C1qbp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	C1qbp
Entrez Gene ID	29681
Full Name	complement C1q binding protein
Synonyms	Habp1,gC1qR
General protein information	Preferred Names complement C1q binding protein Names complement component 1 Q subcomponent-binding protein, mitochondrial GC1q-R protein complement component 1, q subcomponent binding protein glycoprotein gC1qBP
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q24
Summary	binds to the globular heads of complement component C1q [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019259.2	NP_062132.2	complement component 1 Q subcomponent-binding protein, mitochondrial precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	C1QBP	NP_001203.1
Canis lupus familiaris (dog)	C1QBP	XP_546568.2
Mus musculus (house mouse)	C1qbp	NP_031599.2
	LOC711817	XP_001100940.1
Bos taurus (cattle)	C1QBP	NP_001029699.1
Rattus norvegicus (Norway rat)	C1qbp	NP_062132.2
Drosophila melanogaster (fruit fly)	P32	NP_611243.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003987	XP_318437.3
Caenorhabditis elegans (roundworm)	cri-3	NP_497701.1
Gallus gallus (chicken)	C1QBP	XP_415748.4
Xenopus tropicalis (tropical clawed frog)	c1qbp	XP_002936868.2
Pan troglodytes (chimpanzee)	C1QBP	XP_003952998.1
Danio rerio (zebrafish)	c1qbp	NP_001017858.2

Gene Ontology
Bibliography

Related articles in PubMed

Synaptic proteome changes in the hypothalamus of mother rats.
Udvari EB, V?lgyi K, Guly?ssy P, Dim?n D, Kis V, Barna J, Szab? ?R, Lubec G, Juh?sz G, K?kesi KA, Dobolyi ?
Journal of proteomics15954-66(2017 04)

Disrupted hyaluronan binding protein 1 (HABP1) expression: one of the key mediator for ovarian dysfunction in polycystic ovary rat.
Arif M, Thakur SC, Datta K
Molecular and cellular biochemistry398(1-2)233-44(2015 Jan)

Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses.
Boyken J, Gr?nborg M, Riedel D, Urlaub H, Jahn R, Chua JJ
Neuron78(2)285-97(2013 Apr)

p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability.
Yagi M, Uchiumi T, Takazaki S, Okuno B, Nomura M, Yoshida S, Kanki T, Kang D
Nucleic acids research40(19)9717-37(2012 Oct)

Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles.
Yoshikawa H, Komatsu W, Hayano T, Miura Y, Homma K, Izumikawa K, Ishikawa H, Miyazawa N, Tachikawa H, Yamauchi Y, Isobe T, Takahashi N
Molecular & cellular proteomics : MCP10(8)M110.006148(2011 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that disrupted ovarian hyaluronan binding protein 1 (HABP1) along with concurrent altered expression and hyperactivation of related MMPs can lead to abnormal follicular maturation resulting into ovarian dysfunction in polycystic ovary (PCO).
Title: Disrupted hyaluronan binding protein 1 (HABP1) expression: one of the key mediator for ovarian dysfunction in polycystic ovary rat.

findings indicate a possible role for HABP1 proprotein in apoptosis induction of germ cells in the cryptorchid testes
Title: Simultaneous accumulation of hyaluronan binding protein 1 (HABP1/p32/gC1qR) and apoptotic induction of germ cells in cryptorchid testis.

The present study provides evidence of the ability of soluble gC1qR to enhance S. aureus-fibrinogen interactions via simultaneously binding fibrinogen and S. aureus in a S. aureus endocarditis model. [gClqR/p33]
Title: gC1qR/p33 blockade reduces Staphylococcus aureus colonization of target tissues in an animal model of infective endocarditis.

these findings demonstrate the appearance of HABP1 proprotein in the pachytene spermatocytes and the round spermatids during the initial stages of postnatal testis development and suggest that this expression may be crucial for spermatogenesis.
Title: Appearance of hyaluronan binding protein 1 proprotein in pachytene spermatocytes and round spermatids correlates with spermatogenesis.

These studies suggest that gC1qR interacts specifically with alpha1B- and alpha1D-, but not alpha1A-ARs, and this interaction depends on the presence of an intact C-tail [gC1qR].
Title: Specific interactions between gC1qR and alpha1-adrenoceptor subtypes.

The following C1qbp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C1qbp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12940	NM_019259.2 Latest version!	Rattus norvegicus complement C1q binding protein (C1qbp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C1qbp ( NM_019259.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062132.2 Rattus norvegicus complement C1q binding protein (C1qbp), mRNA.

