Jph2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Jph2
Entrez Gene ID	296345
Full Name	junctophilin 2
General protein information	Preferred Names junctophilin 2 Names junctophilin-2 JP-2 junctophilin type 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q42

mRNA and Protein(s)

mRNA	Protein	Name
XM_006235526.3	XP_006235588.1	junctophilin-2 isoform X1
NM_001037974.1	NP_001033063.1	junctophilin-2

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	jph2	XP_002933232.1
Bos taurus (cattle)	JPH2	XP_002692371.3
Rattus norvegicus (Norway rat)	Jph2	NP_001033063.1
Gallus gallus (chicken)	JPH2	XP_001234186.3
	JPH2	XP_001083346.1
Mus musculus (house mouse)	Jph2	NP_001192005.1
Homo sapiens (human)	JPH2	NP_065166.2
Pan troglodytes (chimpanzee)	JPH2	XP_525332.2
Danio rerio (zebrafish)	jph2	NP_001082833.1

Gene Ontology
Bibliography

Related articles in PubMed

Colchicine Depolymerizes Microtubules, Increases Junctophilin-2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension.
Prins KW, Tian L, Wu D, Thenappan T, Metzger JM, Archer SL
Journal of the American Heart Association6(6)(2017 May)

Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response.
Bennett HJ, Davenport JB, Collins RF, Trafford AW, Pinali C, Kitmitto A
The Biochemical journal456(2)205-17(2013 Dec)

Morphogenesis of T-tubules in heart cells: the role of junctophilin-2.
Han J, Wu H, Wang Q, Wang S
Science China. Life sciences56(7)647-52(2013 Jul)

Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle.
Murphy RM, Dutka TL, Horvath D, Bell JR, Delbridge LM, Lamb GD
The Journal of physiology591(3)719-29(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

JP2 is required for the morphogenesis of T-tubules during heart development
Title: Morphogenesis of T-tubules in heart cells: the role of junctophilin-2.

This study demonstrates that both Jph1 and Jph2 in skeletal muscle undergo Ca2+-dependent proteolysis by endogenous proteases when the intracellular Ca2+ is raised within the physiological range for a sustained period
Title: Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle.

JPH2 is dispersed throughout RyR clusters and that the packing of JPH2 into junctions and the assembly of RyR clusters are tightly linked
Title: Nanoscale organization of junctophilin-2 and ryanodine receptors within peripheral couplings of rat ventricular cardiomyocytes.

The following Jph2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Jph2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09562	NM_001037974.1 Latest version!	Rattus norvegicus junctophilin 2 (Jph2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
ORa26656	XM_006235526.3 Latest version!	Rattus norvegicus junctophilin 2 (Jph2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Jph2 ( NM_001037974.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001033063.1 Rattus norvegicus junctophilin 2 (Jph2), mRNA.

