Scn8a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Scn8a
Entrez Gene ID	29710
Full Name	sodium voltage-gated channel alpha subunit 8
General protein information	Preferred Names sodium voltage-gated channel alpha subunit 8 Names sodium channel protein type 8 subunit alpha Na+ channel PN4 naCh6 peripheral nerve protein type 4 sodium channel 6 sodium channel protein type VIII subunit alpha sodium channel, voltage gated, type VIII, alpha subunit sodium channel, voltage-gated, type 8, alpha polypeptide sodium channel, voltage-gated, type 8, alpha subunit sodium channel, voltage-gated, type VIII, alpha polypeptide voltage-gated sodium channel subunit alpha Nav1.6
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q36
Summary	tetrodotoxin-sensitive sodium channel alpha subunit [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019266.2	NP_062139.2	sodium channel protein type 8 subunit alpha

Pathways from BioSystems

Homologies

Homo sapiens (human)	SCN8A	NP_055006.1
Pan troglodytes (chimpanzee)	SCN8A	XP_001141985.3
Canis lupus familiaris (dog)	SCN8A	XP_850134.1
Bos taurus (cattle)	SCN8A	NP_001180031.1
Mus musculus (house mouse)	Scn8a	NP_001070967.1
Rattus norvegicus (Norway rat)	Scn8a	NP_062139.2
Danio rerio (zebrafish)	scn8ab	NP_001038648.1
Gallus gallus (chicken)	SCN8A	XP_003643160.1
Xenopus tropicalis (tropical clawed frog)	LOC101731347	XP_004911965.1
	SCN8A	XP_001090295.1
Danio rerio (zebrafish)	scn8aa	NP_571703.1

Gene Ontology
Bibliography

Related articles in PubMed

Local knockdown of Nav1.6 relieves pain behaviors induced by BmK I.
Qin S, Jiang F, Zhou Y, Zhou G, Ye P, Ji Y
Acta biochimica et biophysica Sinica49(8)713-721(2017 Aug)

Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis.
Zhu H, Zhao Y, Wu H, Jiang N, Wang Z, Lin W, Jin J, Ji Y
Scientific reports638108(2016 Dec)

Single-Molecule Imaging of Nav1.6 on the Surface of Hippocampal Neurons Reveals Somatic Nanoclusters.
Akin EJ, Sol? L, Johnson B, Beheiry ME, Masson JB, Krapf D, Tamkun MM
Biophysical journal111(6)1235-1247(2016 Sep)

Preferential targeting of Nav1.6 voltage-gated Na+ Channels to the axon initial segment during development.
Akin EJ, Sol? L, Dib-Hajj SD, Waxman SG, Tamkun MM
PloS one10(4)e0124397(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study provides insight into the dynamics of Nav1.6 on the cell surface and raises new questions such as how somatic localization and function are linked and how localized regulation of these channels may influence overall neuronal physiology.
Title: Single-Molecule Imaging of Nav1.6 on the Surface of Hippocampal Neurons Reveals Somatic Nanoclusters.

Results highlight the relative importance of abnormal sensory neuron spontaneous activity in establishing both pain behaviors and sympathetic sprouting, and suggest that the NaV1.6 isoform may have value as a therapeutic target
Title: Local knockdown of the NaV1.6 sodium channel reduces pain behaviors, sensory neuron excitability, and sympathetic sprouting in rat models of neuropathic pain.

The data support a model where ankyrinG-binding is required for preferential Nav1.6 insertion into the axon initial segment plasma membrane during development.
Title: Preferential targeting of Nav1.6 voltage-gated Na+ Channels to the axon initial segment during development.

This study demonistrated that Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia in rats.
Title: Knockdown of sodium channel NaV1.6 blocks mechanical pain and abnormal bursting activity of afferent neurons in inflamed sensory ganglia.

inhibition of GSK3 reduces the assembly of the FGF14.Nav channel complex, modifies FGF14-dependent regulation of Na(+) currents, and induces dissociation and subcellular redistribution of the native FGF14.Nav channel complex in hippocampal neurons.
Title: The fibroblast growth factor 14?voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3).

The following Scn8a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Scn8a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04213	NM_019266.2 Latest version!	Rattus norvegicus sodium voltage-gated channel alpha subunit 8 (Scn8a), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	19-21	$951.30 $1359.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Scn8a ( NM_019266.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062139.2 Rattus norvegicus sodium voltage-gated channel alpha subunit 8 (Scn8a), mRNA.

