Lrrk2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lrrk2
Entrez Gene ID	300160
Full Name	leucine-rich repeat kinase 2
General protein information	Preferred Names leucine-rich repeat kinase 2 Names leucine-rich repeat serine/threonine-protein kinase 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q35

mRNA and Protein(s)

mRNA	Protein	Name
XM_008765689.2	XP_008763911.1	leucine-rich repeat serine/threonine-protein kinase 2 isoform X2
XM_006242190.3	XP_006242252.1	leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
NM_001191789.1	NP_001178718.1	leucine-rich repeat serine/threonine-protein kinase 2

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	LRRK2	XP_003640388.2
Xenopus tropicalis (tropical clawed frog)	lrrk2	XP_002932250.2
	LRRK2	XP_002798616.1
Mus musculus (house mouse)	Lrrk2	NP_080006.3
Rattus norvegicus (Norway rat)	Lrrk2	NP_001178718.1
Danio rerio (zebrafish)	lrrk2	NP_001188385.1
Homo sapiens (human)	LRRK2	NP_940980.3
Pan troglodytes (chimpanzee)	LRRK2	XP_001168494.1
Canis lupus familiaris (dog)	LRRK2	XP_543734.3
Bos taurus (cattle)	LRRK2	NP_001193015.1

Gene Ontology
Bibliography

Related articles in PubMed

LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson's disease.
Howlett EH, Jensen N, Belmonte F, Zafar F, Hu X, Kluss J, Sch?le B, Kaufman BA, Greenamyre JT, Sanders LH
Human molecular genetics26(22)4340-4351(2017 Nov)

Parkinson disease-associated
Park J, Lee JW, Cooper SC, Broxmeyer HE, Cannon JR, Kim CH
Journal of leukocyte biology102(4)1093-1102(2017 Oct)

Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.
Chen ZC, Zhang W, Chua LL, Chai C, Li R, Lin L, Cao Z, Angeles DC, Stanton LW, Peng JH, Zhou ZD, Lim KL, Zeng L, Tan EK
Science signaling10(488)(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results indicate that abnormal LRRK2 activity can alter bone marrow myelopoiesis, peripheral myeloid cell differentiation, and intestinal immune homeostasis.
Title: Parkinson disease-associated

These findings support a close link between LRKK2 functional state and L-DOPA-induced abnormal motor behavior.
Title: LRRK2 phosphorylation level correlates with abnormal motor behaviour in an experimental model of levodopa-induced dyskinesias.

LRRK2 transgenic rats develop progressive, Parkinson-like, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.
Title: LRRK2 BAC transgenic rats develop progressive, L-DOPA-responsive motor impairment, and deficits in dopamine circuit function.

G2019S mutation carrying LRRK2 microglia show retarded ADP-induced motility and delayed isolation of injury. LRRK2 knockdown microglia are highly motile compared with control cells. Lrrk2 phosphorylates and inhibits focal adhesion kinase.
Title: LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase.

Phosphorylation of p53 by LRRK2 induces p21(WAF1/CIP1) expression and apoptosis.
Title: Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression.

The following Lrrk2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lrrk2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa12164	NM_001191789.1 Latest version!	Rattus norvegicus leucine-rich repeat kinase 2 (Lrrk2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24	$1301.30 $1859.00
ORa30666	XM_006242190.3 Latest version!	Rattus norvegicus leucine-rich repeat kinase 2 (Lrrk2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	30	$1301.30 $1859.00
ORa45692	XM_008765689.2 Latest version!	Rattus norvegicus leucine-rich repeat kinase 2 (Lrrk2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	30	$1301.30 $1859.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lrrk2 ( NM_001191789.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001178718.1 Rattus norvegicus leucine-rich repeat kinase 2 (Lrrk2), mRNA.

Price & Availability↑

CloneID	ORa12164
Clone ID Related Accession (Same CDS sequence)	NM_001191789.1
Accession Version	NM_001191789.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 7581bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Rattus norvegicus(Norway rat)
Product	leucine-rich repeat serine/threonine-protein kinase 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC112081.8 and AC108595.5. On Jul 17, 2010 this sequence version replaced XM_235581.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGGCCAGTG GCGCCTGTCA GGGCTGCGAC GAGGAAGAGG AGGAGGAGGC TCTGAAGAAG 
TTGATAGTCA GGCTGAATAA TGTCCAGGAA GGCAAGCAGA TCGAGACGTT GCTCCAGCTC 
CTGGAGGACA TTCTGGTGTT CACCTACTCC GACCGCGCCT CCAAGTTATT TGAAGGCAAA 
AATGTCCACG TGCCTCTGTT GATAGTCCTG GACTCCTACA TGAGAGTCGC CAGTGTGCAG 
CAGGTGGGGT GGTCACTTCT GTGCAAATTA ATAGAAGTCT GTCCAGGGAC ATTGCAAAGC 
TTAATAGGAC CCCAGGATAT TGGGAATGAT TGGGAAGTCC TTGGTATTCA CCGACTGATT 
CTTAAAATGT TAACTGTTCA TCATGCCAAC GTAAACCTGT CAATAGTTGG ACTAAAAGCC 
TTAGATCTCC TCCTAGATTC AGGTAAAATT ACTCTGCTGA TACTGGATGA AGAATGTGAT 
GTTTTCCTGT TAATTTTTGA TGCCATGCAC AGATATTCAG CCAACGAGGA AGTCCAGAAG 
CTTGCGTGCA AGGCTTTACA TGTGCTGTTC GAGAGAGTGT CCGAGGAGCA ACTGACTGAG 
TTTGTGGAGA ACAAAGATTA CATGACCCTG CTGAGTACGT TCCGCAGCTT CAAGAGGGAC 
GAGGAGATTG TGCACCATGT ACTCTGCTGC CTGCATTCTC TGGCCGTCAC TTGCAGCAAT 
GTGGAGGTCC TCATGAGTGG GAATGTCAGG TGTTACAATA TTGTGGTGGA AGCCATGAAA 
ACATTCCCCA CCAGTGAAAA CATTCAAGAG GTGAGCTGCT CCTTGCTCCA CAAGCTTACA 
TTAGGTAATT TTTTCAACAT CCTGGTGTTG AACGAAGTCC ATGTCTTTGT GGTGAAAGCC 
GTCCAGCGGT ATCCCGAGAA CGTAGCCTTA CAGATCTCTG CACTCAGCTG CTTAGCCCTC 
CTCACCGAGA CTATTTTCTT AAACCAAGAC CTGGAAGAAA GAAGTGAGAC TCAGGAAAAC 
AGCGATGAGG ACAGTGAGAA GCCTTTCTGG TTGGAACCCT GCTATAAAGC CCTGATGCGC 
CATCGAAAGA ACAAACACGT GCAGGAGGCC GCCTGCTGGG CCCTAAATAA TCTCCTCATG 
TACCAGAGCA GTTTGCACGA GAAGATTGGA GATGAAGATG GCCAGTTCCC GGCGCACAGG 
GAAGTGATGC TGTCTATGCT GATGCACTCT TCTTCCAAAG ACGTCTTCCA AGCAGCTGCG 
CATGCTCTGT CCACTCTCTT GGAACAAAAC GTTAATTTCA GGAAAATCCT GCTTGCAAAA 
GGAGTGTACC TGAATGTCTT GGAGTTGATG CAGCGGCACG CCCAGGTTCC TGAGGTGGCA 
GAGAGTGGCT GCAAGATGCT GAGTCATCTG TTTGAAGGAA GCAACCCTTC TTTGGATACA 
GTGGCGGCAG TGATCCCCAA AATACTAACA GTGATGAGAA CCCATGGAAC GTCTCTGTCA 
GTCCAGCTGG AGGCACTGCG AGCTCTTCTG CATTTTGTGG TGCCGGGAGT ATCAGAAGAT 
TCCAGGGATG ACTCGCGATG CCAACCAAAC GTGCTCAGAA CACAGTGCTT CAGGACTGAC 
ATCCACAAGC TGGTTCTAGC CGCTCTGAAC AGGTTCATTG GGAATCCCGG GATTCAGAAA 
TGTGGATTGA AAGTCATCTC TTCTTTCGCA CATCTTCCCG ATGCCTTAGA GATGTTATCC 
CTGCATGGAG CAGTTGACTC AGTCCTCCAT ACCTTACAGA TGTATCCAGA TGACCAAGAA 
ATTCAGTGTC TGGGCTTACA CCTTATGGGA TGCCTGATGA CAAAGAAGAA TTTCTGCATA 
GGGACAGGGC ACCTCCTGGC AAAAATTCTG GCTTCCACCT TGCAGCGATT TAAAGATGTT 
GCTGAAGTAC AGACTACAGG ATTACAGACG GTCTTGTCAA TGCTTGACCT GTCCGTATCT 
TTCTCCAAGC TGCTAGTGCA CTATTCATTT GATGTGGTGA TGTTTCATCA GATGTCTTCC 
GGTGTCCTGG AACAAAAGGA TGAGCAGTTT CTCAACTTAT GCTGCAAATG CTTTGCAAAA 
GTGGCTGTGG ATGATGAGCT GAAAAGCAAG ATGCTAGAGA GAGCCTGCGA TCAGAACAAC 
AGCATCATGG TCGAATGTTT GCTCCTCTTG GGAGCCGATG CCAATCAAGC GAAGGGGGCA 
ACTTCTTTAA TCTATCAGGT ATGTGAGAAA GAGAGCAGCC CTAAATTGGT GGAACTATTG 
CTTAACAGTG GGTGCCGTGA ACAAGATGTA CGGAAAGCCC TGACAGTAAG CATCCAAAAG 
GGCGACAACC AGGTCATCAG CTTACTCCTG AGGAGACTTG CCCTGGACCT GGCCAACAAC 
AGCATTTGCC TTGGAGGATT TTGCATAGGA AAACTTGATC CTTCTTGGCT AGGCCCTTTA 
TTTCCAGATA AGTCATCTAA TTTGAGGAAA CAAACAAATG CGGGGTCTGT CCTAGCGAGG 
AAAGTGCTCC GGTATCAGAT GAGAAACACT CTTCAAGAAG GCGTGGCCTC AGGCAGTGAG 
GGCAACTTCT CTGAGGATGC GCTGGCGAAA TTTGGCGAAT GGACCTTCAT TCCCGACTCT 
TCTATGGACA GTGTGTTTGG CCAGAGTGAC GATCTGGATA GCGAAGGCAG CGAGAGCTCC 
TTTCTGGTGA AGAAGAAGTC CAACTCAGTT AGTGTAGGAG AAGTTTACAG GGACCTAGCT 
CTGCAGCGCT GCTCACCAAA TGCTCAGAGG CACTCCAGTT CCTTGGGTCC TGTTTTTGAT 
CACGAAGATC TACTGAGACG AAAAAGAAAA ATACTGTCCT CAGATGAGTC TCTCAGATCC 
TCAAGGCTGC AGTCCCATAC GAGACAATCA GATAGCTCTT CTTCTCTGGC TTCTGAGAGA 
GAACACATCA CGTCTTTAGA CCTTTCTGCC AACGAACTGA AAGATATTGA TGCTCTGGGC 
