Nampt cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nampt
Entrez Gene ID	297508
Full Name	nicotinamide phosphoribosyltransferase
Synonyms	Pbef,Pbef1
General protein information	Preferred Names nicotinamide phosphoribosyltransferase Names nicotinamide phosphoribosyltransferase NAmPRTase pre-B-cell colony enhancing factor 1 pre-B-cell colony-enhancing factor 1 homolog visfatin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 6 Map Location: 6q16
Summary	has similarity to cytokines but is not secreted; localized to the nucleus and cytoplasm, changes in subcellular localization may be associated with the cell cycle [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_177928.3	NP_808789.1	nicotinamide phosphoribosyltransferase

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	LOC557816	XP_686052.3
	NAMPT	XP_001090562.2
Bos taurus (cattle)	NAMPT	NP_001231070.1
Mus musculus (house mouse)	Nampt	NP_067499.2
Gallus gallus (chicken)	NAMPT	NP_001025899.1
Danio rerio (zebrafish)	LOC100150117	XP_001920626.3
Homo sapiens (human)	NAMPT	NP_005737.1
Rattus norvegicus (Norway rat)	Nampt	NP_808789.1
Danio rerio (zebrafish)	LOC557751	XP_001920646.3
Xenopus tropicalis (tropical clawed frog)	nampt	NP_001011388.1
Pan troglodytes (chimpanzee)	NAMPT	XP_519302.2
Canis lupus familiaris (dog)	NAMPT	XP_005631071.1
Danio rerio (zebrafish)	si:dkey-145c18.2	XP_001919206.2
Danio rerio (zebrafish)	si:dkey-145c18.3	XP_001919220.2
Danio rerio (zebrafish)	LOC100330160	XP_002661386.1

Gene Ontology
Bibliography

Related articles in PubMed

Sleep restriction induced energy, methylation and lipogenesis metabolic switches in rat liver.
Sengupta A, Rhoades SD, Kim EJ, Nayak S, Grant GR, Meerlo P, Weljie AM
The international journal of biochemistry & cell biology93129-135(2017 Dec)

Salidroside protects PC12 cells from A?1?40?induced cytotoxicity by regulating the nicotinamide phosphoribosyltransferase signaling pathway.
Huang X, Xing S, Chen C, Yu Z, Chen J
Molecular medicine reports16(3)2700-2706(2017 Sep)

NAMPT inhibitor protects ischemic neuronal injury in rat brain via anti-neuroinflammation.
Chen CX, Huang J, Tu GQ, Lu JT, Xie X, Zhao B, Wu M, Shi QJ, Fang SH, Wei EQ, Zhang WP, Lu YB
Neuroscience356193-206(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Thus, it can be suggested that visfatin may play an important role in testicular aging by regulating testicular steroidogenesis and spermatogenesis.
Title: Localization pattern of visfatin (NAMPT) in d-galactose induced aged rat testis.

visfatin plays a dual role in the apoptosis in rat Mesenteric lymph nodes, which is mediated by both the mitochondrial apoptotic pathway and the death-receptor apoptotic pathway.
Title: The regulation mechanism of apoptosis by visfatin in the mesenteric lymph nodes of LPS-treated rats.

this study shows that serum visfatin levels, and white adipose tissue and hepatic visfatin mRNA levels of both male and female rats were increased by LPS injection
Title: The sensitivity of adipose tissue visfatin mRNA expression to lipopolysaccharide-induced endotoxemia is increased by ovariectomy in female rats.

Visfatin was expressed in the rats' retinas, mainly in the retinal nerve fibre layer, inner plexiform layer and outer plexiform layer. As the development of diabetes mellitus course, its expression was gradually increased.
Title: Expression of visfatin in the diabetic rat retina.

NAMPT protects against 6-hydroxydopamine-induced neurotoxicity in PC12 cells through modulating SIRT1 activity
Title: NAMPT protects against 6-hydroxydopamine-induced neurotoxicity in PC12 cells through modulating SIRT1 activity.

The following Nampt gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nampt cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13154	NM_177928.3 Latest version!	Rattus norvegicus nicotinamide phosphoribosyltransferase (Nampt), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$286.30 $409.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nampt ( NM_177928.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_808789.1 Rattus norvegicus nicotinamide phosphoribosyltransferase (Nampt), mRNA.

