Gabra6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gabra6
Entrez Gene ID	29708
Full Name	gamma-aminobutyric acid type A receptor alpha 6 subunit
General protein information	Preferred Names gamma-aminobutyric acid type A receptor alpha 6 subunit Names gamma-aminobutyric acid receptor subunit alpha-6 GABA(A) receptor subunit alpha-6 GABA-A receptor alpha-6 subunit gamma-aminobutyric acid A receptor, alpha 6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 6
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q21
Summary	GABAA receptor subunit; part of a cerebellar receptor subtype, selective for antagonist of alcohol-induced motor incoordination and ataxia [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006246128.3	XP_006246190.1	gamma-aminobutyric acid receptor subunit alpha-6 isoform X1
XM_008767636.2	XP_008765858.1	gamma-aminobutyric acid receptor subunit alpha-6 isoform X2
NM_021841.1	NP_068613.1	gamma-aminobutyric acid receptor subunit alpha-6 precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	GABRA6	NP_990389.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000039	XP_001237369.2
	GABRA6	XP_001086065.1
Bos taurus (cattle)	GABRA6	NP_001137557.1
Rattus norvegicus (Norway rat)	Gabra6	NP_068613.1
Mus musculus (house mouse)	Gabra6	NP_001093111.1
Drosophila melanogaster (fruit fly)	CG8916	NP_001162770.1
Xenopus tropicalis (tropical clawed frog)	gabra6	XP_002943228.2
Danio rerio (zebrafish)	gabra6b	XP_002667403.3
Caenorhabditis elegans (roundworm)	lgc-37	NP_499662.2
Homo sapiens (human)	GABRA6	NP_000802.2
Pan troglodytes (chimpanzee)	GABRA6	XP_001144345.1
Canis lupus familiaris (dog)	GABRA6	XP_546263.2

Gene Ontology
Bibliography

Related articles in PubMed

The essential role of hippocampal alpha6 subunit-containing GABAA receptors in maternal separation stress-induced adolescent depressive behaviors.
Yang L, Xu T, Zhang K, Wei Z, Li X, Huang M, Rose GM, Cai X
Behavioural brain research313135-43(2016 10)

?6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells.
Accardi MV, Brown PM, Miraucourt LS, Orser BA, Bowie D
The Journal of neuroscience : the official journal of the Society for Neuroscience35(26)9676-88(2015 Jul)

Infusion of Gabr?6 siRNA into the trigeminal ganglia increased the myogenic orofacial nociceptive response of ovariectomized rats treated with 17?-estradiol.
Kramer PR, Bellinger LL
Neuroscience278144-53(2014 Oct)

Reduced GABAA receptor ?6 expression in the trigeminal ganglion enhanced myofascial nociceptive response.
Kramer PR, Bellinger LL
Neuroscience2451-11(2013 Aug)

Reduced GABA(A) receptor ?6 expression in the trigeminal ganglion alters inflammatory TMJ hypersensitivity.
Puri J, Vinothini P, Reuben J, Bellinger LL, Ailing L, Peng YB, Kramer PR
Neuroscience213179-90(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results indicate that the Gabra6-containing GABAA receptor is a key modulator of hippocampal synaptic transmission and likely plays a crucial role in the pathophysiology of maternal separation-induced depression.
Title: The essential role of hippocampal alpha6 subunit-containing GABAA receptors in maternal separation stress-induced adolescent depressive behaviors.

Results suggest estradiol decreased the orofacial nociceptive response, in part, by causing an increase in Gabralpha6 expression.
Title: Infusion of Gabr?6 siRNA into the trigeminal ganglia increased the myogenic orofacial nociceptive response of ovariectomized rats treated with 17?-estradiol.

The Gabralpha6 subunit inhibits trigeminal ganglion nociceptive sensory afferents and regulates myofascial nociception.
Title: Reduced GABAA receptor ?6 expression in the trigeminal ganglion enhanced myofascial nociceptive response.

