Srebf2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Srebf2
Entrez Gene ID	300095
Full Name	sterol regulatory element binding transcription factor 2
Synonyms	SREBP-2,SREBP2,Srebf2_retired
General protein information	Preferred Names sterol regulatory element binding transcription factor 2 Names sterol regulatory element-binding protein 2 sterol regulatory element binding factor 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q34
Summary	transcription factor; may be involved in spermatogenesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001033694.1	NP_001028866.1	sterol regulatory element-binding protein 2
XM_006242079.3	XP_006242141.1	sterol regulatory element-binding protein 2 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SREBF2	XP_849087.3
Danio rerio (zebrafish)	srebf2	NP_001082935.1
	SREBF2	XP_001101257.2
Homo sapiens (human)	SREBF2	NP_004590.2
Pan troglodytes (chimpanzee)	SREBF2	XP_003317335.1
Rattus norvegicus (Norway rat)	Srebf2	NP_001028866.1
Gallus gallus (chicken)	SREBF2	XP_004937758.1
Xenopus tropicalis (tropical clawed frog)	srebf2	NP_001116910.2
Bos taurus (cattle)	SREBF2	NP_001192529.1
Mus musculus (house mouse)	Srebf2	NP_150087.1

Gene Ontology
Bibliography

Related articles in PubMed

A? inhibits SREBP-2 activation through Akt inhibition.
Mohamed A, Viveiros A, Williams K, Posse de Chaves E
Journal of lipid research59(1)1-13(2018 Jan)

Sterol regulatory element-binding proteins are transcriptional regulators of the thyroglobulin gene in thyroid cells.
Wen G, Eder K, Ringseis R
Biochimica et biophysica acta1859(8)994-1003(2016 08)

Nutrient deprivation induces ?-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway.
Jiang P, Gan M, Lin WL, Yen SH
Frontiers in aging neuroscience6268(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SREBP1c and SREBP2 are transcriptional regulators of the thyroglobulin gene in thyroid cells.
Title: Sterol regulatory element-binding proteins are transcriptional regulators of the thyroglobulin gene in thyroid cells.

data provided the first line of the evidence that BBR, similar to the Sim, could increase the expression of PCSK9 levels in HFD rats through SREBP-2 activation
Title: Enhanced circulating PCSK9 concentration by berberine through SREBP-2 pathway in high fat diet-fed rats.

results provide the first evidence that alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) is associated with cholesterol metabolism, and ACMSD gene expression may be upregulated by sterol regulatory element-binding protein-2
Title: Regulation of rat hepatic ?-amino-?-carboxymuconate-?-semialdehyde decarboxylase, a key enzyme in the tryptophan- NAD pathway, by dietary cholesterol and sterol regulatory element-binding protein-2.

SREBP-1c and SREBP-2 are regulators of the rat thyroid peroxidase gene in thyroid cells
Title: Sterol regulatory element-binding proteins are regulators of the rat thyroid peroxidase gene in thyroid cells.

Inflammation disrupts LDLr feedback regulation through the activation of the mTOR pathway, increasing mTORC1 activity and up-regulating SREBP-2-mediated cholesterol uptake through Rb phosphorylation.
Title: Activation of mTOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylation.

The following Srebf2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Srebf2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08602	NM_001033694.1 Latest version!	Rattus norvegicus sterol regulatory element binding transcription factor 2 (Srebf2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	16	$832.30 $1189.00
ORa30616	XM_006242079.3 Latest version!	Rattus norvegicus sterol regulatory element binding transcription factor 2 (Srebf2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Srebf2 ( NM_001033694.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001028866.1 Rattus norvegicus sterol regulatory element binding transcription factor 2 (Srebf2), mRNA.

