Bag1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bag1
Entrez Gene ID	297994
Full Name	Bcl2 associated athanogene 1
Synonyms	Bag-1
General protein information	Preferred Names Bcl2 associated athanogene 1 Names BAG family molecular chaperone regulator 1 BCL2-associated athanogene bcl-2-associated athanogene 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q22
Summary	The oncogene Bcl2 encodes a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. Studies in human and mouse suggest that the protein encoded by this gene (referred to as Bcl2-associated athanogene) binds to Bcl2 protein. It enhances the anti-apoptotic effects of Bcl2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least two protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) start site and an alternative, downstream, AUG translation initiation site. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001256084.1	NP_001243013.1	BAG family molecular chaperone regulator 1 isoform 1S
NM_001106647.3	NP_001100117.2	BAG family molecular chaperone regulator 1 isoform 1L

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	BAG1	XP_520528.3
Canis lupus familiaris (dog)	BAG1	XP_005627044.1
Bos taurus (cattle)	BAG1	NP_001069759.1
Rattus norvegicus (Norway rat)	Bag1	NP_001100117.2
	BAG1	XP_002800106.1
Gallus gallus (chicken)	BAG1	NP_001103162.1
Danio rerio (zebrafish)	bag1	NP_001092206.1
Xenopus tropicalis (tropical clawed frog)	bag1	XP_002939543.2
Mus musculus (house mouse)	Bag1	NP_033866.4
Homo sapiens (human)	BAG1	NP_004314.5

Gene Ontology
Bibliography

Related articles in PubMed

Chaperone mediated autophagy to the rescue: A new-fangled target for the treatment of neurodegenerative diseases.
Xilouri M, Stefanis L
Molecular and cellular neurosciences66(Pt A)29-36(2015 May)

Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.
Rauch JN, Gestwicki JE
The Journal of biological chemistry289(3)1402-14(2014 Jan)

Changes in the BAG1 expression of Schwann cells after sciatic nerve crush.
Wu H, Liu Y, Zhou Y, Long L, Cheng X, Ji L, Weng H, Ding T, Yang J, Wei H, Li M, Huan W, Deng X, Wang Y
Journal of molecular neuroscience : MN49(3)512-22(2013 Mar)

Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner.
Bourke CH, Raees MQ, Malviya S, Bradburn CA, Binder EB, Neigh GN
Psychoneuroendocrinology38(1)84-93(2013 Jan)

A novel role for Bcl-2 associated-athanogene-1 (Bag-1) in regulation of the endoplasmic reticulum stress response in mammalian chondrocytes.
Yang L, McBurney D, Tang SC, Carlson SG, Horton WE Jr
Journal of cellular biochemistry102(3)786-800(2007 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

BAG1 expression increased progressively after sciatic nerve crush, reached a peak 2 weeks post-injury. It returned to the normal level 4 weeks post-injury. Spatially, BAG1 was mainly expressed in Schwann cells.
Title: Changes in the BAG1 expression of Schwann cells after sciatic nerve crush.

After chronic adolescent stress, females displayed elevated hippocampal expression of Bag1 genes that was not observed in males.
Title: Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner.

BAG-1 may play an important role in astrocytes proliferation after CNS injury.
Title: Increased expression of BAG-1 in rat brain cortex after traumatic brain injury.

These results clearly indicate that myocardial protection elicited by adaptation is mediated at least in part via up-regulation of autophagy in association with BAG-1 protein.
Title: Cardioprotection by adaptation to ischaemia augments autophagy in association with BAG-1 protein.

Forced BAG1 expression within the nucleus when compared to full-length BAG1 expression and to control cells completely abolishes the neuroprotective effects of BAG1.
Title: Subcellular distribution affects BAG1 function.

