Pias1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pias1
Entrez Gene ID	300772
Full Name	protein inhibitor of activated STAT, 1
General protein information	Preferred Names protein inhibitor of activated STAT, 1 Names E3 SUMO-protein ligase PIAS1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q24

mRNA and Protein(s)

mRNA	Protein	Name
NM_001106829.2	NP_001100299.2	E3 SUMO-protein ligase PIAS1

Pathways from BioSystems

Homologies

Homo sapiens (human)	PIAS1	NP_057250.1
Canis lupus familiaris (dog)	PIAS1	XP_535524.2
Bos taurus (cattle)	PIAS1	NP_001068864.1
Mus musculus (house mouse)	Pias1	NP_062637.2
Pan troglodytes (chimpanzee)	PIAS1	XP_523109.3
Drosophila melanogaster (fruit fly)	Su(var)2-10	NP_001188888.1
	PIAS1	XP_001082929.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005031	XP_313897.4
Rattus norvegicus (Norway rat)	Pias1	NP_001100299.2
Gallus gallus (chicken)	PIAS1	NP_001026627.1
Xenopus tropicalis (tropical clawed frog)	pias1	XP_002932990.1

Gene Ontology
Bibliography

Related articles in PubMed

CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory.
Chen YC, Hsu WL, Ma YL, Tai DJ, Lee EH
The Journal of neuroscience : the official journal of the Society for Neuroscience34(29)9574-89(2014 Jul)

Protein inhibitor of activated STAT 1 (PIAS1) is identified as the SUMO E3 ligase of CCAAT/enhancer-binding protein ? (C/EBP?) during adipogenesis.
Liu Y, Zhang YD, Guo L, Huang HY, Zhu H, Huang JX, Liu Y, Zhou SR, Dang YJ, Li X, Tang QQ
Molecular and cellular biology33(22)4606-17(2013 Nov)

Push back to respond better: regulatory inhibition of the DNA double-strand break response.
Panier S, Durocher D
Nature reviews. Molecular cell biology14(10)661-72(2013 Oct)

NMDA receptor signaling mediates the expression of protein inhibitor of activated STAT1 (PIAS1) in rat hippocampus.
Liu SY, Ma YL, Lee EH
Neuropharmacology65101-13(2013 Feb)

Forkhead box protein A2 (FOXA2) protein stability and activity are regulated by sumoylation.
Belaguli NS, Zhang M, Brunicardi FC, Berger DH
PloS one7(10)e48019(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study provide the first evidence that CREB could be SUMO-modified by the E3 ligase PIAS1 and that CREB SUMOylation plays an important role in spatial memory formation
Title: CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory.

PIAS1 may function as an immediate early gene in an activity-dependent manner: its expression is rapidly induced upon NMDA receptor activation in rat hippocampus.
Title: NMDA receptor signaling mediates the expression of protein inhibitor of activated STAT1 (PIAS1) in rat hippocampus.

PIAS1 could augment anti-inflammatory activity by inhibiting STAT1, thus attenuating the severity of SAP associated with acute lung injury
Title: Upregulation of PIAS1 protects against sodium taurocholate-induced severe acute pancreatitis associated with acute lung injury.

SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b.
Title: SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b.

The results indicated that in the cerulein-stimulated PIASI silencing cells, the activity of p38 MAP kinase was enhanced, while the levels of inflammatory mediators were markedly higher than those of other cerulein-stimulated cells.
Title: SiRNA-mediated PIAS1 silencing promotes inflammatory response and leads to injury of cerulein-stimulated pancreatic acinar cells via regulation of the P38MAPK signaling pathway.

The following Pias1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pias1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02295	NM_001106829.2 Latest version!	Rattus norvegicus protein inhibitor of activated STAT, 1 (Pias1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$384.30 $549.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pias1 ( NM_001106829.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100299.2 Rattus norvegicus protein inhibitor of activated STAT, 1 (Pias1), mRNA.

