Sh3bp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sh3bp1
Entrez Gene ID	300067
Full Name	SH3-domain binding protein 1
General protein information	Preferred Names SH3-domain binding protein 1 Names SH3 domain-binding protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q34

mRNA and Protein(s)

mRNA	Protein	Name
NM_001171981.1	NP_001165452.1	SH3 domain-binding protein 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SH3BP1	XP_002687966.1
Homo sapiens (human)	SH3BP1	NP_061830.3
Pan troglodytes (chimpanzee)	SH3BP1	XP_515119.2
	SH3BP1	XP_002798436.1
Mus musculus (house mouse)	Sh3bp1	NP_033190.2
Gallus gallus (chicken)	SH3BP1	XP_428489.3
Canis lupus familiaris (dog)	SH3BP1	XP_538386.3
Danio rerio (zebrafish)	sh3bp1	XP_001345357.4
Rattus norvegicus (Norway rat)	Sh3bp1	NP_001165452.1
Xenopus tropicalis (tropical clawed frog)	sh3bp1	XP_004913943.1

Gene Ontology
Bibliography

Related articles in PubMed

Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins.
Schlam D, Bagshaw RD, Freeman SA, Collins RF, Pawson T, Fairn GD, Grinstein S
Nature communications68623(2015 Oct)

An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E-PlexinD1 signaling.
Tata A, Stoppel DC, Hong S, Ben-Zvi A, Xie T, Gu C
The Journal of cell biology205(4)573-90(2014 May)

Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex.
Elbediwy A, Zihni C, Terry SJ, Clark P, Matter K, Balda MS
The Journal of cell biology198(4)677-93(2012 Aug)

SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility.
Parrini MC, Sadou-Dubourgnoux A, Aoki K, Kunida K, Biondini M, Hatzoglou A, Poullet P, Formstecher E, Yeaman C, Matsuda M, Ross? C, Camonis J
Molecular cell42(5)650-61(2011 Jun)

Identification of a ten-amino acid proline-rich SH3 binding site.
Ren R, Mayer BJ, Cicchetti P, Baltimore D
Science (New York, N.Y.)259(5098)1157-61(1993 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SH3BP1 downregulates Rac1 at the motile-cell front and is required for cell motility.
Title: SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility.

The following Sh3bp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sh3bp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06413	NM_001171981.1 Latest version!	Rattus norvegicus SH3-domain binding protein 1 (Sh3bp1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sh3bp1 ( NM_001171981.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001165452.1 Rattus norvegicus SH3-domain binding protein 1 (Sh3bp1), mRNA.

