Hexa cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hexa
Entrez Gene ID	300757
Full Name	hexosaminidase subunit alpha
General protein information	Preferred Names hexosaminidase subunit alpha Names beta-hexosaminidase subunit alpha Hexose aminidase A (alpha polypeptide) N-acetyl-beta-glucosaminidase subunit alpha beta-N-acetylhexosaminidase subunit alpha hexosaminidase A hexosaminidase subunit A
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q24
Summary	mouse homolog is the alpha subunit of lysosomal beta-hexosaminidase A [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017595561.1	XP_017451050.1	beta-hexosaminidase subunit alpha isoform X1
NM_001004443.1	NP_001004443.1	beta-hexosaminidase subunit alpha precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	HEXA	NP_000511.2
	HEXA	XP_001092589.1
Canis lupus familiaris (dog)	HEXA	XP_544758.2
Danio rerio (zebrafish)	zgc:112084	NP_001017763.1
Bos taurus (cattle)	HEXA	NP_001068632.1
Rattus norvegicus (Norway rat)	Hexa	NP_001004443.1
Gallus gallus (chicken)	HEXA	NP_001025561.1
Mus musculus (house mouse)	Hexa	NP_034551.2
Arabidopsis thaliana (thale cress)	HEXO3	NP_176737.2
Pan troglodytes (chimpanzee)	HEXA	XP_001175124.1
Oryza sativa (rice)	Os05g0415700	NP_001055557.1
Oryza sativa (rice)	Os01g0891000	NP_001045052.1

Gene Ontology
Bibliography

Related articles in PubMed

Murine Sialidase Neu3 facilitates GM2 degradation and bypass in mouse model of Tay-Sachs disease.
Seyrantepe V, Demir SA, Timur ZK, Von Gerichten J, Marsching C, Erdemli E, Oztas E, Takahashi K, Yamaguchi K, Ates N, D?nmez Demir B, Dalkara T, Erich K, Hopf C, Sandhoff R, Miyagi T
Experimental neurology299(Pt A)26-41(2018 Jan)

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
Thaysen-Andersen M, Venkatakrishnan V, Loke I, Laurini C, Diestel S, Parker BL, Packer NH
The Journal of biological chemistry290(14)8789-802(2015 Apr)

TGF-?/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos.
Redshaw N, Camps C, Sharma V, Motallebipour M, Guzman-Ayala M, Oikonomopoulos S, Thymiakou E, Ragoussis J, Episkopou V
PloS one8(1)e55186(2013)

Defining the membrane proteome of NK cells.
Ghosh D, Lippert D, Krokhin O, Cortens JP, Wilkins JA
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)

Late onset Tay-Sachs disease in mice with targeted disruption of the Hexa gene: behavioral changes and pathology of the central nervous system.
Miklyaeva EI, Dong W, Bureau A, Fattahie R, Xu Y, Su M, Fick GH, Huang JQ, Igdoura S, Hanai N, Gravel RA
Brain research1001(1-2)37-50(2004 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

different regulatory factors are responsible for onset of Hex expression in these cell types during development.
Title: Postnatal development and regulation of beta-hexosaminidase in epithelial cells of the rat epididymis.

The following Hexa gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hexa cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10373	NM_001004443.1 Latest version!	Rattus norvegicus hexosaminidase subunit alpha (Hexa), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$314.30 $449.00
ORa31227	XM_017595561.1 Latest version!	Rattus norvegicus hexosaminidase subunit alpha (Hexa), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hexa ( NM_001004443.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001004443.1 Rattus norvegicus hexosaminidase subunit alpha (Hexa), mRNA.