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CloneID	ORa04213
Clone ID Related Accession (Same CDS sequence)	NM_019266.2
Accession Version	NM_019266.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5937bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-14
Organism	Rattus norvegicus(Norway rat)
Product	sodium channel protein type 8 subunit alpha
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF049239.1. On Oct 26, 2005 this sequence version replaced NM_019266.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF049239.1, L39018.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGCGC GGCTGCTCGC ACCACCAGGC CCTGATAGTT TCAAGCCTTT CACCCCTGAG 
TCGCTGGCAA ACATCGAGAG GCGTATTGCC GAGAGCAAGC TCAAGAAACC ACCAAAGGCG 
GATGGCAGCC ACCGGGAGGA CGATGAAGAC AGCAAGCCCA AGCCAAACAG TGACCTGGAG 
GCTGGGAAGA GTTTGCCTTT CATCTACGGG GACATCCCGC AAGGCCTGGT TGCGGTTCCC 
CTGGAGGACT TTGACCCTTA CTATTTGACG CAGAAAACCT TTGTAGTATT AAACAGAGGG 
AAAACTCTCT TCAGATTTAG TGCCACACCT GCCTTGTACA TTTTAAGCCC TTTTAACCTG 
ATAAGAAGAA TAGCTATTAA AATTTTGATA CACTCAGTTT TCAGCATGAT CATCATGTGC 
ACCATCCTGA CCAACTGTGT GTTCATGACC TTTAGTAACC CTCCAGAATG GTCCAAGAAT 
GTGGAGTACA CATTCACAGG GATTTACACA TTTGAATCAC TAGTGAAAAT CATCGCAAGA 
GGTTTCTGCA TAGACGGCTT CACCTTCTTG CGAGACCCGT GGAACTGGTT AGACTTCAGT 
GTCATCATGA TGGCATATGT GACAGAGTTT GTGGACCTGG GCAATGTCTC AGCGCTGAGA 
ACATTCAGGG TTCTCCGAGC TTTGAAAACT ATCTCTGTAA TTCCAGGCCT GAAGACAATC 
GTGGGCGCCC TAATCCAGTC CGTGAAGAAG CTGTCGGACG TGATGATCCT GACAGTGTTC 
TGCCTGAGTG TTTTCGCCCT GATTGGCCTG CAGCTCTTCA TGGGGAACCT TCGAAACAAG 
TGTGTCGTGT GGCCCATAAA CTTCAACGAG AGCTACCTGG AGAACGGCAC CAGAGGCTTT 
GACTGGGAGG AATATATCAA CAATAAAACA AACTTTTACA TGGTTCCTGG CATGCTAGAA 
CCCTTGCTCT GCGGGAACAG TTCTGATGCT GGGCAATGCC CAGAGGGATT CCAGTGCATG 
AAAGCAGGAA GGAACCCCAA CTACGGTTAC ACCAGCTTTG ACACCTTCAG CTGGGCCTTC 
TTGGCATTAT TCCGCCTTAT GACCCAGGAC TATTGGGAGA ACTTATACCA GCTGACCTTA 
CGAGCCGCTG GGAAAACGTA CATGATCTTC TTTGTCTTGG TCATCTTCGT GGGTTCTTTC 
TATCTGGTGA ACTTGATCTT GGCTGTGGTG GCCATGGCTT ATGAGGAACA GAACCAGGCA 
ACACTGGAGG AGGCAGAGCA AAAAGAGGCC GAGTTCAAGG CAATGCTGGA GCAACTCAAG 
AAGCAGCAGG AGGAGGCACA GGCTGCTGCA ATGGCCACCT CAGCGGGCAC TGTCTCGGAA 
GACGCCATTG AAGAAGAAGG GGAAGATGGG GTAGGCTCTC CGAGGAGCTC TTCTGAACTG 
TCTAAACTCA GTTCCAAGAG CGCGAAGGAG CGGCGGAACC GACGGAAGAA GAGGAAGCAG 
AAGGAGCTCT CTGAAGGCGA GGAGAAAGGG GACCCGGAGA AGGTGTTTAA GTCAGAGTCG 
GAAGACGGTA TGAGAAGGAA GGCCTTCCGG CTGCCAGACA ACAGGATAGG GAGGAAGTTT 
TCCATCATGA ATCAGTCGCT GCTCAGCATT CCAGGCTCGC CCTTCCTCTC CCGACATAAC 
AGCAAAAGCA GCATCTTCAG CTTCCGGGGA CCCGGTCGGT TCCGGGACCC CGGCTCTGAG 
AATGAGTTCG CAGACGATGA ACACAGCACC GTGGAGGAGA GCGAGGGCCG GCGTGACTCG 
CTCTTCATCC CGATCCGCGC CCGCGAGCGC CGCAGCAGCT ACAGTGGCTA CAGCGGCTAC 
