Nub1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nub1
Entrez Gene ID	296731
Full Name	negative regulator of ubiquitin-like proteins 1
Synonyms	BS4,NYREN18
General protein information	Preferred Names negative regulator of ubiquitin-like proteins 1 Names NEDD8 ultimate buster 1 NY-REN-18 antigen
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001013925.1	NP_001013947.1	NEDD8 ultimate buster 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NUB1	XP_532765.3
Bos taurus (cattle)	NUB1	NP_001074375.1
	NUB1	XP_001104453.2
Drosophila melanogaster (fruit fly)	CG5111	NP_651402.1
Homo sapiens (human)	NUB1	NP_001230280.1
Rattus norvegicus (Norway rat)	Nub1	NP_001013947.1
Danio rerio (zebrafish)	nub1	XP_005170703.1
Drosophila melanogaster (fruit fly)	CG15445	NP_728390.1
Pan troglodytes (chimpanzee)	NUB1	XP_003318970.1
Mus musculus (house mouse)	Nub1	NP_058016.2
Gallus gallus (chicken)	NUB1	NP_001264424.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011519	XP_307212.4
Arabidopsis thaliana (thale cress)	AT2G12550	NP_178939.2
Xenopus tropicalis (tropical clawed frog)	nub1	NP_001017076.2

Gene Ontology
Bibliography

Related articles in PubMed

NUB1 modulation of GSK3? reduces tau aggregation.
Richet E, Pooler AM, Rodriguez T, Novoselov SS, Schmidtke G, Groettrup M, Hanger DP, Cheetham ME, van der Spuy J
Human molecular genetics21(24)5254-67(2012 Dec)

The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10.
Schmidtke G, Kalveram B, Weber E, Bochtler P, Lukasiak S, Hipp MS, Groettrup M
The Journal of biological chemistry281(29)20045-54(2006 Jul)

Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins.
Parry G, Estelle M
Seminars in cell & developmental biology15(2)221-9(2004 Apr)

NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression.
Kito K, Yeh ET, Kamitani T
The Journal of biological chemistry276(23)20603-9(2001 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data propose that NUB1, by regulating GSK3beta levels, modulates tau phosphorylation and aggregation, and is a key player in neurodegeneration associated with tau pathology.
Title: NUB1 modulation of GSK3? reduces tau aggregation.

The following Nub1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nub1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04292	NM_001013925.1 Latest version!	Rattus norvegicus negative regulator of ubiquitin-like proteins 1 (Nub1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nub1 ( NM_001013925.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001013947.1 Rattus norvegicus negative regulator of ubiquitin-like proteins 1 (Nub1), mRNA.