These results suggest that maintaining Gabralpha6 expression was necessary to inhibit primary sensory afferents in the trigeminal pathway and reduce inflammatory orofacial nociception
Title: Reduced GABA(A) receptor ?6 expression in the trigeminal ganglion alters inflammatory TMJ hypersensitivity.

expression of delta and alpha6, a subunit normally found exclusively in the cerebellum, is observed after 14 days in pons in chronic hypobaric hypoxia
Title: Adaptation to hypobaric hypoxia involves GABA A receptors in the pons.

The following Gabra6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gabra6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa05248	NM_021841.1 Latest version!	Rattus norvegicus gamma-aminobutyric acid type A receptor subunit alpha6 (Gabra6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
ORa32966	XM_006246128.3 Latest version!	Rattus norvegicus gamma-aminobutyric acid type A receptor alpha 6 subunit (Gabra6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
ORa43352	XM_008767636.2 Latest version!	Rattus norvegicus gamma-aminobutyric acid type A receptor alpha 6 subunit (Gabra6), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gabra6 ( NM_021841.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_068613.1 Rattus norvegicus gamma-aminobutyric acid type A receptor subunit alpha6 (Gabra6), mRNA.

Price & Availability↑

CloneID	ORa05248
Clone ID Related Accession (Same CDS sequence)	NM_021841.1
Accession Version	NM_021841.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-10
Organism	Rattus norvegicus(Norway rat)
Product	gamma-aminobutyric acid receptor subunit alpha-6 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X55742.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2689595, SAMN02642596 [ECO:0000348] ##Evidence-Data-END##

ATGCTGTTGC TTCTCCCCTG GCTCTTCAGT TTACTATGGA TAGAAAATGC CCAAGCTCAA 
CTTGAAGATG AAGGGAACTT CTATTCTGAA AATGTCAGTC GGATTCTTGA CAACTTGCTG 
GAGGGCTATG ACAACCGTCT ACGGCCGGGA TTTGGAGGTG CTGTAACAGA GGTCAAAACA 
GATATCTATG TGACCAGCTT TGGGCCTGTG TCAGATGTGG AGATGGAGTA CACAATGGAT 
GTTTTCTTCC GACAGACATG GACTGATGAG AGGCTGAAGT TCAAAGGCCC TGCTGAGATT 
TTGAGTTTAA ATAACTTGAT GGTCAGTAAG ATCTGGACTC CGGACACATT TTTCCGAAAT 
GGGAAAAAGT CAATTGCTCA CAACATGACC ACCCCTAACA AACTCTTCCG ATTGATGCAT 
AATGGAACGA TCCTGTACAC CATGAGGCTT ACCATCAACG CTGACTGTCC GATGAGACTG 
GTTAACTTCC CTATGGATGG ACACGCATGT CCACTCAAGT TTGGGAGCTA TGCCTATCCG 
AAAAGCGAAA TCATATATAC ATGGAAAAAA GGACCGCTTT ATTCAGTAGA GGTCCCAGAA 
GAATCTTCAA GCCTCCTCCA GTATGATTTG ATTGGGCAAA CAGTTTCTAG TGAGACTATT 
AAATCGAACA CAGGTGAATA TGTAATAATG ACAGTCTACT TCCACTTACA AAGGAAGATG 
GGCTATTTCA TGATCCAGAT TTACACTCCG TGCATCATGA CAGTCATTCT CTCTCAAGTG 
TCTTTCTGGA TTAATAAGGA GTCGGTCCCA GCAAGAACCG TCTTTGGAAT CACCACGGTT 
TTAACCATGA CCACCTTAAG CATCAGTGCT CGGCACTCTC TACCCAAAGT GTCCTATGCA 
ACCGCCATGG ATTGGTTCAT AGCTGTATGC TTTGCGTTTG TCTTTTCTGC TCTCATTGAA 
TTCGCAGCTG TCAACTACTT CACCAATCTC CAGTCCCAGA AAGCCGAAAG GCAGGCACAG 
ACTGCAGCCA AGCCCCCGGT AGCAAAGTCA AAAACAACTG AATCACTGGA AGCTGAGATT 
GTTGTGCACT CTGACTCCAA GTACCATCTG AAGAAGAGAA TCAGCTCTCT GACTTTGCCA 
ATCGTTCCAT CTTCTGAGGC CAGCAAAGTC CTCAGTAGAA CGCCCATCTT ACCATCAACG 
CCGGTCACTC CCCCATTGCT CTTACCAGCC ATTGGCGGCA CCAGCAAAAT AGATCAATAT 
TCTCGAATTC TCTTCCCAGT AGCATTTGCA GGATTCAACC TTGTGTACTG GATAGTTTAC 
CTTTCCAAAG ATACAATGGA AGTGAGCAGT ACTGTCGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_068613.1
CDS	1..1362
Translation	MLLLLPWLFSLLWIENAQAQLEDEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFKGPAEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRLMHNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQSQKAERQAQTAAKPPVAKSKTTESLEAEIVVHSDSKYHLKKRISSLTLPIVPSSEASKVLSRTPILPSTPVTPPLLLPAIGGTSKIDQYSRILFPVAFAGFNLVYWIVYLSKDTMEVSSTVE