Price & Availability↑

CloneID	ORa09562
Clone ID Related Accession (Same CDS sequence)	NM_001037974.1
Accession Version	NM_001037974.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2079bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	junctophilin-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ304564.1. On Dec 23, 2005 this sequence version replaced XM_230853.3. ##Evidence-Data-START## Transcript exon combination :: DQ304564.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689596, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGAGCGGGG GCCGCTTTGA CTTTGATGAT GGCGGGGCGT ATTGTGGGGG CTGGGAAGGG 
GGGAAGGCAC ATGGGCACGG ACTGTGCACC GGCCCTAAGG GCCAAGGTGA ATACTCGGGC 
TCCTGGAATT TTGGCTTTGA AGTGGCAGGC GTCTACACCT GGCCCAGTGG GAATACCTTT 
GAGGGATATT GGAGCCAGGG CAAACGACAT GGACTTGGCA TAGAGACCAA GGGGCGATGG 
CTCTACAAGG GGGAGTGGAC ACATGGCTTC AAGGGGCGCT ACGGAATCCG GCAGAGCACA 
AACAGTGGTG CCAAGTACGA GGGCACTTGG AATAACGGCC TACAGGATGG TTATGGCACG 
GAGACCTATG CAGACGGAGG GACCTACCAA GGCCAATTCA CCAACGGCAT GCGGCATGGC 
TACGGCGTGC GCCAAAGCGT GCCCTACGGG ATGGCAGTGG TGGTGCGCTC CCCGCTGCGC 
ACCTCGCTGT CCTCGCTGCG CAGCGAGCAC AGCAATGGCA CAGTGGCTCC AGACTCGCCG 
GCGGCAGACG GGCCCACGCT GCCCTTGCCC CCGGTGCCGC GTGGTGGCTT CGCGCTCAGC 
CTACTGGCCA CGGCCGAGGC TGCGCGTCCC CCAGGGCTGT TCACACGAGG CGCACTGCTG 
GGTCGACTGC GACGCTCAGA GTCACGCACG TCGCTGGGCA GCCAGCGCAG CCGCTTGAGC 
TTCCTCAAGA GCGAGCTGAG CTCAGGAGCC AGCGATGCCG CGTCCACCGG CAGCCTGGCC 
GAAGGCGCCG AGGGCCCTGA CGACGCGGCT GCACCCTTCG ACGCCGACAT CGACGCCACC 
ACCACGGAGA CCTACATGGG CGAGTGGAAG AACGACAAAC GCTCGGGCTT CGGTGTGAGC 
GAACGTTCCA GCGGCCTTCG CTACGAGGGC GAGTGGCTGG ACAACCTGCG CCACGGTTAC 
GGTCGCACCA CGCTGCCCGA CGGCCACCGC GAGGAGGGCA AGTACCGCCA CAATGTGCTG 
GTCAAGGGCA CCAAGCGCCG CGTGCTGCCG CTCAAGAGCA ACAAGGTTCG CCAGAAGGTG 
GAGCATGGGG TCGAGGGTGC GCAACGCGCA GCAGCCATTG CGCGCCAGAA GGCTGAGATT 