CAGAAGTGTT GCCTCAGTAG CCACCTGGAG CATCTCACCA AGCTGGAACT TCACCAGAAT 
TCACTCACGA GCTTCCCACA ACAGCTGTGT GAGACTCTGA AGTGCTTGAC ACATCTGGAT 
TTGCACAGTA ACAAATTCGC CACCTTTCCC TCCTTCATGT TGAAAATGCC AAGTGTTATC 
CACCTAGACG CCTCTCGAAA TGACATCGGA CCAACAGTTG TTTTAGACCC TGTGGTGAAG 
TGTCCAAGCC TCAAACAGTT TAACCTGTCC TACAACCAGC TCTCTTCCAT CCCAGAGAAC 
CTGGACCAAG TGGTGGAGAA ACTGGAGCAG CTCCTACTGG AAGGAAACAA AATATCCGGG 
ATTTGTTCTC CCTTGAGCCT GAAGGAACTG AAGATTTTAA ACCTTAGTAA AAACCACATT 
CCATCCCTAC CTGAAGACTT TCTCGAGGCT TGCCCGAAAG TGGAGAGCTT CAGTGCCCGC 
ATGAATTTTC TCGCTGCAAT GCCTGCCTTA CCGTCTTCCA TAACTAGCTT AAAATTGTCT 
CAAAACTCTT TCACGTGCAT TCCAGAAGCG ATCTTCAGTC TTCCACACTT GCGGTCCTTG 
GATATGAGTC ACAACAACAT TGAACACCTG CCGGGACCTG CACATTGGAA GTCTCTGAAC 
TTAAGGGAAC TCATTTTTAG CAAGAATCAG ATCAGCACCT TAGACTTGAG CGAAAACCCA 
CACATATGGT CAAGAGTAGA GAAGCTGCAT CTCTCTCATA ATAAACTGAA AGAGATTCCT 
CCAGAAATTG GCCGTCTTGA AAACCTGACA TCTCTTGATG TCAGTTACAA CCTGGAACTG 
AGGTCCTTTC CAAACGAAAT GGGGAAGTTA AGCAAAATAT GGGATCTTCC CTTGGATGGA 
CTGCACCTCA ACTTTGACTT TAAGCACATA GGATGCAAAG CCAAAGACAT CATAAGGTTT 
CTACAACAAC GTCTGAAAAA GGCCGTGCCC TACAACCGAA TGAAGCTCAT GATTGTGGGC 
AATACGGGGA GTGGTAAGAC CACTCTACTG CAGCAGCTCA TGAAAATGAA GAAATCAGAA 
CTCGGCATGC AGGGCGCCAC GGTTGGCATA GACGTGCGAG ACTGGCCCAT CCAAATACGA 
GGCAAAAGGA AAAAGGACCT TGTTCTAAAC GTGTGGGACT TTGCAGGCCG TGAGGAATTC 
TACAGCACTC ACCCCCACTT CATGACCCAG AGAGCCCTGT ACCTGGCTGT CTACGACCTC 
AGCAAGGGGC AGGCGGAGGT GGATGCCATG AAGCCCTGGC TCTTCAACAT CAAGGCTCGT 
GCCTCTTCTT CCCCGGTGAT TCTGGTGGGC ACACATTTGG ATGTTTCTGA TGAGAAGCAG 
CGCAAAGCCT GCATAGGCAA AATCACGAAG GAACTCCTTA ATAAGCGAGG ATTCCCCACC 
ATCCGGGACT ACCACTTCGT GAATGCCACT GAGGAGTCGG ATGCGCTGGC AAAGCTCCGG 
AAAACCATCA TAAATGAGAG TCTTAATTTC AAGATCCGAG ATCAGCCCGT GGTTGGGCAG 
CTAATTCCAG ATTGCTACGT AGAACTGGAG AAAATAATCT TATCGGAGCG TAAAGCTGTA 
CCAACGGAGT TTCCTGTAAT TAACCGGAAA CACTTACTCC AGCTGGTGAA GGAACACCAG 
CTGCAGCTGG ATGAGAACGA GCTCCCCCAC GCTGTTCACT TCCTGAATGA GTCAGGAGTT 
CTTCTGCATT TTCAAGACCC CGCATTGCAG CTGAGTGACC TGTACTTTGT GGAACCCAAG 
TGGCTTTGTA AAGTCATGGC ACAGATTTTG ACCGTGAAAG TGGACGGCTG CCTGAAGCAT 
CCTAAGGGCA TCATTTCACG GAGAGATGTG GAAAAATTCC TTTCCAAGAA AAAGCGATTC 
CCTAAGAACT ACATGGCGCA GTACTTCAAA CTTTTAGAAA AATTTCAGAT CGCATTACCA 
ATAGGGGAAG AATATCTGCT GGTTCCAAGC AGCTTATCTG ACCACAGGCC AGTGATAGAG 
CTCCCCCACT GTGAGAACTC TGAGATCATC ATCCGGCTGT ATGAAATGCC ATACTTTCCA 
ATGGGATTTT GGTCAAGATT GATTAACCGA TTACTTGAAA TCTCACCTTT CATGCTTTCT 
GGAAGAGAGA GAGCACTACG CCCAAACCGA ATGTACTGGC GCCAAGGCAT CTACTTGAAT 
TGGTCTCCAG AAGCCTACTG TCTGGTGGGC TCTGAAGTCT TAGACAGTCG CCCAGAGAGT 
TTCTTGAAAA TCACAGTTCC ATCTTGTAGA AAAGGTTGTA TTCTTTTGGG CCGAGTTGTG 
GATCATATTG ACTCACTCAT GGAAGAATGG TTTCCTGGAT TGCTGGAGAT TGACATTTGT 
GGGGAAGGAG AAACTTTGTT GAAAAAATGG GCATTGTATA GTTTTAATGA TGGCGAAGAA 
CATCAGAAGA TCTTGCTTGA TGAGTTGATG AAGAAGGCTG AAGAAGGAGA CCTGTTAATA 
AATCCAGATC AACCAAGGCT CACCATTCCA ATATCCCAGA TTGCTCCGGA CTTGATCTTG 
GCTGACCTGC CTAGAAATAT TATGTTGAAC AATGACGAAC TGGAATTTGA GGAAGCACCC 
GAGTTTCTCT TAGGTGATGG AAGTTTCGGA TCAGTTTATC GAGCTGCCTA CGAAGGAGAG 
GAAGTGGCTG TGAAGATTTT TAATAAGCAC ACATCGCTTA GGCTGTTAAG ACAAGAGTTG 
GTGGTACTCT GTCATCTCCA CCATCCCAGC TTGATCTCCC TGTTGGCGGC TGGGATTCGT 
CCTCGGATGC TGGTAATGGA GTTGGCCTCC AAGGGTTCCT TGGATCGCCT GCTGCAGCAG 
GACAAAGCCA GCCTCACCCG GACCCTCCAG CACAGAATCG CATTGCATGT GGCCGATGGC 
CTGAGATATC TGCACTCGGC CATGATTATT TACCGTGATC TGAAGCCCCA CAACGTGCTA 
CTCTTCACCC TGTATCCCAA TGCCGCCATC ATTGCGAAGA TTGCGGACTA CGGGATTGCA 
CAGTACTGCT GTAGGATGGG AATAAAGACC TCAGAGGGCA CCCCAGGGTT CCGAGCACCT 
GAAGTTGCCA GAGGAAATGT CATTTATAAC CAACAGGCTG ATGTTTATTC TTTTGGCTTA 
CTACTTCATG ATATCTGGAC AACTGGGAAT AGAATCATGG AGGGTTTGAG GTTTCCAAAT 
GAGTTTGATG AACTGGCCAT ACAAGGGAAA TTGCCAGACC CAGTTAAAGA ATATGGCTGT 
GCCCCGTGGC CTATGGTTGA GAAGTTAATT ACAAAATGTT TGAAAGAAAA TCCTCAAGAA 
AGACCCACTT CTGCCCAGGT CTTTGACATT TTGAATTCAG CTGAGTTAAT TTGCCTCATG 
CGACACATTT TCATACCTAA GGACATCACT GTTGAATGCA TAGCTGCTAC AAACCTCAAT 
AGCAAGCGAG CGACTCTCTG GTTGGGCTGT GGGAACACAG AAAAAGGGCA GCTTTCCTTA 
CTTGACTTGA ACACGGAAAG ATACAGCTAT GAGGAAGTTA CTGATAGTAG AATACTGTGC 
CTGGCTTTGG TGCATCTTGC TGCTGAGAAA GAGAGCTGGG TTGTGTGTGG GACACAGTCC 
GGAGCTCTCC TGGTCATCAA TGCTGAAGAT GAGACAAGGA GACACACCCT CGACAAGATG 
ACTGATTCTG TTACTTGCTT GTATTGCAAT TCCTTTGCCA AGCAGAGCAA GCAAAGTCAC 
TTCCTTTTGG TGGGAACTGC TGATGGCAAC TTAATGATAT TTGAAGATAA GACCATTAAG 
TGTAAAGGAG CTGCCCCATT GAAGACACTA CACATAGGCG ATGTCAGTAC GCCCCTGATG 
TGCCTGAGCG AGTCCATGAA TTCATCTGAA AGACACATCA CATGGGGAGG GTGTGGCACA 
AAGATCTTCT CCTTTTCCAA TGATTTCACC ATTCAGAAAC TCATCGAGAC AAGAACCAAC 
CAGCTGTTTT CTTACTCAGC GTTCAGCGAT TCTAACATCA TAGCGGTGGC AGTGGACACA 
GCGCTTTATA TTGCCAAGAA AAACAGCCCT GTCGTAGAGG TGTGGGACAA GAAGACAGAA 
AAACTCTGTG AACTAATAGA CTGTGTGCAC TTCTTAAAGG AGGTGATGGT GAAAATAAAC 
AAGGACTCGA AGCACAAGCT GTCCTACTCT GGGAGGGTGA AGGCACTCTG CCTGCAGAAG 
AACACAGCTC TCTGGATCGG AACTGGAGGA GGCCACATCT TACTCCTGGA TCTTTCTACA 
CGGCGAGTCA TCCGCACCAT CCACAATTTC TGTGATTCCG TGAGAGCCAT GGCCACAGCT 
CAGTTAGGCA ACCTTAAAAA TGTCATGCTG GTTTTGGGGT ACAAGCGGAA GAGTACAGAA 
GGAACCCAAG AACAAAAAGA GATACAATCT TGTTTGTCTA TTTGGGACCT CAATCTTCCA 
CATGAAGTGC AAAACTTAGA AAAACACATT GAAGTAAGAA CAGAACTGGC TGATAAAATG 
AGGAAAACAT CTGTCGAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001178718.1
CDS	1..7581
Translation	MASGACQGCDEEEEEEALKKLIVRLNNVQEGKQIETLLQLLEDILVFTYSDRASKLFEGKNVHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTLQSLIGPQDIGNDWEVLGIHRLILKMLTVHHANVNLSIVGLKALDLLLDSGKITLLILDEECDVFLLIFDAMHRYSANEEVQKLACKALHVLFERVSEEQLTEFVENKDYMTLLSTFRSFKRDEEIVHHVLCCLHSLAVTCSNVEVLMSGNVRCYNIVVEAMKTFPTSENIQEVSCSLLHKLTLGNFFNILVLNEVHVFVVKAVQRYPENVALQISALSCLALLTETIFLNQDLEERSETQENSDEDSEKPFWLEPCYKALMRHRKNKHVQEAACWALNNLLMYQSSLHEKIGDEDGQFPAHREVMLSMLMHSSSKDVFQAAAHALSTLLEQNVNFRKILLAKGVYLNVLELMQRHAQVPEVAESGCKMLSHLFEGSNPSLDTVAAVIPKILTVMRTHGTSLSVQLEALRALLHFVVPGVSEDSRDDSRCQPNVLRTQCFRTDIHKLVLAALNRFIGNPGIQKCGLKVISSFAHLPDALEMLSLHGAVDSVLHTLQMYPDDQEIQCLGLHLMGCLMTKKNFCIGTGHLLAKILASTLQRFKDVAEVQTTGLQTVLSMLDLSVSFSKLLVHYSFDVVMFHQMSSGVLEQKDEQFLNLCCKCFAKVAVDDELKSKMLERACDQNNSIMVECLLLLGADANQAKGATSLIYQVCEKESSPKLVELLLNSGCREQDVRKALTVSIQKGDNQVISLLLRRLALDLANNSICLGGFCIGKLDPSWLGPLFPDKSSNLRKQTNAGSVLARKVLRYQMRNTLQEGVASGSEGNFSEDALAKFGEWTFIPDSSMDSVFGQSDDLDSEGSESSFLVKKKSNSVSVGEVYRDLALQRCSPNAQRHSSSLGPVFDHEDLLRRKRKILSSDESLRSSRLQSHTRQSDSSSSLASEREHITSLDLSANELKDIDALGQKCCLSSHLEHLTKLELHQNSLTSFPQQLCETLKCLTHLDLHSNKFATFPSFMLKMPSVIHLDASRNDIGPTVVLDPVVKCPSLKQFNLSYNQLSSIPENLDQVVEKLEQLLLEGNKISGICSPLSLKELKILNLSKNHIPSLPEDFLEACPKVESFSARMNFLAAMPALPSSITSLKLSQNSFTCIPEAIFSLPHLRSLDMSHNNIEHLPGPAHWKSLNLRELIFSKNQISTLDLSENPHIWSRVEKLHLSHNKLKEIPPEIGRLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDGLHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKMKKSELGMQGATVGIDVRDWPIQIRGKRKKDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACIGKITKELLNKRGFPTIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKAVPTEFPVINRKHLLQLVKEHQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVDGCLKHPKGIISRRDVEKFLSKKKRFPKNYMAQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPFMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDSRPESFLKITVPSCRKGCILLGRVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDELMKKAEEGDLLINPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEEAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLHDIWTTGNRIMEGLRFPNEFDELAIQGKLPDPVKEYGCAPWPMVEKLITKCLKENPQERPTSAQVFDILNSAELICLMRHIFIPKDITVECIAATNLNSKRATLWLGCGNTEKGQLSLLDLNTERYSYEEVTDSRILCLALVHLAAEKESWVVCGTQSGALLVINAEDETRRHTLDKMTDSVTCLYCNSFAKQSKQSHFLLVGTADGNLMIFEDKTIKCKGAAPLKTLHIGDVSTPLMCLSESMNSSERHITWGGCGTKIFSFSNDFTIQKLIETRTNQLFSYSAFSDSNIIAVAVDTALYIAKKNSPVVEVWDKKTEKLCELIDCVHFLKEVMVKINKDSKHKLSYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRTIHNFCDSVRAMATAQLGNLKNVMLVLGYKRKSTEGTQEQKEIQSCLSIWDLNLPHEVQNLEKHIEVRTELADKMRKTSVE