Target ORF information:

RefSeq Version	NM_021841.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus gamma-aminobutyric acid type A receptor subunit alpha6 (Gabra6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021841.1

ORF Insert Sequence:

ATGCTGTTGC TTCTCCCCTG GCTCTTCAGT TTACTATGGA TAGAAAATGC CCAAGCTCAA 
CTTGAAGATG AAGGGAACTT CTATTCTGAA AATGTCAGTC GGATTCTTGA CAACTTGCTG 
GAGGGCTATG ACAACCGTCT ACGGCCGGGA TTTGGAGGTG CTGTAACAGA GGTCAAAACA 
GATATCTATG TGACCAGCTT TGGGCCTGTG TCAGATGTGG AGATGGAGTA CACAATGGAT 
GTTTTCTTCC GACAGACATG GACTGATGAG AGGCTGAAGT TCAAAGGCCC TGCTGAGATT 
TTGAGTTTAA ATAACTTGAT GGTCAGTAAG ATCTGGACTC CGGACACATT TTTCCGAAAT 
GGGAAAAAGT CAATTGCTCA CAACATGACC ACCCCTAACA AACTCTTCCG ATTGATGCAT 
AATGGAACGA TCCTGTACAC CATGAGGCTT ACCATCAACG CTGACTGTCC GATGAGACTG 
GTTAACTTCC CTATGGATGG ACACGCATGT CCACTCAAGT TTGGGAGCTA TGCCTATCCG 
AAAAGCGAAA TCATATATAC ATGGAAAAAA GGACCGCTTT ATTCAGTAGA GGTCCCAGAA 
GAATCTTCAA GCCTCCTCCA GTATGATTTG ATTGGGCAAA CAGTTTCTAG TGAGACTATT 
AAATCGAACA CAGGTGAATA TGTAATAATG ACAGTCTACT TCCACTTACA AAGGAAGATG 
GGCTATTTCA TGATCCAGAT TTACACTCCG TGCATCATGA CAGTCATTCT CTCTCAAGTG 
TCTTTCTGGA TTAATAAGGA GTCGGTCCCA GCAAGAACCG TCTTTGGAAT CACCACGGTT 
TTAACCATGA CCACCTTAAG CATCAGTGCT CGGCACTCTC TACCCAAAGT GTCCTATGCA 
ACCGCCATGG ATTGGTTCAT AGCTGTATGC TTTGCGTTTG TCTTTTCTGC TCTCATTGAA 
TTCGCAGCTG TCAACTACTT CACCAATCTC CAGTCCCAGA AAGCCGAAAG GCAGGCACAG 
ACTGCAGCCA AGCCCCCGGT AGCAAAGTCA AAAACAACTG AATCACTGGA AGCTGAGATT 
GTTGTGCACT CTGACTCCAA GTACCATCTG AAGAAGAGAA TCAGCTCTCT GACTTTGCCA 
ATCGTTCCAT CTTCTGAGGC CAGCAAAGTC CTCAGTAGAA CGCCCATCTT ACCATCAACG 
CCGGTCACTC CCCCATTGCT CTTACCAGCC ATTGGCGGCA CCAGCAAAAT AGATCAATAT 
TCTCGAATTC TCTTCCCAGT AGCATTTGCA GGATTCAACC TTGTGTACTG GATAGTTTAC 
CTTTCCAAAG ATACAATGGA AGTGAGCAGT ACTGTCGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gabra6 ( XM_006246128.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006246190.1 Rattus norvegicus gamma-aminobutyric acid type A receptor alpha 6 subunit (Gabra6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa32966
Clone ID Related Accession (Same CDS sequence)	XM_006246128.3