Price & Availability↑

CloneID	ORa02295
Clone ID Related Accession (Same CDS sequence)	NM_001106829.2
Accession Version	NM_001106829.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1956bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-07-06
Organism	Rattus norvegicus(Norway rat)
Product	E3 SUMO-protein ligase PIAS1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY644724.1. On Jan 13, 2008 this sequence version replaced NM_001106829.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY644724.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGACA GTGCGGAACT AAAGCAAATG GTTATGAGCC TTAGAGTTTC TGAACTCCAA 
GTACTGTTGG GCTACGCTGG GAGAAACAAG CACGGACGCA AACACGAACT TCTTACAAAA 
GCCCTGCATT TGTTAAAGGC TGGCTGTAGT CCTGCTGTAC AAATGAAAAT TAAAGAACTC 
TACAGGCGGC GGTTCCCTCA GAAAATTATG ACACCTGCGG ACTTGTCTAT CCCCAACGTA 
CATTCAAGTC CTATGCCAGC GACTCTTTCT CCATCCACCA TTCCACAGCT CACTTACGAT 
GGTCACCCTG CATCGTCCCC ATTACTCCCT GTTTCTCTTC TGGGACCTAA ACATGAACTG 
GAACTCCCAC ATCTCACATC AGCGCTGCAC CCAGTCCATC CGGACATAAA GCTGCAAAAG 
CTACCATTCT ATGACCTGCT GGACGAACTG ATCAAACCCA CCAGTCTAGC TTCAGACAAC 
AGCCAGCGCT TTCGGGAAAC CTGTTTTGCA TTTGCCTTGA CACCACAACA GGTGCAGCAG 
ATCGGCAGCT CCATGGATAT TTCTGGGACC AAATGTGACT TCACAGTGCA GGTCCAATTA 
AGGTTTTGTT TATCAGAAAC CAGTTGTCCA CAAGAAGATC ACTTCCCACC CAATCTTTGT 
GTAAAAGTGA ATACAAAACC TTGCAGCCTT CCAGGTTACC TTCCACCTAC TAAAAATGGT 
GTGGAACCAA AGCGACCTAG CCGACCAATT AATATCACCT CACTTGTCCG ATTGTCCACG 
ACAGTACCAA ATACCATTGT TGTTTCTTGG ACTGCAGAAA TTGGAAGAAC CTATTCCATG 
GCAGTATATC TTGTAAAACA GTTGTCCTCA ACAGTTCTTC TTCAGAGGTT ACGAGCAAAG 
GGGATAAGGA ATCCGGATCA TTCTAGAGCT TTAATTAAAG AGAAGTTAAC TGCAGATCCA 
GATAGTGAGA TAGCTACTAC CAGCCTACGG GTTTCGCTGC TGTGTCCACT TGGGAAAATG 
CGACTGACAA TTCCATGTCG GGCACTTACC TGTTCCCACC TCCAGTGTTT TGATGCAACT 
CTTTATATTC AAATGAATGA GAAAAAGCCA ACATGGGTTT GTCCTGTGTG TGATAAGAAG 
GCCCCATATG AACACCTCAT TATTGATGGG TTGTTTATGG AAATCCTAAA GTACTGTACA 
GACTGTGACG AGATACAGTT TAAGGAGGAT GGCTCGTGGG CTCCGATGAG GTCAAAAAAG 
GAAGTGCAAG AAGTCACTGC CTCCTACAAT GGGGTCGATG GATGCTTGAG CTCCACATTG 
GAGCATCAGG TGGCTTCCCA CAACCAGTCT TCAAATAAAA ACAAGAAAGT GGAGGTGATT 
GACCTAACCA TTGACAGTTC ATCAGATGAA GAGGAGGAAG AACCCCCTGC CAAGAGGACC 
TGTCCTTCCC TGTCTCCTAC GTCACCACTA AGTAATAAAG GCATCTTAAG TCTTCCTCAT 
CAAGCATCGC CTGTGTCCCG CACCCCAAGC CTTCCTGCTG TAGATACAAG CTACATCAAC 
ACCTCCCTCA TCCAGGACTA CAGACACCCT TTCCACATGA CGCCCATGCC TTATGACTTA 
CAAGGATTAG ATTTCTTTCC TTTCTTATCA GGAGACAATC AGCATTACAA CACCTCCCTG 
CTTGCCGCAG CGGCAGCTGC GGTCTCAGAT GACCAGGACC TCCTGCACTC CTCCCGATTT 
TTCCCGTATA CCTCCTCGCA GATGTTTCTC GATCAGCTAA GTGCAGGAGG GAGCACTTCT 
CTGCCAGCCA CCAATGGAAG CAGTAGTGGC AGCAACAGCA GCCTTGTGTC TTCCAACAGT 
CTGAGGGAGA GCCATGGCCA TGGTGTGGCC AGCAGGAGCA GCGCAGACAC GGCATCCATC 
TTTGGCATCA TACCAGACAT TATCTCGTTG GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100299.2
CDS	25..1980
Translation	MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELYRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQIGSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNGVEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRTYSMAVYLVKQLSSTVLLQRLRAKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLLCPLGKMRLTIPCRALTCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYCTDCDEIQFKEDGSWAPMRSKKEVQEVTASYNGVDGCLSSTLEHQVASHNQSSNKNKKVEVIDLTIDSSSDEEEEEPPAKRTCPSLSPTSPLSNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDLQGLDFFPFLSGDNQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSAGGSTSLPATNGSSSGSNSSLVSSNSLRESHGHGVASRSSADTASIFGIIPDIISLD

