Tgfbr3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Tgfbr3
Entrez Gene ID	29610
Full Name	transforming growth factor beta receptor 3
Synonyms	betaglycan
General protein information	Preferred Names transforming growth factor beta receptor 3 Names transforming growth factor beta receptor type 3 TGF-beta receptor type 3 TGF-beta receptor type III TGFR-3 transforming growth factor, beta receptor III
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 14 Map Location: 14p22
Summary	binds TGF-beta; may regulate TGF-beta receptor type II expression or ligand-binding activity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017256.1	NP_058952.1	transforming growth factor beta receptor type 3 precursor

Pathways from BioSystems

Homologies

	TGFBR3	XP_001098070.1
Gallus gallus (chicken)	TGFBR3	NP_989670.1
Pan troglodytes (chimpanzee)	TGFBR3	XP_513555.2
Danio rerio (zebrafish)	tgfbr3	XP_002662477.3
Canis lupus familiaris (dog)	TGFBR3	XP_005621992.1
Bos taurus (cattle)	TGFBR3	XP_005204393.1
Homo sapiens (human)	TGFBR3	NP_003234.2
Xenopus tropicalis (tropical clawed frog)	tgfbr3	XP_002933852.2
Mus musculus (house mouse)	Tgfbr3	NP_035708.2
Rattus norvegicus (Norway rat)	Tgfbr3	NP_058952.1

Gene Ontology
Bibliography

Related articles in PubMed

Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis.
Hill CR, Jacobs BH, Brown CB, Barnett JV, Goudy SL
Developmental dynamics : an official publication of the American Association of Anatomists244(2)122-33(2015 Feb)

Mating decreases plasma levels of TGF?1 and regulates myosalpinx expression of TGF?1/TGFBR3 in the rat.
Or?stica ML, L?pez J, Zu?iga LM, Utz D, D?az P, Reuquen P, Parada-Bustamante A, Cardenas H, Orihuela PA
Molecular reproduction and development81(11)1053-61(2014 Nov)

A novel reciprocal loop between microRNA-21 and TGF?RIII is involved in cardiac fibrosis.
Liang H, Zhang C, Ban T, Liu Y, Mei L, Piao X, Zhao D, Lu Y, Chu W, Yang B
The international journal of biochemistry & cell biology44(12)2152-60(2012 Dec)

Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-beta binding.
Lin SJ, Hu Y, Zhu J, Woodruff TK, Jardetzky TS
Proceedings of the National Academy of Sciences of the United States of America108(13)5232-6(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mating decreases plasma levels of TGFbeta1 and regulates myosalpinx expression of TGFbeta1/TGFBR3 in the rat.
Title: Mating decreases plasma levels of TGF?1 and regulates myosalpinx expression of TGF?1/TGFBR3 in the rat.

Data present the 2.0-A resolution crystal structure of the betaglycan ZP-C region in combination with a downstream region known as the external hydrophobic patch.
Title: Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-beta binding.

Betaglycan is an endogenous inhibin coreceptor required for high-sensitivity inhibin antagonism of activin signaling in rat anterior pituitary gonadotropes.
Title: Endogenous betaglycan is essential for high-potency inhibin antagonism in gonadotropes.

A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats.
Title: A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats.

Prostaglandin E2 increases transforming growth factor-beta type III receptor expression through CCAAT enhancer-binding protein delta in osteoblasts
Title: Prostaglandin E2 increases transforming growth factor-beta type III receptor expression through CCAAT enhancer-binding protein delta in osteoblasts.

The following Tgfbr3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tgfbr3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03424	NM_017256.1 Latest version!	Rattus norvegicus transforming growth factor beta receptor 3 (Tgfbr3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Tgfbr3 ( NM_017256.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058952.1 Rattus norvegicus transforming growth factor beta receptor 3 (Tgfbr3), mRNA.

