Cib2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cib2
Entrez Gene ID	300719
Full Name	calcium and integrin binding family member 2
General protein information	Preferred Names calcium and integrin binding family member 2 Names calcium and integrin-binding family member 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q24

mRNA and Protein(s)

mRNA	Protein	Name
NM_001015010.1	NP_001015010.1	calcium and integrin-binding family member 2
XM_006243071.3	XP_006243133.1	calcium and integrin-binding family member 2 isoform X1

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	CG9236	NP_611523.3
Bos taurus (cattle)	CIB2	XP_002696710.2
Danio rerio (zebrafish)	cib2	NP_957000.1
Pan troglodytes (chimpanzee)	CIB2	XP_510523.1
Mus musculus (house mouse)	Cib2	NP_062660.1
Homo sapiens (human)	CIB2	NP_006374.1
Canis lupus familiaris (dog)	CIB2	XP_548660.1
Gallus gallus (chicken)	CIB2	XP_413749.1
	CIB2	XP_001106401.1
Rattus norvegicus (Norway rat)	Cib2	NP_001015010.1
Caenorhabditis elegans (roundworm)	calm-1	NP_492514.2
Xenopus tropicalis (tropical clawed frog)	cib2	NP_001072810.1

Gene Ontology
Bibliography

Related articles in PubMed

Novel and recurrent CIB2 variants, associated with nonsyndromic deafness, do not affect calcium buffering and localization in hair cells.
Seco CZ, Giese AP, Shafique S, Schraders M, Oonk AM, Grossheim M, Oostrik J, Strom T, Hegde R, van Wijk E, Frolenkov GI, Azam M, Yntema HG, Free RH, Riazuddin S, Verheij JB, Admiraal RJ, Qamar R, Ahmed ZM, Kremer H
European journal of human genetics : EJHG24(4)542-9(2016 Apr)

A Novel C-Terminal CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family.
Patel K, Giese AP, Grossheim JM, Hegde RS, Hegde RS, Delio M, Samanich J, Riazuddin S, Frolenkov GI, Cai J, Ahmed ZM, Morrow BE
PloS one10(10)e0133082(2015)

Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48.
Riazuddin S, Belyantseva IA, Giese AP, Lee K, Indzhykulian AA, Nandamuri SP, Yousaf R, Sinha GP, Lee S, Terrell D, Hegde RS, Ali RA, Anwar S, Andrade-Elizondo PB, Sirmaci A, Parise LV, Basit S, Wali A, Ayub M, Ansar M, Ahmad W, Khan SN, Akram J, Tekin M, Riazuddin S, Cook T, Buschbeck EK, Frolenkov GI, Leal SM, Friedman TB, Ahmed ZM
Nature genetics44(11)1265-71(2012 Nov)

Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences.
Huang H, Bogstie JN, Vogel HJ
Biochemistry and cell biology = Biochimie et biologie cellulaire90(5)646-56(2012 Oct)

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Bastos-Amador P, Royo F, Gonzalez E, Conde-Vancells J, Palomo-Diez L, Borras FE, Falcon-Perez JM
Journal of proteomics75(12)3574-84(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CaMy2 binds Ca2+ and exhibits Ca2+/conformational switch. Moreover, CaMy2 undergoes N-myristoylation without Ca2+/myristoyl switch, is membrane-associated and localizes in neurons together with Golgi apparatus and dendrite markers.
Title: Biochemical characterization and expression analysis of a novel EF-hand Ca2+ binding protein calmyrin2 (Cib2) in brain indicates its function in NMDA receptor mediated Ca2+ signaling.

The following Cib2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cib2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05685	NM_001015010.1 Latest version!	Rattus norvegicus calcium and integrin binding family member 2 (Cib2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa31167	XM_006243071.3 Latest version!	Rattus norvegicus calcium and integrin binding family member 2 (Cib2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cib2 ( NM_001015010.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001015010.1 Rattus norvegicus calcium and integrin binding family member 2 (Cib2), mRNA.

