a regulator of cell division and neuronal migration during cortical development.
Title: EFHC1 interacts with microtubules to regulate cell division and cortical development.

Data report the expression profile and distribution of Efhc1 messenger RNA during mouse and rat brain development, and suggest that Efhc1 expression is more important during initial phases of brain development.
Title: Expression profile and distribution of Efhc1 gene transcript during rodent brain development.

The following Efhc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Efhc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01243	NM_001122947.2 Latest version!	Rattus norvegicus EF-hand domain containing 1 (Efhc1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$356.30 $509.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Efhc1 ( NM_001122947.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001116419.2 Rattus norvegicus EF-hand domain containing 1 (Efhc1), mRNA.

Price & Availability↑

CloneID	ORa01243
Clone ID Related Accession (Same CDS sequence)	NM_001122947.2
Accession Version	NM_001122947.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1947bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-02-04
Organism	Rattus norvegicus(Norway rat)
Product	EF-hand domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07067033.1. On Jul 22, 2009 this sequence version replaced NM_001122947.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGTGACCA ACCCGGTGCA CGGCCTGCCC TTACTCCCGG GCTCGTCCTT TACGGACTCC 
ACGAAAACAG CATTCCACAG AAGCCAGACA CTCGGCTACA GGAATGGCTA TGCATTTGTC 
CGACGTCCAA CCATGGGCAT AGGTGGAGAC CGGCTCCCCT ACAACCAACT GTCTCCGGCT 
GAGCTGGATG AGTTGGCCAA TAAGGCACCC ATCTTGACTT ATGGCCCACT CAAGCAGGCC 
GCACCAGCAG AGTTTGTTCC TGCGCATGTG GCTTTTGACA AAAAGGTGCT GAAATTTAGC 
GCCTACTTCC AAGAAGATGT TCCCATATCA ATGGAGGAGC ATTACCGAAT CCGCCGGGTG 
AACATTTACT ACTACCTAGA GGATGACAGC ATGTCTGTCA TCGAGCCTGT CGTGGAGAAC 
TCTGGGATCC CACAAGGCAA GCTAGTCAAA CGCCAGCGAC TAGCCAAGAA TGATGTGGGA 
GACCACTACC ACTGGAAGGA CCTGAACCGT GGAATCAACC TTACAATTTA TGGCAAAACC 
TTCCGCATTG TTGACTGCGA CCGATTCACT CAGGATTTTT TGGAAAGTCA AGGCATTGAA 
TTAAATCCAT CAGAGAAGAT GCCTCTAGAC CCTTACACTG AACTCCGAAA AGAACCTGTT 