Price & Availability↑

CloneID	ORa03424
Clone ID Related Accession (Same CDS sequence)	NM_017256.1
Accession Version	NM_017256.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2562bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	transforming growth factor beta receptor type 3 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M77809.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M77809.1, M80784.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCAGTGA CATCCCACCA CATGATCCCG GTGATGGTTG TCCTGATGAG CGCCTGCCTG 
GCCACCGCCG GTCCAGAGCC CAGCACCCGG TGTGAACTGT CACCAATCAA CGCCTCTCAC 
CCAGTCCAGG CCTTGATGGA GAGCTTCACC GTTCTGTCTG GCTGTGCCAG CAGAGGCACC 
ACCGGGCTGC CAAGGGAGGT CCATGTCCTA AACCTCCGAA GTACAGATCA GGGACCAGGC 
CAGCGGCAGA GAGAGGTTAC CCTGCACCTG AACCCCATTG CCTCGGTGCA CACTCACCAC 
AAACCTATCG TGTTCCTGCT CAACTCCCCC CAGCCCCTGG TGTGGCATCT GAAGACGGAG 
AGACTGGCCG CTGGTGTCCC CAGACTCTTC CTGGTTTCAG AGGGTTCTGT GGTCCAGTTT 
CCATCAGGAA ACTTCTCCTT GACAGCAGAA ACAGAGGAAA GGAATTTCCC TCAAGAAAAT 
GAACATCTGC TGCGCTGGGC CCAAAAGGAA TATGGAGCAG TGACTTCGTT CACCGAACTC 
AAGATAGCAA GAAACATCTA TATTAAAGTG GGAGAAGATC AAGTGTTTCC TCCTACGTGT 
AACATAGGGA AGAATTTCCT CTCACTCAAT TACCTTGCCG AGTACCTTCA ACCCAAAGCC 
GCCGAAGGTT GTGTCCTGCC CAGTCAACCC CATGAAAAGG AAGTACACAT CATCGAGTTA 
ATTACCCCCA GCTCGAACCC TTACAGCGCT TTCCAGGTGG ATATAATAGT TGACATACGA 
CCTGCTCAAG AGGATCCCGA GGTGGTCAAA AACCTTGTCC TGATCTTGAA GTGCAAAAAG 
TCTGTCAACT GGGTGATCAA GTCTTTTGAC GTCAAGGGAA ACTTGAAAGT CATTGCTCCC 
AACAGTATCG GCTTTGGAAA AGAGAGTGAA CGATCCATGA CAATGACCAA ATTGGTAAGA 
GATGACATCC CTTCCACCCA AGAGAATCTG ATGAAGTGGG CACTGGACAA TGGCTACAGG 
CCAGTGACGT CATACACAAT GGCTCCCGTG GCTAATAGAT TTCATCTTCG GCTTGAGAAC 
AACGAGGAGA TGAGAGATGA GGAAGTCCAC ACCATTCCTC CTGAGCTTCG TATCCTGCTG 
GACCCTGACC ACCCGCCCGC CCTGGACAAC CCACTCTTCC CAGGAGAGGG AAGCCCAAAT 
GGTGGTCTCC CCTTTCCATT CCCGGATATC CCCAGGAGAG GCTGGAAGGA GGGCGAAGAT 
AGGATCCCCC GGCCAAAGCA GCCCATCGTT CCCAGTGTTC AACTGCTTCC TGACCACCGA 
GAACCAGAAG AAGTGCAAGG GGGCGTGGAC ATCGCCCTGT CAGTCAAATG TGACCATGAA 
AAGATGGTCG TGGCTGTAGA CAAAGACTCT TTCCAGACCA ATGGCTACTC AGGGATGGAG 
CTCACCCTGT TGGATCCTTC GTGTAAAGCC AAAATGAATG GTACTCACTT TGTTCTCGAG 