GCTGCCTCCA GGACAAGCCA TGCCAAAGCC AAGGCCGAGG CAGCAGAACA GGCTGCCCTG 
GCTGCCAACC AGGAGTCCAA CATTGCCCGT ACATTGGCCA AGGAGCTGGC TCCAGACTTC 
TACCAGCCAG GTCCGGAGTA TCAGAAGCGT CGGCTGCTCC AGGAGATCCT GGAGAACTCA 
GAGAGCCTGC TGGAGCCCCG GGAGCGGGGC CCGGGCACCG GCCTCCCCGA ACGGCCCCGG 
GAAAGCCCAC AGCTGCATGA GCGCGAGACC CCGCAGCCGG AGGGCGGACC CCCTTCCCCG 
GCCGGAACGC CCCCGCAACC CAAGAGACCC CGGCCGGGAT CGTCAAAGGA CGGTCTGCTG 
AGTCCGGGTG CCTGGAACGG CGAGCCCGGT GGAGAGGGCA GCCGGCCCGC CACGCCATCG 
GATGGCGCCG GCCGTCGTAG CCCCGCGCGT CCGGCTTCGG AGCACATGGC CATCGAGGCG 
CTGCAGCCAC CGCCCGCGCC CTCGCGGGAG CCTGAGGTGG CACTGTACCG CGGTTACCAC 
AGCTACGCTG TGCGCACCGG GCCACCCGAG CCCCCGCCCT TGGAGGATGA GCCCGAGCCC 
GAGCCCGAGG TCCCGCGATC CGACTCGGAG CCCCCGTCCC CCGTCTCCGC CACGGTCCAG 
GAAGAGGAGT CCCCTGCGCC GCGAAGCCGG GTGCCCGCCA AGCCCGCCAC CTTGGAGCCC 
AAGCCCATAG TCCCCAAAGC CGAGCCCAAG GCCAAGGCGC GCAAGACAGA GGCCCGCGGG 
CTGAGCAAGG CGGGTGCCAA GAAGAAGGGC CGGAAAGAAG TGGCACAGGA GGCCGAGGCC 
GAGGTGGAGG TAGAGGAGGT CCCCAACACC GTCCTCATCT GTATGGTGAT CCTGCTGAAC 
ATCGGCCTGG CTATCCTATT CGTTCACCTC CTGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001033063.1
CDS	41..2119
Translation	MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSTNSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPAADGPTLPLPPVPRGGFALSLLATAEAARPPGLFTRGALLGRLRRSESRTSLGSQRSRLSFLKSELSSGASDAASTGSLAEGAEGPDDAAAPFDADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGRTTLPDGHREEGKYRHNVLVKGTKRRVLPLKSNKVRQKVEHGVEGAQRAAAIARQKAEIAASRTSHAKAKAEAAEQAALAANQESNIARTLAKELAPDFYQPGPEYQKRRLLQEILENSESLLEPRERGPGTGLPERPRESPQLHERETPQPEGGPPSPAGTPPQPKRPRPGSSKDGLLSPGAWNGEPGGEGSRPATPSDGAGRRSPARPASEHMAIEALQPPPAPSREPEVALYRGYHSYAVRTGPPEPPPLEDEPEPEPEVPRSDSEPPSPVSATVQEEESPAPRSRVPAKPATLEPKPIVPKAEPKAKARKTEARGLSKAGAKKKGRKEVAQEAEAEVEVEEVPNTVLICMVILLNIGLAILFVHLLT