Price & Availability↑

CloneID	ORa06413
Clone ID Related Accession (Same CDS sequence)	NM_001171981.1
Accession Version	NM_001171981.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2070bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	SH3 domain-binding protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC096473.8. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGATGAAGA GGCAGCTGCA CCGCATGCGG CAGCTGGCCC ACACGGGCAG CTCGGGACGC 
ACCCCTGAGA CTGCCGAGTT CTTGGGTGAG GACCTGCTGC AGGTAGAGCA GCGGTTGGAA 
CCAGCTAAGC GAGCAGCCCA CAATGTTCAC AAAAGGCTGC AGGCCTGTCT GCAGGGCCAA 
AGCGGGGCTG ACATGGACAA GCGGGTGAAG AAGCTTCCCC TCATGGCTCT TTCTACCGCA 
ATGGCTGAAA GCTTCAAGGA GTTGGATCCC GATTCCAGCA TGGGGAAAGC CTTAGAGATG 
AGCTGTGCCA TCCAGAACCA GCTGGCCAGA ATCCTAGCAG AGTTTGAGAT GACCCTGGAG 
AGAGATGTCC TGCAGCCGCT CAACAGGCTG AGCGAGGAGG AGCTGCCTGC CATCCTCAAG 
CGCAAGAAGA GCCTTCAGAA GCTGGTGTCT GACTGGAACA CCCTCAAAAG CAGGCTCAGC 
CAGGCAGCCA AGAACTCGGG AAGCAGCCAA AGCCTGGGTG GTGGCTCAAG CAGTCACACC 
CACATGGCCA CTGCCAACAA GGTGGAGACG CTGAAGGAAG ACGAGGAGGA GCTGAAGAGA 
AAGGTGGAAC AGTGCAAGGA TGAGTACCTG GCTGATCTCT ACCACTTCTC CACCAAGGAG 
GACTCATATG CCAACTACTT TACTCATCTC CTGGAGATTC AGGCTGACTA CCATCGCAAG 
TCACTAACCT CCCTTGACAC GGCCCTAGCT GAGCTGAGGG ACAACCACAG CCAAGCAGAC 
TCCTCCCCCT TGACGACGGC TGCCCCCTTC TCCAGAGTAT ATGGGGTGTC CCTGAGAACC 
CACCTGCAAG ATCTAGGCCG TGACATTGCC CTGCCCATCG AGGCTTGTGT CCTGTTGCTG 
CTGTCGGAGG GCATGCAGGA GGAGGGCCTC TTCCGTCTGG CTGCTGGGGC CTCTGTGCTG 
AAGCGCCTTA AGCAGACCAT GGCCTCAGAT CCCCACAGCC TGGAGGAATT CTGCTCGGAC 
CCCCATGCTG TAGCAGGTGC CCTCAAGTCC TATCTCCGGG AGCTGCCAGA GCCCCTGATG 
ACCTCTGACC TCTATGATGA CTGGATGAGA GCAGCCAGCC TGAAGGAACC AGGAGCCCGC 
CTGGAGGCCC TTCATGATGT TTGCAGCCGT CTACCCCAGG AGAACTTCAA CAACCTCCGG 
