Cybrd1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Cybrd1
Entrez Gene ID	295669
Full Name	cytochrome b reductase 1
Synonyms	Dcytb
General protein information	Preferred Names cytochrome b reductase 1 Names cytochrome b reductase 1 duodenal cytochrome b
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q22

mRNA and Protein(s)

mRNA	Protein	Name
NM_001011954.1	NP_001011954.1	cytochrome b reductase 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CYBRD1	NP_079119.3
Canis lupus familiaris (dog)	CYBRD1	XP_535960.2
Drosophila melanogaster (fruit fly)	CG1275	NP_728726.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005520	XP_315519.4
Rattus norvegicus (Norway rat)	Cybrd1	NP_001011954.1
Gallus gallus (chicken)	CYBRD1	XP_421999.4
Danio rerio (zebrafish)	cybrd1	NP_001018336.1
Pan troglodytes (chimpanzee)	CYBRD1	XP_001143044.1
	CYBRD1	XP_001084738.1
Bos taurus (cattle)	CYBRD1	NP_001192978.1
Mus musculus (house mouse)	Cybrd1	NP_082869.2
Xenopus tropicalis (tropical clawed frog)	cybrd1	NP_001165750.1

Gene Ontology
Bibliography

Related articles in PubMed

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.
Lane DJ, Merlot AM, Huang ML, Bae DH, Jansson PJ, Sahni S, Kalinowski DS, Richardson DR
Biochimica et biophysica acta1853(5)1130-44(2015 May)

Effects of prebiotic supplementation on the expression of proteins regulating iron absorption in anaemic growing rats.
Marciano R, Santamarina AB, de Santana AA, Silva Mde L, Amancio OM, do Nascimento CM, Oyama LM, de Morais MB
The British journal of nutrition113(6)901-8(2015 Mar)

Expression and localization of duodenal cytochrome b in the rat hippocampus after kainate-induced excitotoxicity.
Loke SY, Siddiqi NJ, Alhomida AS, Kim HC, Ong WY
Neuroscience245179-90(2013 Aug)

Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats.
Thomas CE, Gaffney-Stomberg E, Sun BH, O'Brien KO, Kerstetter JE, Insogna KL
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(6)2476-83(2013 Jun)

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that expression of Cybrd1 in intestinal mucosa can be regulated by dietary factors; here, expression of Cybrd1 in mucosa of duodenum is up-regulated by prebiotic supplement, inulin, in iron-deficiency anemia.
Title: Effects of prebiotic supplementation on the expression of proteins regulating iron absorption in anaemic growing rats.

There is an increase in hippocampal expression of duodenal Cybrd1 following kainic acid-induced excitotoxicity.
Title: Expression and localization of duodenal cytochrome b in the rat hippocampus after kainate-induced excitotoxicity.

Whole-genome profiling reveals that increasing dietary protein from 5 to 40% increases duodenal transcript expression of divalent metal transporter 1 (DMT1) 3.2-fold, duodenal cytochrome b (Dcytb) 1.8-fold, and transferrin receptor (TfR) 1.8-fold.
Title: Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats.

Results suggest that the presence of duodenal cytochrome b (Dcytb) in airway epithelial cells and its regulation by iron may contribute to pulmonary cytoprotection [Dcytb].
Title: Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells.

The following Cybrd1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cybrd1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01718	NM_001011954.1 Latest version!	Rattus norvegicus cytochrome b reductase 1 (Cybrd1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Cybrd1 ( NM_001011954.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001011954.1 Rattus norvegicus cytochrome b reductase 1 (Cybrd1), mRNA.

