Sv2c cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sv2c
Entrez Gene ID	29643
Full Name	synaptic vesicle glycoprotein 2c
General protein information	Preferred Names synaptic vesicle glycoprotein 2c Names synaptic vesicle glycoprotein 2C synaptic vesicle protein 2C
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q12
Summary	a synaptic vesicle protein; conserved between vertebrates and invertebrates [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017590796.1	XP_017446285.1	synaptic vesicle glycoprotein 2C isoform X1
NM_031593.1	NP_113781.1	synaptic vesicle glycoprotein 2C

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SV2C	XP_526889.2
	SV2C	XP_001105846.1
Canis lupus familiaris (dog)	LOC488943	XP_546060.2
Mus musculus (house mouse)	Sv2c	NP_083486.1
Danio rerio (zebrafish)	sv2c	NP_001121811.1
Rattus norvegicus (Norway rat)	Sv2c	NP_113781.1
Homo sapiens (human)	SV2C	NP_055794.1
Bos taurus (cattle)	SV2C	NP_001178948.1
Gallus gallus (chicken)	SV2C	XP_004937396.1
Xenopus tropicalis (tropical clawed frog)	sv2c	XP_002934873.1

Gene Ontology
Bibliography

Related articles in PubMed

Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A.
Strotmeier J, Mahrhold S, Krez N, Janzen C, Lou J, Marks JD, Binz T, Rummel A
FEBS letters588(7)1087-93(2014 Apr)

Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses.
Boyken J, Gr?nborg M, Riedel D, Urlaub H, Jahn R, Chua JJ
Neuron78(2)285-97(2013 Apr)

The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves.
Mahrhold S, Rummel A, Bigalke H, Davletov B, Binz T
FEBS letters580(8)2011-4(2006 Apr)

SV2 is the protein receptor for botulinum neurotoxin A.
Dong M, Yeh F, Tepp WH, Dean C, Johnson EA, Janz R, Chapman ER
Science (New York, N.Y.)312(5773)592-6(2006 Apr)

SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment.
Iezzi M, Theander S, Janz R, Loze C, Wollheim CB
Journal of cell science118(Pt 23)5647-60(2005 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

findings show that botulinum neurotoxin (BoNT/A) enters neurons by binding to the synaptic vesicle protein SV2 (isoforms A, B, and C);SV2 acts as the protein receptor for BoNT/A
Title: SV2 is the protein receptor for botulinum neurotoxin A.

SV2-synaptotagmin interaction act in regulated exocytosis and SV2A and SV2C, via their additional synaptotagmin binding site, function differently than SV2B.
Title: SV2A and SV2C contain a unique synaptotagmin-binding site.

The following Sv2c gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sv2c cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12580	NM_031593.1 Latest version!	Rattus norvegicus synaptic vesicle glycoprotein 2c (Sv2c), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa59704	XM_017590796.1 Latest version!	Rattus norvegicus synaptic vesicle glycoprotein 2c (Sv2c), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sv2c ( NM_031593.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113781.1 Rattus norvegicus synaptic vesicle glycoprotein 2c (Sv2c), mRNA.

