Hsp90ab1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hsp90ab1
Entrez Gene ID	301252
Full Name	heat shock protein 90 alpha family class B member 1
Synonyms	HSP90-BETA,HSP90B,HSPC2,Hspcb
General protein information	Preferred Names heat shock protein 90 alpha family class B member 1 Names heat shock protein HSP 90-beta HSP 84 HSP84 heat shock 84 kDa heat shock 90kDa protein 1, beta heat shock protein 90 alpha (cytosolic), class B member 1 heat shock protein 90kDa alpha (cytosolic), class B member 1 heat shock protein 90kDa alpha family class B member 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q12
Summary	heat shock protein; displays chaperone activity; binds to peptides and facilitates their appropriate transport and/or secondary structure [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001004082.3	NP_001004082.3	heat shock protein HSP 90-beta

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	Hsp83	NP_001261362.1
Arabidopsis thaliana (thale cress)	HSP90.1	NP_200076.1
Mus musculus (house mouse)	Hsp90ab1	NP_032328.2
Gallus gallus (chicken)	HSP90AB1	NP_996842.1
Saccharomyces cerevisiae (baker's yeast)	HSP82	NP_015084.1
Kluyveromyces lactis	KLLA0D12958g	XP_453640.1
Schizosaccharomyces pombe (fission yeast)	hsp90	NP_594365.1
Canis lupus familiaris (dog)	HSP90AB1	XP_532154.4
Bos taurus (cattle)	HSP90AB1	NP_001073105.1
Danio rerio (zebrafish)	hsp90ab1	NP_571385.2
Caenorhabditis elegans (roundworm)	daf-21	NP_506626.1
Neurospora crassa	NCU04142	XP_961298.1
Oryza sativa (rice)	Os08g0500700	NP_001062159.1
Homo sapiens (human)	HSP90AB1	NP_001258898.1
Pan troglodytes (chimpanzee)	HSP90AB1	XP_003311385.1
	HSP90AB1	XP_001099135.2
Rattus norvegicus (Norway rat)	Hsp90ab1	NP_001004082.3
Anopheles gambiae (African malaria mosquito)	HSP83_ANOGA	XP_308800.3
Eremothecium gossypii	AGOS_AFL148C	NP_985402.1
Magnaporthe oryzae (rice blast fungus)	MGG_06759	XP_003709473.1
Xenopus tropicalis (tropical clawed frog)	hsp90ab1	NP_001025655.1
Saccharomyces cerevisiae (baker's yeast)	HSC82	NP_013911.1

Gene Ontology
Bibliography

Related articles in PubMed

Interaction of a Novel Chaperone PhLP2A With the Heat Shock Protein Hsp90.
Krzemie?-Ojak ?, G?ral A, Joachimiak E, Filipek A, Fabczak H
Journal of cellular biochemistry118(2)420-429(2017 Feb)

REV-ERB? influences the stability and nuclear localization of the glucocorticoid receptor.
Okabe T, Chavan R, Fonseca Costa SS, Brenna A, Ripperger JA, Albrecht U
Journal of cell science129(21)4143-4154(2016 11)

Hsp90? is involved in the development of high salt-diet-induced nephropathy via interaction with various signalling proteins.
Yan SH, Zhao NW, Jiang WM, Wang XT, Zhang SQ, Zhu XX, Zhang CB, Gao YH, Gao F, Liu FM, Fang ZY
Open biology6(4)150159(2016 Apr)

The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90.
Haslbeck V, Eckl JM, Drazic A, Rutz DA, Lorenz OR, Zimmermann K, Kriehuber T, Lindemann C, Madl T, Richter K
Scientific reports517058(2015 Nov)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hsp90beta inhibition caused the destabilization of upstream mediators in various pathogenic signalling events, thereby effectively ameliorating this nephropathy owing to renal hypoxia and oxidative stress.
Title: Hsp90? is involved in the development of high salt-diet-induced nephropathy via interaction with various signalling proteins.

aldosterone nongenomically elevates Hsp90( alpha and beta ) protein expressions in rat kidney. Aldosterone had no effect on pc-Src protein levels but modulated localization.
Title: Rapid nongenomic action of aldosterone on protein expressions of Hsp90( ? and ? ) and pc-Src in rat kidney.

