Gabrd cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gabrd
Entrez Gene ID	29689
Full Name	gamma-aminobutyric acid type A receptor delta subunit
Synonyms	GABAA-RD
General protein information	Preferred Names gamma-aminobutyric acid type A receptor delta subunit Names gamma-aminobutyric acid receptor subunit delta GABA(A) receptor subunit delta GABA-A receptor delta-subunit GABAA receptor delta subunit gamma-aminobutyric acid A receptor, delta gamma-aminobutyric acid (GABA) A receptor, delta gamma-aminobutyric acid (GABA-A) receptor, subunit delta
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36
Summary	GABA-A receptor subunit that contributes to slow phases of GABA-induced desensitization; plays a role in synaptic transmission [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017289.1	NP_058985.1	gamma-aminobutyric acid receptor subunit delta precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	GABRD	NP_001075184.1
Pan troglodytes (chimpanzee)	GABRD	XP_001156161.1
Gallus gallus (chicken)	GABRD	XP_001234041.2
Canis lupus familiaris (dog)	GABRD	XP_005620471.1
Rattus norvegicus (Norway rat)	Gabrd	NP_058985.1
Danio rerio (zebrafish)	gabrd	XP_700099.5
Xenopus tropicalis (tropical clawed frog)	gabrd	XP_002936608.2
Homo sapiens (human)	GABRD	NP_000806.2
Mus musculus (house mouse)	Gabrd	NP_032098.2

Gene Ontology
Bibliography

Related articles in PubMed

Toward Understanding Functional Properties and Subunit Arrangement of ?4?2? ?-Aminobutyric Acid, Type A (GABAA) Receptors.
Wongsamitkul N, Baur R, Sigel E
The Journal of biological chemistry291(35)18474-83(2016 08)

Etomidate produces similar allosteric modulation in ?1?3? and ?1?3?2L GABA(A) receptors.
Feng HJ, Jounaidi Y, Haburcak M, Yang X, Forman SA
British journal of pharmacology171(3)789-98(2014 Feb)

The influence of stress at puberty on mood and learning: role of the ?4?? GABAA receptor.
Smith SS
Neuroscience249192-213(2013 Sep)

Altered gamma oscillations during pregnancy through loss of ? subunit-containing GABA(A) receptors on parvalbumin interneurons.
Ferando I, Mody I
Frontiers in neural circuits7144(2013)

Adolescent female rats exhibiting activity-based anorexia express elevated levels of GABA(A) receptor ?4 and ? subunits at the plasma membrane of hippocampal CA1 spines.
Aoki C, Sabaliauskas N, Chowdhury T, Min JY, Colacino AR, Laurino K, Barbarich-Marsteller NC
Synapse (New York, N.Y.)66(5)391-407(2012 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the subunit arrangement of alpha4beta2delta GABAA receptors is not strongly predefined but is mostly satisfying the 2:2:1 subunit stoichiometry for alpha4, beta2, and delta subunits and that several subunit arrangements result in receptors with similar functional properties tuned to physiological conditions.
Title: Toward Understanding Functional Properties and Subunit Arrangement of ?4?2? ?-Aminobutyric Acid, Type A (GABAA) Receptors.

Data suggest that GABA(A) receptor subunits (alpha-1 and beta-3) are able to form homologous receptors with either delta (extrasynaptic) or gamma-2 subunits (synaptic); allosteric modulation appears similar in the presence of agonist etomidate.
Title: Etomidate produces similar allosteric modulation in ?1?3? and ?1?3?2L GABA(A) receptors.

Expression of alpha4betadelta GABA receptors increases on the dendrites of CA1 pyramidal cells at the onset of puberty in the hippocampus, part of the limbic circuitry which governs emotion.
Title: The influence of stress at puberty on mood and learning: role of the ?4?? GABAA receptor.

pregnancy may provoke perturbations in gamma oscillatory activity through direct effects on the GABAergic system, and underscore the importance of delta-GABA(A)Rs homeostatic plasticity in maintaining constant network output despite large hormonal changes.
Title: Altered gamma oscillations during pregnancy through loss of ? subunit-containing GABA(A) receptors on parvalbumin interneurons.

Adolescent female rats exhibiting activity-based anorexia express elevated levels of GABAA receptor delta subunit at the plasma membrane of hippocampal CA1 spines
Title: Adolescent female rats exhibiting activity-based anorexia express elevated levels of GABA(A) receptor ?4 and ? subunits at the plasma membrane of hippocampal CA1 spines.