Price & Availability↑

CloneID	ORa10373
Clone ID Related Accession (Same CDS sequence)	NM_001004443.1
Accession Version	NM_001004443.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1587bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Rattus norvegicus(Norway rat)
Product	beta-hexosaminidase subunit alpha precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC082097.1. On Sep 17, 2004 this sequence version replaced XM_217144.2. Sequence Note: This sequence has been modified as follows: removed 35 bp suspected to be vector contamination from the 3' end. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC082097.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCGGCT GCAGGCTCTG GGTTTCGCTG CTGCTGGCGG CGGCGTTGGC TTGCTTGGCC 
ACGGCGCTGT GGCCCTGGCC CCAGTACATC CAAACCTCCC ACCGGCGCTA CACCCTGTAC 
CCCAACAACT TCCAGTTCCG GTACCATGCC GGTTCGGCCG CGCAGGCGGG CTGCGTTGTC 
CTCGACGAGG CCTTTCGACG CTACCGTAGC CTGCTCTTCG GTTCCGGCTC TTGGCCCCGA 
CCCAGCTTCT CAAAAAAACA GCAGCCGTTG GGGAAGAACA TTCTGATGGT CTCTGTCGTC 
ACAGCCGAAT GTAATGAGTT TCCTAATTTG GAGTCCGTAG AAAATTACAC CCTAACCATT 
AATGATGACC AGTGTTTACT CTCCTCTGAG ACTGTCTGGG GCGCTCTGCG AGGTCTGGAG 
ACTTTCAGTC AGCTTGTTTG GAAGTCAGCT GAGGGCACGT TCTTTATCAA CAAGACAAAG 
ATTACAGACT TTCCTCGATT CCCTCACCGG GGCATACTGC TGGATACATC TCGCCATTAC 
CTGCCGTTAT CTAGCATCCT GAACACACTG GATGTCATGG CGTACAATAA ATTCAACGTG 
TTCCACTGGC ACTTGGTGGA CGACTCTTCC TTCCCATACG AGAGCTTCAC CTTCCCAGAG 
CTCACCAGAA AGGGGTCCTT CAACCCTGTT ACCCACATCT ACACAGCACA GGATGTGAAG 
GAGGTCATTG AATATGCAAG GCTTCGGGGT ATCCGAGTGC TGGCCGAATT TGACACTCCT 
GGCCACACTT TGTCCTGGGG GGCAGGTGTC CCTGGATTAT TAACACCTTG CTACTCTGGG 
TCCCGTCTCT CTGGCACCTA TGGACCTGTG AACCCCAGCC TCAACAGCAC CTACGACTTC 
ATGAGCACAT TCTTCCTGGA GATCAGCTCT GTCTTCCCTG ACTTTTATCT CCACCTGGGA 
GGAGATGAAG TTGACTTCAC CTGCTGGAAG TCCAACCCCA ACATCCAGGC CTTCATGAAG 
AAAAAGGGCT TTACTGACTA CAAGCAGCTG GAGTCATTCT ACATCCAGAC GCTGCTGGAC 
ATCGTCTCTG ATTATGACAA GGGCTATGTG GTGTGGCAGG AAGTATTTGA TAATAAAGTG 
AAGGTTCGGC CAGACACAAT CATACAGGTG TGGCGGGAAG AGATGCCGGT CCAGTACATG 
AAGGAGATAG AGGCCATCAC CCAGGCTGGC TTCCGGGCCC TGCTGTCTGC TCCCTGGTAC 
CTGAACCGGG TGAAGTATGG CCCTGACTGG AAGGAAATGT ACAAAGTGGA GCCCCTGGCA 
TTTCGTGGTA CACCTGCACA AAAGGCTCTG GTCATTGGAG GGGAAGCCTG TATGTGGGGA 
GAGTATGTGG ACAGCACAAA CCTTGTCCCC AGGCTCTGGC CCAGAGCAGG TGCCATTGCC 
GAAAGACTGT GGAGCAGTAA CCTGACGACT AATATGGACT TTGCCTTTAA ACGTCTGTCC 
CATTTCCGCT GTGAGCTGCT GAGGAGAGGA ATCCAGGCCC AGCCCATCAG CGTGGGCTAC 
TGTGAGCAGG AGTTTGAGCA TACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001004443.1
CDS	32..1618
Translation	MAGCRLWVSLLLAAALACLATALWPWPQYIQTSHRRYTLYPNNFQFRYHAGSAAQAGCVVLDEAFRRYRSLLFGSGSWPRPSFSKKQQPLGKNILMVSVVTAECNEFPNLESVENYTLTINDDQCLLSSETVWGALRGLETFSQLVWKSAEGTFFINKTKITDFPRFPHRGILLDTSRHYLPLSSILNTLDVMAYNKFNVFHWHLVDDSSFPYESFTFPELTRKGSFNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGAGVPGLLTPCYSGSRLSGTYGPVNPSLNSTYDFMSTFFLEISSVFPDFYLHLGGDEVDFTCWKSNPNIQAFMKKKGFTDYKQLESFYIQTLLDIVSDYDKGYVVWQEVFDNKVKVRPDTIIQVWREEMPVQYMKEIEAITQAGFRALLSAPWYLNRVKYGPDWKEMYKVEPLAFRGTPAQKALVIGGEACMWGEYVDSTNLVPRLWPRAGAIAERLWSSNLTTNMDFAFKRLSHFRCELLRRGIQAQPISVGYCEQEFEHT