TCTCCCCTGA ATGGCTGTGG TACTCGACAT CGGAGGTCGA CCCCGGATGG TGTGGTTTAC 
TATAACTCTA TTGTGGTGCA GGCTCCGTCC CCTGGGGATA GCAGTGGCTG GCCTGATGGC 
TATGAAGACT TGGAGTCAGG CGATAATGGA TTTCCTGGAG ACGGGGATGA AGGAGAAACT 
GCCCCCCTGA GCCGAGCTGG AGTGGTGGTG TTTAACTGCA GCTTGCGGCA GCTGAGGAAT 
CCCAGTGGCT TCCAGGGCCA GCTCGATGGA AATGCTACCT TCAACATGGA GCTGTATAAC 
ACAGACCTCT TTCTGGTGCC CTCCCCAGGG GTCTTCTCTG TGGCAGAGAA CGAGCATGTT 
TATGTTGAGG TGTCTGTCAC CAAGGCTGAC CAAGATCTGG GATTCGCCAT CCAAACCTGC 
TTTCTCTCTC CATACTCCAA CCCAGACAGA ATGTCTGATT ACACCATCAT CGAGAACATC 
TGTCCGAAAG ACGACTCTGT GAAGTTCTAC AGCTCCAAGA GAGTGCACTT TCCCATCCCG 
CATGCTGAGG TGGACAAGAA GCGCTTCAGC TTCCTGTTCA AGTCTGTGTT CAACACCTCC 
CTGCTCTTCC TGCACTGCGA GTTGACTCTG TGCTCCAGGA AGAAGGGCTC CCTGAAGCTG 
CCGAGGTGTG TGACTCCTGA CGACGCCTGC ACTTCTCTCG ATGCCACCAT GATCTGGACC 
ATGATGCAGA ATAAGAAGAC ATTCACCAAG CCCCTGGCTG TGGTCCTCCA GGTAGACTAT 
AAAGAAAATG TTCCCAGCAC TAAGGATTCC AGTCCAATTC CTCCTCCTCC TCCACAGATT 
TTCCATGGCC TGGACACGCT CACCGTGATG GGCATTGCAT TTGCAGCATT TGTGATCGGA 
GCGCTCCTGA CGGGGGCCTT GTGGTACATC TACTCCCACA CAGGGGAGAC AGCACGAAGG 
CAGCAAGTCC CTACCTCGCC GCCAGCCTCG GAGAACAGCA GCGCGGCCCA CAGCATCGGC 
AGCACTCAGA GTACCCCCTG CTCTAGCAGC AGCACAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058952.1
CDS	335..2896
Translation	MAVTSHHMIPVMVVLMSACLATAGPEPSTRCELSPINASHPVQALMESFTVLSGCASRGTTGLPREVHVLNLRSTDQGPGQRQREVTLHLNPIASVHTHHKPIVFLLNSPQPLVWHLKTERLAAGVPRLFLVSEGSVVQFPSGNFSLTAETEERNFPQENEHLLRWAQKEYGAVTSFTELKIARNIYIKVGEDQVFPPTCNIGKNFLSLNYLAEYLQPKAAEGCVLPSQPHEKEVHIIELITPSSNPYSAFQVDIIVDIRPAQEDPEVVKNLVLILKCKKSVNWVIKSFDVKGNLKVIAPNSIGFGKESERSMTMTKLVRDDIPSTQENLMKWALDNGYRPVTSYTMAPVANRFHLRLENNEEMRDEEVHTIPPELRILLDPDHPPALDNPLFPGEGSPNGGLPFPFPDIPRRGWKEGEDRIPRPKQPIVPSVQLLPDHREPEEVQGGVDIALSVKCDHEKMVVAVDKDSFQTNGYSGMELTLLDPSCKAKMNGTHFVLESPLNGCGTRHRRSTPDGVVYYNSIVVQAPSPGDSSGWPDGYEDLESGDNGFPGDGDEGETAPLSRAGVVVFNCSLRQLRNPSGFQGQLDGNATFNMELYNTDLFLVPSPGVFSVAENEHVYVEVSVTKADQDLGFAIQTCFLSPYSNPDRMSDYTIIENICPKDDSVKFYSSKRVHFPIPHAEVDKKRFSFLFKSVFNTSLLFLHCELTLCSRKKGSLKLPRCVTPDDACTSLDATMIWTMMQNKKTFTKPLAVVLQVDYKENVPSTKDSSPIPPPPPQIFHGLDTLTVMGIAFAAFVIGALLTGALWYIYSHTGETARRQQVPTSPPASENSSAAHSIGSTQSTPCSSSSTA