Target ORF information:

RefSeq Version	NM_001037974.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus junctophilin 2 (Jph2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001037974.1

ORF Insert Sequence:

ATGAGCGGGG GCCGCTTTGA CTTTGATGAT GGCGGGGCGT ATTGTGGGGG CTGGGAAGGG 
GGGAAGGCAC ATGGGCACGG ACTGTGCACC GGCCCTAAGG GCCAAGGTGA ATACTCGGGC 
TCCTGGAATT TTGGCTTTGA AGTGGCAGGC GTCTACACCT GGCCCAGTGG GAATACCTTT 
GAGGGATATT GGAGCCAGGG CAAACGACAT GGACTTGGCA TAGAGACCAA GGGGCGATGG 
CTCTACAAGG GGGAGTGGAC ACATGGCTTC AAGGGGCGCT ACGGAATCCG GCAGAGCACA 
AACAGTGGTG CCAAGTACGA GGGCACTTGG AATAACGGCC TACAGGATGG TTATGGCACG 
GAGACCTATG CAGACGGAGG GACCTACCAA GGCCAATTCA CCAACGGCAT GCGGCATGGC 
TACGGCGTGC GCCAAAGCGT GCCCTACGGG ATGGCAGTGG TGGTGCGCTC CCCGCTGCGC 
ACCTCGCTGT CCTCGCTGCG CAGCGAGCAC AGCAATGGCA CAGTGGCTCC AGACTCGCCG 
GCGGCAGACG GGCCCACGCT GCCCTTGCCC CCGGTGCCGC GTGGTGGCTT CGCGCTCAGC 
CTACTGGCCA CGGCCGAGGC TGCGCGTCCC CCAGGGCTGT TCACACGAGG CGCACTGCTG 
GGTCGACTGC GACGCTCAGA GTCACGCACG TCGCTGGGCA GCCAGCGCAG CCGCTTGAGC 
TTCCTCAAGA GCGAGCTGAG CTCAGGAGCC AGCGATGCCG CGTCCACCGG CAGCCTGGCC 
GAAGGCGCCG AGGGCCCTGA CGACGCGGCT GCACCCTTCG ACGCCGACAT CGACGCCACC 
ACCACGGAGA CCTACATGGG CGAGTGGAAG AACGACAAAC GCTCGGGCTT CGGTGTGAGC 
GAACGTTCCA GCGGCCTTCG CTACGAGGGC GAGTGGCTGG ACAACCTGCG CCACGGTTAC 
GGTCGCACCA CGCTGCCCGA CGGCCACCGC GAGGAGGGCA AGTACCGCCA CAATGTGCTG 
GTCAAGGGCA CCAAGCGCCG CGTGCTGCCG CTCAAGAGCA ACAAGGTTCG CCAGAAGGTG 
GAGCATGGGG TCGAGGGTGC GCAACGCGCA GCAGCCATTG CGCGCCAGAA GGCTGAGATT 
GCTGCCTCCA GGACAAGCCA TGCCAAAGCC AAGGCCGAGG CAGCAGAACA GGCTGCCCTG 
GCTGCCAACC AGGAGTCCAA CATTGCCCGT ACATTGGCCA AGGAGCTGGC TCCAGACTTC 
TACCAGCCAG GTCCGGAGTA TCAGAAGCGT CGGCTGCTCC AGGAGATCCT GGAGAACTCA 
GAGAGCCTGC TGGAGCCCCG GGAGCGGGGC CCGGGCACCG GCCTCCCCGA ACGGCCCCGG 
GAAAGCCCAC AGCTGCATGA GCGCGAGACC CCGCAGCCGG AGGGCGGACC CCCTTCCCCG 
GCCGGAACGC CCCCGCAACC CAAGAGACCC CGGCCGGGAT CGTCAAAGGA CGGTCTGCTG 
AGTCCGGGTG CCTGGAACGG CGAGCCCGGT GGAGAGGGCA GCCGGCCCGC CACGCCATCG 
GATGGCGCCG GCCGTCGTAG CCCCGCGCGT CCGGCTTCGG AGCACATGGC CATCGAGGCG 