Accession Version	XM_006246128.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1332bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	gamma-aminobutyric acid receptor subunit alpha-6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006246128.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGTTGC TTCTCCCCTG GCTCTTCAGT TTACTATGGA TAGAAAATGC CCAAGCTCAA 
CTTGAAGATG AAGGGAACTT CTATTCTGAA AATGTCAGTC GGATTCTTGA CAACTTGCTG 
GAGGGCTATG ACAACCGTCT ACGGCCGGGA TTTGGAGGTG CTGTAACAGA GGTCAAAACA 
GATATCTATG TGACCAGCTT TGGGCCTGTG TCAGATGTGG AGATGACATG GACTGATGAG 
AGGCTGAAGT TCAAAGGCCC TGCTGAGATT TTGAGTTTAA ATAACTTGAT GGTCAGTAAG 
ATCTGGACTC CGGACACATT TTTCCAAAAT GGGAAAAAGT CAATTGCTCA CAACATGACC 
ACCCCTAACA AACTCTTCCG ATTGATGCAG AATGGAACGA TCCTGTACAC CATGAGGCTT 
ACCATCAACG CTGACTGTCC GATGAGACTG GTTAACTTCC CTATGGATGG ACACGCATGT 
CCACTCAAGT TTGGGAGCTA TGCCTATCCG AAAAGCGAAA TCATATATAC ATGGAAAAAA 
GGACCGCTTT ATTCAGTAGA GGTCCCAGAA GAATCTTCAA GCCTCCTCCA GTATGATTTG 
ATTGGGCAAA CAGTTTCTAG TGAGACTATT AAATCGAACA CAGGTGAATA TGTAATAATG 
ACAGTCTACT TCCACTTACA AAGGAAGATG GGCTATTTCA TGATCCAGAT TTACACTCCG 
TGCATCATGA CAGTCATTCT CTCTCAAGTG TCTTTCTGGA TTAATAAGGA GTCGGTCCCA 
GCAAGAACCG TCTTTGGAAT CACCACGGTT TTAACCATGA CCACCTTAAG CATCAGTGCT 
CGGCACTCTC TACCCAAAGT GTCCTATGCA ACCGCCATGG ATTGGTTCAT AGCTGTATGC 
TTTGCGTTTG TCTTTTCTGC TCTCATTGAA TTCGCAGCTG TCAACTACTT CACCAATCTC 
CAGTCCCAGA AAGCCGAAAG GCAGGCACAG ACTGCAGCCA AGCCCCCGGT AGCAAAGTCA 
AAAACAACTG AATCACTGGA AGCTGAGATT GTTGTGCACT CTGACTCCAA GTACCATCTG 
AAGAAGAGAA TCAGCTCTCT GACTTTGCCA ATCGTTCCAT CTTCTGAGGC CAGCAAAGTC 
CTCAGTAGAA CGCCCATCTT ACCATCAACG CCGGTCACTC CCCCATTGCT CTTACCAGCC 
ATTGGCGGCA CCAGCAAAAT AGATCAATAT TCTCGAATTC TCTTCCCAGT AGCATTTGCA 
GGATTCAACC TTGTGTACTG GATAGTTTAC CTTTCCAAAG ATACAATGGA AGTGAGCAGT 
ACTGTCGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006246190.1
CDS	391..1722
Translation	MLLLLPWLFSLLWIENAQAQLEDEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMTWTDERLKFKGPAEILSLNNLMVSKIWTPDTFFQNGKKSIAHNMTTPNKLFRLMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQSQKAERQAQTAAKPPVAKSKTTESLEAEIVVHSDSKYHLKKRISSLTLPIVPSSEASKVLSRTPILPSTPVTPPLLLPAIGGTSKIDQYSRILFPVAFAGFNLVYWIVYLSKDTMEVSSTVE

