Kcna3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcna3
Entrez Gene ID	29731
Full Name	potassium voltage-gated channel subfamily A member 3
General protein information	Preferred Names potassium voltage-gated channel subfamily A member 3 Names potassium voltage-gated channel subfamily A member 3 KV3 RCK3 RGK5 potassium channel, voltage gated shaker related subfamily A, member 3 potassium voltage-gated channel, shaker-related subfamily, member 3 voltage-gated potassium channel subunit Kv1.3 voltage-gated potassium channel subunit Kv3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34
Summary	encodes a lymphocyte potassium channel [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019270.3	NP_062143.3	potassium voltage-gated channel subfamily A member 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	KCNA3	XP_524797.1
Gallus gallus (chicken)	KCNA3	NP_001025549.1
Danio rerio (zebrafish)	LOC100150068	XP_005172172.1
Danio rerio (zebrafish)	LOC100330283	XP_005174156.1
Bos taurus (cattle)	KCNA3	XP_005204275.1
Drosophila melanogaster (fruit fly)	Sh	NP_523393.3
Xenopus tropicalis (tropical clawed frog)	kcna1	XP_004910792.1
Homo sapiens (human)	KCNA3	NP_002223.3
	KCNA3	XP_001101652.1
Rattus norvegicus (Norway rat)	Kcna3	NP_062143.3
Canis lupus familiaris (dog)	KCNA3	XP_003434878.2
Mus musculus (house mouse)	Kcna3	NP_032444.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000254	XP_310869.5
Caenorhabditis elegans (roundworm)	shk-1	NP_496104.2

Gene Ontology
Bibliography

Related articles in PubMed

Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats.
Bergmann R, Kubeil M, Zarschler K, Chhabra S, Tajhya RB, Beeton C, Pennington MW, Bachmann M, Norton RS, Stephan H
Scientific reports7(1)3756(2017 Jun)

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions.
Chiang EY, Li T, Jeet S, Peng I, Zhang J, Lee WP, DeVoss J, Caplazi P, Chen J, Warming S, Hackos DH, Mukund S, Koth CM, Grogan JL
Nature communications814644(2017 Mar)

Ubiquitination mediates Kv1.3 endocytosis as a mechanism for protein kinase C-dependent modulation.
Mart?nez-M?rmol R, Styrczewska K, P?rez-Verdaguer M, Vallejo-Gracia A, Comes N, Sorkin A, Felipe A
Scientific reports742395(2017 Feb)

Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life.
Edwards W, Fung-Leung WP, Huang C, Chi E, Wu N, Liu Y, Maher MP, Bonesteel R, Connor J, Fellows R, Garcia E, Lee J, Lu L, Ngo K, Scott B, Zhou H, Swanson RV, Wickenden AD
The Journal of biological chemistry289(33)22704-14(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life
Title: Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life.

Kv1.3 appears to be distributed to the cis-Golgi membrane of rat astrocytes in a similar way as a Golgi resident protein.
Title: The Kv1.3 potassium channel is localized to the cis-Golgi and Kv1.6 is localized to the endoplasmic reticulum in rat astrocytes.

Results suggest that voltage-gated KV1.3 potassium channe represent effective targets for the treatment of allergic asthma.
Title: Blocking KV1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma.

Kv1.3 is involved in methamphetamine-mediated microglial damage
Title: Effect of methamphetamine on the microglial damage: role of potassium channel Kv1.3.

A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation
Title: A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation.

The following Kcna3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcna3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42753	NM_019270.3 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily A member 3 (Kcna3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcna3 ( NM_019270.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062143.3 Rattus norvegicus potassium voltage-gated channel subfamily A member 3 (Kcna3), mRNA.

Price & Availability↑

CloneID	ORa42753
Clone ID Related Accession (Same CDS sequence)	NM_019270.3
Accession Version	NM_019270.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1578bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily A member 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M31744.1. On May 25, 2007 this sequence version replaced NM_019270.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