AGCCAGTGCA GCCGCTCGTC GCGCATCTTC CCCAGCCTGC GGCGCAGCGT GAAGCGCAAC 
AGCACGGTGG ACTGCAACGG CGTAGTGTCA CTCATCGGGC CCGGCTCACA CATCGGGCGG 
CTCCTGCCTG AGGCAACGAC TGAGGTGGAA ATTAAGAAGA AAGGCCCTGG ATCTCTTTTA 
GTTTCTATGG ACCAACTCGC CTCCTACGGA CGGAAGGACA GAATCAACAG CATAATGAGC 
GTGGTCACAA ACACGCTAGT GGAAGAGCTG GAAGAGTCTC AGAGAAAGTG CCCACCGTGC 
TGGTATAAGT TTGCCAACAC TTTCCTCATC TGGGAGTGTC ACCCCTACTG GATAAAACTG 
AAGGAGATCG TGAACTTAAT CGTCATGGAC CCTTTTGTAG ACTTAGCCAT CACCATCTGC 
ATCGTTCTGA ATACGCTATT TATGGCAATG GAGCACCATC CCATGACACC ACAGTTCGAA 
CACGTCTTGG CCGTAGGAAA TCTGGTGTTC ACCGGGATCT TCACGGCGGA AATGTTTCTG 
AAGCTCATAG CCATGGACCC CTACTATTAT TTCCAAGAAG GCTGGAACAT TTTTGACGGA 
TTTATTGTCT CCCTCAGTTT AATGGAGCTG AGTCTCGCAG ATGTGGAGGG GCTCTCAGTG 
CTGCGGTCTT TCCGACTGCT CCGAGTCTTC AAGCTGGCCA AGTCCTGGCC CACCCTGAAC 
ATGCTGATCA AGATCATCGG GAACTCCGTG GGTGCCCTGG GCAACCTGAC CCTGGTGCTG 
GCCATCATCG TCTTCATCTT CGCCGTGGTG GGGATGCAGC TGTTTGGAAA GAGTTACAAG 
GAGTGCGTCT GTAAGATCAA CCAGGAGTGC AAGCTCCCGC GCTGGCACAT GAACGACTTC 
TTCCACTCCT TCCTCATCGT CTTCCGAGTG CTGTGTGGGG AGTGGATCGA GACCATGTGG 
GACTGCATGG AGGTGGCCGG CCAGGCCATG TGCCTCATTG TCTTCATGAT GGTTATGGTC 
ATTGGCAACC TGGTGGTGCT GAATCTATTC CTGGCCTTGC TTCTGAGCTC CTTCAGCGCA 
GACAACCTGG CGGCCACAGA CGACGACGGG GAAATGAACA ACCTGCAGAT CTCAGTGATC 
CGGATCAAGA AGGGCGTGGC CTGGACCAAA GTGAAGGTGC ACGCCTTCAT GCAGGCTCAC 
TTCAAGCAGC GGGAGGCGGA TGAAGTGAAA CCCCTCGACG AGCTGTATGA GAAGAAGGCC 
AACTGCATCG CCAACCACAC GGGCGTGGAT ATCCACCGGA ACGGCGACTT CCAGAAGAAC 
GGGAACGGAA CCACCAGCGG CATCGGCAGC AGCGTGGAGA AGTACATCAT CGACGAGGAC 
CACATGTCCT TCATTAACAA CCCAAACCTG ACCGTCCGGG TGCCCATTGC TGTGGGCGAG 
TCTGACTTCG AGAACCTCAA CACAGAGGAT GTTAGCAGCG AATCAGACCC TGAAGGCAGC 
AAAGATAAAC TGGACGATAC CAGCTCCTCA GAAGGAAGTA CCATCGACAT CAAGCCTGAG 
GTGGAAGAAG TTCCCGTGGA GCAACCTGAG GAATACTTGG ATCCGGACGC CTGCTTTACA 
GAGGGTTGCG TCCAGCGGTT CAAGTGCTGC CAGGTCAACA TCGAGGAAGG ACTAGGCAAG 
TCGTGGTGGA TCTTGCGGAA AACCTGCTTC CTCATTGTGG AGCACAATTG GTTTGAGACC 
TTCATCATCT TCATGATTCT GCTCAGCAGT GGCGCCCTGG CCTTTGAGGA CATCTACATT 
GAGCAGAGGA AGACCATCCG CACCATCCTG GAGTATGCGG ACAAGGTCTT CACCTACATC 
TTCATCCTGG AGATGTTGCT CAAGTGGACA GCCTACGGCT TCGTCAAGTT CTTCACCAAT 
GCCTGGTGCT GGTTGGACTT CCTCATTGTG GCTGTCTCTT TAGTCAGCCT TATAGCTAAT 
GCCCTGGGCT ACTCGGAACT AGGTGCCATA AAGTCCCTTA GGACCCTAAG AGCTTTGAGA 
CCCTTAAGAG CCTTATCACG ATTTGAAGGG ATGAGGGTGG TGGTGAATGC CTTGGTGGGC 
GCCATCCCCT CCATCATGAA TGTGCTGCTG GTGTGTCTCA TCTTCTGGCT GATTTTCAGC 
ATCATGGGAG TTAACCTGTT TGCGGGGAAA TACCACTACT GCTTTAATGA GACTTCTGAA 
ATCCGGTTCG AAATCGATAT TGTCAACAAT AAAACGGACT GTGAGAAGCT CATGGAGGGC 
AACAGCACGG AGATCCGATG GAAGAATGTC AAGATCAACT TTGACAATGT CGGAGCAGGG 
TACCTGGCCC TTCTTCAAGT GGCAACCTTC AAAGGCTGGA TGGACATCAT GTATGCGGCT 