The Hsp90 beta reduced significantly NO(2)/NO(3) and increased O(2)(-) generation.
Title: Opposite effect of Hsp90? and Hsp90? on eNOS ability to produce nitric oxide or superoxide anion in human embryonic kidney cells.

mRNA expression levels of heat shock proteins HSP27, HSP70, HSP84 in the soleus muscle were inhibited by hindlimb suspension & spaceflight; mRNA expression levels of the HSPs in the plantaris muscle did not change after hindlimb suspension.
Title: Gene expression levels of heat shock proteins in the soleus and plantaris muscles of rats after hindlimb suspension or spaceflight.

results indicate geldanamycin exerts its regulatory effects through transcription elements including heat-shock elements, boxes and TATA boxes, resulting in differential transactivation of hsp90alpha and hsp90beta in rat gliosarcoma 9L cells
Title: Concerted actions of multiple transcription elements confer differential transactivation of HSP90 isoforms in geldanamycin-treated 9L rat gliosarcoma cells.

The following Hsp90ab1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hsp90ab1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09959	NM_001004082.3 Latest version!	Rattus norvegicus heat shock protein 90 alpha family class B member 1 (Hsp90ab1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$426.30 $609.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hsp90ab1 ( NM_001004082.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001004082.3 Rattus norvegicus heat shock protein 90 alpha family class B member 1 (Hsp90ab1), mRNA.

Price & Availability↑

CloneID	ORa09959
Clone ID Related Accession (Same CDS sequence)	NM_001004082.3
Accession Version	NM_001004082.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2175bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Rattus norvegicus(Norway rat)
Product	heat shock protein HSP 90-beta
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY695392.1. On Jun 10, 2007 this sequence version replaced NM_001004082.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY695392.1, BC082009.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCTGAGG AAGTGCACCA TGGAGAGGAA GAGGTGGAGA CCTTCGCCTT TCAGGCAGAA 
ATTGCCCAGC TGATGTCCCT CATCATCAAC ACTTTCTACT CAAACAAAGA GATTTTCCTC 
CGGGAGTTGA TCTCTAATGC TTCTGATGCC CTGGACAAGA TTCGGTATGA GAGCCTGACT 
GACCCTTCCA AGTTGGACAG CGGGAAAGAG CTGAAGATTG ACATCATCCC CAACCCTCAG 
