Fam227b cDNA ORF clone, Rattus norvegicus(Norway rat)

The following Fam227b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fam227b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa04266 NM_001013920.2
Latest version!
Rattus norvegicus family with sequence similarity 227, member B (Fam227b), mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $307.30
$439.00
ORa26314 XM_006234909.3
Latest version!
Rattus norvegicus family with sequence similarity 227, member B (Fam227b), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $307.30
$439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

  • Reference Sequences (Refseq)
    CloneID ORa04266
    Clone ID Related Accession (Same CDS sequence) NM_001013920.2
    Accession Version NM_001013920.2 Latest version! Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 1722bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2018-09-15
    Organism Rattus norvegicus(Norway rat)
    Product protein FAM227B
    Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CK653446.1 and BC089861.1. On Oct 17, 2007 this sequence version replaced NM_001013920.1. ##Evidence-Data-START## Transcript exon combination :: BC089861.1, BC079426.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    ATGGAGTTGC CTACCCCTCA GAAAGTCCAA GAGCCCCCAA AGAGCTTTGA AGAATTCTTA 
    AAGTCTCAGA ACTGGGATTA TTGGCCCAGG GATGTTCACA TTAGAGATGG TGATATATGG
    GAAAACACTC TGAGAAAACT AGAAGAGGCT GTTTCATATA ATTCAGTTTA TTCTTATCTG
    TGGACCAACG TTCCTAGACT ATATGAAATC GTCGACAGCA TGGAGTCAAA GTTAAAGGAA
    TGTTCACATC TTTTGCAACA GCATGCCTCC AGATTATTTG AAAGTGACAG ACTGATCTCC
    AAGAAAAGGA CATATACAAA CCTGGACCGC TACAAGGCAT TTCTAAAAGA ACACTATAGG
    CGAAAGAAGA TAGTGCTTTC AGATCAAATG GAGACAGAGA AGAATATAGA GGGTTGCACC
    TTTTTACTCA AACAAAATGA GCTGACACAA TTACCCAGAC ATTTGGATGC TAAACAGATT
    TATCTTTATG TTTTAAGAAC CCATAACCTT GAGGAAAAGG TATTTAAAGT CTGGAAAACC
    CACATTCTCT CAGACTGCTC CATTGCTCTT TTGCATGACT GCTTTTGGTG GTGGTTTCTG
    CATAAATTCA AGCCTGACAA AAGAGATCAA GATTGGTTAT TTGACAGAAT CGCAGAAAGT
    TATGTCACTC TTTTCATGAG AATACCTCTA AGGAGAAAGG ATATATTCTT TCAGATGTAT
    CCCGACTGGT TGGCTCAAGC TGTCTACACA ACCTTCCAGG AATCATTTCC AGAATCCTGC
    AGCCTCTTCA ATGATAACTT CAAAGAAGAC CTAGGAAATA CTATTTTTCT TTGGTTGTCA
    GGTCTAAAAC CTGCGCCTGG CTTTTGGACC CACTGGAAAC TGCAAGACCT CTGCACAACC
    ACCATTCATG GCTGCAGGCG TGTACCTGTG AAGTTGAGAA GGGGGATCAT GTCCAGCCAG
    GAGCACACAT CAGCCACTGT AGGTCTCAAA ATCGAGGATA TTTTGAAGAA CCCAAGAGCA
    CTGCCTGTAC TCAAGGAAGA GTCTGCAGCA TCAAAAGTGA CAACCAAGTC CCACTATAGG
    AGCTTGGGTC CAGAGTTTTA CAAAGTTCTC TTTGACTTTG GGGGTCAGAG TCCACTGATT
    CTGTACTATC TTAAGATGCA CGAGTTAGGT GGTATTTCCG TCACTTATAA TCCGAAGGGA
    AGCAAGTTCA CCAAGATACT CCGAGAGCCA CCGCCTGCTC CAACATACTG TGAAATCATC
    AAGGATGCCA AAAGAAAATT TGCAGATAAC AAAAAGGATT TTAAGAGAGT AAAGCAAAGA
    ATCAAAGACG ACATCAAGTT CCTGAAAGAG CAACAGGAAC AAATCGACAA GGAGCTTGAC
    CGGCTCCAAG CAAAGGCTTC CAAAAATCTC CAAGAAGTCA AAAATGATTT TGAAAATTTT
    CTACATAAGC TGCGTGTTGA GGCTAAACTC AAAGAGGAAT ACAGAGGATC AGCATCACCA
    TCGGAGTCGC TACAGTCACT GCAGTCACCA AATTCATCGT TGTCATCCCC TGCCATGTCA
    GAAGACTTCA ACTCTGTGGA AGAAGGAGGG CTAAAGGAAG CCAGGAGCGA CCACTATTTA
    AGAACAACAC ACAGTTCATT CAGCTCTATC AATTTAATTG GAGGAGAGTG TACAACTAAA
    AGTACATTTT GCTGTTCATC TTTAAAATCT TCACATCAAT AA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq NP_001013942.2
    CDS83..1804
    Translation