Target ORF information:

RefSeq Version	NM_001004443.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus hexosaminidase subunit alpha (Hexa), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001004443.1

ORF Insert Sequence:

ATGGCCGGCT GCAGGCTCTG GGTTTCGCTG CTGCTGGCGG CGGCGTTGGC TTGCTTGGCC 
ACGGCGCTGT GGCCCTGGCC CCAGTACATC CAAACCTCCC ACCGGCGCTA CACCCTGTAC 
CCCAACAACT TCCAGTTCCG GTACCATGCC GGTTCGGCCG CGCAGGCGGG CTGCGTTGTC 
CTCGACGAGG CCTTTCGACG CTACCGTAGC CTGCTCTTCG GTTCCGGCTC TTGGCCCCGA 
CCCAGCTTCT CAAAAAAACA GCAGCCGTTG GGGAAGAACA TTCTGATGGT CTCTGTCGTC 
ACAGCCGAAT GTAATGAGTT TCCTAATTTG GAGTCCGTAG AAAATTACAC CCTAACCATT 
AATGATGACC AGTGTTTACT CTCCTCTGAG ACTGTCTGGG GCGCTCTGCG AGGTCTGGAG 
ACTTTCAGTC AGCTTGTTTG GAAGTCAGCT GAGGGCACGT TCTTTATCAA CAAGACAAAG 
ATTACAGACT TTCCTCGATT CCCTCACCGG GGCATACTGC TGGATACATC TCGCCATTAC 
CTGCCGTTAT CTAGCATCCT GAACACACTG GATGTCATGG CGTACAATAA ATTCAACGTG 
TTCCACTGGC ACTTGGTGGA CGACTCTTCC TTCCCATACG AGAGCTTCAC CTTCCCAGAG 
CTCACCAGAA AGGGGTCCTT CAACCCTGTT ACCCACATCT ACACAGCACA GGATGTGAAG 
GAGGTCATTG AATATGCAAG GCTTCGGGGT ATCCGAGTGC TGGCCGAATT TGACACTCCT 
GGCCACACTT TGTCCTGGGG GGCAGGTGTC CCTGGATTAT TAACACCTTG CTACTCTGGG 
TCCCGTCTCT CTGGCACCTA TGGACCTGTG AACCCCAGCC TCAACAGCAC CTACGACTTC 
ATGAGCACAT TCTTCCTGGA GATCAGCTCT GTCTTCCCTG ACTTTTATCT CCACCTGGGA 
GGAGATGAAG TTGACTTCAC CTGCTGGAAG TCCAACCCCA ACATCCAGGC CTTCATGAAG 
AAAAAGGGCT TTACTGACTA CAAGCAGCTG GAGTCATTCT ACATCCAGAC GCTGCTGGAC 
ATCGTCTCTG ATTATGACAA GGGCTATGTG GTGTGGCAGG AAGTATTTGA TAATAAAGTG 
AAGGTTCGGC CAGACACAAT CATACAGGTG TGGCGGGAAG AGATGCCGGT CCAGTACATG 
AAGGAGATAG AGGCCATCAC CCAGGCTGGC TTCCGGGCCC TGCTGTCTGC TCCCTGGTAC 
CTGAACCGGG TGAAGTATGG CCCTGACTGG AAGGAAATGT ACAAAGTGGA GCCCCTGGCA 
TTTCGTGGTA CACCTGCACA AAAGGCTCTG GTCATTGGAG GGGAAGCCTG TATGTGGGGA 
GAGTATGTGG ACAGCACAAA CCTTGTCCCC AGGCTCTGGC CCAGAGCAGG TGCCATTGCC 
GAAAGACTGT GGAGCAGTAA CCTGACGACT AATATGGACT TTGCCTTTAA ACGTCTGTCC 
CATTTCCGCT GTGAGCTGCT GAGGAGAGGA ATCCAGGCCC AGCCCATCAG CGTGGGCTAC 
TGTGAGCAGG AGTTTGAGCA TACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hexa ( XM_017595561.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017451050.1 Rattus norvegicus hexosaminidase subunit alpha (Hexa), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa31227