GTAGATTCCC GAAAGCCAGA CGAGCAGCCT GACTACGAGG GCAACATCTA CATGTACATC 
TACTTCGTCA TCTTCATCAT CTTCGGCTCC TTCTTCACCC TCAACCTGTT CATCGGTGTC 
ATCATCGACA ACTTCAACCA GCAGAAGAAA AAGTTTGGAG GTCAGGACAT CTTCATGACA 
GAGGAACAGA AGAAGTACTA CAATGCCATG AAAAAGCTGG GCTCCAAGAA GCCACAGAAG 
CCCATCCCCC GACCCTTGAA CAAAATCCAA GGGATTGTCT TTGATTTCGT CACTCAACAA 
GCCTTTGACA TTGTGATCAT GATGCTCATC TGCCTTAACA TGGTGACAAT GATGGTGGAG 
ACAGACACTC AGAGCAAGCA GATGGAGAAC ATTCTTTACT GGATTAATCT GGTCTTTGTC 
ATCTTCTTCA CCTGCGAGTG TGTGCTCAAA ATGTTTGCCT TGAGACACTA CTATTTCACC 
ATTGGCTGGA ACATCTTTGA CTTTGTGGTG GTCATCCTCT CCATTGTGGG AATGTTCCTG 
GCTGATATCA TTGAGAAGTA CTTCGTCTCC CCAACCCTAT TCCGAGTTAT CCGATTGGCC 
CGTATTGGGC GCATCTTGCG TCTGATCAAG GGCGCCAAAG GGATCCGCAC CCTGCTCTTT 
GCCTTAATGA TGTCGCTGCC CGCCCTGTTC AACATCGGCC TCCTGCTCTT CCTCGTCATG 
TTCATCTTCT CCATTTTTGG CATGTCCAAC TTCGCATACG TGAAGCACGA GGCCGGCATT 
GACGACATGT TCAACTTCGA GACATTTGGC AACAGCATGA TCTGTTTGTT CCAGATCACA 
ACGTCTGCTG GCTGGGATGG CCTGCTGCTG CCAATCCTGA ACCGCCCCCC TGACTGCAGC 
TTGGACAAAG AGCACCCAGG GAGTGGCTTC AAAGGGGACT GTGGGAACCC CTCGGTGGGC 
ATCTTCTTCT TTGTGAGCTA CATCATCATC TCCTTCCTGA TTGTGGTGAA CATGTACATC 
GCCATCATCC TGGAGAACTT CAGCGTGGCC ACCGAGGAGA GCGCCGACCC TCTGAGTGAG 
GATGACTTCG AGACTTTCTA TGAGATCTGG GAGAAGTTTG ACCCAGACGC CACCCAGTTC 
ATCGAGTACT GTAAGCTGGC AGACTTTGCC GACGCCCTGG AGCACCCGCT CCGAGTACCC 
AAGCCCAACA CCATCGAGCT CATCGCCATG GACCTGCCCA TGGTGAGCGG AGATCGCATC 
CACTGCTTGG ACATCCTTTT CGCCTTCACC AAGCGAGTCC TGGGAGACAG TGGGGAGTTG 
GACATCCTGC GGCAGCAGAT GGAGGAGCGG TTCGTGGCAT CCAATCCTTC CAAAGTGTCT 
TACGAGCCTA TCACAACCAC TCTGCGGCGC AAGCAGGAGG AGGTGTCTGC AGTGGTCCTG 
CAGCGTGCCT ACAGGGGACA CTTGGCTAGG CGGGGCTTCA TCTGCAGAAA GATGGCCTCC 
AACAAGCTGG AGAATGGAGG CACACACAGA GACAAGAAGG AGAGCACCCC GTCCACAGCC 
TCCCTCCCCT CTTACGACAG CGTCACAAAG CCAGACAAGG AGAAGCAGCA GCGTGCGGAG 
GAGGGCAGAA GGGAAAGAGC CAAGAGGCAA AAAGAGGTCA GGGAGTCCAA GTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062139.2
CDS	169..6105
Translation	MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPEWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTRGFDWEEYINNKTNFYMVPGMLEPLLCGNSSDAGQCPEGFQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEDGVGSPRSSSELSKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQCSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGPGSHIGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQECKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKVKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGVDIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIDIVNNKTDCEKLMEGNSTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPDYEGNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICRKMASNKLENGGTHRDKKESTPSTASLPSYDSVTKPDKEKQQRAEEGRRERAKRQKEVRESKC