Price & Availability↑

CloneID	ORa08602
Clone ID Related Accession (Same CDS sequence)	NM_001033694.1
Accession Version	NM_001033694.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3402bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	sterol regulatory element-binding protein 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC101902.1. On Sep 25, 2005 this sequence version replaced XM_216989.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC101902.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGATGAGA ACAGCGAGCT GGGCGGTCTG GAGACCATGG AGACCCTCAC GGAGCTGGGC 
GATGAGCTGA CTCTCGGGGA CATCGACGAG ATGCTACAGT TTGTCAGCAA TCAAGTGGGA 
GAGTTCTCTG ACTTGTTTTC AGAGCAACTA TGTAGCTCCT TCCCTGGAGG TGGTGGCGGC 
AGTGGCAGTG GTGGCACCAG CAACAACAGC AGTGGCAGAG GCACCAGTGG TGGAGCTGCA 
GATCCCGCAG TACAGCGGTC ATTCAGCCAG GTCCCATTGT CTACCTTCTC TCCCTCATCC 
ACCTCCCCTC AGGCTCCAGC CCTGCAGGTC AAAGTCTCTC CTACCCCACC AAGGGCAACC 
CCTGTTCTCC AGCCCCGACC CCAGCCCCAG CCTCAACCTC CAGCTCAGCT GCAGCAGCAG 
ACGGTGATGA TCACCCCGAC CTTCAGCACC GCTCCACAGA CCAGGATCAT CCAGCAGCCT 
TTGATATACC AGAATGCCGC AACCAGCTTT CAAGTCCTGC AGCCTCAAGT GCAAAGCCTC 
GTGACATCCT CGCAGGTACA GCCAGTTACC ATCCAGCAGC AGGTGCAGAC GGTACAGGCC 
CAGCGGGTGT TGACTCAGAC AGCCAATGGC ACACTGCAGA CCCTTGCCCC AGCCACAGTG 
CAGACAGTCG CTACACCACA GGTGCAGCAG GTCCCGGTCC TGGTTCAGCC TCAGATTATT 
AAGACAGATT CCCTTGTTTT GACCACGCTG AAAACAGATG GCAGCCCTGT CATGGCCGCC 
GTCCAGAACC CGGCCCTCAC TGCCCTCACC GCCCCCATCC AGACGGCCGC CCTTCAAGTA 
CCAACCCTGG TGGGCAGCAA CGGGGCCATT CTGACCACAA TGCCGGTAAT GATGGGCCAA 
GAGAAAGTCC CCATTAAGCA AGTGCCTGGG GGTGTAAAGC AGCTCGAGCC TCCCAAAGAA 
GGAGAGAGGC GGACAACACA CAATATCATT GAGAAGCGGT ACCGGTCCTC CATCAACGAC 
AAAATCATAG AGTTGAAAGA CTTGGTCATG GGGACAGATG CCAAGATGCA CAAGTCTGGC 
GTTCTGAGGA AGGCCATTGA TTACATCAAG TACCTGCAGC AGGTCAACCA CAAGCTGCGC 
CAGGAGAACA TGGTGCTGAA GCTGGCAAAT CAGAAAAACA AGCTCCTGAA GGGCATCGAC 
TTGGGCAGTC TGGTGGACAG TGATGTGGAC TTGAAGATCG ATGACTTCAA TCAGAATGTC 
CTTCTGATGT CTCCCCCGGC CTCGGACTCC GGGTCCCAGG CTGGCTTCTC CCCCTATTCC 
ATTGACTCTG AGCCGGGCAG CCCTCTGCTG GATGATGCAA AGGTCAAGGA TGAACCGGAC 
TCTCCCCCTG TGGCACTGGG CATGGTGGAC CGATCTCGAA TTCTCTTATG TGTCCTCACC 
TTCCTGGGTC TCTCCTTTAA CCCCTTGACT TCATTGCTGC AGTGGGGAGG GGCCCACAAC 
CCTGACCAAC ACCCGTACTC AGGCTCTGGC CGCAATGTAC TGTCACTGGA GTCAGGTTCT 
GGAGGCTGGT TTGACTGGAT GATGCCGACT CTACTGCTGT GGCTGCTAAA CGGTGTGATT 
GTCTTGAGCG TCTTCGTGAA GCTGTTGGTC CATGGGGAGC CAGTGATCCG CCCACACTCA 
CGCTCCTCGG TCACCTTCTG GAGACACCGG AAGCAGGCAG ACCTAGACCT CGCCAAAGGT 
GACTTTGCAG CTGCTGCTGC CAACCTACAG ACCTGCTTAT CCGTTTTGGG CCGGGCGCTG 
CCCACCTCCC GCCTGGACTT GGCCTGCAGC CTCTCCTGGA ACGTGATCCG CTACAGCCTG 
CAGAAGCTGC GCCTGGTACG CTGGTTACTC AAAAAGGTCT TCCAGCGCTG GCGGGCTACC 
CCCGCCACTG CAGCCGGCTT TGAGGATGAA GCTAAGAGCA GTGCGAGGGA TGCGGCCCTG 