Price & Availability↑

CloneID	ORa12940
Clone ID Related Accession (Same CDS sequence)	NM_019259.2
Accession Version	NM_019259.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 840bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	complement component 1 Q subcomponent-binding protein, mitochondrial precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC070510.1. On or before Aug 30, 2004 this sequence version replaced XM_346398.1, NM_019259.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC070510.1, FQ214480.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689601, SAMN01906347 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGCTCCCTC TGCTGCGCTG CGTGCCCCGC GCCCTGGGTG CCGCCGCCAC GGGCCTCCGA 
GCCTCCATCC CGGCCCCGCC GCTTCGGCAT TTACTGCAGC CCGCGCCCCG GCCATGCCTC 
CGGCCCTTCG GTTTGCTCAG CGTACGAGCC GGCTCCGCTC GGCGCTCTGG CCTCCTGCAG 
CCCCCGGTTC CCTGCGCGTG CGGCTGCGGC GCTCTGCACA CGGAAGGAGA CAAGGCCTTT 
GTTGAATTTT TGACTGATGA AATTAAGGAA GAAAAGAAGA TCCAGAAGCA TAAGTCCCTT 
CCCAAAATGT CTGGAGATTG GGAGCTGGAA GTGAACGGCA CGGAGGCTAA ATTATTGCGC 
AAAGTTGCCG GAGAAAAGAT CACTGTCACT TTCAACATTA ACAATAGCAT CCCTCCAACC 
TTTGATGGTG AAGAGGAGCC CTCACAGGGG CAGAAGGCCG AAGAGCAGGA GCCAGAACTG 
ACATCAACTC CCAATTTTGT GGTTGAAGTT ACAAAGACTG ATGGCAAGAA GACCCTTGTA 
CTGGACTGCC ACTATCCTGA GGACGAGATC GGACACGAAG ATGAGGCCGA GAGTGACATT 
TTCTCTATTA AGGAAGTGAG CTTTCAGACC ACTGGTGACT CTGAGTGGAG GGATACAAAC 
TACACACTCA ACACAGACTC CCTGGACTGG GCCTTGTATG ACCACCTAAT GGATTTCCTT 
GCGGACCGAG GGGTGGATAA CACTTTTGCA GATGAGTTGG TGGAGCTCAG CACAGCCCTG 
GAGCACCAGG AATATATCAC CTTTCTTGAG GACCTCAAAA GCTTTGTCAA GAGTCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062132.2
CDS	2..841
Translation	MLPLLRCVPRALGAAATGLRASIPAPPLRHLLQPAPRPCLRPFGLLSVRAGSARRSGLLQPPVPCACGCGALHTEGDKAFVEFLTDEIKEEKKIQKHKSLPKMSGDWELEVNGTEAKLLRKVAGEKITVTFNINNSIPPTFDGEEEPSQGQKAEEQEPELTSTPNFVVEVTKTDGKKTLVLDCHYPEDEIGHEDEAESDIFSIKEVSFQTTGDSEWRDTNYTLNTDSLDWALYDHLMDFLADRGVDNTFADELVELSTALEHQEYITFLEDLKSFVKSQ

Target ORF information:

RefSeq Version	NM_019259.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus complement C1q binding protein (C1qbp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019259.2

ORF Insert Sequence:

ATGCTCCCTC TGCTGCGCTG CGTGCCCCGC GCCCTGGGTG CCGCCGCCAC GGGCCTCCGA 
GCCTCCATCC CGGCCCCGCC GCTTCGGCAT TTACTGCAGC CCGCGCCCCG GCCATGCCTC 
CGGCCCTTCG GTTTGCTCAG CGTACGAGCC GGCTCCGCTC GGCGCTCTGG CCTCCTGCAG 
CCCCCGGTTC CCTGCGCGTG CGGCTGCGGC GCTCTGCACA CGGAAGGAGA CAAGGCCTTT 
GTTGAATTTT TGACTGATGA AATTAAGGAA GAAAAGAAGA TCCAGAAGCA TAAGTCCCTT 
CCCAAAATGT CTGGAGATTG GGAGCTGGAA GTGAACGGCA CGGAGGCTAA ATTATTGCGC 
AAAGTTGCCG GAGAAAAGAT CACTGTCACT TTCAACATTA ACAATAGCAT CCCTCCAACC 
TTTGATGGTG AAGAGGAGCC CTCACAGGGG CAGAAGGCCG AAGAGCAGGA GCCAGAACTG 
ACATCAACTC CCAATTTTGT GGTTGAAGTT ACAAAGACTG ATGGCAAGAA GACCCTTGTA 
CTGGACTGCC ACTATCCTGA GGACGAGATC GGACACGAAG ATGAGGCCGA GAGTGACATT 
TTCTCTATTA AGGAAGTGAG CTTTCAGACC ACTGGTGACT CTGAGTGGAG GGATACAAAC 
TACACACTCA ACACAGACTC CCTGGACTGG GCCTTGTATG ACCACCTAAT GGATTTCCTT 
GCGGACCGAG GGGTGGATAA CACTTTTGCA GATGAGTTGG TGGAGCTCAG CACAGCCCTG 
GAGCACCAGG AATATATCAC CTTTCTTGAG GACCTCAAAA GCTTTGTCAA GAGTCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Synaptic proteome changes in the hypothalamus of mother rats.
Journal of proteomics15954-66(2017 04)
Udvari EB,V?lgyi K,Guly?ssy P,Dim?n D,Kis V,Barna J,Szab? ?R,Lubec G,Juh?sz G,K?kesi KA,Dobolyi ?

Disrupted hyaluronan binding protein 1 (HABP1) expression: one of the key mediator for ovarian dysfunction in polycystic ovary rat.
Molecular and cellular biochemistry398(1-2)233-44(2015 Jan)
Arif M,Thakur SC,Datta K

Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses.
Neuron78(2)285-97(2013 Apr)
Boyken J,Gr?nborg M,Riedel D,Urlaub H,Jahn R,Chua JJ

p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability.
Nucleic acids research40(19)9717-37(2012 Oct)
Yagi M,Uchiumi T,Takazaki S,Okuno B,Nomura M,Yoshida S,Kanki T,Kang D

Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles.
Molecular & cellular proteomics : MCP10(8)M110.006148(2011 Aug)
Yoshikawa H,Komatsu W,Hayano T,Miura Y,Homma K,Izumikawa K,Ishikawa H,Miyazawa N,Tachikawa H,Yamauchi Y,Isobe T,Takahashi N

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C1qbp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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