Target ORF information:

RefSeq Version	NM_001191789.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus leucine-rich repeat kinase 2 (Lrrk2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001191789.1

ORF Insert Sequence:

ATGGCCAGTG GCGCCTGTCA GGGCTGCGAC GAGGAAGAGG AGGAGGAGGC TCTGAAGAAG 
TTGATAGTCA GGCTGAATAA TGTCCAGGAA GGCAAGCAGA TCGAGACGTT GCTCCAGCTC 
CTGGAGGACA TTCTGGTGTT CACCTACTCC GACCGCGCCT CCAAGTTATT TGAAGGCAAA 
AATGTCCACG TGCCTCTGTT GATAGTCCTG GACTCCTACA TGAGAGTCGC CAGTGTGCAG 
CAGGTGGGGT GGTCACTTCT GTGCAAATTA ATAGAAGTCT GTCCAGGGAC ATTGCAAAGC 
TTAATAGGAC CCCAGGATAT TGGGAATGAT TGGGAAGTCC TTGGTATTCA CCGACTGATT 
CTTAAAATGT TAACTGTTCA TCATGCCAAC GTAAACCTGT CAATAGTTGG ACTAAAAGCC 
TTAGATCTCC TCCTAGATTC AGGTAAAATT ACTCTGCTGA TACTGGATGA AGAATGTGAT 
GTTTTCCTGT TAATTTTTGA TGCCATGCAC AGATATTCAG CCAACGAGGA AGTCCAGAAG 
CTTGCGTGCA AGGCTTTACA TGTGCTGTTC GAGAGAGTGT CCGAGGAGCA ACTGACTGAG 
TTTGTGGAGA ACAAAGATTA CATGACCCTG CTGAGTACGT TCCGCAGCTT CAAGAGGGAC 
GAGGAGATTG TGCACCATGT ACTCTGCTGC CTGCATTCTC TGGCCGTCAC TTGCAGCAAT 
GTGGAGGTCC TCATGAGTGG GAATGTCAGG TGTTACAATA TTGTGGTGGA AGCCATGAAA 
ACATTCCCCA CCAGTGAAAA CATTCAAGAG GTGAGCTGCT CCTTGCTCCA CAAGCTTACA 
TTAGGTAATT TTTTCAACAT CCTGGTGTTG AACGAAGTCC ATGTCTTTGT GGTGAAAGCC 
GTCCAGCGGT ATCCCGAGAA CGTAGCCTTA CAGATCTCTG CACTCAGCTG CTTAGCCCTC 
CTCACCGAGA CTATTTTCTT AAACCAAGAC CTGGAAGAAA GAAGTGAGAC TCAGGAAAAC 
AGCGATGAGG ACAGTGAGAA GCCTTTCTGG TTGGAACCCT GCTATAAAGC CCTGATGCGC 
CATCGAAAGA ACAAACACGT GCAGGAGGCC GCCTGCTGGG CCCTAAATAA TCTCCTCATG 
TACCAGAGCA GTTTGCACGA GAAGATTGGA GATGAAGATG GCCAGTTCCC GGCGCACAGG 
GAAGTGATGC TGTCTATGCT GATGCACTCT TCTTCCAAAG ACGTCTTCCA AGCAGCTGCG 
CATGCTCTGT CCACTCTCTT GGAACAAAAC GTTAATTTCA GGAAAATCCT GCTTGCAAAA 
GGAGTGTACC TGAATGTCTT GGAGTTGATG CAGCGGCACG CCCAGGTTCC TGAGGTGGCA 
GAGAGTGGCT GCAAGATGCT GAGTCATCTG TTTGAAGGAA GCAACCCTTC TTTGGATACA 
GTGGCGGCAG TGATCCCCAA AATACTAACA GTGATGAGAA CCCATGGAAC GTCTCTGTCA 
GTCCAGCTGG AGGCACTGCG AGCTCTTCTG CATTTTGTGG TGCCGGGAGT ATCAGAAGAT 
TCCAGGGATG ACTCGCGATG CCAACCAAAC GTGCTCAGAA CACAGTGCTT CAGGACTGAC 
ATCCACAAGC TGGTTCTAGC CGCTCTGAAC AGGTTCATTG GGAATCCCGG GATTCAGAAA 
TGTGGATTGA AAGTCATCTC TTCTTTCGCA CATCTTCCCG ATGCCTTAGA GATGTTATCC 
CTGCATGGAG CAGTTGACTC AGTCCTCCAT ACCTTACAGA TGTATCCAGA TGACCAAGAA 
ATTCAGTGTC TGGGCTTACA CCTTATGGGA TGCCTGATGA CAAAGAAGAA TTTCTGCATA 
GGGACAGGGC ACCTCCTGGC AAAAATTCTG GCTTCCACCT TGCAGCGATT TAAAGATGTT 
GCTGAAGTAC AGACTACAGG ATTACAGACG GTCTTGTCAA TGCTTGACCT GTCCGTATCT 
TTCTCCAAGC TGCTAGTGCA CTATTCATTT GATGTGGTGA TGTTTCATCA GATGTCTTCC 
GGTGTCCTGG AACAAAAGGA TGAGCAGTTT CTCAACTTAT GCTGCAAATG CTTTGCAAAA 
GTGGCTGTGG ATGATGAGCT GAAAAGCAAG ATGCTAGAGA GAGCCTGCGA TCAGAACAAC 
AGCATCATGG TCGAATGTTT GCTCCTCTTG GGAGCCGATG CCAATCAAGC GAAGGGGGCA 
ACTTCTTTAA TCTATCAGGT ATGTGAGAAA GAGAGCAGCC CTAAATTGGT GGAACTATTG 
CTTAACAGTG GGTGCCGTGA ACAAGATGTA CGGAAAGCCC TGACAGTAAG CATCCAAAAG 
GGCGACAACC AGGTCATCAG CTTACTCCTG AGGAGACTTG CCCTGGACCT GGCCAACAAC 
AGCATTTGCC TTGGAGGATT TTGCATAGGA AAACTTGATC CTTCTTGGCT AGGCCCTTTA 
TTTCCAGATA AGTCATCTAA TTTGAGGAAA CAAACAAATG CGGGGTCTGT CCTAGCGAGG 
AAAGTGCTCC GGTATCAGAT GAGAAACACT CTTCAAGAAG GCGTGGCCTC AGGCAGTGAG 
GGCAACTTCT CTGAGGATGC GCTGGCGAAA TTTGGCGAAT GGACCTTCAT TCCCGACTCT 
TCTATGGACA GTGTGTTTGG CCAGAGTGAC GATCTGGATA GCGAAGGCAG CGAGAGCTCC 
TTTCTGGTGA AGAAGAAGTC CAACTCAGTT AGTGTAGGAG AAGTTTACAG GGACCTAGCT 
CTGCAGCGCT GCTCACCAAA TGCTCAGAGG CACTCCAGTT CCTTGGGTCC TGTTTTTGAT 
CACGAAGATC TACTGAGACG AAAAAGAAAA ATACTGTCCT CAGATGAGTC TCTCAGATCC 
TCAAGGCTGC AGTCCCATAC GAGACAATCA GATAGCTCTT CTTCTCTGGC TTCTGAGAGA 
GAACACATCA CGTCTTTAGA CCTTTCTGCC AACGAACTGA AAGATATTGA TGCTCTGGGC 
CAGAAGTGTT GCCTCAGTAG CCACCTGGAG CATCTCACCA AGCTGGAACT TCACCAGAAT 
TCACTCACGA GCTTCCCACA ACAGCTGTGT GAGACTCTGA AGTGCTTGAC ACATCTGGAT 
TTGCACAGTA ACAAATTCGC CACCTTTCCC TCCTTCATGT TGAAAATGCC AAGTGTTATC 
CACCTAGACG CCTCTCGAAA TGACATCGGA CCAACAGTTG TTTTAGACCC TGTGGTGAAG 
TGTCCAAGCC TCAAACAGTT TAACCTGTCC TACAACCAGC TCTCTTCCAT CCCAGAGAAC 
CTGGACCAAG TGGTGGAGAA ACTGGAGCAG CTCCTACTGG AAGGAAACAA AATATCCGGG 
ATTTGTTCTC CCTTGAGCCT GAAGGAACTG AAGATTTTAA ACCTTAGTAA AAACCACATT 
CCATCCCTAC CTGAAGACTT TCTCGAGGCT TGCCCGAAAG TGGAGAGCTT CAGTGCCCGC 
ATGAATTTTC TCGCTGCAAT GCCTGCCTTA CCGTCTTCCA TAACTAGCTT AAAATTGTCT 
CAAAACTCTT TCACGTGCAT TCCAGAAGCG ATCTTCAGTC TTCCACACTT GCGGTCCTTG 
GATATGAGTC ACAACAACAT TGAACACCTG CCGGGACCTG CACATTGGAA GTCTCTGAAC 
TTAAGGGAAC TCATTTTTAG CAAGAATCAG ATCAGCACCT TAGACTTGAG CGAAAACCCA 
CACATATGGT CAAGAGTAGA GAAGCTGCAT CTCTCTCATA ATAAACTGAA AGAGATTCCT 
CCAGAAATTG GCCGTCTTGA AAACCTGACA TCTCTTGATG TCAGTTACAA CCTGGAACTG 
AGGTCCTTTC CAAACGAAAT GGGGAAGTTA AGCAAAATAT GGGATCTTCC CTTGGATGGA 
CTGCACCTCA ACTTTGACTT TAAGCACATA GGATGCAAAG CCAAAGACAT CATAAGGTTT 
CTACAACAAC GTCTGAAAAA GGCCGTGCCC TACAACCGAA TGAAGCTCAT GATTGTGGGC 
AATACGGGGA GTGGTAAGAC CACTCTACTG CAGCAGCTCA TGAAAATGAA GAAATCAGAA 
CTCGGCATGC AGGGCGCCAC GGTTGGCATA GACGTGCGAG ACTGGCCCAT CCAAATACGA 
GGCAAAAGGA AAAAGGACCT TGTTCTAAAC GTGTGGGACT TTGCAGGCCG TGAGGAATTC 
TACAGCACTC ACCCCCACTT CATGACCCAG AGAGCCCTGT ACCTGGCTGT CTACGACCTC 
AGCAAGGGGC AGGCGGAGGT GGATGCCATG AAGCCCTGGC TCTTCAACAT CAAGGCTCGT 
GCCTCTTCTT CCCCGGTGAT TCTGGTGGGC ACACATTTGG ATGTTTCTGA TGAGAAGCAG 
CGCAAAGCCT GCATAGGCAA AATCACGAAG GAACTCCTTA ATAAGCGAGG ATTCCCCACC 
ATCCGGGACT ACCACTTCGT GAATGCCACT GAGGAGTCGG ATGCGCTGGC AAAGCTCCGG 
AAAACCATCA TAAATGAGAG TCTTAATTTC AAGATCCGAG ATCAGCCCGT GGTTGGGCAG 
CTAATTCCAG ATTGCTACGT AGAACTGGAG AAAATAATCT TATCGGAGCG TAAAGCTGTA 
CCAACGGAGT TTCCTGTAAT TAACCGGAAA CACTTACTCC AGCTGGTGAA GGAACACCAG 
CTGCAGCTGG ATGAGAACGA GCTCCCCCAC GCTGTTCACT TCCTGAATGA GTCAGGAGTT 
CTTCTGCATT TTCAAGACCC CGCATTGCAG CTGAGTGACC TGTACTTTGT GGAACCCAAG 
TGGCTTTGTA AAGTCATGGC ACAGATTTTG ACCGTGAAAG TGGACGGCTG CCTGAAGCAT 
CCTAAGGGCA TCATTTCACG GAGAGATGTG GAAAAATTCC TTTCCAAGAA AAAGCGATTC 
CCTAAGAACT ACATGGCGCA GTACTTCAAA CTTTTAGAAA AATTTCAGAT CGCATTACCA 
ATAGGGGAAG AATATCTGCT GGTTCCAAGC AGCTTATCTG ACCACAGGCC AGTGATAGAG 
CTCCCCCACT GTGAGAACTC TGAGATCATC ATCCGGCTGT ATGAAATGCC ATACTTTCCA 
ATGGGATTTT GGTCAAGATT GATTAACCGA TTACTTGAAA TCTCACCTTT CATGCTTTCT 
GGAAGAGAGA GAGCACTACG CCCAAACCGA ATGTACTGGC GCCAAGGCAT CTACTTGAAT 
TGGTCTCCAG AAGCCTACTG TCTGGTGGGC TCTGAAGTCT TAGACAGTCG CCCAGAGAGT 
TTCTTGAAAA TCACAGTTCC ATCTTGTAGA AAAGGTTGTA TTCTTTTGGG CCGAGTTGTG 
GATCATATTG ACTCACTCAT GGAAGAATGG TTTCCTGGAT TGCTGGAGAT TGACATTTGT 
GGGGAAGGAG AAACTTTGTT GAAAAAATGG GCATTGTATA GTTTTAATGA TGGCGAAGAA 
CATCAGAAGA TCTTGCTTGA TGAGTTGATG AAGAAGGCTG AAGAAGGAGA CCTGTTAATA 
AATCCAGATC AACCAAGGCT CACCATTCCA ATATCCCAGA TTGCTCCGGA CTTGATCTTG 
GCTGACCTGC CTAGAAATAT TATGTTGAAC AATGACGAAC TGGAATTTGA GGAAGCACCC 
GAGTTTCTCT TAGGTGATGG AAGTTTCGGA TCAGTTTATC GAGCTGCCTA CGAAGGAGAG 
GAAGTGGCTG TGAAGATTTT TAATAAGCAC ACATCGCTTA GGCTGTTAAG ACAAGAGTTG 
GTGGTACTCT GTCATCTCCA CCATCCCAGC TTGATCTCCC TGTTGGCGGC TGGGATTCGT 
CCTCGGATGC TGGTAATGGA GTTGGCCTCC AAGGGTTCCT TGGATCGCCT GCTGCAGCAG 
GACAAAGCCA GCCTCACCCG GACCCTCCAG CACAGAATCG CATTGCATGT GGCCGATGGC 
CTGAGATATC TGCACTCGGC CATGATTATT TACCGTGATC TGAAGCCCCA CAACGTGCTA 
CTCTTCACCC TGTATCCCAA TGCCGCCATC ATTGCGAAGA TTGCGGACTA CGGGATTGCA 
CAGTACTGCT GTAGGATGGG AATAAAGACC TCAGAGGGCA CCCCAGGGTT CCGAGCACCT 
GAAGTTGCCA GAGGAAATGT CATTTATAAC CAACAGGCTG ATGTTTATTC TTTTGGCTTA 
CTACTTCATG ATATCTGGAC AACTGGGAAT AGAATCATGG AGGGTTTGAG GTTTCCAAAT 
GAGTTTGATG AACTGGCCAT ACAAGGGAAA TTGCCAGACC CAGTTAAAGA ATATGGCTGT 
GCCCCGTGGC CTATGGTTGA GAAGTTAATT ACAAAATGTT TGAAAGAAAA TCCTCAAGAA 
AGACCCACTT CTGCCCAGGT CTTTGACATT TTGAATTCAG CTGAGTTAAT TTGCCTCATG 
CGACACATTT TCATACCTAA GGACATCACT GTTGAATGCA TAGCTGCTAC AAACCTCAAT 
AGCAAGCGAG CGACTCTCTG GTTGGGCTGT GGGAACACAG AAAAAGGGCA GCTTTCCTTA 
CTTGACTTGA ACACGGAAAG ATACAGCTAT GAGGAAGTTA CTGATAGTAG AATACTGTGC 
CTGGCTTTGG TGCATCTTGC TGCTGAGAAA GAGAGCTGGG TTGTGTGTGG GACACAGTCC 
GGAGCTCTCC TGGTCATCAA TGCTGAAGAT GAGACAAGGA GACACACCCT CGACAAGATG 
ACTGATTCTG TTACTTGCTT GTATTGCAAT TCCTTTGCCA AGCAGAGCAA GCAAAGTCAC 
TTCCTTTTGG TGGGAACTGC TGATGGCAAC TTAATGATAT TTGAAGATAA GACCATTAAG 
TGTAAAGGAG CTGCCCCATT GAAGACACTA CACATAGGCG ATGTCAGTAC GCCCCTGATG 
TGCCTGAGCG AGTCCATGAA TTCATCTGAA AGACACATCA CATGGGGAGG GTGTGGCACA 
AAGATCTTCT CCTTTTCCAA TGATTTCACC ATTCAGAAAC TCATCGAGAC AAGAACCAAC 
CAGCTGTTTT CTTACTCAGC GTTCAGCGAT TCTAACATCA TAGCGGTGGC AGTGGACACA 
GCGCTTTATA TTGCCAAGAA AAACAGCCCT GTCGTAGAGG TGTGGGACAA GAAGACAGAA 
AAACTCTGTG AACTAATAGA CTGTGTGCAC TTCTTAAAGG AGGTGATGGT GAAAATAAAC 
AAGGACTCGA AGCACAAGCT GTCCTACTCT GGGAGGGTGA AGGCACTCTG CCTGCAGAAG 
AACACAGCTC TCTGGATCGG AACTGGAGGA GGCCACATCT TACTCCTGGA TCTTTCTACA 
CGGCGAGTCA TCCGCACCAT CCACAATTTC TGTGATTCCG TGAGAGCCAT GGCCACAGCT 
CAGTTAGGCA ACCTTAAAAA TGTCATGCTG GTTTTGGGGT ACAAGCGGAA GAGTACAGAA 
GGAACCCAAG AACAAAAAGA GATACAATCT TGTTTGTCTA TTTGGGACCT CAATCTTCCA 
CATGAAGTGC AAAACTTAGA AAAACACATT GAAGTAAGAA CAGAACTGGC TGATAAAATG 
AGGAAAACAT CTGTCGAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lrrk2 ( XM_006242190.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006242252.1 Rattus norvegicus leucine-rich repeat kinase 2 (Lrrk2), transcript variant X1, mRNA.