GCCTACCACA GGCTGCACCA GCTGCACATC ACAGGGAAGC TTCCAGCAGG ATCTGCCTGT 
TCCGATGTGC ACATGGCTCT GTGTGCTGTG AACCTCGCCG AGTGTGCAGA GGAGAAAATC 
CCACCAAGCA CACTTGTCGA GATCCACCTG ACCGCTGCCA TGGGGCTCAA GACCCGATGC 
GGGGGCAAGC TGGGCTTCTT GGCTAGCTAC TTCTTAAATC GTGCCCAGAG TCTGTGTGGC 
CCAGAGCATA GCGCTGTCCC CGACTCCCTG CGCTGGCTGT GCCATCCCCT GGGCCAGAAG 
TTTTTCATGG AGCGAAGCTG GTCGATCAAG TCAGCAGCCA AGGACAGCCT GTACTGCGCC 
CAGAGGAACC CAGCTGACCC CATTGCCCAG GTACACCAGG CTTTCTGCAA ACACCTGCTG 
GAAAGAGCTG TGGAGGCCTT GGTGAAGCCT CAGGCCAAGA AGAAGGCAGG TGACCGGGAA 
GAAGAGAGCT GTGAATTTTC CAGTGCTCTA GAGTTTTTGA AATTACTTCA CTCTTTTGTG 
GACTCTGTGG GATTTGTGGC CTCACCATTC TCCAGCAGTT CTGTGCTCAG GTCAGCCCTT 
GGTCCCGATG TCGTCTGTCG GTGGTGGACG TCCGCGATCA CCGTGGCCAT CAGCTGGCTC 
CAGGGCGATG ATGCAGCTGT GCGCTCGCAT TTCACTGAAG TAGAGCGGGT CCCCAAGGCC 
CTGGAAGTGA CTGAGAGTCC CTTGGTGAAG GCCGTCTTCT ATGCCTGTAG AGCCATGCAT 
GCCTCACTCT CTGGAAAGGC CGATGGGCAA CAGAACTCCT TCTGTCATTG TGAGAGGGCC 
AGTGGTCACC TGTGGAGCAG TCTCAATGTC AGCGGCACTA CTTCTGACCC TTCACTTAAC 
CATGTGGTCC AGCTGCTCAC CTGTGATCTG CTACTGTCAC TGAGGACAAC ACTCTGGCAA 
AAGCAGGCCA GCGCCAGCCA GCTCCTGGGC GAGACCTACC ACGCGTCAGG CACTGAGCTG 
GCCGGCTTCC AGCGGGACCT GGGCAGCCTT CGAAGGCTGG CCCACAGTTT CCGCCCAGCA 
TACCGCAAGG TGTTCCTGCA TGAAGCAACT GTTCGACTAA TGGCGGGAGC CAGCCCCACC 
CGTACACACC AGCTGCTGGA GCACAGCCTA CGGCGCCGCA CCACTCAGAA CACCAAACAC 
GGAGAAGTAG ACACCTGGCC TGGCCAGCGA GAACGAGCCA CTGCCATCCT GCTGGCCTGC 
CGCCATCTTC CCCTCTCCTT CCTATCTTCC CCGGGCCAGC GGGCAGTGCT GCTGGCTGAA 
GCTGCCCGCA CCCTGGAGAA GGTGGGTGAC CGCCGTTCCT GCAGTGACTG CCAGCAGATG 
ATTGTCAAGC TGGGCGGTGG CACTGCCATC GCTGCTTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001028866.1
CDS	141..3542
Translation	MDENSELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFSDLFSEQLCSSFPGGGGGSGSGGTSNNSSGRGTSGGAADPAVQRSFSQVPLSTFSPSSTSPQAPALQVKVSPTPPRATPVLQPRPQPQPQPPAQLQQQTVMITPTFSTAPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVATPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTAPIQTAALQVPTLVGSNGAILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDSDVDLKIDDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLGLSFNPLTSLLQWGGAHNPDQHPYSGSGRNVLSLESGSGGWFDWMMPTLLLWLLNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLAKGDFAAAAANLQTCLSVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQRWRATPATAAGFEDEAKSSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFLASYFLNRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSIKSAAKDSLYCAQRNPADPIAQVHQAFCKHLLERAVEALVKPQAKKKAGDREEESCEFSSALEFLKLLHSFVDSVGFVASPFSSSSVLRSALGPDVVCRWWTSAITVAISWLQGDDAAVRSHFTEVERVPKALEVTESPLVKAVFYACRAMHASLSGKADGQQNSFCHCERASGHLWSSLNVSGTTSDPSLNHVVQLLTCDLLLSLRTTLWQKQASASQLLGETYHASGTELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQNTKHGEVDTWPGQRERATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCSDCQQMIVKLGGGTAIAAS

Target ORF information:

RefSeq Version	NM_001033694.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sterol regulatory element binding transcription factor 2 (Srebf2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001033694.1

ORF Insert Sequence:

ATGGATGAGA ACAGCGAGCT GGGCGGTCTG GAGACCATGG AGACCCTCAC GGAGCTGGGC 
GATGAGCTGA CTCTCGGGGA CATCGACGAG ATGCTACAGT TTGTCAGCAA TCAAGTGGGA 
GAGTTCTCTG ACTTGTTTTC AGAGCAACTA TGTAGCTCCT TCCCTGGAGG TGGTGGCGGC 
AGTGGCAGTG GTGGCACCAG CAACAACAGC AGTGGCAGAG GCACCAGTGG TGGAGCTGCA 
GATCCCGCAG TACAGCGGTC ATTCAGCCAG GTCCCATTGT CTACCTTCTC TCCCTCATCC 
ACCTCCCCTC AGGCTCCAGC CCTGCAGGTC AAAGTCTCTC CTACCCCACC AAGGGCAACC 
CCTGTTCTCC AGCCCCGACC CCAGCCCCAG CCTCAACCTC CAGCTCAGCT GCAGCAGCAG 
ACGGTGATGA TCACCCCGAC CTTCAGCACC GCTCCACAGA CCAGGATCAT CCAGCAGCCT 
TTGATATACC AGAATGCCGC AACCAGCTTT CAAGTCCTGC AGCCTCAAGT GCAAAGCCTC 
GTGACATCCT CGCAGGTACA GCCAGTTACC ATCCAGCAGC AGGTGCAGAC GGTACAGGCC 
CAGCGGGTGT TGACTCAGAC AGCCAATGGC ACACTGCAGA CCCTTGCCCC AGCCACAGTG 
CAGACAGTCG CTACACCACA GGTGCAGCAG GTCCCGGTCC TGGTTCAGCC TCAGATTATT 
AAGACAGATT CCCTTGTTTT GACCACGCTG AAAACAGATG GCAGCCCTGT CATGGCCGCC 
GTCCAGAACC CGGCCCTCAC TGCCCTCACC GCCCCCATCC AGACGGCCGC CCTTCAAGTA 
CCAACCCTGG TGGGCAGCAA CGGGGCCATT CTGACCACAA TGCCGGTAAT GATGGGCCAA 
GAGAAAGTCC CCATTAAGCA AGTGCCTGGG GGTGTAAAGC AGCTCGAGCC TCCCAAAGAA 
GGAGAGAGGC GGACAACACA CAATATCATT GAGAAGCGGT ACCGGTCCTC CATCAACGAC 
AAAATCATAG AGTTGAAAGA CTTGGTCATG GGGACAGATG CCAAGATGCA CAAGTCTGGC 
GTTCTGAGGA AGGCCATTGA TTACATCAAG TACCTGCAGC AGGTCAACCA CAAGCTGCGC 
CAGGAGAACA TGGTGCTGAA GCTGGCAAAT CAGAAAAACA AGCTCCTGAA GGGCATCGAC 
TTGGGCAGTC TGGTGGACAG TGATGTGGAC TTGAAGATCG ATGACTTCAA TCAGAATGTC 
CTTCTGATGT CTCCCCCGGC CTCGGACTCC GGGTCCCAGG CTGGCTTCTC CCCCTATTCC 
ATTGACTCTG AGCCGGGCAG CCCTCTGCTG GATGATGCAA AGGTCAAGGA TGAACCGGAC 
TCTCCCCCTG TGGCACTGGG CATGGTGGAC CGATCTCGAA TTCTCTTATG TGTCCTCACC 
TTCCTGGGTC TCTCCTTTAA CCCCTTGACT TCATTGCTGC AGTGGGGAGG GGCCCACAAC 
CCTGACCAAC ACCCGTACTC AGGCTCTGGC CGCAATGTAC TGTCACTGGA GTCAGGTTCT 
GGAGGCTGGT TTGACTGGAT GATGCCGACT CTACTGCTGT GGCTGCTAAA CGGTGTGATT 
GTCTTGAGCG TCTTCGTGAA GCTGTTGGTC CATGGGGAGC CAGTGATCCG CCCACACTCA 
CGCTCCTCGG TCACCTTCTG GAGACACCGG AAGCAGGCAG ACCTAGACCT CGCCAAAGGT 
GACTTTGCAG CTGCTGCTGC CAACCTACAG ACCTGCTTAT CCGTTTTGGG CCGGGCGCTG 
CCCACCTCCC GCCTGGACTT GGCCTGCAGC CTCTCCTGGA ACGTGATCCG CTACAGCCTG 
CAGAAGCTGC GCCTGGTACG CTGGTTACTC AAAAAGGTCT TCCAGCGCTG GCGGGCTACC 
CCCGCCACTG CAGCCGGCTT TGAGGATGAA GCTAAGAGCA GTGCGAGGGA TGCGGCCCTG 
GCCTACCACA GGCTGCACCA GCTGCACATC ACAGGGAAGC TTCCAGCAGG ATCTGCCTGT 
TCCGATGTGC ACATGGCTCT GTGTGCTGTG AACCTCGCCG AGTGTGCAGA GGAGAAAATC 
CCACCAAGCA CACTTGTCGA GATCCACCTG ACCGCTGCCA TGGGGCTCAA GACCCGATGC 
GGGGGCAAGC TGGGCTTCTT GGCTAGCTAC TTCTTAAATC GTGCCCAGAG TCTGTGTGGC 
CCAGAGCATA GCGCTGTCCC CGACTCCCTG CGCTGGCTGT GCCATCCCCT GGGCCAGAAG 
TTTTTCATGG AGCGAAGCTG GTCGATCAAG TCAGCAGCCA AGGACAGCCT GTACTGCGCC 
CAGAGGAACC CAGCTGACCC CATTGCCCAG GTACACCAGG CTTTCTGCAA ACACCTGCTG 
GAAAGAGCTG TGGAGGCCTT GGTGAAGCCT CAGGCCAAGA AGAAGGCAGG TGACCGGGAA 
GAAGAGAGCT GTGAATTTTC CAGTGCTCTA GAGTTTTTGA AATTACTTCA CTCTTTTGTG 
GACTCTGTGG GATTTGTGGC CTCACCATTC TCCAGCAGTT CTGTGCTCAG GTCAGCCCTT 
GGTCCCGATG TCGTCTGTCG GTGGTGGACG TCCGCGATCA CCGTGGCCAT CAGCTGGCTC 