Target ORF information:

RefSeq Version	NM_019266.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus sodium voltage-gated channel alpha subunit 8 (Scn8a), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019266.2

ORF Insert Sequence:

ATGGCAGCGC GGCTGCTCGC ACCACCAGGC CCTGATAGTT TCAAGCCTTT CACCCCTGAG 
TCGCTGGCAA ACATCGAGAG GCGTATTGCC GAGAGCAAGC TCAAGAAACC ACCAAAGGCG 
GATGGCAGCC ACCGGGAGGA CGATGAAGAC AGCAAGCCCA AGCCAAACAG TGACCTGGAG 
GCTGGGAAGA GTTTGCCTTT CATCTACGGG GACATCCCGC AAGGCCTGGT TGCGGTTCCC 
CTGGAGGACT TTGACCCTTA CTATTTGACG CAGAAAACCT TTGTAGTATT AAACAGAGGG 
AAAACTCTCT TCAGATTTAG TGCCACACCT GCCTTGTACA TTTTAAGCCC TTTTAACCTG 
ATAAGAAGAA TAGCTATTAA AATTTTGATA CACTCAGTTT TCAGCATGAT CATCATGTGC 
ACCATCCTGA CCAACTGTGT GTTCATGACC TTTAGTAACC CTCCAGAATG GTCCAAGAAT 
GTGGAGTACA CATTCACAGG GATTTACACA TTTGAATCAC TAGTGAAAAT CATCGCAAGA 
GGTTTCTGCA TAGACGGCTT CACCTTCTTG CGAGACCCGT GGAACTGGTT AGACTTCAGT 
GTCATCATGA TGGCATATGT GACAGAGTTT GTGGACCTGG GCAATGTCTC AGCGCTGAGA 
ACATTCAGGG TTCTCCGAGC TTTGAAAACT ATCTCTGTAA TTCCAGGCCT GAAGACAATC 
GTGGGCGCCC TAATCCAGTC CGTGAAGAAG CTGTCGGACG TGATGATCCT GACAGTGTTC 
TGCCTGAGTG TTTTCGCCCT GATTGGCCTG CAGCTCTTCA TGGGGAACCT TCGAAACAAG 
TGTGTCGTGT GGCCCATAAA CTTCAACGAG AGCTACCTGG AGAACGGCAC CAGAGGCTTT 
GACTGGGAGG AATATATCAA CAATAAAACA AACTTTTACA TGGTTCCTGG CATGCTAGAA 
CCCTTGCTCT GCGGGAACAG TTCTGATGCT GGGCAATGCC CAGAGGGATT CCAGTGCATG 
AAAGCAGGAA GGAACCCCAA CTACGGTTAC ACCAGCTTTG ACACCTTCAG CTGGGCCTTC 
TTGGCATTAT TCCGCCTTAT GACCCAGGAC TATTGGGAGA ACTTATACCA GCTGACCTTA 
CGAGCCGCTG GGAAAACGTA CATGATCTTC TTTGTCTTGG TCATCTTCGT GGGTTCTTTC 
TATCTGGTGA ACTTGATCTT GGCTGTGGTG GCCATGGCTT ATGAGGAACA GAACCAGGCA 
ACACTGGAGG AGGCAGAGCA AAAAGAGGCC GAGTTCAAGG CAATGCTGGA GCAACTCAAG 
AAGCAGCAGG AGGAGGCACA GGCTGCTGCA ATGGCCACCT CAGCGGGCAC TGTCTCGGAA 
GACGCCATTG AAGAAGAAGG GGAAGATGGG GTAGGCTCTC CGAGGAGCTC TTCTGAACTG 
TCTAAACTCA GTTCCAAGAG CGCGAAGGAG CGGCGGAACC GACGGAAGAA GAGGAAGCAG 
AAGGAGCTCT CTGAAGGCGA GGAGAAAGGG GACCCGGAGA AGGTGTTTAA GTCAGAGTCG 