ATGACCGTGG TGCCCGGGGA CCACCTGCTG GAGCCAGAAG CGGCGGGAGG CGGCGGCGGG 
GACCCGCCTC AGGGAGGCTG TGTCAGTGGC GGCGGCTGCG ACCGCTACGA ACCGCTGCCG 
CCCGCGCTGC CCGCCGCGGG CGAGCAGGAT TGCTGCGGGG AGCGCGTGGT CATCAACATC 
TCCGGGCTGC GCTTCGAGAC ACAGCTCAAG ACCCTCTGCC AGTTCCCTGA GACGCTGCTA 
GGCGACCCCA AGCGGCGCAT GCGGTACTTC GACCCGCTCC GCAATGAGTA CTTCTTTGAC 
CGCAACAGAC CCAGCTTCGA CGCCATCCTC TACTACTACC AGTCCGGGGG CCGCATCCGC 
CGGCCGGTCA ACGTGCCCAT CGACATCTTC TCCGAGGAGA TCCGCTTCTA CCAACTGGGT 
GAGGAGGCTA TGGAGAAGTT CCGTGAGGAC GAGGGCTTCC TGCGGGAGGA GGAGCGACCC 
CTGCCCCGCC GTGACTTCCA GCGCCAGGTG TGGCTGCTCT TCGAATACCC CGAGAGCTCC 
GGGCCGGCCC GGGGCATTGC CATCGTGTCA GTGCTGGTCA TTCTCATCTC CATTGTCATC 
TTCTGCTTGG AGACACTACC CGAGTTTCGC GACGAGAAGG ACTATCCCGC CTCTCCGTCG 
CAGGACGTGT TTGAGGCTGC CAACAACAGC ACGTCGGGGG CCTCCTCTGG AGCCTCCAGC 
TTCTCGGACC CCTTCTTCGT AGTGGAGACC CTGTGCATCA TCTGGTTCTC CTTTGAGCTG 
CTGGTGCGAT TCTTTGCTTG CCCCAGTAAA GCCACCTTCT CCAGAAATAT CATGAACCTG 
ATAGACATTG TAGCCATCAT CCCTTATTTT ATTACTCTGG GCACTGAGCT GGCTGAGCGA 
CAGGGTAATG GGCAGCAGGC TATGTCACTG GCCATCCTGA GGGTCATCCG CCTAGTAAGG 
GTCTTCCGCA TCTTCAAGCT CTCCCGCCAT TCTAAGGGGC TGCAGATCCT GGGACAGACA 
CTGAAGGCTT CCATGCGAGA GCTGGGGCTG CTCATTTTCT TCCTTTTCAT TGGGGTCATC 
CTTTTCTCCA GTGCAGTCTA CTTTGCTGAG GCAGACGACC CTTCTTCGGG TTTTAACAGT 
ATCCCGGATG CCTTCTGGTG GGCCGTGGTA ACCATGACAA CTGTCGGTTA TGGTGATATG 
CACCCAGTGA CCATAGGAGG CAAGATTGTG GGCTCTCTTT GTGCCATCGC AGGTGTCTTG 
ACCATTGCAT TGCCGGTTCC TGTGATTGTT TCCAACTTCA ATTACTTCTA CCACCGGGAG 
ACAGAAGGGG AAGAGCAAGC CCAGTACATG CACGTGGGAA GCTGCCAGCA CCTCTCCTCT 
TCAGCAGAGG AGCTCCGAAA AGCCCGGAGT AACTCCACTC TGAGTAAGTC GGAGTATATG 
GTGATCGAAG AGGGGGGTAT GAACCACAGC GCCTTCCCCC AGACCCCCTT CAAAACGGGC 
AACTCCACTG CCACTTGCAC CACCAACAAT AATCCCAACT CCTGTGTCAA CATCAAAAAG 
ATATTCACTG ATGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062143.3
CDS	1..1578
Translation	MTVVPGDHLLEPEAAGGGGGDPPQGGCVSGGGCDRYEPLPPALPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASPSQDVFEAANNSTSGASSGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV

Target ORF information:

RefSeq Version	NM_019270.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily A member 3 (Kcna3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019270.3

ORF Insert Sequence:

ATGACCGTGG TGCCCGGGGA CCACCTGCTG GAGCCAGAAG CGGCGGGAGG CGGCGGCGGG 
GACCCGCCTC AGGGAGGCTG TGTCAGTGGC GGCGGCTGCG ACCGCTACGA ACCGCTGCCG 
CCCGCGCTGC CCGCCGCGGG CGAGCAGGAT TGCTGCGGGG AGCGCGTGGT CATCAACATC 
TCCGGGCTGC GCTTCGAGAC ACAGCTCAAG ACCCTCTGCC AGTTCCCTGA GACGCTGCTA 
GGCGACCCCA AGCGGCGCAT GCGGTACTTC GACCCGCTCC GCAATGAGTA CTTCTTTGAC 
CGCAACAGAC CCAGCTTCGA CGCCATCCTC TACTACTACC AGTCCGGGGG CCGCATCCGC 
CGGCCGGTCA ACGTGCCCAT CGACATCTTC TCCGAGGAGA TCCGCTTCTA CCAACTGGGT 
GAGGAGGCTA TGGAGAAGTT CCGTGAGGAC GAGGGCTTCC TGCGGGAGGA GGAGCGACCC 
CTGCCCCGCC GTGACTTCCA GCGCCAGGTG TGGCTGCTCT TCGAATACCC CGAGAGCTCC 
GGGCCGGCCC GGGGCATTGC CATCGTGTCA GTGCTGGTCA TTCTCATCTC CATTGTCATC 
TTCTGCTTGG AGACACTACC CGAGTTTCGC GACGAGAAGG ACTATCCCGC CTCTCCGTCG 
CAGGACGTGT TTGAGGCTGC CAACAACAGC ACGTCGGGGG CCTCCTCTGG AGCCTCCAGC 
TTCTCGGACC CCTTCTTCGT AGTGGAGACC CTGTGCATCA TCTGGTTCTC CTTTGAGCTG 
CTGGTGCGAT TCTTTGCTTG CCCCAGTAAA GCCACCTTCT CCAGAAATAT CATGAACCTG 
ATAGACATTG TAGCCATCAT CCCTTATTTT ATTACTCTGG GCACTGAGCT GGCTGAGCGA 
CAGGGTAATG GGCAGCAGGC TATGTCACTG GCCATCCTGA GGGTCATCCG CCTAGTAAGG 
GTCTTCCGCA TCTTCAAGCT CTCCCGCCAT TCTAAGGGGC TGCAGATCCT GGGACAGACA 
CTGAAGGCTT CCATGCGAGA GCTGGGGCTG CTCATTTTCT TCCTTTTCAT TGGGGTCATC 
CTTTTCTCCA GTGCAGTCTA CTTTGCTGAG GCAGACGACC CTTCTTCGGG TTTTAACAGT 
ATCCCGGATG CCTTCTGGTG GGCCGTGGTA ACCATGACAA CTGTCGGTTA TGGTGATATG 
CACCCAGTGA CCATAGGAGG CAAGATTGTG GGCTCTCTTT GTGCCATCGC AGGTGTCTTG 
ACCATTGCAT TGCCGGTTCC TGTGATTGTT TCCAACTTCA ATTACTTCTA CCACCGGGAG 
ACAGAAGGGG AAGAGCAAGC CCAGTACATG CACGTGGGAA GCTGCCAGCA CCTCTCCTCT 
TCAGCAGAGG AGCTCCGAAA AGCCCGGAGT AACTCCACTC TGAGTAAGTC GGAGTATATG 
GTGATCGAAG AGGGGGGTAT GAACCACAGC GCCTTCCCCC AGACCCCCTT CAAAACGGGC 
AACTCCACTG CCACTTGCAC CACCAACAAT AATCCCAACT CCTGTGTCAA CATCAAAAAG 
ATATTCACTG ATGTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats.
Scientific reports7(1)3756(2017 Jun)
Bergmann R,Kubeil M,Zarschler K,Chhabra S,Tajhya RB,Beeton C,Pennington MW,Bachmann M,Norton RS,Stephan H

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions.
Nature communications814644(2017 Mar)
Chiang EY,Li T,Jeet S,Peng I,Zhang J,Lee WP,DeVoss J,Caplazi P,Chen J,Warming S,Hackos DH,Mukund S,Koth CM,Grogan JL

Ubiquitination mediates Kv1.3 endocytosis as a mechanism for protein kinase C-dependent modulation.
Scientific reports742395(2017 Feb)
Mart?nez-M?rmol R,Styrczewska K,P?rez-Verdaguer M,Vallejo-Gracia A,Comes N,Sorkin A,Felipe A

Targeting the ion channel Kv1.3 with scorpion venom peptides engineered for potency, selectivity, and half-life.
The Journal of biological chemistry289(33)22704-14(2014 Aug)
Edwards W,Fung-Leung WP,Huang C,Chi E,Wu N,Liu Y,Maher MP,Bonesteel R,Connor J,Fellows R,Garcia E,Lee J,Lu L,Ngo K,Scott B,Zhou H,Swanson RV,Wickenden AD

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Kcna3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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