CTGCAGCCAC CGCCCGCGCC CTCGCGGGAG CCTGAGGTGG CACTGTACCG CGGTTACCAC 
AGCTACGCTG TGCGCACCGG GCCACCCGAG CCCCCGCCCT TGGAGGATGA GCCCGAGCCC 
GAGCCCGAGG TCCCGCGATC CGACTCGGAG CCCCCGTCCC CCGTCTCCGC CACGGTCCAG 
GAAGAGGAGT CCCCTGCGCC GCGAAGCCGG GTGCCCGCCA AGCCCGCCAC CTTGGAGCCC 
AAGCCCATAG TCCCCAAAGC CGAGCCCAAG GCCAAGGCGC GCAAGACAGA GGCCCGCGGG 
CTGAGCAAGG CGGGTGCCAA GAAGAAGGGC CGGAAAGAAG TGGCACAGGA GGCCGAGGCC 
GAGGTGGAGG TAGAGGAGGT CCCCAACACC GTCCTCATCT GTATGGTGAT CCTGCTGAAC 
ATCGGCCTGG CTATCCTATT CGTTCACCTC CTGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Jph2 ( XM_006235526.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006235588.1 Rattus norvegicus junctophilin 2 (Jph2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa26656
Clone ID Related Accession (Same CDS sequence)	XM_006235526.3
Accession Version	XM_006235526.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2079bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	junctophilin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006235526.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCGGGG GCCGCTTTGA CTTTGATGAT GGCGGGGCGT ATTGTGGGGG CTGGGAAGGG 
GGGAAGGCAC ATGGGCACGG ACTGTGCACC GGCCCTAAGG GCCAGGGTGA ATACTCGGGC 
TCCTGGAATT TTGGCTTTGA AGTGGCAGGC GTCTACACCT GGCCCAGTGG GAATACCTTT 
GAGGGATATT GGAGCCAGGG CAAACGACAT GGACTTGGCA TAGAGACCAA GGGGCGATGG 
CTCTACAAGG GGGAGTGGAC ACATGGCTTC AAGGGGCGCT ACGGAATCCG GCAGAGCACA 
AACAGTGGTG CCAAGTACGA GGGCACTTGG AATAACGGCC TACAGGATGG TTATGGCACG 
GAGACCTATG CAGACGGAGG GACCTACCAA GGCCAATTCA CCAACGGCAT GCGGCATGGC 
TACGGCGTGC GCCAAAGCGT GCCCTACGGG ATGGCAGTGG TGGTGCGCTC CCCGCTGCGC 
ACCTCGCTGT CCTCGCTGCG CAGCGAGCAC AGCAATGGCA CAGTGGCTCC AGACTCGCCG 
GCGGCAGACG GGCCCACGCT GCCCTTGCCC CCGGTGCCGC GTGGTGGCTT CGCGCTCAGC 
CTACTGGCCA CGGCCGAGGC TGCGCGTCCC CCAGGGCTGT TCACACGAGG CGCACTGCTG 
GGTCGACTGC GACGCTCAGA GTCACGCACG TCGCTGGGCA GCCAGCGCAG CCGCTTGAGC 
TTCCTCAAGA GCGAGCTGAG CTCAGGAGCC AGCGATGCCG CGTCCACCGG CAGCCTGGCC 
GAAGGCGCCG AGGGCCCTGA CGACGCGGCT GCACCCTTCG ACGCCGACAT CGACGCCACC 
ACCACGGAGA CCTACATGGG CGAGTGGAAG AACGACAAAC GCTCGGGCTT CGGTGTGAGC 