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CloneID	ORa30666
Clone ID Related Accession (Same CDS sequence)	XM_006242190.3
Accession Version	XM_006242190.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 7581bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006242190.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCAGTG GCGCCTGTCA GGGCTGCGAC GAGGAAGAGG AGGAGGAGGC TCTGAAGAAG 
TTGATAGTCA GGCTGAATAA TGTCCAGGAA GGCAAGCAGA TCGAGACGTT GCTCCAGCTC 
CTGGAGGACA TTCTGGTGTT CACCTACTCC GACCGCGCCT CCAAGTTATT TGAAGGCAAA 
AATGTCCACG TGCCTCTGTT GATAGTCCTG GACTCCTACA TGAGAGTCGC CAGTGTGCAG 
CAGGTGGGGT GGTCACTTCT GTGCAAATTA ATAGAAGTCT GTCCAGGGAC ATTGCAAAGC 
TTAATAGGAC CCCAGGATAT TGGGAATGAT TGGGAAGTCC TTGGTATTCA CCGACTGATT 
CTTAAAATGT TAACTGTTCA TCATGCCAAC GTAAACCTGT CAATAGTTGG ACTAAAAGCC 
TTAGATCTCC TCCTAGATTC AGGTAAAATT ACTCTGCTGA TACTGGATGA AGAATGTGAT 
GTTTTCCTGT TAATTTTTGA TGCCATGCAC AGATATTCAG CCAACGAGGA AGTCCAGAAG 
CTTGCGTGCA AGGCTTTACA TGTGCTGTTC GAGAGAGTGT CCGAGGAGCA ACTGACTGAG 
TTTGTGGAGA ACAAAGATTA CATGACCCTG CTGAGTACGT TCCGCAGCTT CAAGAGGGAC 
GAGGAGATTG TGCACCATGT ACTCTGCTGC CTGCATTCTC TGGCCGTCAC TTGCAGCAAT 
GTGGAGGTCC TCATGAGTGG GAATGTCAGG TGTTACAATA TTGTGGTGGA AGCCATGAAA 
ACATTCCCCA CCAGTGAAAA CATTCAAGAG GTGAGCTGCT CCTTGCTCCA CAAGCTTACA 
TTAGGTAATT TTTTCAACAT CCTGGTGTTG AACGAAGTCC ATGTCTTTGT GGTGAAAGCC 
GTCCAGCGGT ATCCCGAGAA CGTAGCCTTA CAGATCTCTG CACTCAGCTG CTTAGCCCTC 
CTCACCGAGA CTATTTTCTT AAACCAAGAC CTGGAAGAAA GAAGTGAGAC TCAGGAAAAC 
AGCGATGAGG ACAGTGAGAA GCCTTTCTGG TTGGAACCCT GCTATAAAGC CCTGATGCGC 
CATCGAAAGA ACAAACACGT GCAGGAGGCC GCCTGCTGGG CCCTAAATAA TCTCCTCATG 
TACCAGAGCA GTTTGCACGA GAAGATTGGA GATGAAGATG GCCAGTTCCC GGCGCACAGG 
GAAGTGATGC TGTCTATGCT GATGCACTCT TCTTCCAAAG ACGTCTTCCA AGCAGCTGCG 
CATGCTCTGT CCACTCTCTT GGAACAAAAC GTTAATTTCA GGAAAATCCT GCTTGCAAAA 
GGAGTGTACC TGAATGTCTT GGAGTTGATG CAGCGGCACG CCCAGGTTCC TGAGGTGGCA 
GAGAGTGGCT GCAAGATGCT GAGTCATCTG TTTGAAGGAA GCAACCCTTC TTTGGATACA 
GTGGCGGCAG TGATCCCCAA AATACTAACA GTGATGAGAA CCCATGGAAC GTCTCTGTCA 
GTCCAGCTGG AGGCACTGCG AGCTCTTCTG CATTTTGTGG TGCCGGGAGT ATCAGAAGAT 
TCCAGGGATG ACTCGCGATG CCAACCAAAC GTGCTCAGAA CACAGTGCTT CAGGACTGAC 
ATCCACAAGC TGGTTCTAGC CGCTCTGAAC AGGTTCATTG GGAATCCCGG GATTCAGAAA 
TGTGGATTGA AAGTCATCTC TTCTTTCGCA CATCTTCCCG ATGCCTTAGA GATGTTATCC 
CTGCATGGAG CAGTTGACTC AGTCCTCCAT ACCTTACAGA TGTATCCAGA TGACCAAGAA 
ATTCAGTGTC TGGGCTTACA CCTTATGGGA TGCCTGATGA CAAAGAAGAA TTTCTGCATA 
GGGACAGGGC ACCTCCTGGC AAAAATTCTG GCTTCCACCT TGCAGCGATT TAAAGATGTT 
GCTGAAGTAC AGACTACAGG ATTACAGACG GTCTTGTCAA TGCTTGACCT GTCCGTATCT 
TTCTCCAAGC TGCTAGTGCA CTATTCATTT GATGTGGTGA TGTTTCATCA GATGTCTTCC 
GGTGTCCTGG AACAAAAGGA TGAGCAGTTT CTCAACTTAT GCTGCAAATG CTTTGCAAAA 
GTGGCTGTGG ATGATGAGCT GAAAAGCAAG ATGCTAGAGA GAGCCTGCGA TCAGAACAAC 
AGCATCATGG TCGAATGTTT GCTCCTCTTG GGAGCCGATG CCAATCAAGC GAAGGGGGCA 
ACTTCTTTAA TCTATCAGGT ATGTGAGAAA GAGAGCAGCC CTAAATTGGT GGAACTATTG 
CTTAACAGTG GGTGCCGTGA ACAAGATGTA CGGAAAGCCC TGACAGTAAG CATCCAAAAG 
GGCGACAACC AGGTCATCAG CTTACTCCTG AGGAGACTTG CCCTGGACCT GGCCAACAAC 
AGCATTTGCC TTGGAGGATT TTGCATAGGA AAACTTGATC CTTCTTGGCT AGGCCCTTTA 
TTTCCAGATA AGTCATCTAA TTTGAGGAAA CAAACAAATG CGGGGTCTGT CCTAGCGAGG 
AAAGTGCTCC GGTATCAGAT GAGAAACACT CTTCAAGAAG GCGTGGCCTC AGGCAGTGAG 
GGCAACTTCT CTGAGGATGC GCTGGCGAAA TTTGGCGAAT GGACCTTCAT TCCCGACTCT 
TCTATGGACA GTGTGTTTGG CCAGAGTGAC GATCTGGATA GCGAAGGCAG CGAGAGCTCC 
TTTCTGGTGA AGAAGAAGTC CAACTCAGTT AGTGTAGGAG AAGTTTACAG GGACCTAGCT 
CTGCAGCGCT GCTCACCAAA TGCTCAGAGG CACTCCAGTT CCTTGGGTCC TGTTTTTGAT 
CACGAAGATC TACTGAGACG AAAAAGAAAA ATACTGTCCT CAGATGAGTC TCTCAGATCC 
TCAAGGCTGC AGTCCCATAC GAGACAATCA GATAGCTCTT CTTCTCTGGC TTCTGAGAGA 
GAACACATCA CGTCTTTAGA CCTTTCTGCC AACGAACTGA AAGATATTGA TGCTCTGGGC 
CAGAAGTGTT GCCTCAGTAG CCACCTGGAG CATCTCACCA AGCTGGAACT TCACCAGAAT 
TCACTCACGA GCTTCCCACA ACAGCTGTGT GAGACTCTGA AGTGCTTGAC ACATCTGGAT 
TTGCACAGTA ACAAATTCGC CACCTTTCCC TCCTTCATGT TGAAAATGCC AAGTGTTATC 
CACCTAGACG CCTCTCGAAA TGACATCGGA CCAACAGTTG TTTTAGACCC TGTGGTGAAG 
TGTCCAAGCC TCAAACAGTT TAACCTGTCC TACAACCAGC TCTCTTCCAT CCCAGAGAAC 
CTGGACCAAG TGGTGGAGAA ACTGGAGCAG CTCCTACTGG AAGGAAACAA AATATCCGGG 
ATTTGTTCTC CCTTGAGCCT GAAGGAACTG AAGATTTTAA ACCTTAGTAA AAACCACATT 
CCATCCCTAC CTGAAGACTT TCTCGAGGCT TGCCCGAAAG TGGAGAGCTT CAGTGCCCGC 
ATGAATTTTC TCGCTGCAAT GCCTGCCTTA CCGTCTTCCA TAACTAGCTT AAAATTGTCT 
CAAAACTCTT TCACGTGCAT TCCAGAAGCG ATCTTCAGTC TTCCACACTT GCGGTCCTTG 
GATATGAGTC ACAACAACAT TGAACACCTG CCGGGACCTG CACATTGGAA GTCTCTGAAC 
TTAAGGGAAC TCATTTTTAG CAAGAATCAG ATCAGCACCT TAGACTTGAG CGAAAACCCA 
CACATATGGT CAAGAGTAGA GAAGCTGCAT CTCTCTCATA ATAAACTGAA AGAGATTCCT 
CCAGAAATTG GCCGTCTTGA AAACCTGACA TCTCTTGATG TCAGTTACAA CCTGGAACTG 
AGGTCCTTTC CAAACGAAAT GGGGAAGTTA AGCAAAATAT GGGATCTTCC CTTGGATGGA 
CTGCACCTCA ACTTTGACTT TAAGCACATA GGATGCAAAG CCAAAGACAT CATAAGGTTT 
CTACAACAAC GTCTGAAAAA GGCCGTGCCC TACAACCGAA TGAAGCTCAT GATTGTGGGC 
AATACGGGGA GTGGTAAGAC CACTCTACTG CAGCAGCTCA TGAAAATGAA GAAATCAGAA 
CTCGGCATGC AGGGCGCCAC GGTTGGCATA GACGTGCGAG ACTGGCCCAT CCAAATACGA 
GGCAAAAGGA AAAAGGACCT TGTTCTAAAC GTGTGGGACT TTGCAGGCCG TGAGGAATTC 
TACAGCACTC ACCCCCACTT CATGACCCAG AGAGCCCTGT ACCTGGCTGT CTACGACCTC 
AGCAAGGGGC AGGCGGAGGT GGATGCCATG AAGCCCTGGC TCTTCAACAT CAAGGCTCGT 
GCCTCTTCTT CCCCGGTGAT TCTGGTGGGC ACACATTTGG ATGTTTCTGA TGAGAAGCAG 
CGCAAAGCCT GCATAGGCAA AATCACGAAG GAACTCCTTA ATAAGCGAGG ATTCCCCACC 
ATCCGGGACT ACCACTTCGT GAATGCCACT GAGGAGTCGG ATGCGCTGGC AAAGCTCCGG 
AAAACCATCA TAAATGAGAG TCTTAATTTC AAGATCCGAG ATCAGCCCGT GGTTGGGCAG 
CTAATTCCAG ATTGCTACGT AGAACTGGAG AAAATAATCT TATCGGAGCG TAAAGCTGTA 
CCAACGGAGT TTCCTGTAAT TAACCGGAAA CACTTACTCC AGCTGGTGAA GGAACACCAG 
CTGCAGCTGG ATGAGAACGA GCTCCCCCAC GCTGTTCACT TCCTGAATGA GTCAGGAGTT 
CTTCTGCATT TTCAAGACCC CGCATTGCAG CTGAGTGACC TGTACTTTGT GGAACCCAAG 