    Target ORF information:

    RefSeq Version NM_001013920.2
    Organism Rattus norvegicus(Norway rat)
    Definition Rattus norvegicus family with sequence similarity 227, member B (Fam227b), mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    NM_001013920.2

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    ATGGAGTTGC CTACCCCTCA GAAAGTCCAA GAGCCCCCAA AGAGCTTTGA AGAATTCTTA 
    AAGTCTCAGA ACTGGGATTA TTGGCCCAGG GATGTTCACA TTAGAGATGG TGATATATGG
    GAAAACACTC TGAGAAAACT AGAAGAGGCT GTTTCATATA ATTCAGTTTA TTCTTATCTG
    TGGACCAACG TTCCTAGACT ATATGAAATC GTCGACAGCA TGGAGTCAAA GTTAAAGGAA
    TGTTCACATC TTTTGCAACA GCATGCCTCC AGATTATTTG AAAGTGACAG ACTGATCTCC
    AAGAAAAGGA CATATACAAA CCTGGACCGC TACAAGGCAT TTCTAAAAGA ACACTATAGG
    CGAAAGAAGA TAGTGCTTTC AGATCAAATG GAGACAGAGA AGAATATAGA GGGTTGCACC
    TTTTTACTCA AACAAAATGA GCTGACACAA TTACCCAGAC ATTTGGATGC TAAACAGATT
    TATCTTTATG TTTTAAGAAC CCATAACCTT GAGGAAAAGG TATTTAAAGT CTGGAAAACC
    CACATTCTCT CAGACTGCTC CATTGCTCTT TTGCATGACT GCTTTTGGTG GTGGTTTCTG
    CATAAATTCA AGCCTGACAA AAGAGATCAA GATTGGTTAT TTGACAGAAT CGCAGAAAGT
    TATGTCACTC TTTTCATGAG AATACCTCTA AGGAGAAAGG ATATATTCTT TCAGATGTAT
    CCCGACTGGT TGGCTCAAGC TGTCTACACA ACCTTCCAGG AATCATTTCC AGAATCCTGC
    AGCCTCTTCA ATGATAACTT CAAAGAAGAC CTAGGAAATA CTATTTTTCT TTGGTTGTCA
    GGTCTAAAAC CTGCGCCTGG CTTTTGGACC CACTGGAAAC TGCAAGACCT CTGCACAACC
    ACCATTCATG GCTGCAGGCG TGTACCTGTG AAGTTGAGAA GGGGGATCAT GTCCAGCCAG
    GAGCACACAT CAGCCACTGT AGGTCTCAAA ATCGAGGATA TTTTGAAGAA CCCAAGAGCA
    CTGCCTGTAC TCAAGGAAGA GTCTGCAGCA TCAAAAGTGA CAACCAAGTC CCACTATAGG
    AGCTTGGGTC CAGAGTTTTA CAAAGTTCTC TTTGACTTTG GGGGTCAGAG TCCACTGATT
    CTGTACTATC TTAAGATGCA CGAGTTAGGT GGTATTTCCG TCACTTATAA TCCGAAGGGA
    AGCAAGTTCA CCAAGATACT CCGAGAGCCA CCGCCTGCTC CAACATACTG TGAAATCATC
    AAGGATGCCA AAAGAAAATT TGCAGATAAC AAAAAGGATT TTAAGAGAGT AAAGCAAAGA
    ATCAAAGACG ACATCAAGTT CCTGAAAGAG CAACAGGAAC AAATCGACAA GGAGCTTGAC
    CGGCTCCAAG CAAAGGCTTC CAAAAATCTC CAAGAAGTCA AAAATGATTT TGAAAATTTT
    CTACATAAGC TGCGTGTTGA GGCTAAACTC AAAGAGGAAT ACAGAGGATC AGCATCACCA
    TCGGAGTCGC TACAGTCACT GCAGTCACCA AATTCATCGT TGTCATCCCC TGCCATGTCA
    GAAGACTTCA ACTCTGTGGA AGAAGGAGGG CTAAAGGAAG CCAGGAGCGA CCACTATTTA
    AGAACAACAC ACAGTTCATT CAGCTCTATC AATTTAATTG GAGGAGAGTG TACAACTAAA
    AGTACATTTT GCTGTTCATC TTTAAAATCT TCACATCAAT AA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    CloneID ORa26314