CGAAAATATG TCACCCCATC AGACTTTGAC CAACTGAAGC AGTTTCTCAC CTTTGACAAA 
CAAGTCCTTC GATTCTACGC GATCTGGGAC GACACGGATA GCTTGTTTGG AGAGTGTCGC 
CACTACATCA TTCATTACTA CCTCATGGAT GACACTGTGG AGATCCGTGA GGTCCACGAA 
CGGAACAACG GGAGGGACCC CTTCCCACTC CTCATGAACC GACAGCGCAT GCCCAAAGTT 
TTGGTGGATA ACGGAAAGAA TTTCCCTCAG TGTGTGCTGG AAATCTCCGA TCAAGAGGTG 
TTAGAGTGGT ACACTGCCAA GGACTTCATC GTGGGAAAGC CACTCACCAT CCTCGGGAGG 
ACCTTCTTCA TTTATGACTG TGATCCGTTC ACCCGACAGT TCTACAAAGA CAAGTTTGGA 
ATGTCCGATT TACCACGAGT TGACGTGAGC AAGAAGGAGC CGCCTCCTGT AAAACAGGAG 
TTGCCTCCTT ATAATGGTTA TGGGCTAATC GAAGACTCTG CTCAGAATTG TTTTGCTCTC 
GTTCCCAAAG CTCCCAGAAA AGATATTGTT AAGATGCTGA TGAACGACAA CAAGGTGCTC 
CGCTACCTGG CGGCACTGGA ATCCCCTATC CCAGAAGACA AAGACCGTCG CTTTGTCTTC 
TCTTATTTTC TTGCCACAGA TATGATCAGT ATCTTTGAGC CACCTGTTCG AAATTCTGGG 
ATCATCGGAG GCAAATTCCT GGGCAGGACT AAAGTTGTTA AATCATTCTC TCCAGTCGAC 
AACCCCATCT ACTATGGACC AAGTGACTTC TTCATCGGTG CTGTGATTGA GGTGTTCGGT 
CATCGGTTTG TTATCCTTGA TACAGATGAG TATGTTTTAA AATACATGGA GAGCAATGCT 
TCCCAGTACT CACCAGAAGC CCTCGCCTCA ATCCAGAACC GTATCCGGAA GCAGGATTCT 
CCTGCACCAG AACTGGAATG CAAGCAAGCT ACAGAAGAAA CCAAGGCACT GGCTACAGAG 
GAACTCAAGG CACAGGGCCT GGACAAACTG ATAGAAAAAA TCCAGATGCA CCTGAAGGAC 
ATTTCATGCA AAGACAACCT CCGGGAAAGG TTCCAAGTAT ACGACAAGGA GGAATCGGGA 
TATGTGGACA AAGAGACGTT CTTTAAAGTC TGCGAAACTC TTAATGTCCC AGTCGACGAC 
TCGTTGATTA AGGAGTTGAT CAGGCTGTGC ACCCATGGAG AAGGCAGGAT TAACTACTAT 
AACTTTGTTC GAGCTTTCTC GGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001116419.2
CDS	47..1993
Translation	MVTNPVHGLPLLPGSSFTDSTKTAFHRSQTLGYRNGYAFVRRPTMGIGGDRLPYNQLSPAELDELANKAPILTYGPLKQAAPAEFVPAHVAFDKKVLKFSAYFQEDVPISMEEHYRIRRVNIYYYLEDDSMSVIEPVVENSGIPQGKLVKRQRLAKNDVGDHYHWKDLNRGINLTIYGKTFRIVDCDRFTQDFLESQGIELNPSEKMPLDPYTELRKEPVRKYVTPSDFDQLKQFLTFDKQVLRFYAIWDDTDSLFGECRHYIIHYYLMDDTVEIREVHERNNGRDPFPLLMNRQRMPKVLVDNGKNFPQCVLEISDQEVLEWYTAKDFIVGKPLTILGRTFFIYDCDPFTRQFYKDKFGMSDLPRVDVSKKEPPPVKQELPPYNGYGLIEDSAQNCFALVPKAPRKDIVKMLMNDNKVLRYLAALESPIPEDKDRRFVFSYFLATDMISIFEPPVRNSGIIGGKFLGRTKVVKSFSPVDNPIYYGPSDFFIGAVIEVFGHRFVILDTDEYVLKYMESNASQYSPEALASIQNRIRKQDSPAPELECKQATEETKALATEELKAQGLDKLIEKIQMHLKDISCKDNLRERFQVYDKEESGYVDKETFFKVCETLNVPVDDSLIKELIRLCTHGEGRINYYNFVRAFSD