TGGCTTTGTA AAGTCATGGC ACAGATTTTG ACCGTGAAAG TGGACGGCTG CCTGAAGCAT 
CCTAAGGGCA TCATTTCACG GAGAGATGTG GAAAAATTCC TTTCCAAGAA AAAGCGATTC 
CCTAAGAACT ACATGGCGCA GTACTTCAAA CTTTTAGAAA AATTTCAGAT CGCATTACCA 
ATAGGGGAAG AATATCTGCT GGTTCCAAGC AGCTTATCTG ACCACAGGCC AGTGATAGAG 
CTCCCCCACT GTGAGAACTC TGAGATCATC ATCCGGCTGT ATGAAATGCC ATACTTTCCA 
ATGGGATTTT GGTCAAGATT GATTAACCGA TTACTTGAAA TCTCACCTTT CATGCTTTCT 
GGAAGAGAGA GAGCACTACG CCCAAACCGA ATGTACTGGC GCCAAGGCAT CTACTTGAAT 
TGGTCTCCAG AAGCCTACTG TCTGGTGGGC TCTGAAGTCT TAGACAGTCG CCCAGAGAGT 
TTCTTGAAAA TCACAGTTCC ATCTTGTAGA AAAGGTTGTA TTCTTTTGGG CCGAGTTGTG 
GATCATATTG ACTCACTCAT GGAAGAATGG TTTCCTGGAT TGCTGGAGAT TGACATTTGT 
GGGGAAGGAG AAACTTTGTT GAAAAAATGG GCATTGTATA GTTTTAATGA TGGCGAAGAA 
CATCAGAAGA TCTTGCTTGA TGAGTTGATG AAGAAGGCTG AAGAAGGAGA CCTGTTAATA 
AATCCAGATC AACCAAGGCT CACCATTCCA ATATCCCAGA TTGCTCCGGA CTTGATCTTG 
GCTGACCTGC CTAGAAATAT TATGTTGAAC AATGACGAAC TGGAATTTGA GGAAGCACCC 
GAGTTTCTCT TAGGTGATGG AAGTTTCGGA TCAGTTTATC GAGCTGCCTA CGAAGGAGAG 
GAAGTGGCTG TGAAGATTTT TAATAAGCAC ACATCGCTTA GGCTGTTAAG ACAAGAGTTG 
GTGGTACTCT GTCATCTCCA CCATCCCAGC TTGATCTCCC TGTTGGCGGC TGGGATTCGT 
CCTCGGATGC TGGTAATGGA GTTGGCCTCC AAGGGTTCCT TGGATCGCCT GCTGCAGCAG 
GACAAAGCCA GCCTCACCCG GACCCTCCAG CACAGAATCG CATTGCATGT GGCCGATGGC 
CTGAGATATC TGCACTCGGC CATGATTATT TACCGTGATC TGAAGCCCCA CAACGTGCTA 
CTCTTCACCC TGTATCCCAA TGCCGCCATC ATTGCGAAGA TTGCGGACTA CGGGATTGCA 
CAGTACTGCT GTAGGATGGG AATAAAGACC TCAGAGGGCA CCCCAGGGTT CCGAGCACCT 
GAAGTTGCCA GAGGAAATGT CATTTATAAC CAACAGGCTG ATGTTTATTC TTTTGGCTTA 
CTACTTCATG ATATCTGGAC AACTGGGAAT AGAATCATGG AGGGTTTGAG GTTTCCAAAT 
GAGTTTGATG AACTGGCCAT ACAAGGGAAA TTGCCAGACC CAGTTAAAGA ATATGGCTGT 
GCCCCGTGGC CTATGGTTGA GAAGTTAATT ACAAAATGTT TGAAAGAAAA TCCTCAAGAA 
AGACCCACTT CTGCCCAGGT CTTTGACATT TTGAATTCAG CTGAGTTAAT TTGCCTCATG 
CGACACATTT TCATACCTAA GGACATCACT GTTGAATGCA TAGCTGCTAC AAACCTCAAT 
AGCAAGCGAG CGACTCTCTG GTTGGGCTGT GGGAACACAG AAAAAGGGCA GCTTTCCTTA 
CTTGACTTGA ACACGGAAAG ATACAGCTAT GAGGAAGTTA CTGATAGTAG AATACTGTGC 
CTGGCTTTGG TGCATCTTGC TGCTGAGAAA GAGAGCTGGG TTGTGTGTGG GACACAGTCC 
GGAGCTCTCC TGGTCATCAA TGCTGAAGAT GAGACAAGGA GACACACCCT CGACAAGATG 
ACTGATTCTG TTACTTGCTT GTATTGCAAT TCCTTTGCCA AGCAGAGCAA GCAAAGTCAC 
TTCCTTTTGG TGGGAACTGC TGATGGCAAC TTAATGATAT TTGAAGATAA GACCATTAAG 
TGTAAAGGAG CTGCCCCATT GAAGACACTA CACATAGGCG ATGTCAGTAC GCCCCTGATG 
TGCCTGAGCG AGTCCATGAA TTCATCTGAA AGACACATCA CATGGGGAGG GTGTGGCACA 
AAGATCTTCT CCTTTTCCAA TGATTTCACC ATTCAGAAAC TCATCGAGAC AAGAACCAAC 
CAGCTGTTTT CTTACTCAGC GTTCAGCGAT TCTAACATCA TAGCGGTGGC AGTGGACACA 
GCGCTTTATA TTGCCAAGAA AAACAGCCCT GTCGTAGAGG TGTGGGACAA GAAGACAGAA 
AAACTCTGTG AACTAATAGA CTGTGTGCAC TTCTTAAAGG AGGTGATGGT GAAAATAAAC 
AAGGACTCGA AGCACAAGCT GTCCTACTCT GGGAGGGTGA AGGCACTCTG CCTGCAGAAG 
AACACAGCTC TCTGGATCGG AACTGGAGGA GGCCACATCT TACTCCTGGA TCTTTCTACA 
CGGCGAGTCA TCCGCACCAT CCACAATTTC TGTGATTCCG TGAGAGCCAT GGCCACAGCT 
CAGTTAGGAA GCCTTAAAAA TGTCATGCTG GTTTTGGGGT ACAAGCGGAA GAGTACAGAA 
GGAACCCAAG AACAAAAAGA GATACAATCT TGTTTGTCTA TTTGGGACCT CAATCTTCCA 
CATGAAGTGC AAAACTTAGA AAAACACATT GAAGTAAGAA CAGAACTGGC TGATAAAATG 
AGGAAAACAT CTGTCGAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006242252.1
CDS	398..7978
Translation	MASGACQGCDEEEEEEALKKLIVRLNNVQEGKQIETLLQLLEDILVFTYSDRASKLFEGKNVHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTLQSLIGPQDIGNDWEVLGIHRLILKMLTVHHANVNLSIVGLKALDLLLDSGKITLLILDEECDVFLLIFDAMHRYSANEEVQKLACKALHVLFERVSEEQLTEFVENKDYMTLLSTFRSFKRDEEIVHHVLCCLHSLAVTCSNVEVLMSGNVRCYNIVVEAMKTFPTSENIQEVSCSLLHKLTLGNFFNILVLNEVHVFVVKAVQRYPENVALQISALSCLALLTETIFLNQDLEERSETQENSDEDSEKPFWLEPCYKALMRHRKNKHVQEAACWALNNLLMYQSSLHEKIGDEDGQFPAHREVMLSMLMHSSSKDVFQAAAHALSTLLEQNVNFRKILLAKGVYLNVLELMQRHAQVPEVAESGCKMLSHLFEGSNPSLDTVAAVIPKILTVMRTHGTSLSVQLEALRALLHFVVPGVSEDSRDDSRCQPNVLRTQCFRTDIHKLVLAALNRFIGNPGIQKCGLKVISSFAHLPDALEMLSLHGAVDSVLHTLQMYPDDQEIQCLGLHLMGCLMTKKNFCIGTGHLLAKILASTLQRFKDVAEVQTTGLQTVLSMLDLSVSFSKLLVHYSFDVVMFHQMSSGVLEQKDEQFLNLCCKCFAKVAVDDELKSKMLERACDQNNSIMVECLLLLGADANQAKGATSLIYQVCEKESSPKLVELLLNSGCREQDVRKALTVSIQKGDNQVISLLLRRLALDLANNSICLGGFCIGKLDPSWLGPLFPDKSSNLRKQTNAGSVLARKVLRYQMRNTLQEGVASGSEGNFSEDALAKFGEWTFIPDSSMDSVFGQSDDLDSEGSESSFLVKKKSNSVSVGEVYRDLALQRCSPNAQRHSSSLGPVFDHEDLLRRKRKILSSDESLRSSRLQSHTRQSDSSSSLASEREHITSLDLSANELKDIDALGQKCCLSSHLEHLTKLELHQNSLTSFPQQLCETLKCLTHLDLHSNKFATFPSFMLKMPSVIHLDASRNDIGPTVVLDPVVKCPSLKQFNLSYNQLSSIPENLDQVVEKLEQLLLEGNKISGICSPLSLKELKILNLSKNHIPSLPEDFLEACPKVESFSARMNFLAAMPALPSSITSLKLSQNSFTCIPEAIFSLPHLRSLDMSHNNIEHLPGPAHWKSLNLRELIFSKNQISTLDLSENPHIWSRVEKLHLSHNKLKEIPPEIGRLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDGLHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKMKKSELGMQGATVGIDVRDWPIQIRGKRKKDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACIGKITKELLNKRGFPTIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKAVPTEFPVINRKHLLQLVKEHQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVDGCLKHPKGIISRRDVEKFLSKKKRFPKNYMAQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPFMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDSRPESFLKITVPSCRKGCILLGRVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDELMKKAEEGDLLINPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEEAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLHDIWTTGNRIMEGLRFPNEFDELAIQGKLPDPVKEYGCAPWPMVEKLITKCLKENPQERPTSAQVFDILNSAELICLMRHIFIPKDITVECIAATNLNSKRATLWLGCGNTEKGQLSLLDLNTERYSYEEVTDSRILCLALVHLAAEKESWVVCGTQSGALLVINAEDETRRHTLDKMTDSVTCLYCNSFAKQSKQSHFLLVGTADGNLMIFEDKTIKCKGAAPLKTLHIGDVSTPLMCLSESMNSSERHITWGGCGTKIFSFSNDFTIQKLIETRTNQLFSYSAFSDSNIIAVAVDTALYIAKKNSPVVEVWDKKTEKLCELIDCVHFLKEVMVKINKDSKHKLSYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRTIHNFCDSVRAMATAQLGSLKNVMLVLGYKRKSTEGTQEQKEIQSCLSIWDLNLPHEVQNLEKHIEVRTELADKMRKTSVE