Price & Availability↑

CloneID	ORa01718
Clone ID Related Accession (Same CDS sequence)	NM_001011954.1
Accession Version	NM_001011954.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	cytochrome b reductase 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC085768.1. On Feb 11, 2005 this sequence version replaced XM_215749.2. ##Evidence-Data-START## Transcript exon combination :: BC085768.1, CF109699.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCATGG AAGGCTACCG GGGCTTCCTG GGACTGCTGG TGTCCGCGCT GCTCGTGGGC 
TTCCTGTCGG TGATCTTCGT GCTCATCTGG GTCCTGCACT TCCGAGAGGG GCTTGGCTGG 
GACGGCGGCG CGCTCGAGTT TAACTGGCAC CCGGTGCTCG CCGTGACCGG CTTCGTCTTC 
ATCCAGGGCA TCGCCATCAT CGTGTACAGA TTGCCATGGA CCTGGAAGTG CAGCAAGTTC 
TTGATGAAAT CCATCCACGC CGGGTTAAAC GCTGTGGCTG CCATCCTGGC CATCATCTCA 
GTCGTGGCCG TGTTTGATTA TCACAATGTC CGAAAAATCC CCCACATGTA CAGTCTGCAC 
AGCTGGGTTG GACTGACAGT TCTCATACTC TACATCCAAC AGCTTGTTGT AGGCTTTTTC 
ATCTTTCTGC TTCCATGGGC TCCGCCCTCT CTCCGGGCAA TCGTCATGCC CATACATGTG 
TATTCTGGAC TCCTCCTCTT TGGAACAGTG ATTGCCACGG TCCTCATGGG AGTGACGGAA 
AAGCTGTTCT TTGTCCTGAA AAATCCTTCG TACCATTCAT TCCCACCAGA AGGTGTTTTT 
ACAAATACCC TGGGCCTTCT GATTCTGGTA TTTGGAGCCC TCATCTTTTG GATTGTCACC 
AGGCCACAAT GGAAACGCCC TAGGGAACCA GGCTCTATCC CTCTTCAGCT AAATGGAGGC 
AACGCAGACG GAATGGAGGG CGCCATAGCA ATAAGCTCCG CCCACAACAT GGACGCTGCA 
GACGCAGAGT TAAGCAGCGA GGGAGCAGCC CGGAAAAGAA CCCTCGGCCT TGTTGACACT 
GGCCAGAGGT CCACCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001011954.1
CDS	6..866
Translation	MAMEGYRGFLGLLVSALLVGFLSVIFVLIWVLHFREGLGWDGGALEFNWHPVLAVTGFVFIQGIAIIVYRLPWTWKCSKFLMKSIHAGLNAVAAILAIISVVAVFDYHNVRKIPHMYSLHSWVGLTVLILYIQQLVVGFFIFLLPWAPPSLRAIVMPIHVYSGLLLFGTVIATVLMGVTEKLFFVLKNPSYHSFPPEGVFTNTLGLLILVFGALIFWIVTRPQWKRPREPGSIPLQLNGGNADGMEGAIAISSAHNMDAADAELSSEGAARKRTLGLVDTGQRSTM

Target ORF information:

RefSeq Version	NM_001011954.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus cytochrome b reductase 1 (Cybrd1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001011954.1

ORF Insert Sequence:

ATGGCCATGG AAGGCTACCG GGGCTTCCTG GGACTGCTGG TGTCCGCGCT GCTCGTGGGC 
TTCCTGTCGG TGATCTTCGT GCTCATCTGG GTCCTGCACT TCCGAGAGGG GCTTGGCTGG 
GACGGCGGCG CGCTCGAGTT TAACTGGCAC CCGGTGCTCG CCGTGACCGG CTTCGTCTTC 
ATCCAGGGCA TCGCCATCAT CGTGTACAGA TTGCCATGGA CCTGGAAGTG CAGCAAGTTC 
TTGATGAAAT CCATCCACGC CGGGTTAAAC GCTGTGGCTG CCATCCTGGC CATCATCTCA 
GTCGTGGCCG TGTTTGATTA TCACAATGTC CGAAAAATCC CCCACATGTA CAGTCTGCAC 
AGCTGGGTTG GACTGACAGT TCTCATACTC TACATCCAAC AGCTTGTTGT AGGCTTTTTC 
ATCTTTCTGC TTCCATGGGC TCCGCCCTCT CTCCGGGCAA TCGTCATGCC CATACATGTG 
TATTCTGGAC TCCTCCTCTT TGGAACAGTG ATTGCCACGG TCCTCATGGG AGTGACGGAA 
AAGCTGTTCT TTGTCCTGAA AAATCCTTCG TACCATTCAT TCCCACCAGA AGGTGTTTTT 
ACAAATACCC TGGGCCTTCT GATTCTGGTA TTTGGAGCCC TCATCTTTTG GATTGTCACC 
AGGCCACAAT GGAAACGCCC TAGGGAACCA GGCTCTATCC CTCTTCAGCT AAATGGAGGC 
AACGCAGACG GAATGGAGGG CGCCATAGCA ATAAGCTCCG CCCACAACAT GGACGCTGCA 
GACGCAGAGT TAAGCAGCGA GGGAGCAGCC CGGAAAAGAA CCCTCGGCCT TGTTGACACT 
GGCCAGAGGT CCACCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.
Biochimica et biophysica acta1853(5)1130-44(2015 May)
Lane DJ,Merlot AM,Huang ML,Bae DH,Jansson PJ,Sahni S,Kalinowski DS,Richardson DR

Effects of prebiotic supplementation on the expression of proteins regulating iron absorption in anaemic growing rats.
The British journal of nutrition113(6)901-8(2015 Mar)
Marciano R,Santamarina AB,de Santana AA,Silva Mde L,Amancio OM,do Nascimento CM,Oyama LM,de Morais MB

Expression and localization of duodenal cytochrome b in the rat hippocampus after kainate-induced excitotoxicity.
Neuroscience245179-90(2013 Aug)
Loke SY,Siddiqi NJ,Alhomida AS,Kim HC,Ong WY

Increasing dietary protein acutely augments intestinal iron transporter expression and significantly increases iron absorption in rats.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(6)2476-83(2013 Jun)
Thomas CE,Gaffney-Stomberg E,Sun BH,O'Brien KO,Kerstetter JE,Insogna KL

Large-scale proteomics and phosphoproteomics of urinary exosomes.
Journal of the American Society of Nephrology : JASN20(2)363-79(2009 Feb)
Gonzales PA,Pisitkun T,Hoffert JD,Tchapyjnikov D,Star RA,Kleta R,Wang NS,Knepper MA

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Cybrd1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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