GAAGACGGTA TGAGAAGGAA GGCCTTCCGG CTGCCAGACA ACAGGATAGG GAGGAAGTTT 
TCCATCATGA ATCAGTCGCT GCTCAGCATT CCAGGCTCGC CCTTCCTCTC CCGACATAAC 
AGCAAAAGCA GCATCTTCAG CTTCCGGGGA CCCGGTCGGT TCCGGGACCC CGGCTCTGAG 
AATGAGTTCG CAGACGATGA ACACAGCACC GTGGAGGAGA GCGAGGGCCG GCGTGACTCG 
CTCTTCATCC CGATCCGCGC CCGCGAGCGC CGCAGCAGCT ACAGTGGCTA CAGCGGCTAC 
AGCCAGTGCA GCCGCTCGTC GCGCATCTTC CCCAGCCTGC GGCGCAGCGT GAAGCGCAAC 
AGCACGGTGG ACTGCAACGG CGTAGTGTCA CTCATCGGGC CCGGCTCACA CATCGGGCGG 
CTCCTGCCTG AGGCAACGAC TGAGGTGGAA ATTAAGAAGA AAGGCCCTGG ATCTCTTTTA 
GTTTCTATGG ACCAACTCGC CTCCTACGGA CGGAAGGACA GAATCAACAG CATAATGAGC 
GTGGTCACAA ACACGCTAGT GGAAGAGCTG GAAGAGTCTC AGAGAAAGTG CCCACCGTGC 
TGGTATAAGT TTGCCAACAC TTTCCTCATC TGGGAGTGTC ACCCCTACTG GATAAAACTG 
AAGGAGATCG TGAACTTAAT CGTCATGGAC CCTTTTGTAG ACTTAGCCAT CACCATCTGC 
ATCGTTCTGA ATACGCTATT TATGGCAATG GAGCACCATC CCATGACACC ACAGTTCGAA 
CACGTCTTGG CCGTAGGAAA TCTGGTGTTC ACCGGGATCT TCACGGCGGA AATGTTTCTG 
AAGCTCATAG CCATGGACCC CTACTATTAT TTCCAAGAAG GCTGGAACAT TTTTGACGGA 
TTTATTGTCT CCCTCAGTTT AATGGAGCTG AGTCTCGCAG ATGTGGAGGG GCTCTCAGTG 
CTGCGGTCTT TCCGACTGCT CCGAGTCTTC AAGCTGGCCA AGTCCTGGCC CACCCTGAAC 
ATGCTGATCA AGATCATCGG GAACTCCGTG GGTGCCCTGG GCAACCTGAC CCTGGTGCTG 
GCCATCATCG TCTTCATCTT CGCCGTGGTG GGGATGCAGC TGTTTGGAAA GAGTTACAAG 
GAGTGCGTCT GTAAGATCAA CCAGGAGTGC AAGCTCCCGC GCTGGCACAT GAACGACTTC 
TTCCACTCCT TCCTCATCGT CTTCCGAGTG CTGTGTGGGG AGTGGATCGA GACCATGTGG 
GACTGCATGG AGGTGGCCGG CCAGGCCATG TGCCTCATTG TCTTCATGAT GGTTATGGTC 
ATTGGCAACC TGGTGGTGCT GAATCTATTC CTGGCCTTGC TTCTGAGCTC CTTCAGCGCA 
GACAACCTGG CGGCCACAGA CGACGACGGG GAAATGAACA ACCTGCAGAT CTCAGTGATC 
CGGATCAAGA AGGGCGTGGC CTGGACCAAA GTGAAGGTGC ACGCCTTCAT GCAGGCTCAC 
TTCAAGCAGC GGGAGGCGGA TGAAGTGAAA CCCCTCGACG AGCTGTATGA GAAGAAGGCC 
AACTGCATCG CCAACCACAC GGGCGTGGAT ATCCACCGGA ACGGCGACTT CCAGAAGAAC 
GGGAACGGAA CCACCAGCGG CATCGGCAGC AGCGTGGAGA AGTACATCAT CGACGAGGAC 
CACATGTCCT TCATTAACAA CCCAAACCTG ACCGTCCGGG TGCCCATTGC TGTGGGCGAG 