Target ORF information:

RefSeq Version	XM_006242190.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus leucine-rich repeat kinase 2 (Lrrk2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006242190.3

ORF Insert Sequence:

ATGGCCAGTG GCGCCTGTCA GGGCTGCGAC GAGGAAGAGG AGGAGGAGGC TCTGAAGAAG 
TTGATAGTCA GGCTGAATAA TGTCCAGGAA GGCAAGCAGA TCGAGACGTT GCTCCAGCTC 
CTGGAGGACA TTCTGGTGTT CACCTACTCC GACCGCGCCT CCAAGTTATT TGAAGGCAAA 
AATGTCCACG TGCCTCTGTT GATAGTCCTG GACTCCTACA TGAGAGTCGC CAGTGTGCAG 
CAGGTGGGGT GGTCACTTCT GTGCAAATTA ATAGAAGTCT GTCCAGGGAC ATTGCAAAGC 
TTAATAGGAC CCCAGGATAT TGGGAATGAT TGGGAAGTCC TTGGTATTCA CCGACTGATT 
CTTAAAATGT TAACTGTTCA TCATGCCAAC GTAAACCTGT CAATAGTTGG ACTAAAAGCC 
TTAGATCTCC TCCTAGATTC AGGTAAAATT ACTCTGCTGA TACTGGATGA AGAATGTGAT 
GTTTTCCTGT TAATTTTTGA TGCCATGCAC AGATATTCAG CCAACGAGGA AGTCCAGAAG 
CTTGCGTGCA AGGCTTTACA TGTGCTGTTC GAGAGAGTGT CCGAGGAGCA ACTGACTGAG 
TTTGTGGAGA ACAAAGATTA CATGACCCTG CTGAGTACGT TCCGCAGCTT CAAGAGGGAC 
GAGGAGATTG TGCACCATGT ACTCTGCTGC CTGCATTCTC TGGCCGTCAC TTGCAGCAAT 
GTGGAGGTCC TCATGAGTGG GAATGTCAGG TGTTACAATA TTGTGGTGGA AGCCATGAAA 
ACATTCCCCA CCAGTGAAAA CATTCAAGAG GTGAGCTGCT CCTTGCTCCA CAAGCTTACA 
TTAGGTAATT TTTTCAACAT CCTGGTGTTG AACGAAGTCC ATGTCTTTGT GGTGAAAGCC 
GTCCAGCGGT ATCCCGAGAA CGTAGCCTTA CAGATCTCTG CACTCAGCTG CTTAGCCCTC 
CTCACCGAGA CTATTTTCTT AAACCAAGAC CTGGAAGAAA GAAGTGAGAC TCAGGAAAAC 
AGCGATGAGG ACAGTGAGAA GCCTTTCTGG TTGGAACCCT GCTATAAAGC CCTGATGCGC 
CATCGAAAGA ACAAACACGT GCAGGAGGCC GCCTGCTGGG CCCTAAATAA TCTCCTCATG 
TACCAGAGCA GTTTGCACGA GAAGATTGGA GATGAAGATG GCCAGTTCCC GGCGCACAGG 
GAAGTGATGC TGTCTATGCT GATGCACTCT TCTTCCAAAG ACGTCTTCCA AGCAGCTGCG 
CATGCTCTGT CCACTCTCTT GGAACAAAAC GTTAATTTCA GGAAAATCCT GCTTGCAAAA 
GGAGTGTACC TGAATGTCTT GGAGTTGATG CAGCGGCACG CCCAGGTTCC TGAGGTGGCA 
GAGAGTGGCT GCAAGATGCT GAGTCATCTG TTTGAAGGAA GCAACCCTTC TTTGGATACA 
GTGGCGGCAG TGATCCCCAA AATACTAACA GTGATGAGAA CCCATGGAAC GTCTCTGTCA 
GTCCAGCTGG AGGCACTGCG AGCTCTTCTG CATTTTGTGG TGCCGGGAGT ATCAGAAGAT 
TCCAGGGATG ACTCGCGATG CCAACCAAAC GTGCTCAGAA CACAGTGCTT CAGGACTGAC 
ATCCACAAGC TGGTTCTAGC CGCTCTGAAC AGGTTCATTG GGAATCCCGG GATTCAGAAA 
TGTGGATTGA AAGTCATCTC TTCTTTCGCA CATCTTCCCG ATGCCTTAGA GATGTTATCC 
CTGCATGGAG CAGTTGACTC AGTCCTCCAT ACCTTACAGA TGTATCCAGA TGACCAAGAA 
ATTCAGTGTC TGGGCTTACA CCTTATGGGA TGCCTGATGA CAAAGAAGAA TTTCTGCATA 
GGGACAGGGC ACCTCCTGGC AAAAATTCTG GCTTCCACCT TGCAGCGATT TAAAGATGTT 
GCTGAAGTAC AGACTACAGG ATTACAGACG GTCTTGTCAA TGCTTGACCT GTCCGTATCT 
TTCTCCAAGC TGCTAGTGCA CTATTCATTT GATGTGGTGA TGTTTCATCA GATGTCTTCC 
GGTGTCCTGG AACAAAAGGA TGAGCAGTTT CTCAACTTAT GCTGCAAATG CTTTGCAAAA 
GTGGCTGTGG ATGATGAGCT GAAAAGCAAG ATGCTAGAGA GAGCCTGCGA TCAGAACAAC 
AGCATCATGG TCGAATGTTT GCTCCTCTTG GGAGCCGATG CCAATCAAGC GAAGGGGGCA 
ACTTCTTTAA TCTATCAGGT ATGTGAGAAA GAGAGCAGCC CTAAATTGGT GGAACTATTG 
CTTAACAGTG GGTGCCGTGA ACAAGATGTA CGGAAAGCCC TGACAGTAAG CATCCAAAAG 
GGCGACAACC AGGTCATCAG CTTACTCCTG AGGAGACTTG CCCTGGACCT GGCCAACAAC 
AGCATTTGCC TTGGAGGATT TTGCATAGGA AAACTTGATC CTTCTTGGCT AGGCCCTTTA 
TTTCCAGATA AGTCATCTAA TTTGAGGAAA CAAACAAATG CGGGGTCTGT CCTAGCGAGG 
AAAGTGCTCC GGTATCAGAT GAGAAACACT CTTCAAGAAG GCGTGGCCTC AGGCAGTGAG 
GGCAACTTCT CTGAGGATGC GCTGGCGAAA TTTGGCGAAT GGACCTTCAT TCCCGACTCT 
TCTATGGACA GTGTGTTTGG CCAGAGTGAC GATCTGGATA GCGAAGGCAG CGAGAGCTCC 
TTTCTGGTGA AGAAGAAGTC CAACTCAGTT AGTGTAGGAG AAGTTTACAG GGACCTAGCT 
CTGCAGCGCT GCTCACCAAA TGCTCAGAGG CACTCCAGTT CCTTGGGTCC TGTTTTTGAT 
CACGAAGATC TACTGAGACG AAAAAGAAAA ATACTGTCCT CAGATGAGTC TCTCAGATCC 
TCAAGGCTGC AGTCCCATAC GAGACAATCA GATAGCTCTT CTTCTCTGGC TTCTGAGAGA 
GAACACATCA CGTCTTTAGA CCTTTCTGCC AACGAACTGA AAGATATTGA TGCTCTGGGC 
CAGAAGTGTT GCCTCAGTAG CCACCTGGAG CATCTCACCA AGCTGGAACT TCACCAGAAT 
TCACTCACGA GCTTCCCACA ACAGCTGTGT GAGACTCTGA AGTGCTTGAC ACATCTGGAT 
TTGCACAGTA ACAAATTCGC CACCTTTCCC TCCTTCATGT TGAAAATGCC AAGTGTTATC 
CACCTAGACG CCTCTCGAAA TGACATCGGA CCAACAGTTG TTTTAGACCC TGTGGTGAAG 
TGTCCAAGCC TCAAACAGTT TAACCTGTCC TACAACCAGC TCTCTTCCAT CCCAGAGAAC 
CTGGACCAAG TGGTGGAGAA ACTGGAGCAG CTCCTACTGG AAGGAAACAA AATATCCGGG 
ATTTGTTCTC CCTTGAGCCT GAAGGAACTG AAGATTTTAA ACCTTAGTAA AAACCACATT 
CCATCCCTAC CTGAAGACTT TCTCGAGGCT TGCCCGAAAG TGGAGAGCTT CAGTGCCCGC 
ATGAATTTTC TCGCTGCAAT GCCTGCCTTA CCGTCTTCCA TAACTAGCTT AAAATTGTCT 
CAAAACTCTT TCACGTGCAT TCCAGAAGCG ATCTTCAGTC TTCCACACTT GCGGTCCTTG 
GATATGAGTC ACAACAACAT TGAACACCTG CCGGGACCTG CACATTGGAA GTCTCTGAAC 
TTAAGGGAAC TCATTTTTAG CAAGAATCAG ATCAGCACCT TAGACTTGAG CGAAAACCCA 
CACATATGGT CAAGAGTAGA GAAGCTGCAT CTCTCTCATA ATAAACTGAA AGAGATTCCT 
CCAGAAATTG GCCGTCTTGA AAACCTGACA TCTCTTGATG TCAGTTACAA CCTGGAACTG 
AGGTCCTTTC CAAACGAAAT GGGGAAGTTA AGCAAAATAT GGGATCTTCC CTTGGATGGA 
CTGCACCTCA ACTTTGACTT TAAGCACATA GGATGCAAAG CCAAAGACAT CATAAGGTTT 
CTACAACAAC GTCTGAAAAA GGCCGTGCCC TACAACCGAA TGAAGCTCAT GATTGTGGGC 
AATACGGGGA GTGGTAAGAC CACTCTACTG CAGCAGCTCA TGAAAATGAA GAAATCAGAA 
CTCGGCATGC AGGGCGCCAC GGTTGGCATA GACGTGCGAG ACTGGCCCAT CCAAATACGA 
GGCAAAAGGA AAAAGGACCT TGTTCTAAAC GTGTGGGACT TTGCAGGCCG TGAGGAATTC 
TACAGCACTC ACCCCCACTT CATGACCCAG AGAGCCCTGT ACCTGGCTGT CTACGACCTC 
AGCAAGGGGC AGGCGGAGGT GGATGCCATG AAGCCCTGGC TCTTCAACAT CAAGGCTCGT 
GCCTCTTCTT CCCCGGTGAT TCTGGTGGGC ACACATTTGG ATGTTTCTGA TGAGAAGCAG 
CGCAAAGCCT GCATAGGCAA AATCACGAAG GAACTCCTTA ATAAGCGAGG ATTCCCCACC 
ATCCGGGACT ACCACTTCGT GAATGCCACT GAGGAGTCGG ATGCGCTGGC AAAGCTCCGG 
AAAACCATCA TAAATGAGAG TCTTAATTTC AAGATCCGAG ATCAGCCCGT GGTTGGGCAG 
CTAATTCCAG ATTGCTACGT AGAACTGGAG AAAATAATCT TATCGGAGCG TAAAGCTGTA 
CCAACGGAGT TTCCTGTAAT TAACCGGAAA CACTTACTCC AGCTGGTGAA GGAACACCAG 
CTGCAGCTGG ATGAGAACGA GCTCCCCCAC GCTGTTCACT TCCTGAATGA GTCAGGAGTT 
CTTCTGCATT TTCAAGACCC CGCATTGCAG CTGAGTGACC TGTACTTTGT GGAACCCAAG 
TGGCTTTGTA AAGTCATGGC ACAGATTTTG ACCGTGAAAG TGGACGGCTG CCTGAAGCAT 
CCTAAGGGCA TCATTTCACG GAGAGATGTG GAAAAATTCC TTTCCAAGAA AAAGCGATTC 
CCTAAGAACT ACATGGCGCA GTACTTCAAA CTTTTAGAAA AATTTCAGAT CGCATTACCA 
ATAGGGGAAG AATATCTGCT GGTTCCAAGC AGCTTATCTG ACCACAGGCC AGTGATAGAG 
CTCCCCCACT GTGAGAACTC TGAGATCATC ATCCGGCTGT ATGAAATGCC ATACTTTCCA 
ATGGGATTTT GGTCAAGATT GATTAACCGA TTACTTGAAA TCTCACCTTT CATGCTTTCT 
GGAAGAGAGA GAGCACTACG CCCAAACCGA ATGTACTGGC GCCAAGGCAT CTACTTGAAT 
TGGTCTCCAG AAGCCTACTG TCTGGTGGGC TCTGAAGTCT TAGACAGTCG CCCAGAGAGT 
TTCTTGAAAA TCACAGTTCC ATCTTGTAGA AAAGGTTGTA TTCTTTTGGG CCGAGTTGTG 
GATCATATTG ACTCACTCAT GGAAGAATGG TTTCCTGGAT TGCTGGAGAT TGACATTTGT 
GGGGAAGGAG AAACTTTGTT GAAAAAATGG GCATTGTATA GTTTTAATGA TGGCGAAGAA 
CATCAGAAGA TCTTGCTTGA TGAGTTGATG AAGAAGGCTG AAGAAGGAGA CCTGTTAATA 
AATCCAGATC AACCAAGGCT CACCATTCCA ATATCCCAGA TTGCTCCGGA CTTGATCTTG 
GCTGACCTGC CTAGAAATAT TATGTTGAAC AATGACGAAC TGGAATTTGA GGAAGCACCC 
GAGTTTCTCT TAGGTGATGG AAGTTTCGGA TCAGTTTATC GAGCTGCCTA CGAAGGAGAG 
GAAGTGGCTG TGAAGATTTT TAATAAGCAC ACATCGCTTA GGCTGTTAAG ACAAGAGTTG 
GTGGTACTCT GTCATCTCCA CCATCCCAGC TTGATCTCCC TGTTGGCGGC TGGGATTCGT 
CCTCGGATGC TGGTAATGGA GTTGGCCTCC AAGGGTTCCT TGGATCGCCT GCTGCAGCAG 
GACAAAGCCA GCCTCACCCG GACCCTCCAG CACAGAATCG CATTGCATGT GGCCGATGGC 
CTGAGATATC TGCACTCGGC CATGATTATT TACCGTGATC TGAAGCCCCA CAACGTGCTA 
CTCTTCACCC TGTATCCCAA TGCCGCCATC ATTGCGAAGA TTGCGGACTA CGGGATTGCA 
CAGTACTGCT GTAGGATGGG AATAAAGACC TCAGAGGGCA CCCCAGGGTT CCGAGCACCT 
GAAGTTGCCA GAGGAAATGT CATTTATAAC CAACAGGCTG ATGTTTATTC TTTTGGCTTA 
CTACTTCATG ATATCTGGAC AACTGGGAAT AGAATCATGG AGGGTTTGAG GTTTCCAAAT 
GAGTTTGATG AACTGGCCAT ACAAGGGAAA TTGCCAGACC CAGTTAAAGA ATATGGCTGT 
GCCCCGTGGC CTATGGTTGA GAAGTTAATT ACAAAATGTT TGAAAGAAAA TCCTCAAGAA 
AGACCCACTT CTGCCCAGGT CTTTGACATT TTGAATTCAG CTGAGTTAAT TTGCCTCATG 
CGACACATTT TCATACCTAA GGACATCACT GTTGAATGCA TAGCTGCTAC AAACCTCAAT 
AGCAAGCGAG CGACTCTCTG GTTGGGCTGT GGGAACACAG AAAAAGGGCA GCTTTCCTTA 
CTTGACTTGA ACACGGAAAG ATACAGCTAT GAGGAAGTTA CTGATAGTAG AATACTGTGC 
CTGGCTTTGG TGCATCTTGC TGCTGAGAAA GAGAGCTGGG TTGTGTGTGG GACACAGTCC 
GGAGCTCTCC TGGTCATCAA TGCTGAAGAT GAGACAAGGA GACACACCCT CGACAAGATG 
ACTGATTCTG TTACTTGCTT GTATTGCAAT TCCTTTGCCA AGCAGAGCAA GCAAAGTCAC 
TTCCTTTTGG TGGGAACTGC TGATGGCAAC TTAATGATAT TTGAAGATAA GACCATTAAG 
TGTAAAGGAG CTGCCCCATT GAAGACACTA CACATAGGCG ATGTCAGTAC GCCCCTGATG 
TGCCTGAGCG AGTCCATGAA TTCATCTGAA AGACACATCA CATGGGGAGG GTGTGGCACA 
AAGATCTTCT CCTTTTCCAA TGATTTCACC ATTCAGAAAC TCATCGAGAC AAGAACCAAC 
CAGCTGTTTT CTTACTCAGC GTTCAGCGAT TCTAACATCA TAGCGGTGGC AGTGGACACA 
GCGCTTTATA TTGCCAAGAA AAACAGCCCT GTCGTAGAGG TGTGGGACAA GAAGACAGAA 
AAACTCTGTG AACTAATAGA CTGTGTGCAC TTCTTAAAGG AGGTGATGGT GAAAATAAAC 
AAGGACTCGA AGCACAAGCT GTCCTACTCT GGGAGGGTGA AGGCACTCTG CCTGCAGAAG 
AACACAGCTC TCTGGATCGG AACTGGAGGA GGCCACATCT TACTCCTGGA TCTTTCTACA 
CGGCGAGTCA TCCGCACCAT CCACAATTTC TGTGATTCCG TGAGAGCCAT GGCCACAGCT 
CAGTTAGGAA GCCTTAAAAA TGTCATGCTG GTTTTGGGGT ACAAGCGGAA GAGTACAGAA 
GGAACCCAAG AACAAAAAGA GATACAATCT TGTTTGTCTA TTTGGGACCT CAATCTTCCA 
CATGAAGTGC AAAACTTAGA AAAACACATT GAAGTAAGAA CAGAACTGGC TGATAAAATG 
AGGAAAACAT CTGTCGAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Lrrk2 ( XM_008765689.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008763911.1 Rattus norvegicus leucine-rich repeat kinase 2 (Lrrk2), transcript variant X2, mRNA.