Price & Availability↑

CloneID	ORa12580
Clone ID Related Accession (Same CDS sequence)	NM_031593.1
Accession Version	NM_031593.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Rattus norvegicus(Norway rat)
Product	synaptic vesicle glycoprotein 2C
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF060174.1. ##Evidence-Data-START## Transcript exon combination :: AF060174.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAAGACT CCTACAAGGA TAGGACTTCA CTGATGAAGG GCGCCAAGGA CATTGCCAAA 
GAGGTGAAGA AGCAAACAGT GAAGAAGGTG AACCAGGCAG TGGACCGGGC CCAGGATGAA 
TACACCCAGC GGTCCTACAG TCGATTCCAG GATGAAGATG ATGATGATGA CTACTACCCA 
CCTGGAGAAA CCTACAGTGG GGAGGCCAAT GATGATGAAG GCTCAAGTGA AGCCACTGAG 
GGTCACGATG AAGAAGACGA GATCTATGAA GGGGAATACC AGGGCATCCC CAGCACGAAC 
CAAGGGAAGG ACAGCATAGT GTCTGTAGGA CAACCCAAAG GAGATGAGTA CAAGGACCGC 
AGAGAGCTGG AGTCAGAGAG GAGGGCTGAT GAGGAGGAGC TCGCCCAGCA GTATGAGCTG 
ATAATCCAAG AGTGTGGCCA TGGCCGTTTC CAGTGGGCCC TTTTCTTCGT CCTGGGCATG 
GCTCTCATGG CAGACGGCGT GGAGGTGTTT GTGGTGGGCT TTGTGTTACC CAGTGCAGAG 
ACAGACCTAT GCATACCGAA TTCAGGATCT GGATGGCTAG GCAGCATAGT GTACCTCGGG 
ATGATGGTGG GGGCGTTCTT CTGGGGAGGA CTGGCAGACA AAGTGGGAAG GAAGCAGTCT 
CTTCTGATTT GCATGTCCGT CAACGGATTC TTTGCCTTCC TTTCTTCATT TGTCCAAGGT 
TACGGCTTCT TTCTCCTCTG TCGTTTGCTT TCAGGATTCG GGATTGGAGG CGCCATTCCC 
ACTGTGTTCT CCTACTTTGC TGAAGTCCTG GCCCGGGAGA AGCGCGGTGA GCACCTCAGT 
TGGCTCTGCA TGTTCTGGAT GATTGGCGGT ATCTATGCTT CAGCCATGGC CTGGGCCATC 
ATCCCCCACT ATGGGTGGAG CTTCAGCATG GGCTCAGCCT ACCAGTTCCA CAGCTGGCGC 
GTCTTCGTCA TCGTCTGTGC CCTCCCGTGC GTCTCCTCGG TGGTGGCCCT CACCTTCATG 
CCCGAAAGCC CTCGGTTCTT GCTGGAGGTA GGAAAACATG ATGAAGCCTG GATGATTCTG 
AAGCTAATTC ATGATACCAA CATGAGAGCC CGGGGCCAGC CAGAGAAGGT CTTCACGGTA 