The following Bag1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bag1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09110	NM_001256084.1 Latest version!	Rattus norvegicus BAG cochaperone 1 (Bag1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa12171	NM_001106647.3 Latest version!	Rattus norvegicus BAG cochaperone 1 (Bag1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bag1 ( NM_001256084.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001243013.1 Rattus norvegicus BAG cochaperone 1 (Bag1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa09110
Clone ID Related Accession (Same CDS sequence)	NM_001256084.1
Accession Version	NM_001256084.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Rattus norvegicus(Norway rat)
Product	BAG family molecular chaperone regulator 1 isoform 1S
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC159418.1 and AC121205.5. Transcript Variant: This variant (1) encodes multiple isoforms due to the use of alternative translation initiation codons. The longer isoform (BAG-1L or p50) is derived from an upstream non-AUG (CUG) start codon, while the shorter isoform (BAG-1S or p32) is derived from a downstream AUG start codon. The shorter isoform (1S) is represented in this RefSeq. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC159418.1, FQ224976.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMN01906348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCAGA CCGAGGAGAT GGTCCAGACG GAGGAAATGG AACCACCCAC ACTCAGCGTG 
GTCGTCACCC ACAGCAATGA GAGGTATGAC CTTCTTGTTA CCCCACAGCA AGGTAACAGT 
GAGCCAATTG TCCAAGACCT GGCTCAGCTT GTTGAAGAGG CCACAGGAGT TCCACTACCT 
TTTCAGAAGC TCATATTTAA GGGCAAATCT CTGAAAGAAA TGGAAACACC CTTGTCAGCA 
CTTGGAATGC AAAATGGTTG CCGAGTCATG TTAATTGGTG AAAAGAGCAA TCCAGAAGAA 
GAGGCTGAGT TGAAAAAGCT GAAGGACTTG GAGGTATCTG TGGAGAAGAC AGCTAACCAC 
CTGGAAGAGT TGAATAAAGA GCTTTCTGAC ATCCAGCAGG GTTTTCTGGC TAAGGAATTA 
CAAGCGGAGG CTCTCTGCAG ACTTGATAGG AAAATAAAGG CCACAATTGA GCAATTCATG 
AAGATCTTGG AGGAGATTGA CACAATGGTC CTACCAGAAA ACTTTAAAGA CAGCAGGCTA 
AAAAGGAAGA ATTTGGTGAA AAAGGTTCAG GTGTTCCTAG CAGAGTGTGA TACAGTGGAG 
CAGTACATCT GCCAAGAGAC AGAGCGGCTG CAGTCTACAA ACTTGGCCCT GCCTGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243013.1
CDS	469..1128
Translation	MAQTEEMVQTEEMEPPTLSVVVTHSNERYDLLVTPQQGNSEPIVQDLAQLVEEATGVPLPFQKLIFKGKSLKEMETPLSALGMQNGCRVMLIGEKSNPEEEAELKKLKDLEVSVEKTANHLEELNKELSDIQQGFLAKELQAEALCRLDRKIKATIEQFMKILEEIDTMVLPENFKDSRLKRKNLVKKVQVFLAECDTVEQYICQETERLQSTNLALPE

Target ORF information:

RefSeq Version	NM_001256084.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus BAG cochaperone 1 (Bag1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256084.1

ORF Insert Sequence:

ATGGCCCAGA CCGAGGAGAT GGTCCAGACG GAGGAAATGG AACCACCCAC ACTCAGCGTG 
GTCGTCACCC ACAGCAATGA GAGGTATGAC CTTCTTGTTA CCCCACAGCA AGGTAACAGT 
GAGCCAATTG TCCAAGACCT GGCTCAGCTT GTTGAAGAGG CCACAGGAGT TCCACTACCT 
TTTCAGAAGC TCATATTTAA GGGCAAATCT CTGAAAGAAA TGGAAACACC CTTGTCAGCA 
CTTGGAATGC AAAATGGTTG CCGAGTCATG TTAATTGGTG AAAAGAGCAA TCCAGAAGAA 
GAGGCTGAGT TGAAAAAGCT GAAGGACTTG GAGGTATCTG TGGAGAAGAC AGCTAACCAC 
CTGGAAGAGT TGAATAAAGA GCTTTCTGAC ATCCAGCAGG GTTTTCTGGC TAAGGAATTA 
CAAGCGGAGG CTCTCTGCAG ACTTGATAGG AAAATAAAGG CCACAATTGA GCAATTCATG 
AAGATCTTGG AGGAGATTGA CACAATGGTC CTACCAGAAA ACTTTAAAGA CAGCAGGCTA 
AAAAGGAAGA ATTTGGTGAA AAAGGTTCAG GTGTTCCTAG CAGAGTGTGA TACAGTGGAG 
CAGTACATCT GCCAAGAGAC AGAGCGGCTG CAGTCTACAA ACTTGGCCCT GCCTGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Bag1 ( NM_001106647.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001100117.2 Rattus norvegicus BAG cochaperone 1 (Bag1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa12171
Clone ID Related Accession (Same CDS sequence)	NM_001106647.3
Accession Version	NM_001106647.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1077bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	BAG family molecular chaperone regulator 1 isoform 1L
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC159418.1 and AC121205.5. On Jan 4, 2012 this sequence version replaced NM_001106647.2. Transcript Variant: This variant (1) encodes multiple isoforms due to the use of alternative translation initiation codons. The longer isoform (BAG-1L or p50) is derived from an upstream non-AUG (CUG) start codon, while the shorter isoform (BAG-1S or p32) is derived from a downstream AUG start codon. The longer isoform (1L) is represented in this RefSeq. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC159418.1, FQ224976.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMN01906348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