Price & Availability↑

CloneID	ORa05685
Clone ID Related Accession (Same CDS sequence)	NM_001015010.1
Accession Version	NM_001015010.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 564bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Rattus norvegicus(Norway rat)
Product	calcium and integrin-binding family member 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC092630.1. On Apr 20, 2005 this sequence version replaced XM_217165.3. ##Evidence-Data-START## Transcript exon combination :: BC092630.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGGGAATA AGCAGACCAT CTTCACAGAA GAGCAGCTGG ACAACTACCA GGACTGCACT 
TTCTTCAATA AGAAGGACAT CCTCAAGCTT CATGCACGGT TCTATGAGCT GGCTCCCAAC 
CTCGTCCCGA TGGACTACAG GAAGAGCCCC ATCGTCCACG TGCCCATGAG CCTCATCATT 
CAGATGCCGG AGCTCCGGGA GAATCCTTTC AAGGAGAGGA TTGTGGAGGC TTTCTCTGAG 
GACGGTGAGG GGAACCTCAC CTTCAATGAC TTTGTGGACA TGTTCTCTGT GCTCTGTGAG 
TCGGCGCCTC GGGAGCTCAA GGCGAACTAT GCCTTCAAGA TCTATGACTT CAACACTGAC 
AATTTCATCT GTAAAGAAGA CTTAGAGCTG ACACTGGCCA GACTTACTAA GTCAGAGCTG 
GATGAAGATG AGGTAGTGCT TGTGTGTGAC AAAGTCATTG AAGAAGCTGA CCTGGACGGT 
GATGGCAAGC TAGGCTTTGC CGACTTTGAG GACATGATCG CCAAGGCCCC TGACTTTCTC 
AGCACTTTCC ACATCCGAAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001015010.1
CDS	180..743
Translation	MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHARFYELAPNLVPMDYRKSPIVHVPMSLIIQMPELRENPFKERIVEAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEDEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFLSTFHIRI

Target ORF information:

RefSeq Version	NM_001015010.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus calcium and integrin binding family member 2 (Cib2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001015010.1

ORF Insert Sequence:

ATGGGGAATA AGCAGACCAT CTTCACAGAA GAGCAGCTGG ACAACTACCA GGACTGCACT 
TTCTTCAATA AGAAGGACAT CCTCAAGCTT CATGCACGGT TCTATGAGCT GGCTCCCAAC 
CTCGTCCCGA TGGACTACAG GAAGAGCCCC ATCGTCCACG TGCCCATGAG CCTCATCATT 
CAGATGCCGG AGCTCCGGGA GAATCCTTTC AAGGAGAGGA TTGTGGAGGC TTTCTCTGAG 
GACGGTGAGG GGAACCTCAC CTTCAATGAC TTTGTGGACA TGTTCTCTGT GCTCTGTGAG 
TCGGCGCCTC GGGAGCTCAA GGCGAACTAT GCCTTCAAGA TCTATGACTT CAACACTGAC 
AATTTCATCT GTAAAGAAGA CTTAGAGCTG ACACTGGCCA GACTTACTAA GTCAGAGCTG 
GATGAAGATG AGGTAGTGCT TGTGTGTGAC AAAGTCATTG AAGAAGCTGA CCTGGACGGT 
GATGGCAAGC TAGGCTTTGC CGACTTTGAG GACATGATCG CCAAGGCCCC TGACTTTCTC 
AGCACTTTCC ACATCCGAAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Cib2 ( XM_006243071.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243133.1 Rattus norvegicus calcium and integrin binding family member 2 (Cib2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa31167
Clone ID Related Accession (Same CDS sequence)	XM_006243071.3
Accession Version	XM_006243071.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	calcium and integrin-binding family member 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006243071.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACTACA GGAAGAGCCC CATCGTCCAC GTGCCCATGA GCCTCATCAT TCAGATGCCG 
GAGCTCCGGG AGAATCCTTT CAAGGAGAGG ATTGTGGAGG CTTTCTCTGA GGACGGTGAG 
GGGAACCTCA CCTTCAATGA CTTTGTGGAC ATGTTCTCTG TGCTCTGTGA GTCGGCGCCT 
CGGGAGCTCA AGGCGAACTA TGCCTTCAAG ATCTATGACT TCAACACTGA CAATTTCATC 
TGTAAAGAAG ACTTAGAGCT GACACTGGCC AGACTTACTA AGTCAGAGCT GGATGAAGAT 
GAGGTAGTGC TTGTGTGTGA CAAAGTCATT GAAGAAGCTG ACCTGGACGG TGATGGCAAG 
CTAGGCTTTG CCGACTTTGA GGACATGATC GCCAAGGCCC CTGACTTTCT CAGCACTTTC 
CACATCCGAA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243133.1
CDS	256..690
Translation	MDYRKSPIVHVPMSLIIQMPELRENPFKERIVEAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEDEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFLSTFHIRI