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CloneID	ORa45692
Clone ID Related Accession (Same CDS sequence)	XM_008765689.2
Accession Version	XM_008765689.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 7434bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	leucine-rich repeat serine/threonine-protein kinase 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008765689.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCAGTG GCGCCTGTCA GGGCTGCGAC GAGGAAGAGG AGGAGGAGGC TCTGAAGAAG 
TTGATAGTCA GGCTGAATAA TGTCCAGGAA GGCAAGCAGA TCGAGACGTT GCTCCAGCTC 
CTGGAGGACA TTCTGGTGTT CACCTACTCC GACCGCGCCT CCAAGTTATT TGAAGGCAAA 
AATGTCCACG TGCCTCTGTT GATAGTCCTG GACTCCTACA TGAGAGTCGC CAGTGTGCAG 
CAGGTGGGGT GGTCACTTCT GTGCAAATTA ATAGAAGTCT GTCCAGGGAC ATTGCAAAGC 
TTAATAGGAC CCCAGGATAT TGGGAATGAT TGGGAAGTCC TTGGTATTCA CCGACTGATT 
CTTAAAATGT TAACTGTTCA TCATGCCAAC GTAAACCTGT CAATAGTTGG ACTAAAAGCC 
TTAGATCTCC TCCTAGATTC AGGTAAAATT ACTCTGCTGA TACTGGATGA AGAATGTGAT 
GTTTTCCTGT TAATTTTTGA TGCCATGCAC AGATATTCAG CCAACGAGGA AGTCCAGAAG 
CTTGCGTGCA AGGCTTTACA TGTGCTGTTC GAGAGAGTGT CCGAGGAGCA ACTGACTGAG 
TTTGTGGAGA ACAAAGATTA CATGACCCTG CTGAGTACGT TCCGCAGCTT CAAGAGGGAC 
GAGGAGATTG TGCACCATGT ACTCTGCTGC CTGCATTCTC TGGCCGTCAC TTGCAGCAAT 
GTGGAGGTCC TCATGAGTGG GAATGTCAGG TGTTACAATA TTGTGGTGGA AGCCATGAAA 
ACATTCCCCA CCAGTGAAAA CATTCAAGAG GTGAGCTGCT CCTTGCTCCA CAAGCTTACA 
TTAGGTAATT TTTTCAACAT CCTGGTGTTG AACGAAGTCC ATGTCTTTGT GGTGAAAGCC 
GTCCAGCGGT ATCCCGAGAA CGTAGCCTTA CAGATCTCTG CACTCAGCTG CTTAGCCCTC 
CTCACCGAGA CTATTTTCTT AAACCAAGAC CTGGAAGAAA GAAGTGAGAC TCAGGAAAAC 
AGCGATGAGG ACAGTGAGAA GCCTTTCTGG TTGGAACCCT GCTATAAAGC CCTGATGCGC 
CATCGAAAGA ACAAACACGT GCAGGAGGCC GCCTGCTGGG CCCTAAATAA TCTCCTCATG 
TACCAGAGCA GTTTGCACGA GAAGATTGGA GATGAAGATG GCCAGTTCCC GGCGCACAGG 
GAAGTGATGC TGTCTATGCT GATGCACTCT TCTTCCAAAG ACGTCTTCCA AGCAGCTGCG 
CATGCTCTGT CCACTCTCTT GGAACAAAAC GTTAATTTCA GGAAAATCCT GCTTGCAAAA 
GGAGTGTACC TGAATGTCTT GGAGTTGATG CAGCGGCACG CCCAGGTTCC TGAGGTGGCA 
GAGAGTGGCT GCAAGATGCT GAGTCATCTG TTTGAAGGAA GCAACCCTTC TTTGGATACA 
GTGGCGGCAG TGATCCCCAA AATACTAACA GTGATGAGAA CCCATGGAAC GTCTCTGTCA 
GTCCAGCTGG AGGCACTGCG AGCTCTTCTG CATTTTGTGG TGCCGGGAGT ATCAGAAGAT 
TCCAGGGATG ACTCGCGATG CCAACCAAAC GTGCTCAGAA CACAGTGCTT CAGGACTGAC 
ATCCACAAGC TGGTTCTAGC CGCTCTGAAC AGGTTCATTG GGAATCCCGG GATTCAGAAA 
TGTGGATTGA AAGTCATCTC TTCTTTCGCA CATCTTCCCG ATGCCTTAGA GATGTTATCC 
CTGCATGGAG CAGTTGACTC AGTCCTCCAT ACCTTACAGA TGTATCCAGA TGACCAAGAA 
ATTCAGTGTC TGGGCTTACA CCTTATGGGA TGCCTGATGA CAAAGAAGAA TTTCTGCATA 
GGGACAGGGC ACCTCCTGGC AAAAATTCTG GCTTCCACCT TGCAGCGATT TAAAGATGTT 
GCTGAAGTAC AGACTACAGG ATTACAGACG GTCTTGTCAA TGCTTGACCT GTCCGTATCT 
TTCTCCAAGC TGCTAGTGCA CTATTCATTT GATGTGGTGA TGTTTCATCA GATGTCTTCC 
GGTGTCCTGG AACAAAAGGA TGAGCAGTTT CTCAACTTAT GCTGCAAATG CTTTGCAAAA 
GTGGCTGTGG ATGATGAGCT GAAAAGCAAG ATGCTAGAGA GAGCCTGCGA TCAGAACAAC 
AGCATCATGG TCGAATGTTT GCTCCTCTTG GGAGCCGATG CCAATCAAGC GAAGGGGGCA 
ACTTCTTTAA TCTATCAGGT ATGTGAGAAA GAGAGCAGCC CTAAATTGGT GGAACTATTG 
CTTAACAGTG GGTGCCGTGA ACAAGATGTA CGGAAAGCCC TGACAGTAAG CATCCAAAAG 
GGCGACAACC AGGTCATCAG CTTACTCCTG AGGAGACTTG CCCTGGACCT GGCCAACAAC 
AGCATTTGCC TTGGAGGATT TTGCATAGGA AAACTTGATC CTTCTTGGCT AGGCCCTTTA 
TTTCCAGATA AGTCATCTAA TTTGAGGAAA CAAACAAATG CGGGGTCTGT CCTAGCGAGG 
AAAGTGCTCC GGTATCAGAT GAGAAACACT CTTCAAGAAG GCGTGGCCTC AGGCAGTGAG 
GGCAACTTCT CTGAGGATGC GCTGGCGAAA TTTGGCGAAT GGACCTTCAT TCCCGACTCT 
TCTATGGACA GTGTGTTTGG CCAGAGTGAC GATCTGGATA GCGAAGGCAG CGAGAGCTCC 
TTTCTGGTGA AGAAGAAGTC CAACTCAGTT AGTGTAGGAG AAGTTTACAG GGACCTAGCT 
CTGCAGCGCT GCTCACCAAA TGCTCAGAGG CACTCCAGTT CCTTGGGTCC TGTTTTTGAT 
CACGAAGATC TACTGAGACG AAAAAGAAAA ATACTGTCCT CAGATGAGTC TCTCAGATCC 
TCAAGGCTGC AGTCCCATAC GAGACAATCA GATAGCTCTT CTTCTCTGGC TTCTGAGAGA 
GAACACATCA CGTCTTTAGA CCTTTCTGCC AACGAACTGA AAGATATTGA TGCTCTGGGC 
CAGAAGTGTT GCCTCAGTAG CCACCTGGAG CATCTCACCA AGCTGGAACT TCACCAGAAT 
TCACTCACGA GCTTCCCACA ACAGCTGTGT GAGACTCTGA AGTGCTTGAC ACATCTGGAT 
TTGCACAGTA ACAAATTCGC CACCTTTCCC TCCTTCATGT TGAAAATGCC AAGTGTTATC 
CACCTAGACG CCTCTCGAAA TGACATCGGA CCAACAGTTG TTTTAGACCC TGTGGTGAAG 
TGTCCAAGCC TCAAACAGTT TAACCTGTCC TACAACCAGC TCTCTTCCAT CCCAGAGAAC 
CTGGACCAAG TGGTGGAGAA ACTGGAGCAG CTCCTACTGG AAGGAAACAA AATATCCGGG 
ATTTGTTCTC CCTTGAGCCT GAAGGAACTG AAGATTTTAA ACCTTAGTAA AAACCACATT 
CCATCCCTAC CTGAAGACTT TCTCGAGGCT TGCCCGAAAG TGGAGAGCTT CAGTGCCCGC 
ATGAATTTTC TCGCTGCAAT GCCTGCCTTA CCGTCTTCCA TAACTAGCTT AAAATTGTCT 
CAAAACTCTT TCACGTGCAT TCCAGAAGCG ATCTTCAGTC TTCCACACTT GCGGTCCTTG 
GATATGAGTC ACAACAACAT TGAACACCTG CCGGGACCTG CACATTGGAA GTCTCTGAAC 
TTAAGGGAAC TCATTTTTAG CAAGAATCAG ATCAGCACCT TAGACTTGAG CGAAAACCCA 
CACATATGGT CAAGAGTAGA GAAGCTGCAT CTCTCTCATA ATAAACTGAA AGAGATTCCT 
CCAGAAATTG GCCGTCTTGA AAACCTGACA TCTCTTGATG TCAGTTACAA CCTGGAACTG 
AGGTCCTTTC CAAACGAAAT GGGGAAGTTA AGCAAAATAT GGGATCTTCC CTTGGATGGA 
CTGCACCTCA ACTTTGACTT TAAGCACATA GGATGCAAAG CCAAAGACAT CATAAGGTTT 
CTACAACAAC GTCTGAAAAA GGCCGTGCCC TACAACCGAA TGAAGCTCAT GATTGTGGGC 
AATACGGGGA GTGGTAAGAC CACTCTACTG CAGCAGCTCA TGAAAATGAA GAAATCAGAA 
CTCGGCATGC AGGGCGCCAC GGTTGGCATA GACGTGCGAG ACTGGCCCAT CCAAATACGA 
GGCAAAAGGA AAAAGGACCT TGTTCTAAAC GTGTGGGACT TTGCAGGCCG TGAGGAATTC 
TACAGCACTC ACCCCCACTT CATGACCCAG AGAGCCCTGT ACCTGGCTGT CTACGACCTC 
AGCAAGGGGC AGGCGGAGGT GGATGCCATG AAGCCCTGGC TCTTCAACAT CAAGGCTCGT 
GCCTCTTCTT CCCCGGTGAT TCTGGTGGGC ACACATTTGG ATGTTTCTGA TGAGAAGCAG 
CGCAAAGCCT GCATAGGCAA AATCACGAAG GAACTCCTTA ATAAGCGAGG ATTCCCCACC 
ATCCGGGACT ACCACTTCGT GAATGCCACT GAGGAGTCGG ATGCGCTGGC AAAGCTCCGG 
AAAACCATCA TAAATGAGAG TCTTAATTTC AAGATCCGAG ATCAGCCCGT GGTTGGGCAG 
CTAATTCCAG ATTGCTACGT AGAACTGGAG AAAATAATCT TATCGGAGCG TAAAGCTGTA 
CCAACGGAGT TTCCTGTAAT TAACCGGAAA CACTTACTCC AGCTGGTGAA GGAACACCAG 
CTGCAGCTGG ATGAGAACGA GCTCCCCCAC GCTGTTCACT TCCTGAATGA GTCAGGAGTT 
CTTCTGCATT TTCAAGACCC CGCATTGCAG CTGAGTGACC TGTACTTTGT GGAACCCAAG 
TGGCTTTGTA AAGTCATGGC ACAGATTTTG ACCGTGAAAG TGGACGGCTG CCTGAAGCAT 
CCTAAGGGCA TCATTTCACG GAGAGATGTG GAAAAATTCC TTTCCAAGAA AAAGCGATTC 
CCTAAGAACT ACATGGCGCA GTACTTCAAA CTTTTAGAAA AATTTCAGAT CGCATTACCA 
ATAGGGGAAG AATATCTGCT GGTTCCAAGC AGCTTATCTG ACCACAGGCC AGTGATAGAG 
CTCCCCCACT GTGAGAACTC TGAGATCATC ATCCGGCTGT ATGAAATGCC ATACTTTCCA 
ATGGGATTTT GGTCAAGATT GATTAACCGA TTACTTGAAA TCTCACCTTT CATGCTTTCT 
GGAAGAGGTT GTATTCTTTT GGGCCGAGTT GTGGATCATA TTGACTCACT CATGGAAGAA 
TGGTTTCCTG GATTGCTGGA GATTGACATT TGTGGGGAAG GAGAAACTTT GTTGAAAAAA 
TGGGCATTGT ATAGTTTTAA TGATGGCGAA GAACATCAGA AGATCTTGCT TGATGAGTTG 
ATGAAGAAGG CTGAAGAAGG AGACCTGTTA ATAAATCCAG ATCAACCAAG GCTCACCATT 
CCAATATCCC AGATTGCTCC GGACTTGATC TTGGCTGACC TGCCTAGAAA TATTATGTTG 
AACAATGACG AACTGGAATT TGAGGAAGCA CCCGAGTTTC TCTTAGGTGA TGGAAGTTTC 
GGATCAGTTT ATCGAGCTGC CTACGAAGGA GAGGAAGTGG CTGTGAAGAT TTTTAATAAG 
CACACATCGC TTAGGCTGTT AAGACAAGAG TTGGTGGTAC TCTGTCATCT CCACCATCCC 
AGCTTGATCT CCCTGTTGGC GGCTGGGATT CGTCCTCGGA TGCTGGTAAT GGAGTTGGCC 
TCCAAGGGTT CCTTGGATCG CCTGCTGCAG CAGGACAAAG CCAGCCTCAC CCGGACCCTC 
CAGCACAGAA TCGCATTGCA TGTGGCCGAT GGCCTGAGAT ATCTGCACTC GGCCATGATT 
ATTTACCGTG ATCTGAAGCC CCACAACGTG CTACTCTTCA CCCTGTATCC CAATGCCGCC 
ATCATTGCGA AGATTGCGGA CTACGGGATT GCACAGTACT GCTGTAGGAT GGGAATAAAG 
ACCTCAGAGG GCACCCCAGG GTTCCGAGCA CCTGAAGTTG CCAGAGGAAA TGTCATTTAT 
AACCAACAGG CTGATGTTTA TTCTTTTGGC TTACTACTTC ATGATATCTG GACAACTGGG 
AATAGAATCA TGGAGGGTTT GAGGTTTCCA AATGAGTTTG ATGAACTGGC CATACAAGGG 
AAATTGCCAG ACCCAGTTAA AGAATATGGC TGTGCCCCGT GGCCTATGGT TGAGAAGTTA 
ATTACAAAAT GTTTGAAAGA AAATCCTCAA GAAAGACCCA CTTCTGCCCA GGTCTTTGAC 
ATTTTGAATT CAGCTGAGTT AATTTGCCTC ATGCGACACA TTTTCATACC TAAGGACATC 
ACTGTTGAAT GCATAGCTGC TACAAACCTC AATAGCAAGC GAGCGACTCT CTGGTTGGGC 
TGTGGGAACA CAGAAAAAGG GCAGCTTTCC TTACTTGACT TGAACACGGA AAGATACAGC 
TATGAGGAAG TTACTGATAG TAGAATACTG TGCCTGGCTT TGGTGCATCT TGCTGCTGAG 
AAAGAGAGCT GGGTTGTGTG TGGGACACAG TCCGGAGCTC TCCTGGTCAT CAATGCTGAA 
GATGAGACAA GGAGACACAC CCTCGACAAG ATGACTGATT CTGTTACTTG CTTGTATTGC 
AATTCCTTTG CCAAGCAGAG CAAGCAAAGT CACTTCCTTT TGGTGGGAAC TGCTGATGGC 
AACTTAATGA TATTTGAAGA TAAGACCATT AAGTGTAAAG GAGCTGCCCC ATTGAAGACA 
CTACACATAG GCGATGTCAG TACGCCCCTG ATGTGCCTGA GCGAGTCCAT GAATTCATCT 
GAAAGACACA TCACATGGGG AGGGTGTGGC ACAAAGATCT TCTCCTTTTC CAATGATTTC 
ACCATTCAGA AACTCATCGA GACAAGAACC AACCAGCTGT TTTCTTACTC AGCGTTCAGC 
GATTCTAACA TCATAGCGGT GGCAGTGGAC ACAGCGCTTT ATATTGCCAA GAAAAACAGC 
CCTGTCGTAG AGGTGTGGGA CAAGAAGACA GAAAAACTCT GTGAACTAAT AGACTGTGTG 
CACTTCTTAA AGGAGGTGAT GGTGAAAATA AACAAGGACT CGAAGCACAA GCTGTCCTAC 
TCTGGGAGGG TGAAGGCACT CTGCCTGCAG AAGAACACAG CTCTCTGGAT CGGAACTGGA 
GGAGGCCACA TCTTACTCCT GGATCTTTCT ACACGGCGAG TCATCCGCAC CATCCACAAT 
TTCTGTGATT CCGTGAGAGC CATGGCCACA GCTCAGTTAG GAAGCCTTAA AAATGTCATG 
CTGGTTTTGG GGTACAAGCG GAAGAGTACA GAAGGAACCC AAGAACAAAA AGAGATACAA 
TCTTGTTTGT CTATTTGGGA CCTCAATCTT CCACATGAAG TGCAAAACTT AGAAAAACAC 
ATTGAAGTAA GAACAGAACT GGCTGATAAA ATGAGGAAAA CATCTGTCGA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008763911.1
CDS	398..7831
Translation	MASGACQGCDEEEEEEALKKLIVRLNNVQEGKQIETLLQLLEDILVFTYSDRASKLFEGKNVHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVCPGTLQSLIGPQDIGNDWEVLGIHRLILKMLTVHHANVNLSIVGLKALDLLLDSGKITLLILDEECDVFLLIFDAMHRYSANEEVQKLACKALHVLFERVSEEQLTEFVENKDYMTLLSTFRSFKRDEEIVHHVLCCLHSLAVTCSNVEVLMSGNVRCYNIVVEAMKTFPTSENIQEVSCSLLHKLTLGNFFNILVLNEVHVFVVKAVQRYPENVALQISALSCLALLTETIFLNQDLEERSETQENSDEDSEKPFWLEPCYKALMRHRKNKHVQEAACWALNNLLMYQSSLHEKIGDEDGQFPAHREVMLSMLMHSSSKDVFQAAAHALSTLLEQNVNFRKILLAKGVYLNVLELMQRHAQVPEVAESGCKMLSHLFEGSNPSLDTVAAVIPKILTVMRTHGTSLSVQLEALRALLHFVVPGVSEDSRDDSRCQPNVLRTQCFRTDIHKLVLAALNRFIGNPGIQKCGLKVISSFAHLPDALEMLSLHGAVDSVLHTLQMYPDDQEIQCLGLHLMGCLMTKKNFCIGTGHLLAKILASTLQRFKDVAEVQTTGLQTVLSMLDLSVSFSKLLVHYSFDVVMFHQMSSGVLEQKDEQFLNLCCKCFAKVAVDDELKSKMLERACDQNNSIMVECLLLLGADANQAKGATSLIYQVCEKESSPKLVELLLNSGCREQDVRKALTVSIQKGDNQVISLLLRRLALDLANNSICLGGFCIGKLDPSWLGPLFPDKSSNLRKQTNAGSVLARKVLRYQMRNTLQEGVASGSEGNFSEDALAKFGEWTFIPDSSMDSVFGQSDDLDSEGSESSFLVKKKSNSVSVGEVYRDLALQRCSPNAQRHSSSLGPVFDHEDLLRRKRKILSSDESLRSSRLQSHTRQSDSSSSLASEREHITSLDLSANELKDIDALGQKCCLSSHLEHLTKLELHQNSLTSFPQQLCETLKCLTHLDLHSNKFATFPSFMLKMPSVIHLDASRNDIGPTVVLDPVVKCPSLKQFNLSYNQLSSIPENLDQVVEKLEQLLLEGNKISGICSPLSLKELKILNLSKNHIPSLPEDFLEACPKVESFSARMNFLAAMPALPSSITSLKLSQNSFTCIPEAIFSLPHLRSLDMSHNNIEHLPGPAHWKSLNLRELIFSKNQISTLDLSENPHIWSRVEKLHLSHNKLKEIPPEIGRLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDGLHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKMKKSELGMQGATVGIDVRDWPIQIRGKRKKDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACIGKITKELLNKRGFPTIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKAVPTEFPVINRKHLLQLVKEHQLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVDGCLKHPKGIISRRDVEKFLSKKKRFPKNYMAQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPFMLSGRGCILLGRVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDELMKKAEEGDLLINPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEEAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLHDIWTTGNRIMEGLRFPNEFDELAIQGKLPDPVKEYGCAPWPMVEKLITKCLKENPQERPTSAQVFDILNSAELICLMRHIFIPKDITVECIAATNLNSKRATLWLGCGNTEKGQLSLLDLNTERYSYEEVTDSRILCLALVHLAAEKESWVVCGTQSGALLVINAEDETRRHTLDKMTDSVTCLYCNSFAKQSKQSHFLLVGTADGNLMIFEDKTIKCKGAAPLKTLHIGDVSTPLMCLSESMNSSERHITWGGCGTKIFSFSNDFTIQKLIETRTNQLFSYSAFSDSNIIAVAVDTALYIAKKNSPVVEVWDKKTEKLCELIDCVHFLKEVMVKINKDSKHKLSYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRTIHNFCDSVRAMATAQLGSLKNVMLVLGYKRKSTEGTQEQKEIQSCLSIWDLNLPHEVQNLEKHIEVRTELADKMRKTSVE