CTGGCGGATC GCGGCGGCGC GCGGCGACCG CGAGGCGACC AGGAGCCGCT GGGACCCCGG 
CTGCGCGCCC CTCGGTCGGC CCGGGAGACG CGCCAGTCGG AGTCCCGGGC CGAGCGTGGC 
TTGCCTCCCT CTCAGCGTTC ATCTGTCCGC AGTGCAGCCA GCGGGCATGA CCGATCCACC 
AGGGGCGCCG CCTCCGGCGC TTGCAAGCCG CGGGTGAAGA AGAAAGTCCG GCCCCGCTCT 
TCTCAGAGCG AGAAGGTAGC TCACAGCAAG GAGTTGACTA GAAGTAAGAA GTTGACCCGC 
AGCAAGAAAG TGACCGGGAC CCAGGAGGCG ACCCAAGTAG AGGAGGTGAC CACGATCGAG 
GAGGCGACCC AGACCGAGGA GATTACGGTA GCGGAAGAGG TGACCCAGAC CGAGAACATG 
GCCCAGACCG AGGAGATGGT CCAGACGGAG GAAATGGAAC CACCCACACT CAGCGTGGTC 
GTCACCCACA GCAATGAGAG GTATGACCTT CTTGTTACCC CACAGCAAGG TAACAGTGAG 
CCAATTGTCC AAGACCTGGC TCAGCTTGTT GAAGAGGCCA CAGGAGTTCC ACTACCTTTT 
CAGAAGCTCA TATTTAAGGG CAAATCTCTG AAAGAAATGG AAACACCCTT GTCAGCACTT 
GGAATGCAAA ATGGTTGCCG AGTCATGTTA ATTGGTGAAA AGAGCAATCC AGAAGAAGAG 
GCTGAGTTGA AAAAGCTGAA GGACTTGGAG GTATCTGTGG AGAAGACAGC TAACCACCTG 
GAAGAGTTGA ATAAAGAGCT TTCTGACATC CAGCAGGGTT TTCTGGCTAA GGAATTACAA 
GCGGAGGCTC TCTGCAGACT TGATAGGAAA ATAAAGGCCA CAATTGAGCA ATTCATGAAG 
ATCTTGGAGG AGATTGACAC AATGGTCCTA CCAGAAAACT TTAAAGACAG CAGGCTAAAA 
AGGAAGAATT TGGTGAAAAA GGTTCAGGTG TTCCTAGCAG AGTGTGATAC AGTGGAGCAG 
TACATCTGCC AAGAGACAGA GCGGCTGCAG TCTACAAACT TGGCCCTGCC TGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001100117.2
CDS	52..1128
Translation	LADRGGARRPRGDQEPLGPRLRAPRSARETRQSESRAERGLPPSQRSSVRSAASGHDRSTRGAASGACKPRVKKKVRPRSSQSEKVAHSKELTRSKKLTRSKKVTGTQEATQVEEVTTIEEATQTEEITVAEEVTQTENMAQTEEMVQTEEMEPPTLSVVVTHSNERYDLLVTPQQGNSEPIVQDLAQLVEEATGVPLPFQKLIFKGKSLKEMETPLSALGMQNGCRVMLIGEKSNPEEEAELKKLKDLEVSVEKTANHLEELNKELSDIQQGFLAKELQAEALCRLDRKIKATIEQFMKILEEIDTMVLPENFKDSRLKRKNLVKKVQVFLAECDTVEQYICQETERLQSTNLALPE