Target ORF information:

RefSeq Version	NM_001106829.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein inhibitor of activated STAT, 1 (Pias1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106829.2

ORF Insert Sequence:

ATGGCGGACA GTGCGGAACT AAAGCAAATG GTTATGAGCC TTAGAGTTTC TGAACTCCAA 
GTACTGTTGG GCTACGCTGG GAGAAACAAG CACGGACGCA AACACGAACT TCTTACAAAA 
GCCCTGCATT TGTTAAAGGC TGGCTGTAGT CCTGCTGTAC AAATGAAAAT TAAAGAACTC 
TACAGGCGGC GGTTCCCTCA GAAAATTATG ACACCTGCGG ACTTGTCTAT CCCCAACGTA 
CATTCAAGTC CTATGCCAGC GACTCTTTCT CCATCCACCA TTCCACAGCT CACTTACGAT 
GGTCACCCTG CATCGTCCCC ATTACTCCCT GTTTCTCTTC TGGGACCTAA ACATGAACTG 
GAACTCCCAC ATCTCACATC AGCGCTGCAC CCAGTCCATC CGGACATAAA GCTGCAAAAG 
CTACCATTCT ATGACCTGCT GGACGAACTG ATCAAACCCA CCAGTCTAGC TTCAGACAAC 
AGCCAGCGCT TTCGGGAAAC CTGTTTTGCA TTTGCCTTGA CACCACAACA GGTGCAGCAG 
ATCGGCAGCT CCATGGATAT TTCTGGGACC AAATGTGACT TCACAGTGCA GGTCCAATTA 
AGGTTTTGTT TATCAGAAAC CAGTTGTCCA CAAGAAGATC ACTTCCCACC CAATCTTTGT 
GTAAAAGTGA ATACAAAACC TTGCAGCCTT CCAGGTTACC TTCCACCTAC TAAAAATGGT 
GTGGAACCAA AGCGACCTAG CCGACCAATT AATATCACCT CACTTGTCCG ATTGTCCACG 
ACAGTACCAA ATACCATTGT TGTTTCTTGG ACTGCAGAAA TTGGAAGAAC CTATTCCATG 
GCAGTATATC TTGTAAAACA GTTGTCCTCA ACAGTTCTTC TTCAGAGGTT ACGAGCAAAG 
GGGATAAGGA ATCCGGATCA TTCTAGAGCT TTAATTAAAG AGAAGTTAAC TGCAGATCCA 
GATAGTGAGA TAGCTACTAC CAGCCTACGG GTTTCGCTGC TGTGTCCACT TGGGAAAATG 
CGACTGACAA TTCCATGTCG GGCACTTACC TGTTCCCACC TCCAGTGTTT TGATGCAACT 
CTTTATATTC AAATGAATGA GAAAAAGCCA ACATGGGTTT GTCCTGTGTG TGATAAGAAG 
GCCCCATATG AACACCTCAT TATTGATGGG TTGTTTATGG AAATCCTAAA GTACTGTACA 
GACTGTGACG AGATACAGTT TAAGGAGGAT GGCTCGTGGG CTCCGATGAG GTCAAAAAAG 
GAAGTGCAAG AAGTCACTGC CTCCTACAAT GGGGTCGATG GATGCTTGAG CTCCACATTG 
GAGCATCAGG TGGCTTCCCA CAACCAGTCT TCAAATAAAA ACAAGAAAGT GGAGGTGATT 