Clone ID Related Accession (Same CDS sequence)	XM_017595561.1
Accession Version	XM_017595561.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1302bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	beta-hexosaminidase subunit alpha isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTCTCTG TCGTCACAGC CGAATGTAAT GAGTTTCCTA ATTTGGAGTC CGTAGAAAAT 
TACACCCTAA CCATTAATGA TGACCAGTGT TTACTCTCCT CTGAGACTGT CTGGGGCGCT 
CTGCGAGGTC TGGAGACTTT CAGTCAGCTT GTTTGGAAGT CAGCTGAGGG CACGTTCTTT 
ATCAACAAGA CAAAGATTAC AGACTTTCCT CGATTCCCTC ACCGGGGCAT ACTGCTGGAT 
ACATCTCGCC ATTACCTGCC GTTATCTAGC ATCCTGAACA CACTGGATGT CATGGCGTAC 
AATAAATTCA ACGTGTTCCA CTGGCACTTG GTGGACGACT CTTCCTTCCC ATACGAGAGC 
TTCACCTTCC CAGAGCTCAC CAGAAAGGGG TCCTTCAACC CTGTTACCCA CATCTACACA 
GCACAGGATG TGAAGGAGGT CATTGAATAT GCAAGGCTTC GGGGTATCCG AGTGCTGGCC 
GAATTTGACA CTCCTGGCCA CACTTTGTCC TGGGGGGCAG GTGTCCCTGG ATTATTAACA 
CCTTGCTACT CTGGGTCCCG TCTCTCTGGC ACCTATGGAC CTGTGAACCC CAGCCTCAAC 
AGCACCTACG ACTTCATGAG CACATTCTTC CTGGAGATCA GCTCTGTCTT CCCTGACTTT 
TATCTCCACC TGGGAGGAGA TGAAGTTGAC TTCACCTGCT GGAAGTCCAA CCCCAACATC 
CAGGCCTTCA TGAAGAAAAA GGGCTTTACT GACTACAAGC AGCTGGAGTC ATTCTACATC 
CAGACGCTGC TGGACATCGT CTCTGATTAT GACAAGGGCT ATGTGGTGTG GCAGGAAGTA 
TTTGATAATA AAGTGAAGGT TCGGCCAGAC ACAATCATAC AGGTGTGGCG GGAAGAGATG 
CCGGTCCAGT ACATGAAGGA GATAGAGGCC ATCACCCAGG CTGGCTTCCG GGCCCTGCTG 
TCTGCTCCCT GGTACCTGAA CCGGGTGAAG TATGGCCCTG ACTGGAAGGA AATGTACAAA 
GTGGAGCCCC TGGCATTTCG TGGTACACCT GCACAAAAGG CTCTGGTCAT TGGAGGGGAA 
GCCTGTATGT GGGGAGAGTA TGTGGACAGC ACAAACCTTG TCCCCAGGCT CTGGCCCAGA 
GCAGGTGCCA TTGCCGAAAG ACTGTGGAGC AGTAACCTGA CGACTAATAT GGACTTTGCC 
TTTAAACGTC TGTCCCATTT CCGCTGTGAG CTGCTGAGGA GAGGAATCCA GGCCCAGCCC 
ATCAGCGTGG GCTACTGTGA GCAGGAGTTT GAGCATACTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017451050.1
CDS	122..1423
Translation	MVSVVTAECNEFPNLESVENYTLTINDDQCLLSSETVWGALRGLETFSQLVWKSAEGTFFINKTKITDFPRFPHRGILLDTSRHYLPLSSILNTLDVMAYNKFNVFHWHLVDDSSFPYESFTFPELTRKGSFNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGAGVPGLLTPCYSGSRLSGTYGPVNPSLNSTYDFMSTFFLEISSVFPDFYLHLGGDEVDFTCWKSNPNIQAFMKKKGFTDYKQLESFYIQTLLDIVSDYDKGYVVWQEVFDNKVKVRPDTIIQVWREEMPVQYMKEIEAITQAGFRALLSAPWYLNRVKYGPDWKEMYKVEPLAFRGTPAQKALVIGGEACMWGEYVDSTNLVPRLWPRAGAIAERLWSSNLTTNMDFAFKRLSHFRCELLRRGIQAQPISVGYCEQEFEHT