GAACGCACGC TGACTTTGGT GGACACAGGC ATTGGCATGA CCAAGGCTGA CCTCATAAAT 
AACTTGGGAA CCATTGCTAA GTCTGGTACA AAGGCGTTCA TGGAGGCTCT CCAGGCTGGT 
GCAGACATCT CCATGATTGG GCAGTTTGGT GTCGGCTTCT ACTCTGCCTA CCTGGTGGCA 
GAGAAAGTGG TTGTGATCAC GAAGCACAAC GATGATGAGC AGTATGCCTG GGAGTCTTCT 
GCTGGTGGAT CCTTCACTGT CCGTGCAGAC CACGGTGAGC CCATTGGCCG GGGTACCAAA 
GTGATCCTTC ACCTCAAAGA AGACCAGACA GAGTACTTAG AGGAGAGGAG GGTCAAGGAG 
GTGGTGAAGA AACACTCACA GTTCATAGGC TACCCCATCA CCCTCTATCT GGAGAAGGAA 
CGCGAGAAGG AGATCAGTGA TGATGAGGCA GAGGAAGAGA AAGGGGAGAA GGAGGAGGAA 
GATAAGGAGG ATGAGGAGAA GCCTAAGATT GAGGATGTGG GATCTGATGA GGAGGATGAC 
AGCGGCAAAG ATAAGAAAAA GAAAACAAAG AAGATCAAGG AGAAGTACAT TGACCAGGAA 
GAGCTGAATA AGACGAAGCC CATCTGGACC AGAAATCCTG ATGACATCAC TCAAGAGGAA 
TATGGTGAAT TCTACAAGAG CCTCACCAAT GACTGGGAAG ACCACTTGGC AGTCAAGCAC 
TTCTCTGTAG AAGGGCAGTT GGAATTCAGG GCATTGCTCT TCATTCCCCG GCGAGCTCCC 
TTTGACCTCT TTGAGAACAA GAAGAAGAAG AACAACATCA AATTGTATGT CCGTCGTGTG 
TTCATCATGG ACAGCTGTGA TGAGCTGATA CCTGAGTACC TCAACTTCAT CCGTGGTGTG 
GTTGATTCCG AGGACCTGCC TCTGAACATC TCCCGAGAAA TGCTCCAGCA GAGCAAGATC 
CTGAAAGTCA TCCGCAAAAA CATTGTGAAG AAGTGCCTTG AGCTCTTCTC TGAGTTGGCT 
GAAGACAAAG AGAACTACAA GAAATTTTAT GAGGCATTCT CTAAGAATTT AAAGCTTGGA 
ATCCATGAGG ATTCCACTAA CCGTCGCCGC CTCTCTGAGC TCCTTCGCTA CCATACCTCT 
CAGTCTGGAG ATGAGATGAC TTCCCTGTCA GAGTATGTGT CTCGCATGAA GGAGACACAG 
AAGTCCATCT ACTATATCAC TGGTGAGAGC AAAGAGCAGG TGGCCAACTC TGCCTTCGTG 
GAGCGTGTGC GGAAACGGGG CTTTGAGGTG GTATACATGA CTGAGCCCAT TGATGAGTAC 
TGCGTACAGC AGCTCAAGGA GTTCGATGGC AAGAGCCTGG TCTCCGTGAC CAAGGAGGGC 
CTGGAGCTAC CAGAGGATGA GGAAGAGAAG AAAAAAATGG AGGAGAGCAA GGCAAAGTTT 
GAGAATCTCT GCAAGCTCAT GAAGGAGATC TTGGACAAGA AGGTTGAAAA AGTGACTATC 
TCCAATAGGC TTGTGTCTTC CCCCTGCTGC ATTGTGACCA GCACCTACGG CTGGACAGCC 
AACATGGAAC GGATTATGAA GGCCCAGGCA CTGCGGGACA ACTCGACAAT GGGCTACATG 
ATGGCCAAGA AACACCTAGA GATCAACCCT GACCACCCCA TTGTGGAGAC TCTGCGGCAG 
AAGGCTGAGG CAGACAAAAA CGACAAAGCT GTCAAAGACC TGGTGGTGCT GCTGTTTGAG 
ACTGCTCTGC TCTCCTCTGG CTTCTCACTT GAGGACCCCC AAACCCACTC CAACCGCATC 
TACCGCATGA TTAAACTAGG CCTGGGCATT GATGAAGATG AGGTCACTGC AGAAGAGCCC 
AGTGCTGCTG TTCCCGATGA GATCCCCCCA CTGGAGGGTG ATGAGGATGC CTCTCGCATG 
GAAGAAGTGG ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004082.3
CDS	46..2220
Translation	MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKEDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVTAEEPSAAVPDEIPPLEGDEDASRMEEVD