TACCTGATGA AGTTCTTGGC ACTGCTGGCC GAGGAGCAGG ACGTGAACAA GATGACACCC 
AGCAACATCG CCATTGTCTT GGGGCCCAAC CTGCTGTGGC CTCCTGAGAA AGAAGGGGAC 
CAGGCTCAAC TGGACGCTGC CTCTGTGTCC TCCATTCAGG TGGTGGGTGT TGTCGAGGTG 
CTGATACAGA ATGCAGACAC CCTCTTTCCT GGAGATATCA ACTTCAGTGT ATCAGGCATC 
TTCTCAGGCC TGGCCCCCCA GGAGAAGCCC AATAGTCAAC AGGTCTCAGA GGAATTGGCA 
CCTGTTGCTG TGCCTGCCAC AGCCGCTACC CCAACTCCCA CCCCAGCTCC TACCCCAGCT 
CCAGCCTCCA TGACAGTAAA AGAAAGGACA GAGTCTGAAT TGCCCAAACC AGCTTCCCCC 
AAGGTCAGCA GGAGCCCCAC AGATACAACT GCTTTGGCAG AGGACATGAC TCGGAAGACC 
AAGCGCCCAG CACCAGCCCG GCCTACCATG CCACCTCCCC AGCCTTCCAG CTCACGCTCA 
TCCCCTCCAG CTCTATCCCT GCCCGCTGGC TCGGTCAGCC CTGGCACTCC CCAAGCTTTG 
CCACGCCGTC TGGTGGGCAC CAGCCTCCGG GCCCCCACCG TACCTCCCCC ATTACCCCCT 
GCTCCTCCAC AACCTGCCCG GCGACAGAGC CGGCGTTTAC CAGTCTCCCC CTGCCCAGCC 
TCCCCTGTCA TTTCAAACAT GCCTGCTCAG GTGGACCAGG GAGCGGCTAC AGAGGACAGA 
GGAGGCCCTG AGGCTGTGGG TGGGCATCCC CCTACCCCAG TTCTGCCACC CCAGCCCCGG 
CCCAGGGGCC TCATTTCAGA GACAGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001165452.1
CDS	1..2070
Translation	MMKRQLHRMRQLAHTGSSGRTPETAEFLGEDLLQVEQRLEPAKRAAHNVHKRLQACLQGQSGADMDKRVKKLPLMALSTAMAESFKELDPDSSMGKALEMSCAIQNQLARILAEFEMTLERDVLQPLNRLSEEELPAILKRKKSLQKLVSDWNTLKSRLSQAAKNSGSSQSLGGGSSSHTHMATANKVETLKEDEEELKRKVEQCKDEYLADLYHFSTKEDSYANYFTHLLEIQADYHRKSLTSLDTALAELRDNHSQADSSPLTTAAPFSRVYGVSLRTHLQDLGRDIALPIEACVLLLLSEGMQEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRELPEPLMTSDLYDDWMRAASLKEPGARLEALHDVCSRLPQENFNNLRYLMKFLALLAEEQDVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEVLIQNADTLFPGDINFSVSGIFSGLAPQEKPNSQQVSEELAPVAVPATAATPTPTPAPTPAPASMTVKERTESELPKPASPKVSRSPTDTTALAEDMTRKTKRPAPARPTMPPPQPSSSRSSPPALSLPAGSVSPGTPQALPRRLVGTSLRAPTVPPPLPPAPPQPARRQSRRLPVSPCPASPVISNMPAQVDQGAATEDRGGPEAVGGHPPTPVLPPQPRPRGLISETD