GAACGTTCCA GCGGCCTTCG CTACGAGGGC GAGTGGCTGG ACAACCTGCG CCACGGTTAC 
GGTCGCACCA CGCTGCCCGA CGGCCACCGC GAGGAGGGCA AGTACCGCCA CAATGTGCTG 
GTCAAGGGCA CCAAGCGCCG CGTGCTGCCG CTCAAGAGCA ACAAGGTTCG CCAGAAGGTG 
GAGCATGGGG TCGAGGGTGC GCAACGCGCA GCAGCCATTG CGCGCCAGAA GGCTGAGATT 
GCTGCCTCCA GGACAAGCCA TGCCAAAGCC AAGGCCGAGG CAGCAGAACA GGCTGCCCTG 
GCTGCCAACC AGGAGTCCAA CATTGCCCGT ACATTGGCCA AGGAGCTGGC TCCAGACTTC 
TACCAGCCAG GTCCGGAGTA TCAGAAGCGT CGGCTGCTCC AGGAGATCCT GGAGAACTCA 
GAGAGCCTGC TGGAGCCCCG GGAGCGGGGC CCGGGCACCG GCCTCCCCGA ACGGCCCCGG 
GAAAGCCCAC AGCTGCATGA GCGCGAGACC CCGCAGCCGG AGGGCGGACC CCCTTCCCCG 
GCCGGAACGC CCCCGCAACC CAAGAGACCC CGGCCGGGAT CGTCAAAGGA CGGTCTGCTG 
AGTCCGGGTG CCTGGAACGG CGAGCCCGGT GGAGAGGGCA GCCGGCCCGC CACGCCATCG 
GATGGCGCCG GCCGTCGTAG CCCCGCGCGT CCGGCTTCGG AGCACATGGC CATCGAGGCG 
CTGCAGCCAC CGCCCGCGCC CTCGCGGGAG CCTGAGGTGG CACTGTACCG CGGTTACCAC 
AGCTACGCTG TGCGCACCGG GCCACCCGAG CCCCCGCCCT TGGAGGATGA GCCCGAGCCC 
GAGCCCGAGG TCCCGCGATC CGACTCGGAG CCCCCGTCCC CCGTCTCCGC CACGGTCCAG 
GAAGAGGAGT CCCCTGCGCC GCGAAGCCGG GTGCCCGCCA AGCCCGCCAC CCTGGAGCCC 
AAGCCCATAG TCCCCAAAGC CGAGCCCAAG GCCAAGGCGC GCAAGACAGA GGCCCGCGGG 
CTGAGCAAGG CGGGTGCCAA GAAGAAGGGC CGGAAAGAAG TGGCACAGGA GGCCGAGGCC 
GAGGTGGAGG TAGAGGAGGT CCCCAACACC GTCCTCATCT GTATGGTGAT CCTGCTGAAC 
ATCGGCCTGG CTATCCTATT CGTTCACCTC CTGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006235588.1
CDS	934..3012
Translation	MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSTNSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPAADGPTLPLPPVPRGGFALSLLATAEAARPPGLFTRGALLGRLRRSESRTSLGSQRSRLSFLKSELSSGASDAASTGSLAEGAEGPDDAAAPFDADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGRTTLPDGHREEGKYRHNVLVKGTKRRVLPLKSNKVRQKVEHGVEGAQRAAAIARQKAEIAASRTSHAKAKAEAAEQAALAANQESNIARTLAKELAPDFYQPGPEYQKRRLLQEILENSESLLEPRERGPGTGLPERPRESPQLHERETPQPEGGPPSPAGTPPQPKRPRPGSSKDGLLSPGAWNGEPGGEGSRPATPSDGAGRRSPARPASEHMAIEALQPPPAPSREPEVALYRGYHSYAVRTGPPEPPPLEDEPEPEPEVPRSDSEPPSPVSATVQEEESPAPRSRVPAKPATLEPKPIVPKAEPKAKARKTEARGLSKAGAKKKGRKEVAQEAEAEVEVEEVPNTVLICMVILLNIGLAILFVHLLT