Price & Availability↑

CloneID	ORa04292
Clone ID Related Accession (Same CDS sequence)	NM_001013925.1
Accession Version	NM_001013925.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1842bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Rattus norvegicus(Norway rat)
Product	NEDD8 ultimate buster 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC083586.1. On Apr 20, 2005 this sequence version replaced XM_231280.3. ##Evidence-Data-START## Transcript exon combination :: BC083586.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGCAGA AGAAATATCT TCAAGCAAAA CTGACCCAGT TTCTAAGGGA AGACAGAATT 
CAACTTTGGA AACCTCCATA TACTGAAGAA AATAAAGAAG TTGGTTTGGC CTTAAAGGAC 
CTTGCTAAGA GGTACTCCGA GCGGCTAGAG TGCTGTGAAA ATGAAGTGGA AAACATAATA 
GAGGAAATCC GATGCAAAGC GATTGAGCGC GGCACTGGGA ATGAGCACTA CCGCACAACT 
GGGATTGCTA CGATTGAGGT GTTCCTGCCT CCGAGGCTCC GGAAAGATAA GAAAAGCTTG 
TTGGAGACCC GCTTGCATGT CACTGGTAGA GACCTGAGGA GTAAAATAGC TGAAACCTTT 
GGATTTCAAG AAAATTACAT CAAGATCGTA ATAAATAAGA AACAGCTTCA ACTAGGGAAA 
AGCCTTGAAG AGCAAGGAGT CACTCACAAT GTGAAGGCCA TGGTGTTGGA GCTGAAACAG 
TCTGAAGAGG ATGTGAGGAG AAACCTGCAG CTGGAGGAGG AGGAACAGAA CGAGGCTGAG 
CAGAAGGAGA AACGCATTCA GAGGACCAAA AGGGGACTGG AGATCCTGGC CGAGAGAGCT 
GAGATGGTGG TAGACCCGGA AACGATGCCT TACTTAGACA TTGCGAACCA GACTGGCAGG 
TCAATCAGAA TTCCCCCTTC AGAAAGAAAA GCCCTAATGT TAGCCATGGG GTACCATGAG 
AAGGGCAGGG CTTTCCTGAA AAGAAAAGAG TATGGGATAG CCTTGCCATG CCTTCTGGAC 
GCCGACAGAT ACTTCTGTGA GTGCAAAGAG CTGCTGGACA CTGTGGACAA CTATGCAGTC 
CTCCAGCTGG ACATCGTGTG GTGCTACTTC CGCCTGGAAC AGCTGGAGTG CCTTGATGAT 
GCAGAGAAAA AGCTGAACTT GGCCCAGACG TGCTTTACAA ACTGTTACGG GGAGAATCAC 
CAGAGACTGG TCAACATAAA AGGGAACTGT GGGAAAGAGA AGGTGTTGTT TTTAAGACTC 
TACTTGCTTC AGGGAATCCG AAACTATCAC AGTGGAAATG GAGAGGAGGC TCGGGAATAT 
CTCAACAAGG CACGTCAGCT CTTTAAAGAG CTGTACATCG ACCCATCGAA AGTTCACAAC 
TTGTTACAGT TGGGGTTCAC TGCCCAGGAA GCACGGCTGG GCCTGCGGGC CTGTGATGGG 
AACGTGGACC ACGCAGCCAC TCACATTTCC AACCGCAGAG AGGAACTGGC CCAGATACGG 
AAGGAAGAGA AGGAGAAGAG GAAACGCCGT CTGGAAAGTG TCAACACTTT GAGAGGAATG 
GGCTACTCCA CACAAGCTGC CAAACAAGCC CTTCACCAGG CCAGAGGCAA CCTGGACGAT 
GCCCTGAAGA TTCTCCTCAG CAACCCCCAC ATGTGGTGGT TACAGGATTC AGACTCTGAG 
AACAACAGCC GGCAAGCAAG CCCTTCCCAA GAAAGCATCG ACCAGCTGGT GTACATGGGC 
TTCGACACAG TGGTGGCCGA AGCTGCGCTG AGGGTGTTTG CAGGCAATGT CCAGCTGGCA 
GCTCAGACCC TGGCACACCA TGGAGGAAGC CTCCCTCCTG ACCTACAGTT CTCAGGAGAG 
GACTCCTCCT CCACCCCATC CACATCCCCG TCTGACTCCG CAGGGACCTC TAGTGCCTCC 
ACGGATGAGG ACATGGAGAC AGAGGCCGTG AACGAAATCC TGGAGGACAT TCCGGAGCAC 
GAGGAAGACT ACCTGGACTC CACACTGGAG GACGAAGAAG TCATCATCGC TGAGTACCTG 
TCCTACGTGG ACAGGACCAG TTCTGCCACA AAGGACAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001013947.1
CDS	94..1935
Translation	MAQKKYLQAKLTQFLREDRIQLWKPPYTEENKEVGLALKDLAKRYSERLECCENEVENIIEEIRCKAIERGTGNEHYRTTGIATIEVFLPPRLRKDKKSLLETRLHVTGRDLRSKIAETFGFQENYIKIVINKKQLQLGKSLEEQGVTHNVKAMVLELKQSEEDVRRNLQLEEEEQNEAEQKEKRIQRTKRGLEILAERAEMVVDPETMPYLDIANQTGRSIRIPPSERKALMLAMGYHEKGRAFLKRKEYGIALPCLLDADRYFCECKELLDTVDNYAVLQLDIVWCYFRLEQLECLDDAEKKLNLAQTCFTNCYGENHQRLVNIKGNCGKEKVLFLRLYLLQGIRNYHSGNGEEAREYLNKARQLFKELYIDPSKVHNLLQLGFTAQEARLGLRACDGNVDHAATHISNRREELAQIRKEEKEKRKRRLESVNTLRGMGYSTQAAKQALHQARGNLDDALKILLSNPHMWWLQDSDSENNSRQASPSQESIDQLVYMGFDTVVAEAALRVFAGNVQLAAQTLAHHGGSLPPDLQFSGEDSSSTPSTSPSDSAGTSSASTDEDMETEAVNEILEDIPEHEEDYLDSTLEDEEVIIAEYLSYVDRTSSATKDN

Target ORF information:

RefSeq Version	NM_001013925.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus negative regulator of ubiquitin-like proteins 1 (Nub1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001013925.1

ORF Insert Sequence:

ATGGCGCAGA AGAAATATCT TCAAGCAAAA CTGACCCAGT TTCTAAGGGA AGACAGAATT 
CAACTTTGGA AACCTCCATA TACTGAAGAA AATAAAGAAG TTGGTTTGGC CTTAAAGGAC 
CTTGCTAAGA GGTACTCCGA GCGGCTAGAG TGCTGTGAAA ATGAAGTGGA AAACATAATA 
GAGGAAATCC GATGCAAAGC GATTGAGCGC GGCACTGGGA ATGAGCACTA CCGCACAACT 
GGGATTGCTA CGATTGAGGT GTTCCTGCCT CCGAGGCTCC GGAAAGATAA GAAAAGCTTG 
TTGGAGACCC GCTTGCATGT CACTGGTAGA GACCTGAGGA GTAAAATAGC TGAAACCTTT 
GGATTTCAAG AAAATTACAT CAAGATCGTA ATAAATAAGA AACAGCTTCA ACTAGGGAAA 
AGCCTTGAAG AGCAAGGAGT CACTCACAAT GTGAAGGCCA TGGTGTTGGA GCTGAAACAG 
TCTGAAGAGG ATGTGAGGAG AAACCTGCAG CTGGAGGAGG AGGAACAGAA CGAGGCTGAG 
CAGAAGGAGA AACGCATTCA GAGGACCAAA AGGGGACTGG AGATCCTGGC CGAGAGAGCT 
GAGATGGTGG TAGACCCGGA AACGATGCCT TACTTAGACA TTGCGAACCA GACTGGCAGG 
TCAATCAGAA TTCCCCCTTC AGAAAGAAAA GCCCTAATGT TAGCCATGGG GTACCATGAG 
AAGGGCAGGG CTTTCCTGAA AAGAAAAGAG TATGGGATAG CCTTGCCATG CCTTCTGGAC 
GCCGACAGAT ACTTCTGTGA GTGCAAAGAG CTGCTGGACA CTGTGGACAA CTATGCAGTC 
CTCCAGCTGG ACATCGTGTG GTGCTACTTC CGCCTGGAAC AGCTGGAGTG CCTTGATGAT 
GCAGAGAAAA AGCTGAACTT GGCCCAGACG TGCTTTACAA ACTGTTACGG GGAGAATCAC 
CAGAGACTGG TCAACATAAA AGGGAACTGT GGGAAAGAGA AGGTGTTGTT TTTAAGACTC 
TACTTGCTTC AGGGAATCCG AAACTATCAC AGTGGAAATG GAGAGGAGGC TCGGGAATAT 
CTCAACAAGG CACGTCAGCT CTTTAAAGAG CTGTACATCG ACCCATCGAA AGTTCACAAC 
TTGTTACAGT TGGGGTTCAC TGCCCAGGAA GCACGGCTGG GCCTGCGGGC CTGTGATGGG 
AACGTGGACC ACGCAGCCAC TCACATTTCC AACCGCAGAG AGGAACTGGC CCAGATACGG 
AAGGAAGAGA AGGAGAAGAG GAAACGCCGT CTGGAAAGTG TCAACACTTT GAGAGGAATG 
GGCTACTCCA CACAAGCTGC CAAACAAGCC CTTCACCAGG CCAGAGGCAA CCTGGACGAT 
GCCCTGAAGA TTCTCCTCAG CAACCCCCAC ATGTGGTGGT TACAGGATTC AGACTCTGAG 
AACAACAGCC GGCAAGCAAG CCCTTCCCAA GAAAGCATCG ACCAGCTGGT GTACATGGGC 
TTCGACACAG TGGTGGCCGA AGCTGCGCTG AGGGTGTTTG CAGGCAATGT CCAGCTGGCA 
GCTCAGACCC TGGCACACCA TGGAGGAAGC CTCCCTCCTG ACCTACAGTT CTCAGGAGAG 
GACTCCTCCT CCACCCCATC CACATCCCCG TCTGACTCCG CAGGGACCTC TAGTGCCTCC 
ACGGATGAGG ACATGGAGAC AGAGGCCGTG AACGAAATCC TGGAGGACAT TCCGGAGCAC 
GAGGAAGACT ACCTGGACTC CACACTGGAG GACGAAGAAG TCATCATCGC TGAGTACCTG 
TCCTACGTGG ACAGGACCAG TTCTGCCACA AAGGACAACT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

NUB1 modulation of GSK3? reduces tau aggregation.
Human molecular genetics21(24)5254-67(2012 Dec)
Richet E,Pooler AM,Rodriguez T,Novoselov SS,Schmidtke G,Groettrup M,Hanger DP,Cheetham ME,van der Spuy J

The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10.
The Journal of biological chemistry281(29)20045-54(2006 Jul)
Schmidtke G,Kalveram B,Weber E,Bochtler P,Lukasiak S,Hipp MS,Groettrup M

Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins.
Seminars in cell & developmental biology15(2)221-9(2004 Apr)
Parry G,Estelle M

NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression.
The Journal of biological chemistry276(23)20603-9(2001 Jun)
Kito K,Yeh ET,Kamitani T

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Nub1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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