Target ORF information:

RefSeq Version	XM_017595561.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus hexosaminidase subunit alpha (Hexa), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017595561.1

ORF Insert Sequence:

ATGGTCTCTG TCGTCACAGC CGAATGTAAT GAGTTTCCTA ATTTGGAGTC CGTAGAAAAT 
TACACCCTAA CCATTAATGA TGACCAGTGT TTACTCTCCT CTGAGACTGT CTGGGGCGCT 
CTGCGAGGTC TGGAGACTTT CAGTCAGCTT GTTTGGAAGT CAGCTGAGGG CACGTTCTTT 
ATCAACAAGA CAAAGATTAC AGACTTTCCT CGATTCCCTC ACCGGGGCAT ACTGCTGGAT 
ACATCTCGCC ATTACCTGCC GTTATCTAGC ATCCTGAACA CACTGGATGT CATGGCGTAC 
AATAAATTCA ACGTGTTCCA CTGGCACTTG GTGGACGACT CTTCCTTCCC ATACGAGAGC 
TTCACCTTCC CAGAGCTCAC CAGAAAGGGG TCCTTCAACC CTGTTACCCA CATCTACACA 
GCACAGGATG TGAAGGAGGT CATTGAATAT GCAAGGCTTC GGGGTATCCG AGTGCTGGCC 
GAATTTGACA CTCCTGGCCA CACTTTGTCC TGGGGGGCAG GTGTCCCTGG ATTATTAACA 
CCTTGCTACT CTGGGTCCCG TCTCTCTGGC ACCTATGGAC CTGTGAACCC CAGCCTCAAC 
AGCACCTACG ACTTCATGAG CACATTCTTC CTGGAGATCA GCTCTGTCTT CCCTGACTTT 
TATCTCCACC TGGGAGGAGA TGAAGTTGAC TTCACCTGCT GGAAGTCCAA CCCCAACATC 
CAGGCCTTCA TGAAGAAAAA GGGCTTTACT GACTACAAGC AGCTGGAGTC ATTCTACATC 
CAGACGCTGC TGGACATCGT CTCTGATTAT GACAAGGGCT ATGTGGTGTG GCAGGAAGTA 
TTTGATAATA AAGTGAAGGT TCGGCCAGAC ACAATCATAC AGGTGTGGCG GGAAGAGATG 
CCGGTCCAGT ACATGAAGGA GATAGAGGCC ATCACCCAGG CTGGCTTCCG GGCCCTGCTG 
TCTGCTCCCT GGTACCTGAA CCGGGTGAAG TATGGCCCTG ACTGGAAGGA AATGTACAAA 
GTGGAGCCCC TGGCATTTCG TGGTACACCT GCACAAAAGG CTCTGGTCAT TGGAGGGGAA 
GCCTGTATGT GGGGAGAGTA TGTGGACAGC ACAAACCTTG TCCCCAGGCT CTGGCCCAGA 
GCAGGTGCCA TTGCCGAAAG ACTGTGGAGC AGTAACCTGA CGACTAATAT GGACTTTGCC 
TTTAAACGTC TGTCCCATTT CCGCTGTGAG CTGCTGAGGA GAGGAATCCA GGCCCAGCCC 
ATCAGCGTGG GCTACTGTGA GCAGGAGTTT GAGCATACTT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Murine Sialidase Neu3 facilitates GM2 degradation and bypass in mouse model of Tay-Sachs disease.
Experimental neurology299(Pt A)26-41(2018 Jan)
Seyrantepe V,Demir SA,Timur ZK,Von Gerichten J,Marsching C,Erdemli E,Oztas E,Takahashi K,Yamaguchi K,Ates N,D?nmez Demir B,Dalkara T,Erich K,Hopf C,Sandhoff R,Miyagi T

Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum.
The Journal of biological chemistry290(14)8789-802(2015 Apr)
Thaysen-Andersen M,Venkatakrishnan V,Loke I,Laurini C,Diestel S,Parker BL,Packer NH

TGF-?/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos.
PloS one8(1)e55186(2013)
Redshaw N,Camps C,Sharma V,Motallebipour M,Guzman-Ayala M,Oikonomopoulos S,Thymiakou E,Ragoussis J,Episkopou V

Defining the membrane proteome of NK cells.
Journal of mass spectrometry : JMS45(1)1-25(2010 Jan)
Ghosh D,Lippert D,Krokhin O,Cortens JP,Wilkins JA

Late onset Tay-Sachs disease in mice with targeted disruption of the Hexa gene: behavioral changes and pathology of the central nervous system.
Brain research1001(1-2)37-50(2004 Mar)
Miklyaeva EI,Dong W,Bureau A,Fattahie R,Xu Y,Su M,Fick GH,Huang JQ,Igdoura S,Hanai N,Gravel RA

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Hexa cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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