The following Gabrd gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gabrd cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12749	NM_017289.1 Latest version!	Rattus norvegicus gamma-aminobutyric acid type A receptor subunit delta (Gabrd), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gabrd ( NM_017289.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058985.1 Rattus norvegicus gamma-aminobutyric acid type A receptor subunit delta (Gabrd), mRNA.

Price & Availability↑

CloneID	ORa12749
Clone ID Related Accession (Same CDS sequence)	NM_017289.1
Accession Version	NM_017289.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1350bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-10
Organism	Rattus norvegicus(Norway rat)
Product	gamma-aminobutyric acid receptor subunit delta precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M35162.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M35162.1, BC087714.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGACGTTC TGGGCTGGCT GCTGCTGCCG CTCCTTCTGC TGTGCACGCA GCCGCACCAT 
GGCGCCAGAG CAATGAATGA CATTGGGGAC TACGTGGGCT CCAACCTGGA GATATCCTGG 
CTCCCCAACC TGGATGGACT AATGGAGGGC TACGCCCGAA ACTTCCGACC AGGCATTGGA 
GGTCCTCCAG TGAATGTGGC GCTTGCCCTA GAGGTGGCCA GCATTGACCA CATCTCAGAA 
GCAAATATGG AATACACCAT GACAGTGTTC CTGCACCAGA GCTGGCGAGA CAGCAGGCTG 
TCCTACAACC ATACCAACGA GACCCTGGGC CTGGATAGCC GCTTCGTGGA CAAGCTGTGG 
CTCCCTGACA CCTTCATTGT GAATGCCAAG TCTGCCTGGT TCCATGATGT GACCGTGGAA 
AACAAGCTTA TCCGCCTACA GCCCGACGGT GTGATTTTAT ACAGCATCCG CATCACCTCC 
ACAGTGGCCT GTGACATGGA CCTTGCCAAG TACCCCATGG ACGAGCAGGA GTGCATGCTG 
GACCTGGAGA GCTATGGCTA CTCTTCTGAG GACATTGTCT ATTATTGGTC AGAAAACCAG 
GAGCAGATCC ACGGGCTGGA CAGGCTGCAA CTGGCCCAGT TCACTATCAC CAGTTACCGC 
TTCACCACGG AGCTGATGAA CTTCAAATCA GCTGGCCAGT TCCCTCGACT CAGCTTACAC 
TTCCAGCTTC GGAGGAACCG GGGTGTCTAC ATCATCCAGT CTTACATGCC CTCTGTCCTC 
CTGGTTGCCA TGTCCTGGGT CTCCTTCTGG ATTAGCCAAG CAGCAGTGCC TGCCAGAGTA 
TCTCTAGGCA TCACCACTGT GCTGACAATG ACCACACTCA TGGTTAGTGC CCGCTCCTCC 
CTCCCGCGGG CTTCTGCTAT CAAGGCTCTG GATGTGTATT TCTGGATCTG CTATGTCTTC 
GTGTTTGCTG CCCTGGTGGA GTATGCATTT GCCCACTTCA ATGCTGACTA CAGGAAGAAA 
CGGAAAGCCA AGGTCAAGGT CACGAAGCCA AGGGCAGAGA TGGACGTGAG GAACGCCATT 
GTCCTCTTCT CCCTCTCTGC TGCTGGGGTC AGCCAGGAGT TGGCTATCTC CCGCCGTCAA 
GGCCGGGTCC CTGGGAACCT CATGGGTTCC TATAGGTCTG TAGAAGTGGA GGCAAAGAAG 
GAGGGGGGGT CCCGCCCAGG AGGCCCAGGA GGCATCCGTT CCAGACTCAA ACCCATCGAT 
GCAGACACCA TCGACATCTA TGCCCGCGCT GTGTTCCCGG CAGCCTTTGC AGCAGTCAAC 
ATCATCTACT GGGCGGCGTA TACCATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058985.1
CDS	50..1399
Translation	MDVLGWLLLPLLLLCTQPHHGARAMNDIGDYVGSNLEISWLPNLDGLMEGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSENQEQIHGLDRLQLAQFTITSYRFTTELMNFKSAGQFPRLSLHFQLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKRKAKVKVTKPRAEMDVRNAIVLFSLSAAGVSQELAISRRQGRVPGNLMGSYRSVEVEAKKEGGSRPGGPGGIRSRLKPIDADTIDIYARAVFPAAFAAVNIIYWAAYTM

Target ORF information:

RefSeq Version	NM_017289.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus gamma-aminobutyric acid type A receptor subunit delta (Gabrd), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017289.1