Target ORF information:

RefSeq Version	XM_006246128.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus gamma-aminobutyric acid type A receptor alpha 6 subunit (Gabra6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006246128.3

ORF Insert Sequence:

ATGCTGTTGC TTCTCCCCTG GCTCTTCAGT TTACTATGGA TAGAAAATGC CCAAGCTCAA 
CTTGAAGATG AAGGGAACTT CTATTCTGAA AATGTCAGTC GGATTCTTGA CAACTTGCTG 
GAGGGCTATG ACAACCGTCT ACGGCCGGGA TTTGGAGGTG CTGTAACAGA GGTCAAAACA 
GATATCTATG TGACCAGCTT TGGGCCTGTG TCAGATGTGG AGATGACATG GACTGATGAG 
AGGCTGAAGT TCAAAGGCCC TGCTGAGATT TTGAGTTTAA ATAACTTGAT GGTCAGTAAG 
ATCTGGACTC CGGACACATT TTTCCAAAAT GGGAAAAAGT CAATTGCTCA CAACATGACC 
ACCCCTAACA AACTCTTCCG ATTGATGCAG AATGGAACGA TCCTGTACAC CATGAGGCTT 
ACCATCAACG CTGACTGTCC GATGAGACTG GTTAACTTCC CTATGGATGG ACACGCATGT 
CCACTCAAGT TTGGGAGCTA TGCCTATCCG AAAAGCGAAA TCATATATAC ATGGAAAAAA 
GGACCGCTTT ATTCAGTAGA GGTCCCAGAA GAATCTTCAA GCCTCCTCCA GTATGATTTG 
ATTGGGCAAA CAGTTTCTAG TGAGACTATT AAATCGAACA CAGGTGAATA TGTAATAATG 
ACAGTCTACT TCCACTTACA AAGGAAGATG GGCTATTTCA TGATCCAGAT TTACACTCCG 
TGCATCATGA CAGTCATTCT CTCTCAAGTG TCTTTCTGGA TTAATAAGGA GTCGGTCCCA 
GCAAGAACCG TCTTTGGAAT CACCACGGTT TTAACCATGA CCACCTTAAG CATCAGTGCT 
CGGCACTCTC TACCCAAAGT GTCCTATGCA ACCGCCATGG ATTGGTTCAT AGCTGTATGC 
TTTGCGTTTG TCTTTTCTGC TCTCATTGAA TTCGCAGCTG TCAACTACTT CACCAATCTC 
CAGTCCCAGA AAGCCGAAAG GCAGGCACAG ACTGCAGCCA AGCCCCCGGT AGCAAAGTCA 
AAAACAACTG AATCACTGGA AGCTGAGATT GTTGTGCACT CTGACTCCAA GTACCATCTG 
AAGAAGAGAA TCAGCTCTCT GACTTTGCCA ATCGTTCCAT CTTCTGAGGC CAGCAAAGTC 
CTCAGTAGAA CGCCCATCTT ACCATCAACG CCGGTCACTC CCCCATTGCT CTTACCAGCC 
ATTGGCGGCA CCAGCAAAAT AGATCAATAT TCTCGAATTC TCTTCCCAGT AGCATTTGCA 
GGATTCAACC TTGTGTACTG GATAGTTTAC CTTTCCAAAG ATACAATGGA AGTGAGCAGT 
ACTGTCGAGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Gabra6 ( XM_008767636.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008765858.1 Rattus norvegicus gamma-aminobutyric acid type A receptor alpha 6 subunit (Gabra6), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa43352
Clone ID Related Accession (Same CDS sequence)	XM_008767636.2