    Clone ID Related Accession (Same CDS sequence) XM_006234909.3
    Accession Version XM_006234909.3 Latest version! Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 1503bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2016-07-25
    Organism Rattus norvegicus(Norway rat)
    Product protein FAM227B isoform X1
    Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006234909.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    ATGGAGTCAA AGTTAAAGGA ATGTTCACAT CTTTTGCAAC AGCATGCCTC CAGATTATTT 
    GAAAGTGACA GACTGATCTC CAAGAAAAGG ACATATACAA ACCTGGACCG CTACAAGGCA
    TTTCTAAAAG AACACTATAG GCGAAAGAAG ATAGTGCTTT CAGATCAAAT GGAGACAGAG
    AAGAATATAG AGGGTTGCAC CTTTTTACTC AAACAAAATG AGCTGACACA ATTACCCAGA
    CATTTGGATG CTAAACAGAT TTATCTTTAT GTTTTAAGAA CCCATAACCT TGAGGAAAAG
    GTATTTAAAG TCTGGAAAAC CCACATTCTC TCAGACTGCT CCATTGCTCT TTTGCATGAC
    TGCTTTTGGT GGTGGTTTCT GCATAAATTC AAGCCTGACA AAAGAGATCA AGATTGGTTA
    TTTGACAGAA TCGCAGAAAG TTATGTCACT CTTTTCATGA GAATACCTCT AAGGAGAAAG
    GATATATTCT TTCAGATGTA TCCCGACTGG TTGGCTCAAG CTGTCTACAC AACCTTCCAG
    GAATCATTTC CAGAATCCTG CAGCCTCTTC AATGATAACT TCAAAGAAGA CCTAGGAAAT
    ACTATTTTTC TTTGGTTGTC AGGTCTAAAA CCTGCGCCTG GCTTTTGGAC CCACTGGAAA
    CTGCAAGACC TCTGCACAAC CACCATTCAT GGCTGCAGGC GTGTACCTGT GAAGTTGAGA
    AGGGGGATCA TGTCCAGCCA GGAGCACACA TCAGCCACTG TAGGTCTCAA AATCGAGGAT
    ATTTTGAAGA ACCCAAGAGC ACTGCCTGTA CTCAAGGAAG AGTCTGCAGC ATCAAAAGTG
    ACAACCAAGT CCCACTATAG GAGCTTGGGT CCAGAGTTTT ACAAAGTTCT CTTTGACTTT
    GGGGGTCAGA GTCCACTGAT TCTGTACTAT CTTAAGATGC ACGAGTTAGG TGGTATTTCC
    GTCACTTATA ATCCGAAGGG AAGCAAGTTC ACCAAGATAC TCCGAGAGCC ACCGCCTGCT
    CCAACATACT GTGAAATCAT CAAGGATGCC AAAAGAAAAT TTGCAGATAA CAAAAAGGAT
    TTTAAGAGAG TAAAGCAAAG AATCAAAGAC GACATCAAGT TCCTGAAAGA GCAACAGGAA
    CAAATCGACA AGGAGCTTGA CCGGCTCCAA GCAAAGGCTT CCAAAAATCT CCAAGAAGTC
    AAAAATGATT TTGAAAATTT TCTACATAAG CTGCGTGTTG AGGCTAAACT CAAAGAGGAA
    TACAGAGGAT CAGCATCACC ATCGGAGTCG CTACAGTCAC TGCAGTCACC AAATTCATCG
    TTGTCATCCC CTGCCATGTC AGAAGACTTC AACTCTGTGG AAGAAGGAGG GCTAAAGGAA
    GCCAGGAGCG ACCACTATTT AAGAACAACA CACAGTTCAT TCAGCTCTAT CAATTTAATT
    GGAGGAGAGT GTACAACTAA AAGTACATTT TGCTGTTCAT CTTTAAAATC TTCACATCAA
    TAA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq XP_006234971.1
    CDS207..1709
    Translation