AATAAAATCA AGACTCCCAA GCAAATAGAT GAGCTGATTG AGATTGAGAG CGACACAGGA 
ACCTGGTACC GGAGGTGTTT TGTTCGGATC CGCACAGAAC TGTACGGAAT TTGGTTGACT 
TTTATGAGAT GCTTCAACTA CCCGGTCAGG GAAAACACCA TAAAGCTTAC GATTGTTTGG 
TTCACCCTGT CCTTTGGGTA CTATGGACTG TCCGTTTGGT TCCCAGATGT CATTAAACAC 
CTCCAGTCTG ACGAGTACGC CCTGCTGACT CGGAATGTGC AGAAGGATAA ATATGCAAAC 
TTTAGCATTA ACTTCACCAT GGAAAACCAG GTCCACACCG GAATGGAATA TGACAATGGC 
AGGTTCCTCG GAGTCAAATT CAAATCGGTA ACCTTCAAGG ATTCAGTGTT TAAGTCCTGC 
ACCTTTGACG ATGTGACCTC AGTCAACACC TACTTCAAGA ACTGCACGTT TATTGATACC 
CTTTTTGAGA ACACAGATTT TGAGCCCTAT AAATTCATAG ACAGCGAGTT TCAAAACTGC 
TCGTTTCTTC ACAATAAGAC GGGATGTCAG ATTACTTTTG ACGACGACTA CAGTGCCTAC 
TGGATTTACT TTGTCAACTT TCTCGGGACA TTGGCAGTGT TACCAGGAAA TATCGTGTCT 
GCTCTCCTGA TGGACAGGAT CGGGCGCTTA ACGATGCTAG GTGGCTCCAT GGTGCTCTCG 
GGGATCAGCT GCTTCTTCCT GTGGTTTGGC ACCAGCGAAT CCATGATGAT AGGCATGCTG 
TGCTTGTACA ACGGACTGAC CATCTCAGCG TGGAACTCTC TTGATGTAGT CACGGTGGAA 
CTATACCCCA CAGACCGGAG AGCAACGGGC TTTGGCTTCT TGAACGCACT CTGTAAAGCA 
GCGGCCGTCC TGGGAAACTT AATATTCGGC TCCTTGGTCA GCATCACCAA AGCAATCCCT 
ATCCTGCTGG CTTCCACCGT GCTCGTGTGT GGAGGACTCG TGGGGCTGCG CCTGCCCGAC 
ACAAGAACCC AGGTTCTGAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113781.1
CDS	224..2407
Translation	MEDSYKDRTSLMKGAKDIAKEVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEDDDDDYYPPGETYSGEANDDEGSSEATEGHDEEDEIYEGEYQGIPSTNQGKDSIVSVGQPKGDEYKDRRELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLLCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRENTIKLTIVWFTLSFGYYGLSVWFPDVIKHLQSDEYALLTRNVQKDKYANFSINFTMENQVHTGMEYDNGRFLGVKFKSVTFKDSVFKSCTFDDVTSVNTYFKNCTFIDTLFENTDFEPYKFIDSEFQNCSFLHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLPDTRTQVLM

Target ORF information:

RefSeq Version	NM_031593.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus synaptic vesicle glycoprotein 2c (Sv2c), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031593.1

ORF Insert Sequence:

ATGGAAGACT CCTACAAGGA TAGGACTTCA CTGATGAAGG GCGCCAAGGA CATTGCCAAA 
GAGGTGAAGA AGCAAACAGT GAAGAAGGTG AACCAGGCAG TGGACCGGGC CCAGGATGAA 
TACACCCAGC GGTCCTACAG TCGATTCCAG GATGAAGATG ATGATGATGA CTACTACCCA 
CCTGGAGAAA CCTACAGTGG GGAGGCCAAT GATGATGAAG GCTCAAGTGA AGCCACTGAG 
GGTCACGATG AAGAAGACGA GATCTATGAA GGGGAATACC AGGGCATCCC CAGCACGAAC 
CAAGGGAAGG ACAGCATAGT GTCTGTAGGA CAACCCAAAG GAGATGAGTA CAAGGACCGC 
AGAGAGCTGG AGTCAGAGAG GAGGGCTGAT GAGGAGGAGC TCGCCCAGCA GTATGAGCTG 
ATAATCCAAG AGTGTGGCCA TGGCCGTTTC CAGTGGGCCC TTTTCTTCGT CCTGGGCATG 
GCTCTCATGG CAGACGGCGT GGAGGTGTTT GTGGTGGGCT TTGTGTTACC CAGTGCAGAG 
ACAGACCTAT GCATACCGAA TTCAGGATCT GGATGGCTAG GCAGCATAGT GTACCTCGGG 
ATGATGGTGG GGGCGTTCTT CTGGGGAGGA CTGGCAGACA AAGTGGGAAG GAAGCAGTCT 
CTTCTGATTT GCATGTCCGT CAACGGATTC TTTGCCTTCC TTTCTTCATT TGTCCAAGGT 
TACGGCTTCT TTCTCCTCTG TCGTTTGCTT TCAGGATTCG GGATTGGAGG CGCCATTCCC 
ACTGTGTTCT CCTACTTTGC TGAAGTCCTG GCCCGGGAGA AGCGCGGTGA GCACCTCAGT 
TGGCTCTGCA TGTTCTGGAT GATTGGCGGT ATCTATGCTT CAGCCATGGC CTGGGCCATC 
ATCCCCCACT ATGGGTGGAG CTTCAGCATG GGCTCAGCCT ACCAGTTCCA CAGCTGGCGC 
GTCTTCGTCA TCGTCTGTGC CCTCCCGTGC GTCTCCTCGG TGGTGGCCCT CACCTTCATG 
CCCGAAAGCC CTCGGTTCTT GCTGGAGGTA GGAAAACATG ATGAAGCCTG GATGATTCTG 
AAGCTAATTC ATGATACCAA CATGAGAGCC CGGGGCCAGC CAGAGAAGGT CTTCACGGTA 
AATAAAATCA AGACTCCCAA GCAAATAGAT GAGCTGATTG AGATTGAGAG CGACACAGGA 
ACCTGGTACC GGAGGTGTTT TGTTCGGATC CGCACAGAAC TGTACGGAAT TTGGTTGACT 
TTTATGAGAT GCTTCAACTA CCCGGTCAGG GAAAACACCA TAAAGCTTAC GATTGTTTGG 
TTCACCCTGT CCTTTGGGTA CTATGGACTG TCCGTTTGGT TCCCAGATGT CATTAAACAC 
CTCCAGTCTG ACGAGTACGC CCTGCTGACT CGGAATGTGC AGAAGGATAA ATATGCAAAC 
TTTAGCATTA ACTTCACCAT GGAAAACCAG GTCCACACCG GAATGGAATA TGACAATGGC 
AGGTTCCTCG GAGTCAAATT CAAATCGGTA ACCTTCAAGG ATTCAGTGTT TAAGTCCTGC 
ACCTTTGACG ATGTGACCTC AGTCAACACC TACTTCAAGA ACTGCACGTT TATTGATACC 
CTTTTTGAGA ACACAGATTT TGAGCCCTAT AAATTCATAG ACAGCGAGTT TCAAAACTGC 