Target ORF information:

RefSeq Version	NM_001171981.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus SH3-domain binding protein 1 (Sh3bp1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001171981.1

ORF Insert Sequence:

ATGATGAAGA GGCAGCTGCA CCGCATGCGG CAGCTGGCCC ACACGGGCAG CTCGGGACGC 
ACCCCTGAGA CTGCCGAGTT CTTGGGTGAG GACCTGCTGC AGGTAGAGCA GCGGTTGGAA 
CCAGCTAAGC GAGCAGCCCA CAATGTTCAC AAAAGGCTGC AGGCCTGTCT GCAGGGCCAA 
AGCGGGGCTG ACATGGACAA GCGGGTGAAG AAGCTTCCCC TCATGGCTCT TTCTACCGCA 
ATGGCTGAAA GCTTCAAGGA GTTGGATCCC GATTCCAGCA TGGGGAAAGC CTTAGAGATG 
AGCTGTGCCA TCCAGAACCA GCTGGCCAGA ATCCTAGCAG AGTTTGAGAT GACCCTGGAG 
AGAGATGTCC TGCAGCCGCT CAACAGGCTG AGCGAGGAGG AGCTGCCTGC CATCCTCAAG 
CGCAAGAAGA GCCTTCAGAA GCTGGTGTCT GACTGGAACA CCCTCAAAAG CAGGCTCAGC 
CAGGCAGCCA AGAACTCGGG AAGCAGCCAA AGCCTGGGTG GTGGCTCAAG CAGTCACACC 
CACATGGCCA CTGCCAACAA GGTGGAGACG CTGAAGGAAG ACGAGGAGGA GCTGAAGAGA 
AAGGTGGAAC AGTGCAAGGA TGAGTACCTG GCTGATCTCT ACCACTTCTC CACCAAGGAG 
GACTCATATG CCAACTACTT TACTCATCTC CTGGAGATTC AGGCTGACTA CCATCGCAAG 
TCACTAACCT CCCTTGACAC GGCCCTAGCT GAGCTGAGGG ACAACCACAG CCAAGCAGAC 
TCCTCCCCCT TGACGACGGC TGCCCCCTTC TCCAGAGTAT ATGGGGTGTC CCTGAGAACC 
CACCTGCAAG ATCTAGGCCG TGACATTGCC CTGCCCATCG AGGCTTGTGT CCTGTTGCTG 
CTGTCGGAGG GCATGCAGGA GGAGGGCCTC TTCCGTCTGG CTGCTGGGGC CTCTGTGCTG 
AAGCGCCTTA AGCAGACCAT GGCCTCAGAT CCCCACAGCC TGGAGGAATT CTGCTCGGAC 
CCCCATGCTG TAGCAGGTGC CCTCAAGTCC TATCTCCGGG AGCTGCCAGA GCCCCTGATG 
ACCTCTGACC TCTATGATGA CTGGATGAGA GCAGCCAGCC TGAAGGAACC AGGAGCCCGC 
CTGGAGGCCC TTCATGATGT TTGCAGCCGT CTACCCCAGG AGAACTTCAA CAACCTCCGG 
TACCTGATGA AGTTCTTGGC ACTGCTGGCC GAGGAGCAGG ACGTGAACAA GATGACACCC 
AGCAACATCG CCATTGTCTT GGGGCCCAAC CTGCTGTGGC CTCCTGAGAA AGAAGGGGAC 
CAGGCTCAAC TGGACGCTGC CTCTGTGTCC TCCATTCAGG TGGTGGGTGT TGTCGAGGTG 
CTGATACAGA ATGCAGACAC CCTCTTTCCT GGAGATATCA ACTTCAGTGT ATCAGGCATC 
TTCTCAGGCC TGGCCCCCCA GGAGAAGCCC AATAGTCAAC AGGTCTCAGA GGAATTGGCA 
CCTGTTGCTG TGCCTGCCAC AGCCGCTACC CCAACTCCCA CCCCAGCTCC TACCCCAGCT 
CCAGCCTCCA TGACAGTAAA AGAAAGGACA GAGTCTGAAT TGCCCAAACC AGCTTCCCCC 
AAGGTCAGCA GGAGCCCCAC AGATACAACT GCTTTGGCAG AGGACATGAC TCGGAAGACC 
AAGCGCCCAG CACCAGCCCG GCCTACCATG CCACCTCCCC AGCCTTCCAG CTCACGCTCA 
TCCCCTCCAG CTCTATCCCT GCCCGCTGGC TCGGTCAGCC CTGGCACTCC CCAAGCTTTG 
CCACGCCGTC TGGTGGGCAC CAGCCTCCGG GCCCCCACCG TACCTCCCCC ATTACCCCCT 
GCTCCTCCAC AACCTGCCCG GCGACAGAGC CGGCGTTTAC CAGTCTCCCC CTGCCCAGCC 
TCCCCTGTCA TTTCAAACAT GCCTGCTCAG GTGGACCAGG GAGCGGCTAC AGAGGACAGA 
GGAGGCCCTG AGGCTGTGGG TGGGCATCCC CCTACCCCAG TTCTGCCACC CCAGCCCCGG 
CCCAGGGGCC TCATTTCAGA GACAGATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins.
Nature communications68623(2015 Oct)
Schlam D,Bagshaw RD,Freeman SA,Collins RF,Pawson T,Fairn GD,Grinstein S

An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E-PlexinD1 signaling.
The Journal of cell biology205(4)573-90(2014 May)
Tata A,Stoppel DC,Hong S,Ben-Zvi A,Xie T,Gu C

Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex.
The Journal of cell biology198(4)677-93(2012 Aug)
Elbediwy A,Zihni C,Terry SJ,Clark P,Matter K,Balda MS

SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility.
Molecular cell42(5)650-61(2011 Jun)
Parrini MC,Sadou-Dubourgnoux A,Aoki K,Kunida K,Biondini M,Hatzoglou A,Poullet P,Formstecher E,Yeaman C,Matsuda M,Ross? C,Camonis J

Identification of a ten-amino acid proline-rich SH3 binding site.
Science (New York, N.Y.)259(5098)1157-61(1993 Feb)
Ren R,Mayer BJ,Cicchetti P,Baltimore D

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Sh3bp1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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