Crhbp cDNA ORF clone, Rattus norvegicus(Norway rat)

CRF binding protein facilitates the presence of CRF type 2? receptor on the cell surface.
Slater PG, Cerda CA, Pereira LA, Andr?s ME, Gysling K
Proceedings of the National Academy of Sciences of the United States of America113(15)4075-80(2016 Apr)

Corticotropin-releasing factor type-2 receptor and corticotropin-releasing factor-binding protein coexist in rat ventral tegmental area nerve terminals originated in the lateral hypothalamic area.
Slater PG, Noches V, Gysling K
The European journal of neuroscience43(2)220-9(2016 Jan)

Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons.
Blanco EH, Z??iga JP, Andr?s ME, Alvarez AR, Gysling K
Neuropeptides45(4)273-9(2011 Aug)

Stress-induced and cue-induced craving for alcohol in heavy drinkers: Preliminary evidence of genetic moderation by the OPRM1 and CRH-BP genes.
Ray LA
Alcoholism, clinical and experimental research35(1)166-74(2011 Jan)

Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats.
Pan Y, Wang FM, Qiang LQ, Zhang DM, Kong LD
Psychoneuroendocrinology35(2)272-83(2010 Feb)

show that CRF-BP physically interacts with the CRF2alphaR but not the CRF2betaR isoform, increasing CRF2alphaR on the cell surface. Thus, CRF-BP emerges as a GPCR escort protein increasing the understanding of GPCR trafficking
Title: CRF binding protein facilitates the presence of CRF type 2? receptor on the cell surface.

Corticotropin-releasing factor type-2 receptor and corticotropin-releasing factor-binding protein mRNA and protein are expressed in the lateral hypothalamic area, and that both proteins are present in orexin-positive ventral tegmental area synaptosomes.
Title: Corticotropin-releasing factor type-2 receptor and corticotropin-releasing factor-binding protein coexist in rat ventral tegmental area nerve terminals originated in the lateral hypothalamic area.

Results show that CRF-BP is efficiently sorted to the regulated secretory pathway in two cellular contexts, suggesting that the extracellular levels of CRF-BP in the central nervous system depends on neuronal activity.
Title: Corticotropin-releasing factor binding protein enters the regulated secretory pathway in neuroendocrine cells and cortical neurons.

The present studies revealed a role of VTA CRF-BP and suggest an involvement of CRF(2)R in the effectiveness of stress in triggering glutamate and dopamine release and cocaine seeking in drug-experienced animals.
Title: Stress-induced relapse to cocaine seeking: roles for the CRF(2) receptor and CRF-binding protein in the ventral tegmental area of the rat.

alterations in basolateral amygdala CRF-BP gene expression are a primary response of the basolateral/central CRF system to acute stress
Title: The effects of acute stress on the regulation of central and basolateral amygdala CRF-binding protein gene expression.