Target ORF information:

RefSeq Version	XM_008765689.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus leucine-rich repeat kinase 2 (Lrrk2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008765689.2

ORF Insert Sequence:

ATGGCCAGTG GCGCCTGTCA GGGCTGCGAC GAGGAAGAGG AGGAGGAGGC TCTGAAGAAG 
TTGATAGTCA GGCTGAATAA TGTCCAGGAA GGCAAGCAGA TCGAGACGTT GCTCCAGCTC 
CTGGAGGACA TTCTGGTGTT CACCTACTCC GACCGCGCCT CCAAGTTATT TGAAGGCAAA 
AATGTCCACG TGCCTCTGTT GATAGTCCTG GACTCCTACA TGAGAGTCGC CAGTGTGCAG 
CAGGTGGGGT GGTCACTTCT GTGCAAATTA ATAGAAGTCT GTCCAGGGAC ATTGCAAAGC 
TTAATAGGAC CCCAGGATAT TGGGAATGAT TGGGAAGTCC TTGGTATTCA CCGACTGATT 
CTTAAAATGT TAACTGTTCA TCATGCCAAC GTAAACCTGT CAATAGTTGG ACTAAAAGCC 
TTAGATCTCC TCCTAGATTC AGGTAAAATT ACTCTGCTGA TACTGGATGA AGAATGTGAT 
GTTTTCCTGT TAATTTTTGA TGCCATGCAC AGATATTCAG CCAACGAGGA AGTCCAGAAG 
CTTGCGTGCA AGGCTTTACA TGTGCTGTTC GAGAGAGTGT CCGAGGAGCA ACTGACTGAG 
TTTGTGGAGA ACAAAGATTA CATGACCCTG CTGAGTACGT TCCGCAGCTT CAAGAGGGAC 
GAGGAGATTG TGCACCATGT ACTCTGCTGC CTGCATTCTC TGGCCGTCAC TTGCAGCAAT 
GTGGAGGTCC TCATGAGTGG GAATGTCAGG TGTTACAATA TTGTGGTGGA AGCCATGAAA 
ACATTCCCCA CCAGTGAAAA CATTCAAGAG GTGAGCTGCT CCTTGCTCCA CAAGCTTACA 
TTAGGTAATT TTTTCAACAT CCTGGTGTTG AACGAAGTCC ATGTCTTTGT GGTGAAAGCC 
GTCCAGCGGT ATCCCGAGAA CGTAGCCTTA CAGATCTCTG CACTCAGCTG CTTAGCCCTC 
CTCACCGAGA CTATTTTCTT AAACCAAGAC CTGGAAGAAA GAAGTGAGAC TCAGGAAAAC 
AGCGATGAGG ACAGTGAGAA GCCTTTCTGG TTGGAACCCT GCTATAAAGC CCTGATGCGC 
CATCGAAAGA ACAAACACGT GCAGGAGGCC GCCTGCTGGG CCCTAAATAA TCTCCTCATG 
TACCAGAGCA GTTTGCACGA GAAGATTGGA GATGAAGATG GCCAGTTCCC GGCGCACAGG 
GAAGTGATGC TGTCTATGCT GATGCACTCT TCTTCCAAAG ACGTCTTCCA AGCAGCTGCG 
CATGCTCTGT CCACTCTCTT GGAACAAAAC GTTAATTTCA GGAAAATCCT GCTTGCAAAA 
GGAGTGTACC TGAATGTCTT GGAGTTGATG CAGCGGCACG CCCAGGTTCC TGAGGTGGCA 
GAGAGTGGCT GCAAGATGCT GAGTCATCTG TTTGAAGGAA GCAACCCTTC TTTGGATACA 
GTGGCGGCAG TGATCCCCAA AATACTAACA GTGATGAGAA CCCATGGAAC GTCTCTGTCA 
GTCCAGCTGG AGGCACTGCG AGCTCTTCTG CATTTTGTGG TGCCGGGAGT ATCAGAAGAT 
TCCAGGGATG ACTCGCGATG CCAACCAAAC GTGCTCAGAA CACAGTGCTT CAGGACTGAC 
ATCCACAAGC TGGTTCTAGC CGCTCTGAAC AGGTTCATTG GGAATCCCGG GATTCAGAAA 
TGTGGATTGA AAGTCATCTC TTCTTTCGCA CATCTTCCCG ATGCCTTAGA GATGTTATCC 
CTGCATGGAG CAGTTGACTC AGTCCTCCAT ACCTTACAGA TGTATCCAGA TGACCAAGAA 
ATTCAGTGTC TGGGCTTACA CCTTATGGGA TGCCTGATGA CAAAGAAGAA TTTCTGCATA 
GGGACAGGGC ACCTCCTGGC AAAAATTCTG GCTTCCACCT TGCAGCGATT TAAAGATGTT 
GCTGAAGTAC AGACTACAGG ATTACAGACG GTCTTGTCAA TGCTTGACCT GTCCGTATCT 
TTCTCCAAGC TGCTAGTGCA CTATTCATTT GATGTGGTGA TGTTTCATCA GATGTCTTCC 
GGTGTCCTGG AACAAAAGGA TGAGCAGTTT CTCAACTTAT GCTGCAAATG CTTTGCAAAA 
GTGGCTGTGG ATGATGAGCT GAAAAGCAAG ATGCTAGAGA GAGCCTGCGA TCAGAACAAC 
AGCATCATGG TCGAATGTTT GCTCCTCTTG GGAGCCGATG CCAATCAAGC GAAGGGGGCA 
ACTTCTTTAA TCTATCAGGT ATGTGAGAAA GAGAGCAGCC CTAAATTGGT GGAACTATTG 
CTTAACAGTG GGTGCCGTGA ACAAGATGTA CGGAAAGCCC TGACAGTAAG CATCCAAAAG 
GGCGACAACC AGGTCATCAG CTTACTCCTG AGGAGACTTG CCCTGGACCT GGCCAACAAC 
AGCATTTGCC TTGGAGGATT TTGCATAGGA AAACTTGATC CTTCTTGGCT AGGCCCTTTA 
TTTCCAGATA AGTCATCTAA TTTGAGGAAA CAAACAAATG CGGGGTCTGT CCTAGCGAGG 
AAAGTGCTCC GGTATCAGAT GAGAAACACT CTTCAAGAAG GCGTGGCCTC AGGCAGTGAG 
GGCAACTTCT CTGAGGATGC GCTGGCGAAA TTTGGCGAAT GGACCTTCAT TCCCGACTCT 
TCTATGGACA GTGTGTTTGG CCAGAGTGAC GATCTGGATA GCGAAGGCAG CGAGAGCTCC 
TTTCTGGTGA AGAAGAAGTC CAACTCAGTT AGTGTAGGAG AAGTTTACAG GGACCTAGCT 
CTGCAGCGCT GCTCACCAAA TGCTCAGAGG CACTCCAGTT CCTTGGGTCC TGTTTTTGAT 
CACGAAGATC TACTGAGACG AAAAAGAAAA ATACTGTCCT CAGATGAGTC TCTCAGATCC 
TCAAGGCTGC AGTCCCATAC GAGACAATCA GATAGCTCTT CTTCTCTGGC TTCTGAGAGA 
GAACACATCA CGTCTTTAGA CCTTTCTGCC AACGAACTGA AAGATATTGA TGCTCTGGGC 
CAGAAGTGTT GCCTCAGTAG CCACCTGGAG CATCTCACCA AGCTGGAACT TCACCAGAAT 
TCACTCACGA GCTTCCCACA ACAGCTGTGT GAGACTCTGA AGTGCTTGAC ACATCTGGAT 
TTGCACAGTA ACAAATTCGC CACCTTTCCC TCCTTCATGT TGAAAATGCC AAGTGTTATC 
CACCTAGACG CCTCTCGAAA TGACATCGGA CCAACAGTTG TTTTAGACCC TGTGGTGAAG 
TGTCCAAGCC TCAAACAGTT TAACCTGTCC TACAACCAGC TCTCTTCCAT CCCAGAGAAC 
CTGGACCAAG TGGTGGAGAA ACTGGAGCAG CTCCTACTGG AAGGAAACAA AATATCCGGG 
ATTTGTTCTC CCTTGAGCCT GAAGGAACTG AAGATTTTAA ACCTTAGTAA AAACCACATT 
CCATCCCTAC CTGAAGACTT TCTCGAGGCT TGCCCGAAAG TGGAGAGCTT CAGTGCCCGC 
ATGAATTTTC TCGCTGCAAT GCCTGCCTTA CCGTCTTCCA TAACTAGCTT AAAATTGTCT 
CAAAACTCTT TCACGTGCAT TCCAGAAGCG ATCTTCAGTC TTCCACACTT GCGGTCCTTG 
GATATGAGTC ACAACAACAT TGAACACCTG CCGGGACCTG CACATTGGAA GTCTCTGAAC 
TTAAGGGAAC TCATTTTTAG CAAGAATCAG ATCAGCACCT TAGACTTGAG CGAAAACCCA 
CACATATGGT CAAGAGTAGA GAAGCTGCAT CTCTCTCATA ATAAACTGAA AGAGATTCCT 
CCAGAAATTG GCCGTCTTGA AAACCTGACA TCTCTTGATG TCAGTTACAA CCTGGAACTG 
AGGTCCTTTC CAAACGAAAT GGGGAAGTTA AGCAAAATAT GGGATCTTCC CTTGGATGGA 
CTGCACCTCA ACTTTGACTT TAAGCACATA GGATGCAAAG CCAAAGACAT CATAAGGTTT 
CTACAACAAC GTCTGAAAAA GGCCGTGCCC TACAACCGAA TGAAGCTCAT GATTGTGGGC 
AATACGGGGA GTGGTAAGAC CACTCTACTG CAGCAGCTCA TGAAAATGAA GAAATCAGAA 
CTCGGCATGC AGGGCGCCAC GGTTGGCATA GACGTGCGAG ACTGGCCCAT CCAAATACGA 
GGCAAAAGGA AAAAGGACCT TGTTCTAAAC GTGTGGGACT TTGCAGGCCG TGAGGAATTC 
TACAGCACTC ACCCCCACTT CATGACCCAG AGAGCCCTGT ACCTGGCTGT CTACGACCTC 
AGCAAGGGGC AGGCGGAGGT GGATGCCATG AAGCCCTGGC TCTTCAACAT CAAGGCTCGT 
GCCTCTTCTT CCCCGGTGAT TCTGGTGGGC ACACATTTGG ATGTTTCTGA TGAGAAGCAG 
CGCAAAGCCT GCATAGGCAA AATCACGAAG GAACTCCTTA ATAAGCGAGG ATTCCCCACC 
ATCCGGGACT ACCACTTCGT GAATGCCACT GAGGAGTCGG ATGCGCTGGC AAAGCTCCGG 
AAAACCATCA TAAATGAGAG TCTTAATTTC AAGATCCGAG ATCAGCCCGT GGTTGGGCAG 
CTAATTCCAG ATTGCTACGT AGAACTGGAG AAAATAATCT TATCGGAGCG TAAAGCTGTA 
CCAACGGAGT TTCCTGTAAT TAACCGGAAA CACTTACTCC AGCTGGTGAA GGAACACCAG 
CTGCAGCTGG ATGAGAACGA GCTCCCCCAC GCTGTTCACT TCCTGAATGA GTCAGGAGTT 
CTTCTGCATT TTCAAGACCC CGCATTGCAG CTGAGTGACC TGTACTTTGT GGAACCCAAG 
TGGCTTTGTA AAGTCATGGC ACAGATTTTG ACCGTGAAAG TGGACGGCTG CCTGAAGCAT 
CCTAAGGGCA TCATTTCACG GAGAGATGTG GAAAAATTCC TTTCCAAGAA AAAGCGATTC 
CCTAAGAACT ACATGGCGCA GTACTTCAAA CTTTTAGAAA AATTTCAGAT CGCATTACCA 
ATAGGGGAAG AATATCTGCT GGTTCCAAGC AGCTTATCTG ACCACAGGCC AGTGATAGAG 
CTCCCCCACT GTGAGAACTC TGAGATCATC ATCCGGCTGT ATGAAATGCC ATACTTTCCA 
ATGGGATTTT GGTCAAGATT GATTAACCGA TTACTTGAAA TCTCACCTTT CATGCTTTCT 
GGAAGAGGTT GTATTCTTTT GGGCCGAGTT GTGGATCATA TTGACTCACT CATGGAAGAA 
TGGTTTCCTG GATTGCTGGA GATTGACATT TGTGGGGAAG GAGAAACTTT GTTGAAAAAA 
TGGGCATTGT ATAGTTTTAA TGATGGCGAA GAACATCAGA AGATCTTGCT TGATGAGTTG 
ATGAAGAAGG CTGAAGAAGG AGACCTGTTA ATAAATCCAG ATCAACCAAG GCTCACCATT 
CCAATATCCC AGATTGCTCC GGACTTGATC TTGGCTGACC TGCCTAGAAA TATTATGTTG 
AACAATGACG AACTGGAATT TGAGGAAGCA CCCGAGTTTC TCTTAGGTGA TGGAAGTTTC 
GGATCAGTTT ATCGAGCTGC CTACGAAGGA GAGGAAGTGG CTGTGAAGAT TTTTAATAAG 
CACACATCGC TTAGGCTGTT AAGACAAGAG TTGGTGGTAC TCTGTCATCT CCACCATCCC 
AGCTTGATCT CCCTGTTGGC GGCTGGGATT CGTCCTCGGA TGCTGGTAAT GGAGTTGGCC 
TCCAAGGGTT CCTTGGATCG CCTGCTGCAG CAGGACAAAG CCAGCCTCAC CCGGACCCTC 
CAGCACAGAA TCGCATTGCA TGTGGCCGAT GGCCTGAGAT ATCTGCACTC GGCCATGATT 
ATTTACCGTG ATCTGAAGCC CCACAACGTG CTACTCTTCA CCCTGTATCC CAATGCCGCC 
ATCATTGCGA AGATTGCGGA CTACGGGATT GCACAGTACT GCTGTAGGAT GGGAATAAAG 
ACCTCAGAGG GCACCCCAGG GTTCCGAGCA CCTGAAGTTG CCAGAGGAAA TGTCATTTAT 
AACCAACAGG CTGATGTTTA TTCTTTTGGC TTACTACTTC ATGATATCTG GACAACTGGG 
AATAGAATCA TGGAGGGTTT GAGGTTTCCA AATGAGTTTG ATGAACTGGC CATACAAGGG 
AAATTGCCAG ACCCAGTTAA AGAATATGGC TGTGCCCCGT GGCCTATGGT TGAGAAGTTA 
ATTACAAAAT GTTTGAAAGA AAATCCTCAA GAAAGACCCA CTTCTGCCCA GGTCTTTGAC 
ATTTTGAATT CAGCTGAGTT AATTTGCCTC ATGCGACACA TTTTCATACC TAAGGACATC 
ACTGTTGAAT GCATAGCTGC TACAAACCTC AATAGCAAGC GAGCGACTCT CTGGTTGGGC 
TGTGGGAACA CAGAAAAAGG GCAGCTTTCC TTACTTGACT TGAACACGGA AAGATACAGC 
TATGAGGAAG TTACTGATAG TAGAATACTG TGCCTGGCTT TGGTGCATCT TGCTGCTGAG 
AAAGAGAGCT GGGTTGTGTG TGGGACACAG TCCGGAGCTC TCCTGGTCAT CAATGCTGAA 
GATGAGACAA GGAGACACAC CCTCGACAAG ATGACTGATT CTGTTACTTG CTTGTATTGC 
AATTCCTTTG CCAAGCAGAG CAAGCAAAGT CACTTCCTTT TGGTGGGAAC TGCTGATGGC 
AACTTAATGA TATTTGAAGA TAAGACCATT AAGTGTAAAG GAGCTGCCCC ATTGAAGACA 
CTACACATAG GCGATGTCAG TACGCCCCTG ATGTGCCTGA GCGAGTCCAT GAATTCATCT 
GAAAGACACA TCACATGGGG AGGGTGTGGC ACAAAGATCT TCTCCTTTTC CAATGATTTC 
ACCATTCAGA AACTCATCGA GACAAGAACC AACCAGCTGT TTTCTTACTC AGCGTTCAGC 
GATTCTAACA TCATAGCGGT GGCAGTGGAC ACAGCGCTTT ATATTGCCAA GAAAAACAGC 
CCTGTCGTAG AGGTGTGGGA CAAGAAGACA GAAAAACTCT GTGAACTAAT AGACTGTGTG 
CACTTCTTAA AGGAGGTGAT GGTGAAAATA AACAAGGACT CGAAGCACAA GCTGTCCTAC 
TCTGGGAGGG TGAAGGCACT CTGCCTGCAG AAGAACACAG CTCTCTGGAT CGGAACTGGA 
GGAGGCCACA TCTTACTCCT GGATCTTTCT ACACGGCGAG TCATCCGCAC CATCCACAAT 
TTCTGTGATT CCGTGAGAGC CATGGCCACA GCTCAGTTAG GAAGCCTTAA AAATGTCATG 
CTGGTTTTGG GGTACAAGCG GAAGAGTACA GAAGGAACCC AAGAACAAAA AGAGATACAA 
TCTTGTTTGT CTATTTGGGA CCTCAATCTT CCACATGAAG TGCAAAACTT AGAAAAACAC 
ATTGAAGTAA GAACAGAACT GGCTGATAAA ATGAGGAAAA CATCTGTCGA ATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson's disease.
Human molecular genetics26(22)4340-4351(2017 Nov)
Howlett EH,Jensen N,Belmonte F,Zafar F,Hu X,Kluss J,Sch?le B,Kaufman BA,Greenamyre JT,Sanders LH

Parkinson disease-associated
Journal of leukocyte biology102(4)1093-1102(2017 Oct)
Park J,Lee JW,Cooper SC,Broxmeyer HE,Cannon JR,Kim CH

Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.
Science signaling10(488)(2017 Jul)
Chen ZC,Zhang W,Chua LL,Chai C,Li R,Lin L,Cao Z,Angeles DC,Stanton LW,Peng JH,Zhou ZD,Lim KL,Zeng L,Tan EK

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Lrrk2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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