ORF Insert Sequence:

ATGGACGTTC TGGGCTGGCT GCTGCTGCCG CTCCTTCTGC TGTGCACGCA GCCGCACCAT 
GGCGCCAGAG CAATGAATGA CATTGGGGAC TACGTGGGCT CCAACCTGGA GATATCCTGG 
CTCCCCAACC TGGATGGACT AATGGAGGGC TACGCCCGAA ACTTCCGACC AGGCATTGGA 
GGTCCTCCAG TGAATGTGGC GCTTGCCCTA GAGGTGGCCA GCATTGACCA CATCTCAGAA 
GCAAATATGG AATACACCAT GACAGTGTTC CTGCACCAGA GCTGGCGAGA CAGCAGGCTG 
TCCTACAACC ATACCAACGA GACCCTGGGC CTGGATAGCC GCTTCGTGGA CAAGCTGTGG 
CTCCCTGACA CCTTCATTGT GAATGCCAAG TCTGCCTGGT TCCATGATGT GACCGTGGAA 
AACAAGCTTA TCCGCCTACA GCCCGACGGT GTGATTTTAT ACAGCATCCG CATCACCTCC 
ACAGTGGCCT GTGACATGGA CCTTGCCAAG TACCCCATGG ACGAGCAGGA GTGCATGCTG 
GACCTGGAGA GCTATGGCTA CTCTTCTGAG GACATTGTCT ATTATTGGTC AGAAAACCAG 
GAGCAGATCC ACGGGCTGGA CAGGCTGCAA CTGGCCCAGT TCACTATCAC CAGTTACCGC 
TTCACCACGG AGCTGATGAA CTTCAAATCA GCTGGCCAGT TCCCTCGACT CAGCTTACAC 
TTCCAGCTTC GGAGGAACCG GGGTGTCTAC ATCATCCAGT CTTACATGCC CTCTGTCCTC 
CTGGTTGCCA TGTCCTGGGT CTCCTTCTGG ATTAGCCAAG CAGCAGTGCC TGCCAGAGTA 
TCTCTAGGCA TCACCACTGT GCTGACAATG ACCACACTCA TGGTTAGTGC CCGCTCCTCC 
CTCCCGCGGG CTTCTGCTAT CAAGGCTCTG GATGTGTATT TCTGGATCTG CTATGTCTTC 
GTGTTTGCTG CCCTGGTGGA GTATGCATTT GCCCACTTCA ATGCTGACTA CAGGAAGAAA 
CGGAAAGCCA AGGTCAAGGT CACGAAGCCA AGGGCAGAGA TGGACGTGAG GAACGCCATT 
GTCCTCTTCT CCCTCTCTGC TGCTGGGGTC AGCCAGGAGT TGGCTATCTC CCGCCGTCAA 
GGCCGGGTCC CTGGGAACCT CATGGGTTCC TATAGGTCTG TAGAAGTGGA GGCAAAGAAG 
GAGGGGGGGT CCCGCCCAGG AGGCCCAGGA GGCATCCGTT CCAGACTCAA ACCCATCGAT 
GCAGACACCA TCGACATCTA TGCCCGCGCT GTGTTCCCGG CAGCCTTTGC AGCAGTCAAC 
ATCATCTACT GGGCGGCGTA TACCATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Toward Understanding Functional Properties and Subunit Arrangement of ?4?2? ?-Aminobutyric Acid, Type A (GABAA) Receptors.
The Journal of biological chemistry291(35)18474-83(2016 08)
Wongsamitkul N,Baur R,Sigel E

Etomidate produces similar allosteric modulation in ?1?3? and ?1?3?2L GABA(A) receptors.
British journal of pharmacology171(3)789-98(2014 Feb)
Feng HJ,Jounaidi Y,Haburcak M,Yang X,Forman SA

The influence of stress at puberty on mood and learning: role of the ?4?? GABAA receptor.
Neuroscience249192-213(2013 Sep)
Smith SS

Altered gamma oscillations during pregnancy through loss of ? subunit-containing GABA(A) receptors on parvalbumin interneurons.
Frontiers in neural circuits7144(2013)
Ferando I,Mody I

Adolescent female rats exhibiting activity-based anorexia express elevated levels of GABA(A) receptor ?4 and ? subunits at the plasma membrane of hippocampal CA1 spines.
Synapse (New York, N.Y.)66(5)391-407(2012 May)
Aoki C,Sabaliauskas N,Chowdhury T,Min JY,Colacino AR,Laurino K,Barbarich-Marsteller NC

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Gabrd cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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