CAGGGCGATG ATGCAGCTGT GCGCTCGCAT TTCACTGAAG TAGAGCGGGT CCCCAAGGCC 
CTGGAAGTGA CTGAGAGTCC CTTGGTGAAG GCCGTCTTCT ATGCCTGTAG AGCCATGCAT 
GCCTCACTCT CTGGAAAGGC CGATGGGCAA CAGAACTCCT TCTGTCATTG TGAGAGGGCC 
AGTGGTCACC TGTGGAGCAG TCTCAATGTC AGCGGCACTA CTTCTGACCC TTCACTTAAC 
CATGTGGTCC AGCTGCTCAC CTGTGATCTG CTACTGTCAC TGAGGACAAC ACTCTGGCAA 
AAGCAGGCCA GCGCCAGCCA GCTCCTGGGC GAGACCTACC ACGCGTCAGG CACTGAGCTG 
GCCGGCTTCC AGCGGGACCT GGGCAGCCTT CGAAGGCTGG CCCACAGTTT CCGCCCAGCA 
TACCGCAAGG TGTTCCTGCA TGAAGCAACT GTTCGACTAA TGGCGGGAGC CAGCCCCACC 
CGTACACACC AGCTGCTGGA GCACAGCCTA CGGCGCCGCA CCACTCAGAA CACCAAACAC 
GGAGAAGTAG ACACCTGGCC TGGCCAGCGA GAACGAGCCA CTGCCATCCT GCTGGCCTGC 
CGCCATCTTC CCCTCTCCTT CCTATCTTCC CCGGGCCAGC GGGCAGTGCT GCTGGCTGAA 
GCTGCCCGCA CCCTGGAGAA GGTGGGTGAC CGCCGTTCCT GCAGTGACTG CCAGCAGATG 
ATTGTCAAGC TGGGCGGTGG CACTGCCATC GCTGCTTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Srebf2 ( XM_006242079.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006242141.1 Rattus norvegicus sterol regulatory element binding transcription factor 2 (Srebf2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa30616
Clone ID Related Accession (Same CDS sequence)	XM_006242079.3
Accession Version	XM_006242079.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3312bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	sterol regulatory element-binding protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006242079.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTACAGT TTGTCAGCAA TCAAGTGGGA GAGTTCTCTG ACTTGTTTTC AGAGCAACTA 
TGTAGCTCCT TCCCTGGAGG TGGTGGCGGC AGTGGCAGTG GTGGCACCAG CAACAACAGC 
AGTGGCAGAG GCACCAGTGG TGGAGCTGCA GATCCCGCAG TACAGCGGTC ATTCAGCCAG 
GTCCCATTGT CTACCTTCTC TCCCTCATCC ACCTCCCCTC AGGCTCCAGC CCTGCAGGTC 
AAAGTCTCTC CTACCCCACC AAGGGCAACC CCTGTTCTCC AGCCCCGACC CCAGCCCCAG 
CCTCAACCTC CAGCTCAGCT GCAGCAGCAG ACGGTGATGA TCACCCCGAC CTTCAGCACC 
GCTCCACAGA CCAGGATCAT CCAGCAGCCT TTGATATACC AGAATGCCGC AACCAGCTTT 
CAAGTCCTGC AGCCTCAAGT GCAAAGCCTC GTGACATCCT CGCAGGTACA GCCAGTTACC 
ATCCAGCAGC AGGTGCAGAC GGTACAGGCC CAGCGGGTGT TGACTCAGAC AGCCAATGGC 
ACACTGCAGA CCCTTGCCCC AGCCACAGTG CAGACAGTCG CTACACCACA GGTGCAGCAG 
GTCCCGGTCC TGGTTCAGCC TCAGATTATT AAGACAGATT CCCTTGTTTT GACCACGCTG 
AAAACAGATG GCAGCCCTGT CATGGCCGCC GTCCAGAACC CGGCCCTCAC TGCCCTCACC 
GCCCCCATCC AGACGGCCGC CCTTCAAGTA CCAACCCTGG TGGGCAGCAA CGGGGCCATT 
CTGACCACAA TGCCGGTAAT GATGGGCCAA GAGAAAGTCC CCATTAAGCA AGTGCCTGGG 
GGTGTAAAGC AGCTCGAGCC TCCCAAAGAA GGAGAGAGGC GGACAACACA CAATATCATT 
GAGAAGCGGT ACCGGTCCTC CATCAACGAC AAAATCATAG AGTTGAAAGA CTTGGTCATG 
GGGACAGATG CCAAGATGCA CAAGTCTGGC GTTCTGAGGA AGGCCATTGA TTACATCAAG 
TACCTGCAGC AGGTCAACCA CAAGCTGCGC CAGGAGAACA TGGTGCTGAA GCTGGCAAAT 
CAGAAAAACA AGCTCCTGAA GGGCATCGAC TTGGGCAGTC TGGTGGACAG TGATGTGGAC 
TTGAAGATCG ATGACTTCAA TCAGAATGTC CTTCTGATGT CTCCCCCGGC CTCGGACTCT 
GGGTCCCAGG CTGGCTTCTC CCCCTATTCC ATTGACTCTG AGCCGGGCAG CCCTCTGCTG 
GATGATGCAA AGGTCAAGGA TGAACCGGAC TCTCCCCCTG TGGCACTGGG CATGGTGGAC 
CGATCTCGAA TTCTCTTATG TGTCCTCACC TTCCTGGGTC TCTCCTTTAA CCCCTTGACT 
TCATTGCTGC AGTGGGGAGG GGCCCACAAC CCTGACCAAC ACCCGTACTC AGGCTCTGGC 
CGCAATGTAC TGTCACTGGA GTCAGGTTCT GGAGGCTGGT TTGACTGGAT GATGCCGACT 