    Target ORF information:

    RefSeq Version XM_006234909.3
    Organism Rattus norvegicus(Norway rat)
    Definition Rattus norvegicus family with sequence similarity 227, member B (Fam227b), transcript variant X1, mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    XM_006234909.3

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    ATGGAGTCAA AGTTAAAGGA ATGTTCACAT CTTTTGCAAC AGCATGCCTC CAGATTATTT 
    GAAAGTGACA GACTGATCTC CAAGAAAAGG ACATATACAA ACCTGGACCG CTACAAGGCA
    TTTCTAAAAG AACACTATAG GCGAAAGAAG ATAGTGCTTT CAGATCAAAT GGAGACAGAG
    AAGAATATAG AGGGTTGCAC CTTTTTACTC AAACAAAATG AGCTGACACA ATTACCCAGA
    CATTTGGATG CTAAACAGAT TTATCTTTAT GTTTTAAGAA CCCATAACCT TGAGGAAAAG
    GTATTTAAAG TCTGGAAAAC CCACATTCTC TCAGACTGCT CCATTGCTCT TTTGCATGAC
    TGCTTTTGGT GGTGGTTTCT GCATAAATTC AAGCCTGACA AAAGAGATCA AGATTGGTTA
    TTTGACAGAA TCGCAGAAAG TTATGTCACT CTTTTCATGA GAATACCTCT AAGGAGAAAG
    GATATATTCT TTCAGATGTA TCCCGACTGG TTGGCTCAAG CTGTCTACAC AACCTTCCAG
    GAATCATTTC CAGAATCCTG CAGCCTCTTC AATGATAACT TCAAAGAAGA CCTAGGAAAT
    ACTATTTTTC TTTGGTTGTC AGGTCTAAAA CCTGCGCCTG GCTTTTGGAC CCACTGGAAA
    CTGCAAGACC TCTGCACAAC CACCATTCAT GGCTGCAGGC GTGTACCTGT GAAGTTGAGA
    AGGGGGATCA TGTCCAGCCA GGAGCACACA TCAGCCACTG TAGGTCTCAA AATCGAGGAT
    ATTTTGAAGA ACCCAAGAGC ACTGCCTGTA CTCAAGGAAG AGTCTGCAGC ATCAAAAGTG
    ACAACCAAGT CCCACTATAG GAGCTTGGGT CCAGAGTTTT ACAAAGTTCT CTTTGACTTT
    GGGGGTCAGA GTCCACTGAT TCTGTACTAT CTTAAGATGC ACGAGTTAGG TGGTATTTCC
    GTCACTTATA ATCCGAAGGG AAGCAAGTTC ACCAAGATAC TCCGAGAGCC ACCGCCTGCT
    CCAACATACT GTGAAATCAT CAAGGATGCC AAAAGAAAAT TTGCAGATAA CAAAAAGGAT
    TTTAAGAGAG TAAAGCAAAG AATCAAAGAC GACATCAAGT TCCTGAAAGA GCAACAGGAA
    CAAATCGACA AGGAGCTTGA CCGGCTCCAA GCAAAGGCTT CCAAAAATCT CCAAGAAGTC
    AAAAATGATT TTGAAAATTT TCTACATAAG CTGCGTGTTG AGGCTAAACT CAAAGAGGAA
    TACAGAGGAT CAGCATCACC ATCGGAGTCG CTACAGTCAC TGCAGTCACC AAATTCATCG
    TTGTCATCCC CTGCCATGTC AGAAGACTTC AACTCTGTGG AAGAAGGAGG GCTAAAGGAA
    GCCAGGAGCG ACCACTATTT AAGAACAACA CACAGTTCAT TCAGCTCTAT CAATTTAATT
    GGAGGAGAGT GTACAACTAA AAGTACATTT TGCTGTTCAT CTTTAAAATC TTCACATCAA
    TAA