TCGTTTCTTC ACAATAAGAC GGGATGTCAG ATTACTTTTG ACGACGACTA CAGTGCCTAC 
TGGATTTACT TTGTCAACTT TCTCGGGACA TTGGCAGTGT TACCAGGAAA TATCGTGTCT 
GCTCTCCTGA TGGACAGGAT CGGGCGCTTA ACGATGCTAG GTGGCTCCAT GGTGCTCTCG 
GGGATCAGCT GCTTCTTCCT GTGGTTTGGC ACCAGCGAAT CCATGATGAT AGGCATGCTG 
TGCTTGTACA ACGGACTGAC CATCTCAGCG TGGAACTCTC TTGATGTAGT CACGGTGGAA 
CTATACCCCA CAGACCGGAG AGCAACGGGC TTTGGCTTCT TGAACGCACT CTGTAAAGCA 
GCGGCCGTCC TGGGAAACTT AATATTCGGC TCCTTGGTCA GCATCACCAA AGCAATCCCT 
ATCCTGCTGG CTTCCACCGT GCTCGTGTGT GGAGGACTCG TGGGGCTGCG CCTGCCCGAC 
ACAAGAACCC AGGTTCTGAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Sv2c ( XM_017590796.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017446285.1 Rattus norvegicus synaptic vesicle glycoprotein 2c (Sv2c), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa59704
Clone ID Related Accession (Same CDS sequence)	XM_017590796.1
Accession Version	XM_017590796.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	synaptic vesicle glycoprotein 2C isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAAGACT CCTACAAGGA TAGGACTTCA CTGATGAAGG GCGCCAAGGA CATTGCCAAA 
GAGGTGAAGA AGCAAACAGT GAAGAAGGTG AACCAGGCAG TGGACCGGGC CCAGGATGAA 
TACACCCAGC GGTCCTACAG CCGATTCCAG GATGAAGATG ATGATGATGA CTACTACCCA 
CCTGGAGAAA CCTACAGTGG GGAGGCCAAT GATGATGAAG GCTCAAGTGA AGCCACTGAG 
GGTCACGATG AAGAAGACGA GATCTATGAA GGGGAATACC AGGGCATCCC CAGCACGAAC 
CAAGGGAAGG ACAGCATAGT GTCTGTAGGA CAACCCAAAG GAGATGAGTA CAAGGACCGC 
AGAGAGCTGG AGTCAGAGAG GAGGGCTGAT GAGGAGGAGC TCGCCCAGCA GTATGAGCTG 
ATAATCCAAG AGTGTGGCCA TGGCCGTTTC CAGTGGGCCC TTTTCTTCGT CCTGGGCATG 
GCTCTCATGG CAGACGGCGT GGAGGTGTTT GTGGTGGGCT TTGTGTTACC CAGTGCAGAG 
ACAGACCTAT GCATACCGAA TTCAGGATCT GGATGGCTAG GCAGCATAGT GTACCTCGGG 
ATGATGGTGG GGGCGTTCTT CTGGGGAGGA CTGGCAGACA AAGTGGGAAG GAAGCAGTCT 
CTTCTGATTT GCATGTCCGT CAACGGATTC TTTGCCTTCC TTTCTTCATT TGTCCAAGGT 
TACGGCTTCT TTCTCCTCTG TCGTTTGCTT TCAGGATTCG GGATTGGAGG CGCCATTCCC 
ACTGTGTTCT CCTACTTTGC TGAAGTCCTG GCCCGGGAGA AGCGCGGTGA GCACCTCAGT 
TGGCTCTGCA TGTTCTGGAT GATTGGCGGT ATCTATGCTT CAGCCATGGC CTGGGCCATC 