GACCTAACCA TTGACAGTTC ATCAGATGAA GAGGAGGAAG AACCCCCTGC CAAGAGGACC 
TGTCCTTCCC TGTCTCCTAC GTCACCACTA AGTAATAAAG GCATCTTAAG TCTTCCTCAT 
CAAGCATCGC CTGTGTCCCG CACCCCAAGC CTTCCTGCTG TAGATACAAG CTACATCAAC 
ACCTCCCTCA TCCAGGACTA CAGACACCCT TTCCACATGA CGCCCATGCC TTATGACTTA 
CAAGGATTAG ATTTCTTTCC TTTCTTATCA GGAGACAATC AGCATTACAA CACCTCCCTG 
CTTGCCGCAG CGGCAGCTGC GGTCTCAGAT GACCAGGACC TCCTGCACTC CTCCCGATTT 
TTCCCGTATA CCTCCTCGCA GATGTTTCTC GATCAGCTAA GTGCAGGAGG GAGCACTTCT 
CTGCCAGCCA CCAATGGAAG CAGTAGTGGC AGCAACAGCA GCCTTGTGTC TTCCAACAGT 
CTGAGGGAGA GCCATGGCCA TGGTGTGGCC AGCAGGAGCA GCGCAGACAC GGCATCCATC 
TTTGGCATCA TACCAGACAT TATCTCGTTG GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory.
The Journal of neuroscience : the official journal of the Society for Neuroscience34(29)9574-89(2014 Jul)
Chen YC,Hsu WL,Ma YL,Tai DJ,Lee EH

Protein inhibitor of activated STAT 1 (PIAS1) is identified as the SUMO E3 ligase of CCAAT/enhancer-binding protein ? (C/EBP?) during adipogenesis.
Molecular and cellular biology33(22)4606-17(2013 Nov)
Liu Y,Zhang YD,Guo L,Huang HY,Zhu H,Huang JX,Liu Y,Zhou SR,Dang YJ,Li X,Tang QQ

Push back to respond better: regulatory inhibition of the DNA double-strand break response.
Nature reviews. Molecular cell biology14(10)661-72(2013 Oct)
Panier S,Durocher D

NMDA receptor signaling mediates the expression of protein inhibitor of activated STAT1 (PIAS1) in rat hippocampus.
Neuropharmacology65101-13(2013 Feb)
Liu SY,Ma YL,Lee EH

Forkhead box protein A2 (FOXA2) protein stability and activity are regulated by sumoylation.
PloS one7(10)e48019(2012)
Belaguli NS,Zhang M,Brunicardi FC,Berger DH

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Pias1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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