Accession Version	XM_008767636.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1161bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	gamma-aminobutyric acid receptor subunit alpha-6 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005109.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008767636.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATATTTC TTTCCAGTTT CCAGGAGTAC ACAATGGATG TTTTCTTCCG ACAGACATGG 
ACTGATGAGA GGCTGAAGTT CAAAGGCCCT GCTGAGATTT TGAGTTTAAA TAACTTGATG 
GTCAGTAAGA TCTGGACTCC GGACACATTT TTCCAAAATG GGAAAAAGTC AATTGCTCAC 
AACATGACCA CCCCTAACAA ACTCTTCCGA TTGATGCAGA ATGGAACGAT CCTGTACACC 
ATGAGGCTTA CCATCAACGC TGACTGTCCG ATGAGACTGG TTAACTTCCC TATGGATGGA 
CACGCATGTC CACTCAAGTT TGGGAGCTAT GCCTATCCGA AAAGCGAAAT CATATATACA 
TGGAAAAAAG GACCGCTTTA TTCAGTAGAG GTCCCAGAAG AATCTTCAAG CCTCCTCCAG 
TATGATTTGA TTGGGCAAAC AGTTTCTAGT GAGACTATTA AATCGAACAC AGGTGAATAT 
GTAATAATGA CAGTCTACTT CCACTTACAA AGGAAGATGG GCTATTTCAT GATCCAGATT 
TACACTCCGT GCATCATGAC AGTCATTCTC TCTCAAGTGT CTTTCTGGAT TAATAAGGAG 
TCGGTCCCAG CAAGAACCGT CTTTGGAATC ACCACGGTTT TAACCATGAC CACCTTAAGC 
ATCAGTGCTC GGCACTCTCT ACCCAAAGTG TCCTATGCAA CCGCCATGGA TTGGTTCATA 
GCTGTATGCT TTGCGTTTGT CTTTTCTGCT CTCATTGAAT TCGCAGCTGT CAACTACTTC 
ACCAATCTCC AGTCCCAGAA AGCCGAAAGG CAGGCACAGA CTGCAGCCAA GCCCCCGGTA 
GCAAAGTCAA AAACAACTGA ATCACTGGAA GCTGAGATTG TTGTGCACTC TGACTCCAAG 
TACCATCTGA AGAAGAGAAT CAGCTCTCTG ACTTTGCCAA TCGTTCCATC TTCTGAGGCC 
AGCAAAGTCC TCAGTAGAAC GCCCATCTTA CCATCAACGC CGGTCACTCC CCCATTGCTC 
TTACCAGCCA TTGGCGGCAC CAGCAAAATA GATCAATATT CTCGAATTCT CTTCCCAGTA 
GCATTTGCAG GATTCAACCT TGTGTACTGG ATAGTTTACC TTTCCAAAGA TACAATGGAA 
GTGAGCAGTA CTGTCGAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008765858.1
CDS	416..1576
Translation	MIFLSSFQEYTMDVFFRQTWTDERLKFKGPAEILSLNNLMVSKIWTPDTFFQNGKKSIAHNMTTPNKLFRLMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQSQKAERQAQTAAKPPVAKSKTTESLEAEIVVHSDSKYHLKKRISSLTLPIVPSSEASKVLSRTPILPSTPVTPPLLLPAIGGTSKIDQYSRILFPVAFAGFNLVYWIVYLSKDTMEVSSTVE

Target ORF information:

RefSeq Version	XM_008767636.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus gamma-aminobutyric acid type A receptor alpha 6 subunit (Gabra6), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008767636.2