Target ORF information:

RefSeq Version	NM_017256.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus transforming growth factor beta receptor 3 (Tgfbr3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017256.1

ORF Insert Sequence:

ATGGCAGTGA CATCCCACCA CATGATCCCG GTGATGGTTG TCCTGATGAG CGCCTGCCTG 
GCCACCGCCG GTCCAGAGCC CAGCACCCGG TGTGAACTGT CACCAATCAA CGCCTCTCAC 
CCAGTCCAGG CCTTGATGGA GAGCTTCACC GTTCTGTCTG GCTGTGCCAG CAGAGGCACC 
ACCGGGCTGC CAAGGGAGGT CCATGTCCTA AACCTCCGAA GTACAGATCA GGGACCAGGC 
CAGCGGCAGA GAGAGGTTAC CCTGCACCTG AACCCCATTG CCTCGGTGCA CACTCACCAC 
AAACCTATCG TGTTCCTGCT CAACTCCCCC CAGCCCCTGG TGTGGCATCT GAAGACGGAG 
AGACTGGCCG CTGGTGTCCC CAGACTCTTC CTGGTTTCAG AGGGTTCTGT GGTCCAGTTT 
CCATCAGGAA ACTTCTCCTT GACAGCAGAA ACAGAGGAAA GGAATTTCCC TCAAGAAAAT 
GAACATCTGC TGCGCTGGGC CCAAAAGGAA TATGGAGCAG TGACTTCGTT CACCGAACTC 
AAGATAGCAA GAAACATCTA TATTAAAGTG GGAGAAGATC AAGTGTTTCC TCCTACGTGT 
AACATAGGGA AGAATTTCCT CTCACTCAAT TACCTTGCCG AGTACCTTCA ACCCAAAGCC 
GCCGAAGGTT GTGTCCTGCC CAGTCAACCC CATGAAAAGG AAGTACACAT CATCGAGTTA 
ATTACCCCCA GCTCGAACCC TTACAGCGCT TTCCAGGTGG ATATAATAGT TGACATACGA 
CCTGCTCAAG AGGATCCCGA GGTGGTCAAA AACCTTGTCC TGATCTTGAA GTGCAAAAAG 
TCTGTCAACT GGGTGATCAA GTCTTTTGAC GTCAAGGGAA ACTTGAAAGT CATTGCTCCC 
AACAGTATCG GCTTTGGAAA AGAGAGTGAA CGATCCATGA CAATGACCAA ATTGGTAAGA 
GATGACATCC CTTCCACCCA AGAGAATCTG ATGAAGTGGG CACTGGACAA TGGCTACAGG 
CCAGTGACGT CATACACAAT GGCTCCCGTG GCTAATAGAT TTCATCTTCG GCTTGAGAAC 
AACGAGGAGA TGAGAGATGA GGAAGTCCAC ACCATTCCTC CTGAGCTTCG TATCCTGCTG 
GACCCTGACC ACCCGCCCGC CCTGGACAAC CCACTCTTCC CAGGAGAGGG AAGCCCAAAT 
GGTGGTCTCC CCTTTCCATT CCCGGATATC CCCAGGAGAG GCTGGAAGGA GGGCGAAGAT 
AGGATCCCCC GGCCAAAGCA GCCCATCGTT CCCAGTGTTC AACTGCTTCC TGACCACCGA 
GAACCAGAAG AAGTGCAAGG GGGCGTGGAC ATCGCCCTGT CAGTCAAATG TGACCATGAA 
AAGATGGTCG TGGCTGTAGA CAAAGACTCT TTCCAGACCA ATGGCTACTC AGGGATGGAG 
CTCACCCTGT TGGATCCTTC GTGTAAAGCC AAAATGAATG GTACTCACTT TGTTCTCGAG 
TCTCCCCTGA ATGGCTGTGG TACTCGACAT CGGAGGTCGA CCCCGGATGG TGTGGTTTAC 
TATAACTCTA TTGTGGTGCA GGCTCCGTCC CCTGGGGATA GCAGTGGCTG GCCTGATGGC 