TCTGACTTCG AGAACCTCAA CACAGAGGAT GTTAGCAGCG AATCAGACCC TGAAGGCAGC 
AAAGATAAAC TGGACGATAC CAGCTCCTCA GAAGGAAGTA CCATCGACAT CAAGCCTGAG 
GTGGAAGAAG TTCCCGTGGA GCAACCTGAG GAATACTTGG ATCCGGACGC CTGCTTTACA 
GAGGGTTGCG TCCAGCGGTT CAAGTGCTGC CAGGTCAACA TCGAGGAAGG ACTAGGCAAG 
TCGTGGTGGA TCTTGCGGAA AACCTGCTTC CTCATTGTGG AGCACAATTG GTTTGAGACC 
TTCATCATCT TCATGATTCT GCTCAGCAGT GGCGCCCTGG CCTTTGAGGA CATCTACATT 
GAGCAGAGGA AGACCATCCG CACCATCCTG GAGTATGCGG ACAAGGTCTT CACCTACATC 
TTCATCCTGG AGATGTTGCT CAAGTGGACA GCCTACGGCT TCGTCAAGTT CTTCACCAAT 
GCCTGGTGCT GGTTGGACTT CCTCATTGTG GCTGTCTCTT TAGTCAGCCT TATAGCTAAT 
GCCCTGGGCT ACTCGGAACT AGGTGCCATA AAGTCCCTTA GGACCCTAAG AGCTTTGAGA 
CCCTTAAGAG CCTTATCACG ATTTGAAGGG ATGAGGGTGG TGGTGAATGC CTTGGTGGGC 
GCCATCCCCT CCATCATGAA TGTGCTGCTG GTGTGTCTCA TCTTCTGGCT GATTTTCAGC 
ATCATGGGAG TTAACCTGTT TGCGGGGAAA TACCACTACT GCTTTAATGA GACTTCTGAA 
ATCCGGTTCG AAATCGATAT TGTCAACAAT AAAACGGACT GTGAGAAGCT CATGGAGGGC 
AACAGCACGG AGATCCGATG GAAGAATGTC AAGATCAACT TTGACAATGT CGGAGCAGGG 
TACCTGGCCC TTCTTCAAGT GGCAACCTTC AAAGGCTGGA TGGACATCAT GTATGCGGCT 
GTAGATTCCC GAAAGCCAGA CGAGCAGCCT GACTACGAGG GCAACATCTA CATGTACATC 
TACTTCGTCA TCTTCATCAT CTTCGGCTCC TTCTTCACCC TCAACCTGTT CATCGGTGTC 
ATCATCGACA ACTTCAACCA GCAGAAGAAA AAGTTTGGAG GTCAGGACAT CTTCATGACA 
GAGGAACAGA AGAAGTACTA CAATGCCATG AAAAAGCTGG GCTCCAAGAA GCCACAGAAG 
CCCATCCCCC GACCCTTGAA CAAAATCCAA GGGATTGTCT TTGATTTCGT CACTCAACAA 
GCCTTTGACA TTGTGATCAT GATGCTCATC TGCCTTAACA TGGTGACAAT GATGGTGGAG 
ACAGACACTC AGAGCAAGCA GATGGAGAAC ATTCTTTACT GGATTAATCT GGTCTTTGTC 
ATCTTCTTCA CCTGCGAGTG TGTGCTCAAA ATGTTTGCCT TGAGACACTA CTATTTCACC 
ATTGGCTGGA ACATCTTTGA CTTTGTGGTG GTCATCCTCT CCATTGTGGG AATGTTCCTG 
GCTGATATCA TTGAGAAGTA CTTCGTCTCC CCAACCCTAT TCCGAGTTAT CCGATTGGCC 
CGTATTGGGC GCATCTTGCG TCTGATCAAG GGCGCCAAAG GGATCCGCAC CCTGCTCTTT 
GCCTTAATGA TGTCGCTGCC CGCCCTGTTC AACATCGGCC TCCTGCTCTT CCTCGTCATG 
TTCATCTTCT CCATTTTTGG CATGTCCAAC TTCGCATACG TGAAGCACGA GGCCGGCATT 