Target ORF information:

RefSeq Version	NM_001106647.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus BAG cochaperone 1 (Bag1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106647.3

ORF Insert Sequence:

CTGGCGGATC GCGGCGGCGC GCGGCGACCG CGAGGCGACC AGGAGCCGCT GGGACCCCGG 
CTGCGCGCCC CTCGGTCGGC CCGGGAGACG CGCCAGTCGG AGTCCCGGGC CGAGCGTGGC 
TTGCCTCCCT CTCAGCGTTC ATCTGTCCGC AGTGCAGCCA GCGGGCATGA CCGATCCACC 
AGGGGCGCCG CCTCCGGCGC TTGCAAGCCG CGGGTGAAGA AGAAAGTCCG GCCCCGCTCT 
TCTCAGAGCG AGAAGGTAGC TCACAGCAAG GAGTTGACTA GAAGTAAGAA GTTGACCCGC 
AGCAAGAAAG TGACCGGGAC CCAGGAGGCG ACCCAAGTAG AGGAGGTGAC CACGATCGAG 
GAGGCGACCC AGACCGAGGA GATTACGGTA GCGGAAGAGG TGACCCAGAC CGAGAACATG 
GCCCAGACCG AGGAGATGGT CCAGACGGAG GAAATGGAAC CACCCACACT CAGCGTGGTC 
GTCACCCACA GCAATGAGAG GTATGACCTT CTTGTTACCC CACAGCAAGG TAACAGTGAG 
CCAATTGTCC AAGACCTGGC TCAGCTTGTT GAAGAGGCCA CAGGAGTTCC ACTACCTTTT 
CAGAAGCTCA TATTTAAGGG CAAATCTCTG AAAGAAATGG AAACACCCTT GTCAGCACTT 
GGAATGCAAA ATGGTTGCCG AGTCATGTTA ATTGGTGAAA AGAGCAATCC AGAAGAAGAG 
GCTGAGTTGA AAAAGCTGAA GGACTTGGAG GTATCTGTGG AGAAGACAGC TAACCACCTG 
GAAGAGTTGA ATAAAGAGCT TTCTGACATC CAGCAGGGTT TTCTGGCTAA GGAATTACAA 
GCGGAGGCTC TCTGCAGACT TGATAGGAAA ATAAAGGCCA CAATTGAGCA ATTCATGAAG 
ATCTTGGAGG AGATTGACAC AATGGTCCTA CCAGAAAACT TTAAAGACAG CAGGCTAAAA 
AGGAAGAATT TGGTGAAAAA GGTTCAGGTG TTCCTAGCAG AGTGTGATAC AGTGGAGCAG 
TACATCTGCC AAGAGACAGA GCGGCTGCAG TCTACAAACT TGGCCCTGCC TGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chaperone mediated autophagy to the rescue: A new-fangled target for the treatment of neurodegenerative diseases.
Molecular and cellular neurosciences66(Pt A)29-36(2015 May)
Xilouri M,Stefanis L

Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro.
The Journal of biological chemistry289(3)1402-14(2014 Jan)
Rauch JN,Gestwicki JE

Changes in the BAG1 expression of Schwann cells after sciatic nerve crush.
Journal of molecular neuroscience : MN49(3)512-22(2013 Mar)
Wu H,Liu Y,Zhou Y,Long L,Cheng X,Ji L,Weng H,Ding T,Yang J,Wei H,Li M,Huan W,Deng X,Wang Y

Glucocorticoid sensitizers Bag1 and Ppid are regulated by adolescent stress in a sex-dependent manner.
Psychoneuroendocrinology38(1)84-93(2013 Jan)
Bourke CH,Raees MQ,Malviya S,Bradburn CA,Binder EB,Neigh GN

A novel role for Bcl-2 associated-athanogene-1 (Bag-1) in regulation of the endoplasmic reticulum stress response in mammalian chondrocytes.
Journal of cellular biochemistry102(3)786-800(2007 Oct)
Yang L,McBurney D,Tang SC,Carlson SG,Horton WE Jr

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Bag1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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