ORF Insert Sequence:

ATGATATTTC TTTCCAGTTT CCAGGAGTAC ACAATGGATG TTTTCTTCCG ACAGACATGG 
ACTGATGAGA GGCTGAAGTT CAAAGGCCCT GCTGAGATTT TGAGTTTAAA TAACTTGATG 
GTCAGTAAGA TCTGGACTCC GGACACATTT TTCCAAAATG GGAAAAAGTC AATTGCTCAC 
AACATGACCA CCCCTAACAA ACTCTTCCGA TTGATGCAGA ATGGAACGAT CCTGTACACC 
ATGAGGCTTA CCATCAACGC TGACTGTCCG ATGAGACTGG TTAACTTCCC TATGGATGGA 
CACGCATGTC CACTCAAGTT TGGGAGCTAT GCCTATCCGA AAAGCGAAAT CATATATACA 
TGGAAAAAAG GACCGCTTTA TTCAGTAGAG GTCCCAGAAG AATCTTCAAG CCTCCTCCAG 
TATGATTTGA TTGGGCAAAC AGTTTCTAGT GAGACTATTA AATCGAACAC AGGTGAATAT 
GTAATAATGA CAGTCTACTT CCACTTACAA AGGAAGATGG GCTATTTCAT GATCCAGATT 
TACACTCCGT GCATCATGAC AGTCATTCTC TCTCAAGTGT CTTTCTGGAT TAATAAGGAG 
TCGGTCCCAG CAAGAACCGT CTTTGGAATC ACCACGGTTT TAACCATGAC CACCTTAAGC 
ATCAGTGCTC GGCACTCTCT ACCCAAAGTG TCCTATGCAA CCGCCATGGA TTGGTTCATA 
GCTGTATGCT TTGCGTTTGT CTTTTCTGCT CTCATTGAAT TCGCAGCTGT CAACTACTTC 
ACCAATCTCC AGTCCCAGAA AGCCGAAAGG CAGGCACAGA CTGCAGCCAA GCCCCCGGTA 
GCAAAGTCAA AAACAACTGA ATCACTGGAA GCTGAGATTG TTGTGCACTC TGACTCCAAG 
TACCATCTGA AGAAGAGAAT CAGCTCTCTG ACTTTGCCAA TCGTTCCATC TTCTGAGGCC 
AGCAAAGTCC TCAGTAGAAC GCCCATCTTA CCATCAACGC CGGTCACTCC CCCATTGCTC 
TTACCAGCCA TTGGCGGCAC CAGCAAAATA GATCAATATT CTCGAATTCT CTTCCCAGTA 
GCATTTGCAG GATTCAACCT TGTGTACTGG ATAGTTTACC TTTCCAAAGA TACAATGGAA 
GTGAGCAGTA CTGTCGAGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The essential role of hippocampal alpha6 subunit-containing GABAA receptors in maternal separation stress-induced adolescent depressive behaviors.
Behavioural brain research313135-43(2016 10)
Yang L,Xu T,Zhang K,Wei Z,Li X,Huang M,Rose GM,Cai X

?6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience35(26)9676-88(2015 Jul)
Accardi MV,Brown PM,Miraucourt LS,Orser BA,Bowie D

Infusion of Gabr?6 siRNA into the trigeminal ganglia increased the myogenic orofacial nociceptive response of ovariectomized rats treated with 17?-estradiol.
Neuroscience278144-53(2014 Oct)
Kramer PR,Bellinger LL

Reduced GABAA receptor ?6 expression in the trigeminal ganglion enhanced myofascial nociceptive response.
Neuroscience2451-11(2013 Aug)
Kramer PR,Bellinger LL

Reduced GABA(A) receptor ?6 expression in the trigeminal ganglion alters inflammatory TMJ hypersensitivity.
Neuroscience213179-90(2012 Jun)
Puri J,Vinothini P,Reuben J,Bellinger LL,Ailing L,Peng YB,Kramer PR

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Gabra6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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