GACGACATGT TCAACTTCGA GACATTTGGC AACAGCATGA TCTGTTTGTT CCAGATCACA 
ACGTCTGCTG GCTGGGATGG CCTGCTGCTG CCAATCCTGA ACCGCCCCCC TGACTGCAGC 
TTGGACAAAG AGCACCCAGG GAGTGGCTTC AAAGGGGACT GTGGGAACCC CTCGGTGGGC 
ATCTTCTTCT TTGTGAGCTA CATCATCATC TCCTTCCTGA TTGTGGTGAA CATGTACATC 
GCCATCATCC TGGAGAACTT CAGCGTGGCC ACCGAGGAGA GCGCCGACCC TCTGAGTGAG 
GATGACTTCG AGACTTTCTA TGAGATCTGG GAGAAGTTTG ACCCAGACGC CACCCAGTTC 
ATCGAGTACT GTAAGCTGGC AGACTTTGCC GACGCCCTGG AGCACCCGCT CCGAGTACCC 
AAGCCCAACA CCATCGAGCT CATCGCCATG GACCTGCCCA TGGTGAGCGG AGATCGCATC 
CACTGCTTGG ACATCCTTTT CGCCTTCACC AAGCGAGTCC TGGGAGACAG TGGGGAGTTG 
GACATCCTGC GGCAGCAGAT GGAGGAGCGG TTCGTGGCAT CCAATCCTTC CAAAGTGTCT 
TACGAGCCTA TCACAACCAC TCTGCGGCGC AAGCAGGAGG AGGTGTCTGC AGTGGTCCTG 
CAGCGTGCCT ACAGGGGACA CTTGGCTAGG CGGGGCTTCA TCTGCAGAAA GATGGCCTCC 
AACAAGCTGG AGAATGGAGG CACACACAGA GACAAGAAGG AGAGCACCCC GTCCACAGCC 
TCCCTCCCCT CTTACGACAG CGTCACAAAG CCAGACAAGG AGAAGCAGCA GCGTGCGGAG 
GAGGGCAGAA GGGAAAGAGC CAAGAGGCAA AAAGAGGTCA GGGAGTCCAA GTGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Local knockdown of Nav1.6 relieves pain behaviors induced by BmK I.
Acta biochimica et biophysica Sinica49(8)713-721(2017 Aug)
Qin S,Jiang F,Zhou Y,Zhou G,Ye P,Ji Y

Remarkable alterations of Nav1.6 in reactive astrogliosis during epileptogenesis.
Scientific reports638108(2016 Dec)
Zhu H,Zhao Y,Wu H,Jiang N,Wang Z,Lin W,Jin J,Ji Y

Single-Molecule Imaging of Nav1.6 on the Surface of Hippocampal Neurons Reveals Somatic Nanoclusters.
Biophysical journal111(6)1235-1247(2016 Sep)
Akin EJ,Sol? L,Johnson B,Beheiry ME,Masson JB,Krapf D,Tamkun MM

Preferential targeting of Nav1.6 voltage-gated Na+ Channels to the axon initial segment during development.
PloS one10(4)e0124397(2015)
Akin EJ,Sol? L,Dib-Hajj SD,Waxman SG,Tamkun MM

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Scn8a cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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