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

  • PubMed

    The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
    Genome research14(10B)2121-7(2004 Oct)
    Gerhard DS,Wagner L,Feingold EA,Shenmen CM,Grouse LH,Schuler G,Klein SL,Old S,Rasooly R,Good P,Guyer M,Peck AM,Derge JG,Lipman D,Collins FS,Jang W,Sherry S,Feolo M,Misquitta L,Lee E,Rotmistrovsky K,Greenhut SF,Schaefer CF,Buetow K,Bonner TI,Haussler D,Kent J,Kiekhaus M,Furey T,Brent M,Prange C,Schreiber K,Shapiro N,Bhat NK,Hopkins RF,Hsie F,Driscoll T,Soares MB,Casavant TL,Scheetz TE,Brown-stein MJ,Usdin TB,Toshiyuki S,Carninci P,Piao Y,Dudekula DB,Ko MS,Kawakami K,Suzuki Y,Sugano S,Gruber CE,Smith MR,Simmons B,Moore T,Waterman R,Johnson SL,Ruan Y,Wei CL,Mathavan S,Gunaratne PH,Wu J,Garcia AM,Hulyk SW,Fuh E,Yuan Y,Sneed A,Kowis C,Hodgson A,Muzny DM,McPherson J,Gibbs RA,Fahey J,Helton E,Ketteman M,Madan A,Rodrigues S,Sanchez A,Whiting M,Madari A,Young AC,Wetherby KD,Granite SJ,Kwong PN,Brinkley CP,Pearson RL,Bouffard GG,Blakesly RW,Green ED,Dickson MC,Rodriguez AC,Grimwood J,Schmutz J,Myers RM,Butterfield YS,Griffith M,Griffith OL,Krzywinski MI,Liao N,Morin R,Morrin R,Palmquist D,Petrescu AS,Skalska U,Smailus DE,Stott JM,Schnerch A,Schein JE,Jones SJ,Holt RA,Baross A,Marra MA,Clifton S,Makowski KA,Bosak S,Malek J,


    Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
    Proceedings of the National Academy of Sciences of the United States of America99(26)16899-903(2002 Dec)
    Strausberg RL,Feingold EA,Grouse LH,Derge JG,Klausner RD,Collins FS,Wagner L,Shenmen CM,Schuler GD,Altschul SF,Zeeberg B,Buetow KH,Schaefer CF,Bhat NK,Hopkins RF,Jordan H,Moore T,Max SI,Wang J,Hsieh F,Diatchenko L,Marusina K,Farmer AA,Rubin GM,Hong L,Stapleton M,Soares MB,Bonaldo MF,Casavant TL,Scheetz TE,Brownstein MJ,Usdin TB,Toshiyuki S,Carninci P,Prange C,Raha SS,Loquellano NA,Peters GJ,Abramson RD,Mullahy SJ,Bosak SA,McEwan PJ,McKernan KJ,Malek JA,Gunaratne PH,Richards S,Worley KC,Hale S,Garcia AM,Gay LJ,Hulyk SW,Villalon DK,Muzny DM,Sodergren EJ,Lu X,Gibbs RA,Fahey J,Helton E,Ketteman M,Madan A,Rodrigues S,Sanchez A,Whiting M,Madan A,Young AC,Shevchenko Y,Bouffard GG,Blakesley RW,Touchman JW,Green ED,Dickson MC,Rodriguez AC,Grimwood J,Schmutz J,Myers RM,Butterfield YS,Krzywinski MI,Skalska U,Smailus DE,Schnerch A,Schein JE,Jones SJ,Marra MA,