Target ORF information:

RefSeq Version	XM_006235526.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus junctophilin 2 (Jph2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006235526.3

ORF Insert Sequence:

ATGAGCGGGG GCCGCTTTGA CTTTGATGAT GGCGGGGCGT ATTGTGGGGG CTGGGAAGGG 
GGGAAGGCAC ATGGGCACGG ACTGTGCACC GGCCCTAAGG GCCAGGGTGA ATACTCGGGC 
TCCTGGAATT TTGGCTTTGA AGTGGCAGGC GTCTACACCT GGCCCAGTGG GAATACCTTT 
GAGGGATATT GGAGCCAGGG CAAACGACAT GGACTTGGCA TAGAGACCAA GGGGCGATGG 
CTCTACAAGG GGGAGTGGAC ACATGGCTTC AAGGGGCGCT ACGGAATCCG GCAGAGCACA 
AACAGTGGTG CCAAGTACGA GGGCACTTGG AATAACGGCC TACAGGATGG TTATGGCACG 
GAGACCTATG CAGACGGAGG GACCTACCAA GGCCAATTCA CCAACGGCAT GCGGCATGGC 
TACGGCGTGC GCCAAAGCGT GCCCTACGGG ATGGCAGTGG TGGTGCGCTC CCCGCTGCGC 
ACCTCGCTGT CCTCGCTGCG CAGCGAGCAC AGCAATGGCA CAGTGGCTCC AGACTCGCCG 
GCGGCAGACG GGCCCACGCT GCCCTTGCCC CCGGTGCCGC GTGGTGGCTT CGCGCTCAGC 
CTACTGGCCA CGGCCGAGGC TGCGCGTCCC CCAGGGCTGT TCACACGAGG CGCACTGCTG 
GGTCGACTGC GACGCTCAGA GTCACGCACG TCGCTGGGCA GCCAGCGCAG CCGCTTGAGC 
TTCCTCAAGA GCGAGCTGAG CTCAGGAGCC AGCGATGCCG CGTCCACCGG CAGCCTGGCC 
GAAGGCGCCG AGGGCCCTGA CGACGCGGCT GCACCCTTCG ACGCCGACAT CGACGCCACC 
ACCACGGAGA CCTACATGGG CGAGTGGAAG AACGACAAAC GCTCGGGCTT CGGTGTGAGC 
GAACGTTCCA GCGGCCTTCG CTACGAGGGC GAGTGGCTGG ACAACCTGCG CCACGGTTAC 
GGTCGCACCA CGCTGCCCGA CGGCCACCGC GAGGAGGGCA AGTACCGCCA CAATGTGCTG 
GTCAAGGGCA CCAAGCGCCG CGTGCTGCCG CTCAAGAGCA ACAAGGTTCG CCAGAAGGTG 
GAGCATGGGG TCGAGGGTGC GCAACGCGCA GCAGCCATTG CGCGCCAGAA GGCTGAGATT 
GCTGCCTCCA GGACAAGCCA TGCCAAAGCC AAGGCCGAGG CAGCAGAACA GGCTGCCCTG 
GCTGCCAACC AGGAGTCCAA CATTGCCCGT ACATTGGCCA AGGAGCTGGC TCCAGACTTC 
TACCAGCCAG GTCCGGAGTA TCAGAAGCGT CGGCTGCTCC AGGAGATCCT GGAGAACTCA 
GAGAGCCTGC TGGAGCCCCG GGAGCGGGGC CCGGGCACCG GCCTCCCCGA ACGGCCCCGG 
GAAAGCCCAC AGCTGCATGA GCGCGAGACC CCGCAGCCGG AGGGCGGACC CCCTTCCCCG 
GCCGGAACGC CCCCGCAACC CAAGAGACCC CGGCCGGGAT CGTCAAAGGA CGGTCTGCTG 
AGTCCGGGTG CCTGGAACGG CGAGCCCGGT GGAGAGGGCA GCCGGCCCGC CACGCCATCG 
GATGGCGCCG GCCGTCGTAG CCCCGCGCGT CCGGCTTCGG AGCACATGGC CATCGAGGCG 
CTGCAGCCAC CGCCCGCGCC CTCGCGGGAG CCTGAGGTGG CACTGTACCG CGGTTACCAC 
AGCTACGCTG TGCGCACCGG GCCACCCGAG CCCCCGCCCT TGGAGGATGA GCCCGAGCCC 
GAGCCCGAGG TCCCGCGATC CGACTCGGAG CCCCCGTCCC CCGTCTCCGC CACGGTCCAG 
GAAGAGGAGT CCCCTGCGCC GCGAAGCCGG GTGCCCGCCA AGCCCGCCAC CCTGGAGCCC 
AAGCCCATAG TCCCCAAAGC CGAGCCCAAG GCCAAGGCGC GCAAGACAGA GGCCCGCGGG 
CTGAGCAAGG CGGGTGCCAA GAAGAAGGGC CGGAAAGAAG TGGCACAGGA GGCCGAGGCC 
GAGGTGGAGG TAGAGGAGGT CCCCAACACC GTCCTCATCT GTATGGTGAT CCTGCTGAAC 
ATCGGCCTGG CTATCCTATT CGTTCACCTC CTGACTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Colchicine Depolymerizes Microtubules, Increases Junctophilin-2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension.
Journal of the American Heart Association6(6)(2017 May)
Prins KW,Tian L,Wu D,Thenappan T,Metzger JM,Archer SL

Human junctophilin-2 undergoes a structural rearrangement upon binding PtdIns(3,4,5)P3 and the S101R mutation identified in hypertrophic cardiomyopathy obviates this response.
The Biochemical journal456(2)205-17(2013 Dec)
Bennett HJ,Davenport JB,Collins RF,Trafford AW,Pinali C,Kitmitto A

Morphogenesis of T-tubules in heart cells: the role of junctophilin-2.
Science China. Life sciences56(7)647-52(2013 Jul)
Han J,Wu H,Wang Q,Wang S

Ca2+-dependent proteolysis of junctophilin-1 and junctophilin-2 in skeletal and cardiac muscle.
The Journal of physiology591(3)719-29(2013 Feb)
Murphy RM,Dutka TL,Horvath D,Bell JR,Delbridge LM,Lamb GD

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Jph2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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