Price & Availability↑

CloneID	ORa13154
Clone ID Related Accession (Same CDS sequence)	NM_177928.3
Accession Version	NM_177928.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1476bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	nicotinamide phosphoribosyltransferase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085681.1. On Nov 15, 2004 this sequence version replaced NM_177928.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC085681.1, AB081730.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGAATGCTG CGGCAGAAGC CGAGTTCAAC ATCCTGCTGG CCACCGACTC GTACAAGGTT 
ACTCACTATA AACAATACCC ACCCAACACA AGCAAAGTTT ATTCCTACTT TGAATGCCGT 
GAAAAGAAGA CAGAAAACTC CAAAGTAAGG AAGGTGAAAT ACGAGGAAAC AGTATTTTAT 
GGGTTGCAGT ACATTCTTAA TAAGTACTTA AAAGGTAAAG TAGTGACCAA AGAGAAAATC 
CAGGAGGCCA AAGAAGTGTA CAGAGAACAT TTCCAAGATG ATGTCTTCAA TGAAAGGGGA 
TGGAACTACA TCCTTGAGAA ATATGACGGT CATCTCCCAA TTGAAGTAAA GGCTGTTCCT 
GAGGGCTCTG TCATCCCCAG AGGGAACGTG CTGTTCACAG TGGAAAACAC AGACCCAGAG 
TGCTACTGGC TCACCAACTG GATTGAGACT ATTCTTGTCC AGTCCTGGTA TCCAATTACA 
GTGGCCACAA ATTCAAGAGA GCAGAAGAAA ATCCTGGCCA AATATTTGTT AGAAACTTCT 
GGTAACTTAG ACGGTCTGGA ATATAAGTTA CATGACTTCG GCTACAGAGG AGTCTCTTCA 
CAAGAGACTG CCGGCATAGG GGCATCTGCT CATTTGGTTA ACTTCAAAGG AACAGATACT 
GTGGCGGGAA TTGCTCTAAT TAAAAAATAC TATGGGACAA AAGATCCTGT TCCAGGCTAT 
TCTGTTCCAG CGGCAGAGCA CAGTACCATA ACAGCGTGGG GGAAAGACCA TGAAAAAGAT 
GCTTTTGAAC ACATAGTAAC ACAGTTCTCA TCAGTGCCTG TGTCTGTGGT CAGCGATAGC 
TATGACATCT ATAACGCGTG TGAGAAAATA TGGGGTGAAG ACCTGAGACA CCTGATAGTG 
TCGAGAAGTA CAGAGGCACC ACTGATCATC AGACCTGATT CTGGAAATCC GCTCGACACT 
GTCCTGAAGG TCTTAGATAT ATTAGGCAAG AAGTTCCCTG TCTCTGAGAA CTCCAAAGGC 
TACAAGTTGC TGCCACCTTA CCTTAGAGTC ATTCAAGGGG ACGGAGTGGA TATCAATACT 
CTACAGGAGA TTGTCGAGGG AATGAAACAG AAAAAGTGGA GTATTGAGAA TGTCTCCTTT 
GGTTCTGGTG GCGCTTTGCT ACAGAAGTTA ACCAGAGACC TCTTGAATTG CTCCTTCAAG 
TGCAGCTATG TTGTAACCAA TGGCCTTGGG GTTAATGTCT TTAAGGACCC AGTTGCTGAT 
CCCAACAAAA GGTCGAAAAA GGGCCGGCTG TCTTTACATA GGACACCAGC AGGGACCTTT 
GTCACCCTTG AAGAAGGAAA AGGAGACCTT GAAGAATATG GCCATGATCT TCTCCATACG 
GTTTTCAAGA ATGGGAAGGT GACAAAAAGC TACTCGTTTG ACGAAGTCAG AAAAAATGCA 
CAGCTGAACA TGGAGCAGGA TGTGGCGCCT CACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808789.1
CDS	28..1503
Translation	MNAAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKVRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKEVYREHFQDDVFNERGWNYILEKYDGHLPIEVKAVPEGSVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGIALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTEAPLIIRPDSGNPLDTVLKVLDILGKKFPVSENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKKWSIENVSFGSGGALLQKLTRDLLNCSFKCSYVVTNGLGVNVFKDPVADPNKRSKKGRLSLHRTPAGTFVTLEEGKGDLEEYGHDLLHTVFKNGKVTKSYSFDEVRKNAQLNMEQDVAPH

Target ORF information:

RefSeq Version	NM_177928.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus nicotinamide phosphoribosyltransferase (Nampt), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177928.3

ORF Insert Sequence:

ATGAATGCTG CGGCAGAAGC CGAGTTCAAC ATCCTGCTGG CCACCGACTC GTACAAGGTT 
ACTCACTATA AACAATACCC ACCCAACACA AGCAAAGTTT ATTCCTACTT TGAATGCCGT 
GAAAAGAAGA CAGAAAACTC CAAAGTAAGG AAGGTGAAAT ACGAGGAAAC AGTATTTTAT 
GGGTTGCAGT ACATTCTTAA TAAGTACTTA AAAGGTAAAG TAGTGACCAA AGAGAAAATC 
CAGGAGGCCA AAGAAGTGTA CAGAGAACAT TTCCAAGATG ATGTCTTCAA TGAAAGGGGA 
TGGAACTACA TCCTTGAGAA ATATGACGGT CATCTCCCAA TTGAAGTAAA GGCTGTTCCT 
GAGGGCTCTG TCATCCCCAG AGGGAACGTG CTGTTCACAG TGGAAAACAC AGACCCAGAG 
TGCTACTGGC TCACCAACTG GATTGAGACT ATTCTTGTCC AGTCCTGGTA TCCAATTACA 
GTGGCCACAA ATTCAAGAGA GCAGAAGAAA ATCCTGGCCA AATATTTGTT AGAAACTTCT 
GGTAACTTAG ACGGTCTGGA ATATAAGTTA CATGACTTCG GCTACAGAGG AGTCTCTTCA 
CAAGAGACTG CCGGCATAGG GGCATCTGCT CATTTGGTTA ACTTCAAAGG AACAGATACT 
GTGGCGGGAA TTGCTCTAAT TAAAAAATAC TATGGGACAA AAGATCCTGT TCCAGGCTAT 
TCTGTTCCAG CGGCAGAGCA CAGTACCATA ACAGCGTGGG GGAAAGACCA TGAAAAAGAT 
GCTTTTGAAC ACATAGTAAC ACAGTTCTCA TCAGTGCCTG TGTCTGTGGT CAGCGATAGC 
TATGACATCT ATAACGCGTG TGAGAAAATA TGGGGTGAAG ACCTGAGACA CCTGATAGTG 
TCGAGAAGTA CAGAGGCACC ACTGATCATC AGACCTGATT CTGGAAATCC GCTCGACACT 
GTCCTGAAGG TCTTAGATAT ATTAGGCAAG AAGTTCCCTG TCTCTGAGAA CTCCAAAGGC 
TACAAGTTGC TGCCACCTTA CCTTAGAGTC ATTCAAGGGG ACGGAGTGGA TATCAATACT 
CTACAGGAGA TTGTCGAGGG AATGAAACAG AAAAAGTGGA GTATTGAGAA TGTCTCCTTT 
GGTTCTGGTG GCGCTTTGCT ACAGAAGTTA ACCAGAGACC TCTTGAATTG CTCCTTCAAG 
TGCAGCTATG TTGTAACCAA TGGCCTTGGG GTTAATGTCT TTAAGGACCC AGTTGCTGAT 
CCCAACAAAA GGTCGAAAAA GGGCCGGCTG TCTTTACATA GGACACCAGC AGGGACCTTT 
GTCACCCTTG AAGAAGGAAA AGGAGACCTT GAAGAATATG GCCATGATCT TCTCCATACG 
GTTTTCAAGA ATGGGAAGGT GACAAAAAGC TACTCGTTTG ACGAAGTCAG AAAAAATGCA 
CAGCTGAACA TGGAGCAGGA TGTGGCGCCT CACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sleep restriction induced energy, methylation and lipogenesis metabolic switches in rat liver.
The international journal of biochemistry & cell biology93129-135(2017 Dec)
Sengupta A,Rhoades SD,Kim EJ,Nayak S,Grant GR,Meerlo P,Weljie AM

Salidroside protects PC12 cells from A?1?40?induced cytotoxicity by regulating the nicotinamide phosphoribosyltransferase signaling pathway.
Molecular medicine reports16(3)2700-2706(2017 Sep)
Huang X,Xing S,Chen C,Yu Z,Chen J

NAMPT inhibitor protects ischemic neuronal injury in rat brain via anti-neuroinflammation.
Neuroscience356193-206(2017 Jul)
Chen CX,Huang J,Tu GQ,Lu JT,Xie X,Zhao B,Wu M,Shi QJ,Fang SH,Wei EQ,Zhang WP,Lu YB

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Nampt cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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