Target ORF information:

RefSeq Version	NM_001004082.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus heat shock protein 90 alpha family class B member 1 (Hsp90ab1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004082.3

ORF Insert Sequence:

ATGCCTGAGG AAGTGCACCA TGGAGAGGAA GAGGTGGAGA CCTTCGCCTT TCAGGCAGAA 
ATTGCCCAGC TGATGTCCCT CATCATCAAC ACTTTCTACT CAAACAAAGA GATTTTCCTC 
CGGGAGTTGA TCTCTAATGC TTCTGATGCC CTGGACAAGA TTCGGTATGA GAGCCTGACT 
GACCCTTCCA AGTTGGACAG CGGGAAAGAG CTGAAGATTG ACATCATCCC CAACCCTCAG 
GAACGCACGC TGACTTTGGT GGACACAGGC ATTGGCATGA CCAAGGCTGA CCTCATAAAT 
AACTTGGGAA CCATTGCTAA GTCTGGTACA AAGGCGTTCA TGGAGGCTCT CCAGGCTGGT 
GCAGACATCT CCATGATTGG GCAGTTTGGT GTCGGCTTCT ACTCTGCCTA CCTGGTGGCA 
GAGAAAGTGG TTGTGATCAC GAAGCACAAC GATGATGAGC AGTATGCCTG GGAGTCTTCT 
GCTGGTGGAT CCTTCACTGT CCGTGCAGAC CACGGTGAGC CCATTGGCCG GGGTACCAAA 
GTGATCCTTC ACCTCAAAGA AGACCAGACA GAGTACTTAG AGGAGAGGAG GGTCAAGGAG 
GTGGTGAAGA AACACTCACA GTTCATAGGC TACCCCATCA CCCTCTATCT GGAGAAGGAA 
CGCGAGAAGG AGATCAGTGA TGATGAGGCA GAGGAAGAGA AAGGGGAGAA GGAGGAGGAA 
GATAAGGAGG ATGAGGAGAA GCCTAAGATT GAGGATGTGG GATCTGATGA GGAGGATGAC 
AGCGGCAAAG ATAAGAAAAA GAAAACAAAG AAGATCAAGG AGAAGTACAT TGACCAGGAA 
GAGCTGAATA AGACGAAGCC CATCTGGACC AGAAATCCTG ATGACATCAC TCAAGAGGAA 
TATGGTGAAT TCTACAAGAG CCTCACCAAT GACTGGGAAG ACCACTTGGC AGTCAAGCAC 
TTCTCTGTAG AAGGGCAGTT GGAATTCAGG GCATTGCTCT TCATTCCCCG GCGAGCTCCC 
TTTGACCTCT TTGAGAACAA GAAGAAGAAG AACAACATCA AATTGTATGT CCGTCGTGTG 
TTCATCATGG ACAGCTGTGA TGAGCTGATA CCTGAGTACC TCAACTTCAT CCGTGGTGTG 
GTTGATTCCG AGGACCTGCC TCTGAACATC TCCCGAGAAA TGCTCCAGCA GAGCAAGATC 
CTGAAAGTCA TCCGCAAAAA CATTGTGAAG AAGTGCCTTG AGCTCTTCTC TGAGTTGGCT 
GAAGACAAAG AGAACTACAA GAAATTTTAT GAGGCATTCT CTAAGAATTT AAAGCTTGGA 
ATCCATGAGG ATTCCACTAA CCGTCGCCGC CTCTCTGAGC TCCTTCGCTA CCATACCTCT 
CAGTCTGGAG ATGAGATGAC TTCCCTGTCA GAGTATGTGT CTCGCATGAA GGAGACACAG 
AAGTCCATCT ACTATATCAC TGGTGAGAGC AAAGAGCAGG TGGCCAACTC TGCCTTCGTG 
GAGCGTGTGC GGAAACGGGG CTTTGAGGTG GTATACATGA CTGAGCCCAT TGATGAGTAC 
TGCGTACAGC AGCTCAAGGA GTTCGATGGC AAGAGCCTGG TCTCCGTGAC CAAGGAGGGC 
CTGGAGCTAC CAGAGGATGA GGAAGAGAAG AAAAAAATGG AGGAGAGCAA GGCAAAGTTT 
GAGAATCTCT GCAAGCTCAT GAAGGAGATC TTGGACAAGA AGGTTGAAAA AGTGACTATC 
TCCAATAGGC TTGTGTCTTC CCCCTGCTGC ATTGTGACCA GCACCTACGG CTGGACAGCC 
AACATGGAAC GGATTATGAA GGCCCAGGCA CTGCGGGACA ACTCGACAAT GGGCTACATG 
ATGGCCAAGA AACACCTAGA GATCAACCCT GACCACCCCA TTGTGGAGAC TCTGCGGCAG 
AAGGCTGAGG CAGACAAAAA CGACAAAGCT GTCAAAGACC TGGTGGTGCT GCTGTTTGAG 
ACTGCTCTGC TCTCCTCTGG CTTCTCACTT GAGGACCCCC AAACCCACTC CAACCGCATC 
TACCGCATGA TTAAACTAGG CCTGGGCATT GATGAAGATG AGGTCACTGC AGAAGAGCCC 
AGTGCTGCTG TTCCCGATGA GATCCCCCCA CTGGAGGGTG ATGAGGATGC CTCTCGCATG 
GAAGAAGTGG ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Interaction of a Novel Chaperone PhLP2A With the Heat Shock Protein Hsp90.
Journal of cellular biochemistry118(2)420-429(2017 Feb)
Krzemie?-Ojak ?,G?ral A,Joachimiak E,Filipek A,Fabczak H

REV-ERB? influences the stability and nuclear localization of the glucocorticoid receptor.
Journal of cell science129(21)4143-4154(2016 11)
Okabe T,Chavan R,Fonseca Costa SS,Brenna A,Ripperger JA,Albrecht U

Hsp90? is involved in the development of high salt-diet-induced nephropathy via interaction with various signalling proteins.
Open biology6(4)150159(2016 Apr)
Yan SH,Zhao NW,Jiang WM,Wang XT,Zhang SQ,Zhu XX,Zhang CB,Gao YH,Gao F,Liu FM,Fang ZY

The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90.
Scientific reports517058(2015 Nov)
Haslbeck V,Eckl JM,Drazic A,Rutz DA,Lorenz OR,Zimmermann K,Kriehuber T,Lindemann C,Madl T,Richter K

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

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Hsp90ab1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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