ATCCCCCACT ATGGGTGGAG CTTCAGCATG GGCTCAGCCT ACCAGTTCCA CAGCTGGCGC 
GTCTTCGTCA TCGTCTGTGC CCTCCCGTGC GTCTCCTCGG TGGTGGCCCT CACCTTCATG 
CCCGAAAGCC CTCGGTTCTT GCTGGAGGTA GGAAAACATG ATGAAGCCTG GATGATTCTG 
AAGCTAATTC ATGATACCAA CATGAGAGCC CGGGGCCAGC CAGAGAAGGT CTTCACGGTA 
AATAAAATCA AGACTCCCAA GCAAATAGAT GAGCTGATTG AGATTGAGAG TGACACAGGA 
ACCTGGTACC GGAGGTGTTT TGTTCGGATC CGCACAGAAC TGTACGGAAT TTGGTTGACT 
TTTATGAGAT GCTTCAACTA CCCGGTCAGG GAAAACACCA TAAAGCTTAC GATTGTTTGG 
TTCACCCTGT CCTTTGGGTA CTATGGACTG TCCGTTTGGT TCCCAGATGT CATTAAACAC 
CTCCAGTCTG ACGAGTACGC CCTGCTGACT CGGAATGTGC AGAAGGATAA ATATGCAAAC 
TTTAGCATTA ACTTCACCAT GGAAAACCAG GTCCACACCG GAATGGAATA TGACAATGGC 
AGGTTCCTCG GAGTCAAATT CAAATCGGTA ACCTTCAAGG ATTCAGTGTT TAAGTCCTGC 
ACCTTTGACG ATGTGACCTC AGTCAACACC TACTTCAAGA ACTGCACGTT TATTGATACC 
CTTTTTGAGA ACACAGATTT TGAGCCCTAT AAATTCATAG ACAGCGAGTT TCAAAACTGC 
TCGTTTCTTC ACAATAAGAC GGGATGTCAG ATTACTTTTG ACGACGACTA CAGTGCCTAC 
TGGATTTACT TTGTCAACTT TCTCGGGACA TTGGCAGTGT TACCAGGAAA TATCGTGTCT 
GCTCTCCTGA TGGACAGGAT CGGGCGCTTA ACGATGCTAG GTGGCTCCAT GGTGCTCTCG 
GGGATCAGCT GCTTCTTCCT GTGGTTTGGC ACCAGCGAAT CCATGATGAT AGGCATGCTG 
TGCTTGTACA ACGGACTGAC CATCTCAGCG TGGAACTCTC TTGATGTAGT CACGGTGGAA 
CTATACCCCA CAGACCGGAG AGCAACGGGC TTTGGCTTCT TGAACGCACT CTGTAAAGCA 
GCGGCCGTCC TGGGAAACTT AATATTCGGC TCCTTGGTCA GCATCACCAA AGCAATCCCT 
ATCCTGCTGG CTTCCACCGT GCTCGTGTGT GGAGGACTCG TGGGGCTGCG CCTGCCCGAC 
ACAAGAACCC AGGTTCTGAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017446285.1
CDS	292..2475
Translation	MEDSYKDRTSLMKGAKDIAKEVKKQTVKKVNQAVDRAQDEYTQRSYSRFQDEDDDDDYYPPGETYSGEANDDEGSSEATEGHDEEDEIYEGEYQGIPSTNQGKDSIVSVGQPKGDEYKDRRELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAETDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFLLCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARGQPEKVFTVNKIKTPKQIDELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRENTIKLTIVWFTLSFGYYGLSVWFPDVIKHLQSDEYALLTRNVQKDKYANFSINFTMENQVHTGMEYDNGRFLGVKFKSVTFKDSVFKSCTFDDVTSVNTYFKNCTFIDTLFENTDFEPYKFIDSEFQNCSFLHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLPDTRTQVLM

Target ORF information:

RefSeq Version	XM_017590796.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus synaptic vesicle glycoprotein 2c (Sv2c), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017590796.1

ORF Insert Sequence:

ATGGAAGACT CCTACAAGGA TAGGACTTCA CTGATGAAGG GCGCCAAGGA CATTGCCAAA 
GAGGTGAAGA AGCAAACAGT GAAGAAGGTG AACCAGGCAG TGGACCGGGC CCAGGATGAA 
TACACCCAGC GGTCCTACAG CCGATTCCAG GATGAAGATG ATGATGATGA CTACTACCCA 
CCTGGAGAAA CCTACAGTGG GGAGGCCAAT GATGATGAAG GCTCAAGTGA AGCCACTGAG 
GGTCACGATG AAGAAGACGA GATCTATGAA GGGGAATACC AGGGCATCCC CAGCACGAAC 
CAAGGGAAGG ACAGCATAGT GTCTGTAGGA CAACCCAAAG GAGATGAGTA CAAGGACCGC 
AGAGAGCTGG AGTCAGAGAG GAGGGCTGAT GAGGAGGAGC TCGCCCAGCA GTATGAGCTG 
ATAATCCAAG AGTGTGGCCA TGGCCGTTTC CAGTGGGCCC TTTTCTTCGT CCTGGGCATG 
GCTCTCATGG CAGACGGCGT GGAGGTGTTT GTGGTGGGCT TTGTGTTACC CAGTGCAGAG 
ACAGACCTAT GCATACCGAA TTCAGGATCT GGATGGCTAG GCAGCATAGT GTACCTCGGG 
ATGATGGTGG GGGCGTTCTT CTGGGGAGGA CTGGCAGACA AAGTGGGAAG GAAGCAGTCT 
CTTCTGATTT GCATGTCCGT CAACGGATTC TTTGCCTTCC TTTCTTCATT TGTCCAAGGT 
TACGGCTTCT TTCTCCTCTG TCGTTTGCTT TCAGGATTCG GGATTGGAGG CGCCATTCCC 
ACTGTGTTCT CCTACTTTGC TGAAGTCCTG GCCCGGGAGA AGCGCGGTGA GCACCTCAGT 
TGGCTCTGCA TGTTCTGGAT GATTGGCGGT ATCTATGCTT CAGCCATGGC CTGGGCCATC 
ATCCCCCACT ATGGGTGGAG CTTCAGCATG GGCTCAGCCT ACCAGTTCCA CAGCTGGCGC 
GTCTTCGTCA TCGTCTGTGC CCTCCCGTGC GTCTCCTCGG TGGTGGCCCT CACCTTCATG 
CCCGAAAGCC CTCGGTTCTT GCTGGAGGTA GGAAAACATG ATGAAGCCTG GATGATTCTG 
AAGCTAATTC ATGATACCAA CATGAGAGCC CGGGGCCAGC CAGAGAAGGT CTTCACGGTA 
AATAAAATCA AGACTCCCAA GCAAATAGAT GAGCTGATTG AGATTGAGAG TGACACAGGA 
ACCTGGTACC GGAGGTGTTT TGTTCGGATC CGCACAGAAC TGTACGGAAT TTGGTTGACT 
TTTATGAGAT GCTTCAACTA CCCGGTCAGG GAAAACACCA TAAAGCTTAC GATTGTTTGG 
TTCACCCTGT CCTTTGGGTA CTATGGACTG TCCGTTTGGT TCCCAGATGT CATTAAACAC 
CTCCAGTCTG ACGAGTACGC CCTGCTGACT CGGAATGTGC AGAAGGATAA ATATGCAAAC 
TTTAGCATTA ACTTCACCAT GGAAAACCAG GTCCACACCG GAATGGAATA TGACAATGGC 
AGGTTCCTCG GAGTCAAATT CAAATCGGTA ACCTTCAAGG ATTCAGTGTT TAAGTCCTGC 
ACCTTTGACG ATGTGACCTC AGTCAACACC TACTTCAAGA ACTGCACGTT TATTGATACC 
CTTTTTGAGA ACACAGATTT TGAGCCCTAT AAATTCATAG ACAGCGAGTT TCAAAACTGC 
TCGTTTCTTC ACAATAAGAC GGGATGTCAG ATTACTTTTG ACGACGACTA CAGTGCCTAC 
TGGATTTACT TTGTCAACTT TCTCGGGACA TTGGCAGTGT TACCAGGAAA TATCGTGTCT 
GCTCTCCTGA TGGACAGGAT CGGGCGCTTA ACGATGCTAG GTGGCTCCAT GGTGCTCTCG 
GGGATCAGCT GCTTCTTCCT GTGGTTTGGC ACCAGCGAAT CCATGATGAT AGGCATGCTG 
TGCTTGTACA ACGGACTGAC CATCTCAGCG TGGAACTCTC TTGATGTAGT CACGGTGGAA 
CTATACCCCA CAGACCGGAG AGCAACGGGC TTTGGCTTCT TGAACGCACT CTGTAAAGCA 
GCGGCCGTCC TGGGAAACTT AATATTCGGC TCCTTGGTCA GCATCACCAA AGCAATCCCT 
ATCCTGCTGG CTTCCACCGT GCTCGTGTGT GGAGGACTCG TGGGGCTGCG CCTGCCCGAC 
ACAAGAACCC AGGTTCTGAT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A.
FEBS letters588(7)1087-93(2014 Apr)
Strotmeier J,Mahrhold S,Krez N,Janzen C,Lou J,Marks JD,Binz T,Rummel A

Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses.
Neuron78(2)285-97(2013 Apr)
Boyken J,Gr?nborg M,Riedel D,Urlaub H,Jahn R,Chua JJ

The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves.
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SV2 is the protein receptor for botulinum neurotoxin A.
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Dong M,Yeh F,Tepp WH,Dean C,Johnson EA,Janz R,Chapman ER

SV2A and SV2C are not vesicular Ca2+ transporters but control glucose-evoked granule recruitment.
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Sv2c cDNA ORF clone, Rattus norvegicus(Norway rat)

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