Target ORF information:

RefSeq Version	NM_001122947.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus EF-hand domain containing 1 (Efhc1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001122947.2

ORF Insert Sequence:

ATGGTGACCA ACCCGGTGCA CGGCCTGCCC TTACTCCCGG GCTCGTCCTT TACGGACTCC 
ACGAAAACAG CATTCCACAG AAGCCAGACA CTCGGCTACA GGAATGGCTA TGCATTTGTC 
CGACGTCCAA CCATGGGCAT AGGTGGAGAC CGGCTCCCCT ACAACCAACT GTCTCCGGCT 
GAGCTGGATG AGTTGGCCAA TAAGGCACCC ATCTTGACTT ATGGCCCACT CAAGCAGGCC 
GCACCAGCAG AGTTTGTTCC TGCGCATGTG GCTTTTGACA AAAAGGTGCT GAAATTTAGC 
GCCTACTTCC AAGAAGATGT TCCCATATCA ATGGAGGAGC ATTACCGAAT CCGCCGGGTG 
AACATTTACT ACTACCTAGA GGATGACAGC ATGTCTGTCA TCGAGCCTGT CGTGGAGAAC 
TCTGGGATCC CACAAGGCAA GCTAGTCAAA CGCCAGCGAC TAGCCAAGAA TGATGTGGGA 
GACCACTACC ACTGGAAGGA CCTGAACCGT GGAATCAACC TTACAATTTA TGGCAAAACC 
TTCCGCATTG TTGACTGCGA CCGATTCACT CAGGATTTTT TGGAAAGTCA AGGCATTGAA 
TTAAATCCAT CAGAGAAGAT GCCTCTAGAC CCTTACACTG AACTCCGAAA AGAACCTGTT 
CGAAAATATG TCACCCCATC AGACTTTGAC CAACTGAAGC AGTTTCTCAC CTTTGACAAA 
CAAGTCCTTC GATTCTACGC GATCTGGGAC GACACGGATA GCTTGTTTGG AGAGTGTCGC 
CACTACATCA TTCATTACTA CCTCATGGAT GACACTGTGG AGATCCGTGA GGTCCACGAA 
CGGAACAACG GGAGGGACCC CTTCCCACTC CTCATGAACC GACAGCGCAT GCCCAAAGTT 
TTGGTGGATA ACGGAAAGAA TTTCCCTCAG TGTGTGCTGG AAATCTCCGA TCAAGAGGTG 
TTAGAGTGGT ACACTGCCAA GGACTTCATC GTGGGAAAGC CACTCACCAT CCTCGGGAGG 
ACCTTCTTCA TTTATGACTG TGATCCGTTC ACCCGACAGT TCTACAAAGA CAAGTTTGGA 
ATGTCCGATT TACCACGAGT TGACGTGAGC AAGAAGGAGC CGCCTCCTGT AAAACAGGAG 
TTGCCTCCTT ATAATGGTTA TGGGCTAATC GAAGACTCTG CTCAGAATTG TTTTGCTCTC 
GTTCCCAAAG CTCCCAGAAA AGATATTGTT AAGATGCTGA TGAACGACAA CAAGGTGCTC 
CGCTACCTGG CGGCACTGGA ATCCCCTATC CCAGAAGACA AAGACCGTCG CTTTGTCTTC 
TCTTATTTTC TTGCCACAGA TATGATCAGT ATCTTTGAGC CACCTGTTCG AAATTCTGGG 
ATCATCGGAG GCAAATTCCT GGGCAGGACT AAAGTTGTTA AATCATTCTC TCCAGTCGAC 
AACCCCATCT ACTATGGACC AAGTGACTTC TTCATCGGTG CTGTGATTGA GGTGTTCGGT 
CATCGGTTTG TTATCCTTGA TACAGATGAG TATGTTTTAA AATACATGGA GAGCAATGCT 
TCCCAGTACT CACCAGAAGC CCTCGCCTCA ATCCAGAACC GTATCCGGAA GCAGGATTCT 
CCTGCACCAG AACTGGAATG CAAGCAAGCT ACAGAAGAAA CCAAGGCACT GGCTACAGAG 
GAACTCAAGG CACAGGGCCT GGACAAACTG ATAGAAAAAA TCCAGATGCA CCTGAAGGAC 
ATTTCATGCA AAGACAACCT CCGGGAAAGG TTCCAAGTAT ACGACAAGGA GGAATCGGGA 
TATGTGGACA AAGAGACGTT CTTTAAAGTC TGCGAAACTC TTAATGTCCC AGTCGACGAC 
TCGTTGATTA AGGAGTTGAT CAGGCTGTGC ACCCATGGAG AAGGCAGGAT TAACTACTAT 
AACTTTGTTC GAGCTTTCTC GGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Microtubule-associated defects caused by EFHC1 mutations in juvenile myoclonic epilepsy.
Human mutation38(7)816-826(2017 Jul)
Raju PK,Satishchandra P,Nayak S,Iyer V,Sinha S,Anand A

Mutations of EFHC1, linked to juvenile myoclonic epilepsy, disrupt radial and tangential migrations during brain development.
Human molecular genetics21(23)5106-17(2012 Dec)
de Nijs L,Wolkoff N,Coumans B,Delgado-Escueta AV,Grisar T,Lakaye B

EFHC1 interacts with microtubules to regulate cell division and cortical development.
Nature neuroscience12(10)1266-74(2009 Oct)
de Nijs L,L?on C,Nguyen L,Loturco JJ,Delgado-Escueta AV,Grisar T,Lakaye B

Expression profile and distribution of Efhc1 gene transcript during rodent brain development.
Journal of molecular neuroscience : MN39(1-2)69-77(2009 Sep)
Conte FF,Ribeiro PA,Marchesini RB,Pascoal VD,Silva JM,Oliveira AR,Gilioli R,Sbragia L,Bittencourt JC,Lopes-Cendes I

The mouse ortholog of EFHC1 implicated in juvenile myoclonic epilepsy is an axonemal protein widely conserved among organisms with motile cilia and flagella.
FEBS letters579(3)819-22(2005 Jan)
Ikeda T,Ikeda K,Enomoto M,Park MK,Hirono M,Kamiya R

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Efhc1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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