TATGAAGACT TGGAGTCAGG CGATAATGGA TTTCCTGGAG ACGGGGATGA AGGAGAAACT 
GCCCCCCTGA GCCGAGCTGG AGTGGTGGTG TTTAACTGCA GCTTGCGGCA GCTGAGGAAT 
CCCAGTGGCT TCCAGGGCCA GCTCGATGGA AATGCTACCT TCAACATGGA GCTGTATAAC 
ACAGACCTCT TTCTGGTGCC CTCCCCAGGG GTCTTCTCTG TGGCAGAGAA CGAGCATGTT 
TATGTTGAGG TGTCTGTCAC CAAGGCTGAC CAAGATCTGG GATTCGCCAT CCAAACCTGC 
TTTCTCTCTC CATACTCCAA CCCAGACAGA ATGTCTGATT ACACCATCAT CGAGAACATC 
TGTCCGAAAG ACGACTCTGT GAAGTTCTAC AGCTCCAAGA GAGTGCACTT TCCCATCCCG 
CATGCTGAGG TGGACAAGAA GCGCTTCAGC TTCCTGTTCA AGTCTGTGTT CAACACCTCC 
CTGCTCTTCC TGCACTGCGA GTTGACTCTG TGCTCCAGGA AGAAGGGCTC CCTGAAGCTG 
CCGAGGTGTG TGACTCCTGA CGACGCCTGC ACTTCTCTCG ATGCCACCAT GATCTGGACC 
ATGATGCAGA ATAAGAAGAC ATTCACCAAG CCCCTGGCTG TGGTCCTCCA GGTAGACTAT 
AAAGAAAATG TTCCCAGCAC TAAGGATTCC AGTCCAATTC CTCCTCCTCC TCCACAGATT 
TTCCATGGCC TGGACACGCT CACCGTGATG GGCATTGCAT TTGCAGCATT TGTGATCGGA 
GCGCTCCTGA CGGGGGCCTT GTGGTACATC TACTCCCACA CAGGGGAGAC AGCACGAAGG 
CAGCAAGTCC CTACCTCGCC GCCAGCCTCG GAGAACAGCA GCGCGGCCCA CAGCATCGGC 
AGCACTCAGA GTACCCCCTG CTCTAGCAGC AGCACAGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists244(2)122-33(2015 Feb)
Hill CR,Jacobs BH,Brown CB,Barnett JV,Goudy SL

Mating decreases plasma levels of TGF?1 and regulates myosalpinx expression of TGF?1/TGFBR3 in the rat.
Molecular reproduction and development81(11)1053-61(2014 Nov)
Or?stica ML,L?pez J,Zu?iga LM,Utz D,D?az P,Reuquen P,Parada-Bustamante A,Cardenas H,Orihuela PA

A novel reciprocal loop between microRNA-21 and TGF?RIII is involved in cardiac fibrosis.
The international journal of biochemistry & cell biology44(12)2152-60(2012 Dec)
Liang H,Zhang C,Ban T,Liu Y,Mei L,Piao X,Zhao D,Lu Y,Chu W,Yang B

Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-beta binding.
Proceedings of the National Academy of Sciences of the United States of America108(13)5232-6(2011 Mar)
Lin SJ,Hu Y,Zhu J,Woodruff TK,Jardetzky TS

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Tgfbr3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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