CTACTGCTGT GGCTGCTAAA CGGTGTGATT GTCTTGAGCG TCTTCGTGAA GCTGTTGGTC 
CATGGGGAGC CAGTGATCCG CCCACACTCA CGCTCCTCGG TCACCTTCTG GAGACACCGG 
AAGCAGGCAG ACCTAGACCT CGCCAAAGGT GACTTTGCAG CTGCTGCTGC CAACCTACAG 
ACCTGCTTAT CCGTTTTGGG CCGGGCGCTG CCCACCTCCC GCCTGGACTT GGCCTGCAGC 
CTCTCCTGGA ACGTGATCCG CTACAGCCTG CAGAAGCTGC GCCTGGTACG CTGGTTACTC 
AAAAAGGTCT TCCAGCGCTG GCGGGCTACC CCCGCCACTG CAGCCGGCTT TGAGGATGAA 
GCTAAGAGCA GTGCGAGGGA TGCGGCCCTG GCCTACCACA GGCTGCACCA GCTGCACATC 
ACAGGGAAGC TTCCAGCAGG ATCTGCCTGT TCCGATGTGC ACATGGCTCT GTGTGCTGTG 
AACCTCGCCG AGTGTGCAGA GGAGAAAATC CCACCAAGCA CACTTGTCGA GATCCACCTG 
ACCGCTGCCA TGGGGCTCAA GACCCGATGC GGGGGCAAGC TGGGCTTCTT GGCTAGCTAC 
TTCTTAAATC GTGCCCAGAG TCTGTGTGGC CCAGAGCATA GCGCTGTCCC CGACTCCCTG 
CGCTGGCTGT GCCATCCCCT GGGCCAGAAG TTTTTCATGG AGCGAAGCTG GTCGATCAAG 
TCAGCAGCCA AGGACAGCCT GTACTGCGCC CAGAGGAACC CAGCTGACCC CATTGCCCAG 
GTACACCAGG CTTTCTGCAA ACACCTGCTG GAAAGAGCTG TGGAGGCCTT GGTGAAGCCT 
CAGGCCAAGA AGAAGGCAGG TGACCGGGAA GAAGAGAGCT GTGAATTTTC CAGTGCTCTA 
GAGTTTTTGA AATTACTTCA CTCTTTTGTG GACTCTGTGG GATTTGTGGC CTCACCATTC 
TCCAGCAGTT CTGTGCTCAG GTCAGCCCTT GGTCCCGATG TCGTCTGTCG GTGGTGGACG 
TCCGCGATCA CCGTGGCCAT CAGCTGGCTC CAGGGCGATG ATGCAGCTGT GCGCTCGCAT 
TTCACTGAAG TAGAGCGGGT CCCCAAGGCC CTGGAAGTGA CTGAGAGTCC CTTGGTGAAG 
GCCGTCTTCT ATGCCTGTAG AGCCATGCAT GCCTCACTCT CTGGAAAGGC CGATGGGCAA 
CAGAACTCCT TCTGTCATTG TGAGAGGGCC AGTGGTCACC TGTGGAGCAG TCTCAATGTC 
AGCGGCACTA CTTCTGACCC TTCACTTAAC CATGTGGTCC AGCTGTTCAC CTGTGATCTG 
CTACTGTCAC TGAGGACAAC ACTCTGGCAA AAGCAGGCCA GCGCCAGCCA GCTCCTGGGC 
GAGACCTACC ACGCGTCAGG CACTGAGCTG GCCGGCTTCC AGCGGGACCT GGGCAGCCTT 
CGAAGGCTGG CCCACAGTTT CCGCCCAGCA TACCGCAAGG TGTTCCTGCA TGAAGCAACT 
GTTCGACTAA TGGCGGGAGC CAGCCCCACC CGTACACACC AGCTGCTGGA GCACAGCCTA 
CGGCGCCGCA CCACTCAGAA CACCAAACAC GGAGAAGTAG ACACCTGGCC TGGCCAGCGA 
GAACGAGCCA CTGCCATCCT GCTGGCCTGC CGCCATCTTC CCCTCTCCTT CCTATCTTCC 
CCGGGCCAGC GGGCAGTGCT GCTGGCTGAA GCTGCCCGCA CCCTGGAGAA GGTGGGTGAC 
CGCCGTTCCT GCAGTGACTG CCAGCAGATG ATTGTCAAGC TGGGCGGTGG CACTGCCATC 
GCTGCTTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006242141.1
CDS	581..3892
Translation	MLQFVSNQVGEFSDLFSEQLCSSFPGGGGGSGSGGTSNNSSGRGTSGGAADPAVQRSFSQVPLSTFSPSSTSPQAPALQVKVSPTPPRATPVLQPRPQPQPQPPAQLQQQTVMITPTFSTAPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVATPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTAPIQTAALQVPTLVGSNGAILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDSDVDLKIDDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLGLSFNPLTSLLQWGGAHNPDQHPYSGSGRNVLSLESGSGGWFDWMMPTLLLWLLNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLAKGDFAAAAANLQTCLSVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQRWRATPATAAGFEDEAKSSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFLASYFLNRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSIKSAAKDSLYCAQRNPADPIAQVHQAFCKHLLERAVEALVKPQAKKKAGDREEESCEFSSALEFLKLLHSFVDSVGFVASPFSSSSVLRSALGPDVVCRWWTSAITVAISWLQGDDAAVRSHFTEVERVPKALEVTESPLVKAVFYACRAMHASLSGKADGQQNSFCHCERASGHLWSSLNVSGTTSDPSLNHVVQLFTCDLLLSLRTTLWQKQASASQLLGETYHASGTELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQNTKHGEVDTWPGQRERATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCSDCQQMIVKLGGGTAIAAS

Target ORF information:

RefSeq Version	XM_006242079.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sterol regulatory element binding transcription factor 2 (Srebf2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006242079.3

ORF Insert Sequence:

ATGCTACAGT TTGTCAGCAA TCAAGTGGGA GAGTTCTCTG ACTTGTTTTC AGAGCAACTA 
TGTAGCTCCT TCCCTGGAGG TGGTGGCGGC AGTGGCAGTG GTGGCACCAG CAACAACAGC 
AGTGGCAGAG GCACCAGTGG TGGAGCTGCA GATCCCGCAG TACAGCGGTC ATTCAGCCAG 
GTCCCATTGT CTACCTTCTC TCCCTCATCC ACCTCCCCTC AGGCTCCAGC CCTGCAGGTC 
AAAGTCTCTC CTACCCCACC AAGGGCAACC CCTGTTCTCC AGCCCCGACC CCAGCCCCAG 
CCTCAACCTC CAGCTCAGCT GCAGCAGCAG ACGGTGATGA TCACCCCGAC CTTCAGCACC 
GCTCCACAGA CCAGGATCAT CCAGCAGCCT TTGATATACC AGAATGCCGC AACCAGCTTT 
CAAGTCCTGC AGCCTCAAGT GCAAAGCCTC GTGACATCCT CGCAGGTACA GCCAGTTACC 
ATCCAGCAGC AGGTGCAGAC GGTACAGGCC CAGCGGGTGT TGACTCAGAC AGCCAATGGC 
ACACTGCAGA CCCTTGCCCC AGCCACAGTG CAGACAGTCG CTACACCACA GGTGCAGCAG 
GTCCCGGTCC TGGTTCAGCC TCAGATTATT AAGACAGATT CCCTTGTTTT GACCACGCTG 
AAAACAGATG GCAGCCCTGT CATGGCCGCC GTCCAGAACC CGGCCCTCAC TGCCCTCACC 
GCCCCCATCC AGACGGCCGC CCTTCAAGTA CCAACCCTGG TGGGCAGCAA CGGGGCCATT 
CTGACCACAA TGCCGGTAAT GATGGGCCAA GAGAAAGTCC CCATTAAGCA AGTGCCTGGG 
GGTGTAAAGC AGCTCGAGCC TCCCAAAGAA GGAGAGAGGC GGACAACACA CAATATCATT 
GAGAAGCGGT ACCGGTCCTC CATCAACGAC AAAATCATAG AGTTGAAAGA CTTGGTCATG 
GGGACAGATG CCAAGATGCA CAAGTCTGGC GTTCTGAGGA AGGCCATTGA TTACATCAAG 
TACCTGCAGC AGGTCAACCA CAAGCTGCGC CAGGAGAACA TGGTGCTGAA GCTGGCAAAT 
CAGAAAAACA AGCTCCTGAA GGGCATCGAC TTGGGCAGTC TGGTGGACAG TGATGTGGAC 
TTGAAGATCG ATGACTTCAA TCAGAATGTC CTTCTGATGT CTCCCCCGGC CTCGGACTCT 
GGGTCCCAGG CTGGCTTCTC CCCCTATTCC ATTGACTCTG AGCCGGGCAG CCCTCTGCTG 
GATGATGCAA AGGTCAAGGA TGAACCGGAC TCTCCCCCTG TGGCACTGGG CATGGTGGAC 
CGATCTCGAA TTCTCTTATG TGTCCTCACC TTCCTGGGTC TCTCCTTTAA CCCCTTGACT 
TCATTGCTGC AGTGGGGAGG GGCCCACAAC CCTGACCAAC ACCCGTACTC AGGCTCTGGC 
CGCAATGTAC TGTCACTGGA GTCAGGTTCT GGAGGCTGGT TTGACTGGAT GATGCCGACT 
CTACTGCTGT GGCTGCTAAA CGGTGTGATT GTCTTGAGCG TCTTCGTGAA GCTGTTGGTC 
CATGGGGAGC CAGTGATCCG CCCACACTCA CGCTCCTCGG TCACCTTCTG GAGACACCGG 
AAGCAGGCAG ACCTAGACCT CGCCAAAGGT GACTTTGCAG CTGCTGCTGC CAACCTACAG 
ACCTGCTTAT CCGTTTTGGG CCGGGCGCTG CCCACCTCCC GCCTGGACTT GGCCTGCAGC 
CTCTCCTGGA ACGTGATCCG CTACAGCCTG CAGAAGCTGC GCCTGGTACG CTGGTTACTC 
AAAAAGGTCT TCCAGCGCTG GCGGGCTACC CCCGCCACTG CAGCCGGCTT TGAGGATGAA 
