Hsp90aa1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.
Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL, Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH, Bourboulia D, Bratslavsky G, Wong M, Mollapour M
The EMBO journal36(24)3650-3665(2017 12)

Antipsychotics promote GABAergic interneuron genesis in the adult rat brain: Role of heat-shock protein production.
Kaneta H, Ukai W, Tsujino H, Furuse K, Kigawa Y, Tayama M, Ishii T, Hashimoto E, Kawanishi C
Journal of psychiatric research92108-118(2017 Sep)

Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy.
Datta R, Bansal T, Rana S, Datta K, Datta Chaudhuri R, Chawla-Sarkar M, Sarkar S
Molecular and cellular biology37(6)(2017 Mar)

Calpain-1 resident in lipid raft/caveolin-1 membrane microdomains plays a protective role in endothelial cells.
Martines A, Stifanese R, Faelli EL, Perasso L, Melloni I, Ruggeri P, Averna M
Biochimie13320-27(2017 Feb)

Novel Functional Role of Heat Shock Protein 90 in Mitochondrial Connexin 43-Mediated Hypoxic Postconditioning.
Tu RH, Li QJ, Huang Z, He Y, Meng JJ, Zheng HL, Zeng ZY, Zhong GQ
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology44(3)982-997(2017)

myocyte-derived exosomes and myocyte-secreted IL-6 are responsible in unison for the biphasic activation of STAT-3 signaling in cardiac fibroblasts that culminates in excess collagen synthesis, leading to severely compromised cardiac function during cardiac hypertrophy.
Title: Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy.

hese results suggest that the protein adjustments observed in lipid raft/caveolin-1 microdomains could be visualized as a process required to protect the cells against NO overproduction and aberrant calpain activation. Alterations in eNOS, calpain-1 and HSP90 levels have been observed in aorta of Zucker Diabetic Rats (ZDR).
Title: Calpain-1 resident in lipid raft/caveolin-1 membrane microdomains plays a protective role in endothelial cells.

Blocking the function of HSP90 with the HSP90 inhibitor geldanamycin or siRNA targeting HSP90 prevented the protection of HPC and the HPC-induced association of Cx43, indicating that mitochondrial HSP90 was important for mitochondrial translocation of Cx43 during HPC.
Title: Novel Functional Role of Heat Shock Protein 90 in Mitochondrial Connexin 43-Mediated Hypoxic Postconditioning.

adenosine-induced translocation of PKCepsilon to mitochondria is mediated by a caveolin-3-dependent mechanism and this process is age-related, possibly in part, through regulation of HSP90 and TOM70 expression
Title: Regulation of protein kinase C-epsilon and its age-dependence.

These results reveal that Hsp90aa1 is a novel target of miR-1, and repression of miR-1 may contribute to the recovery of Hsp90aa1 during myocardial ischemia/reperfusion.
Title: Hsp90aa1: a novel target gene of miR-1 in cardiac ischemia/reperfusion injury.