Target ORF information:

RefSeq Version	XM_006243071.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus calcium and integrin binding family member 2 (Cib2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243071.3

ORF Insert Sequence:

ATGGACTACA GGAAGAGCCC CATCGTCCAC GTGCCCATGA GCCTCATCAT TCAGATGCCG 
GAGCTCCGGG AGAATCCTTT CAAGGAGAGG ATTGTGGAGG CTTTCTCTGA GGACGGTGAG 
GGGAACCTCA CCTTCAATGA CTTTGTGGAC ATGTTCTCTG TGCTCTGTGA GTCGGCGCCT 
CGGGAGCTCA AGGCGAACTA TGCCTTCAAG ATCTATGACT TCAACACTGA CAATTTCATC 
TGTAAAGAAG ACTTAGAGCT GACACTGGCC AGACTTACTA AGTCAGAGCT GGATGAAGAT 
GAGGTAGTGC TTGTGTGTGA CAAAGTCATT GAAGAAGCTG ACCTGGACGG TGATGGCAAG 
CTAGGCTTTG CCGACTTTGA GGACATGATC GCCAAGGCCC CTGACTTTCT CAGCACTTTC 
CACATCCGAA TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel and recurrent CIB2 variants, associated with nonsyndromic deafness, do not affect calcium buffering and localization in hair cells.
European journal of human genetics : EJHG24(4)542-9(2016 Apr)
Seco CZ,Giese AP,Shafique S,Schraders M,Oonk AM,Grossheim M,Oostrik J,Strom T,Hegde R,van Wijk E,Frolenkov GI,Azam M,Yntema HG,Free RH,Riazuddin S,Verheij JB,Admiraal RJ,Qamar R,Ahmed ZM,Kremer H

A Novel C-Terminal CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family.
PloS one10(10)e0133082(2015)
Patel K,Giese AP,Grossheim JM,Hegde RS,Hegde RS,Delio M,Samanich J,Riazuddin S,Frolenkov GI,Cai J,Ahmed ZM,Morrow BE

Alterations of the CIB2 calcium- and integrin-binding protein cause Usher syndrome type 1J and nonsyndromic deafness DFNB48.
Nature genetics44(11)1265-71(2012 Nov)
Riazuddin S,Belyantseva IA,Giese AP,Lee K,Indzhykulian AA,Nandamuri SP,Yousaf R,Sinha GP,Lee S,Terrell D,Hegde RS,Ali RA,Anwar S,Andrade-Elizondo PB,Sirmaci A,Parise LV,Basit S,Wali A,Ayub M,Ansar M,Ahmad W,Khan SN,Akram J,Tekin M,Riazuddin S,Cook T,Buschbeck EK,Frolenkov GI,Leal SM,Friedman TB,Ahmed ZM

Biophysical and structural studies of the human calcium- and integrin-binding protein family: understanding their functional similarities and differences.
Biochemistry and cell biology = Biochimie et biologie cellulaire90(5)646-56(2012 Oct)
Huang H,Bogstie JN,Vogel HJ

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Journal of proteomics75(12)3574-84(2012 Jun)
Bastos-Amador P,Royo F,Gonzalez E,Conde-Vancells J,Palomo-Diez L,Borras FE,Falcon-Perez JM

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Cib2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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