GCTAAGAGCA GTGCGAGGGA TGCGGCCCTG GCCTACCACA GGCTGCACCA GCTGCACATC 
ACAGGGAAGC TTCCAGCAGG ATCTGCCTGT TCCGATGTGC ACATGGCTCT GTGTGCTGTG 
AACCTCGCCG AGTGTGCAGA GGAGAAAATC CCACCAAGCA CACTTGTCGA GATCCACCTG 
ACCGCTGCCA TGGGGCTCAA GACCCGATGC GGGGGCAAGC TGGGCTTCTT GGCTAGCTAC 
TTCTTAAATC GTGCCCAGAG TCTGTGTGGC CCAGAGCATA GCGCTGTCCC CGACTCCCTG 
CGCTGGCTGT GCCATCCCCT GGGCCAGAAG TTTTTCATGG AGCGAAGCTG GTCGATCAAG 
TCAGCAGCCA AGGACAGCCT GTACTGCGCC CAGAGGAACC CAGCTGACCC CATTGCCCAG 
GTACACCAGG CTTTCTGCAA ACACCTGCTG GAAAGAGCTG TGGAGGCCTT GGTGAAGCCT 
CAGGCCAAGA AGAAGGCAGG TGACCGGGAA GAAGAGAGCT GTGAATTTTC CAGTGCTCTA 
GAGTTTTTGA AATTACTTCA CTCTTTTGTG GACTCTGTGG GATTTGTGGC CTCACCATTC 
TCCAGCAGTT CTGTGCTCAG GTCAGCCCTT GGTCCCGATG TCGTCTGTCG GTGGTGGACG 
TCCGCGATCA CCGTGGCCAT CAGCTGGCTC CAGGGCGATG ATGCAGCTGT GCGCTCGCAT 
TTCACTGAAG TAGAGCGGGT CCCCAAGGCC CTGGAAGTGA CTGAGAGTCC CTTGGTGAAG 
GCCGTCTTCT ATGCCTGTAG AGCCATGCAT GCCTCACTCT CTGGAAAGGC CGATGGGCAA 
CAGAACTCCT TCTGTCATTG TGAGAGGGCC AGTGGTCACC TGTGGAGCAG TCTCAATGTC 
AGCGGCACTA CTTCTGACCC TTCACTTAAC CATGTGGTCC AGCTGTTCAC CTGTGATCTG 
CTACTGTCAC TGAGGACAAC ACTCTGGCAA AAGCAGGCCA GCGCCAGCCA GCTCCTGGGC 
GAGACCTACC ACGCGTCAGG CACTGAGCTG GCCGGCTTCC AGCGGGACCT GGGCAGCCTT 
CGAAGGCTGG CCCACAGTTT CCGCCCAGCA TACCGCAAGG TGTTCCTGCA TGAAGCAACT 
GTTCGACTAA TGGCGGGAGC CAGCCCCACC CGTACACACC AGCTGCTGGA GCACAGCCTA 
CGGCGCCGCA CCACTCAGAA CACCAAACAC GGAGAAGTAG ACACCTGGCC TGGCCAGCGA 
GAACGAGCCA CTGCCATCCT GCTGGCCTGC CGCCATCTTC CCCTCTCCTT CCTATCTTCC 
CCGGGCCAGC GGGCAGTGCT GCTGGCTGAA GCTGCCCGCA CCCTGGAGAA GGTGGGTGAC 
CGCCGTTCCT GCAGTGACTG CCAGCAGATG ATTGTCAAGC TGGGCGGTGG CACTGCCATC 
GCTGCTTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A? inhibits SREBP-2 activation through Akt inhibition.
Journal of lipid research59(1)1-13(2018 Jan)
Mohamed A,Viveiros A,Williams K,Posse de Chaves E

Sterol regulatory element-binding proteins are transcriptional regulators of the thyroglobulin gene in thyroid cells.
Biochimica et biophysica acta1859(8)994-1003(2016 08)
Wen G,Eder K,Ringseis R

Nutrient deprivation induces ?-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway.
Frontiers in aging neuroscience6268(2014)
Jiang P,Gan M,Lin WL,Yen SH

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Srebf2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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