Fcgrt cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fcgrt
Entrez Gene ID	29558
Full Name	Fc fragment of IgG receptor and transporter
Synonyms	FcRn
General protein information	Preferred Names Fc fragment of IgG receptor and transporter Names IgG receptor FcRn large subunit p51 Fc fragment immunoglobulin G receptor Fc fragment of IgG, receptor, transporter, alpha Fc receptor, IgG, alpha chain transporter igG Fc fragment receptor transporter alpha chain neonatal Fc receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q22
Summary	binds and transports maternal immunoglobulin gamma from milk; plays a role in providing maternal immunity to neonates [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017589060.1	XP_017444549.1	IgG receptor FcRn large subunit p51 isoform X2
XM_006229043.2	XP_006229105.1	IgG receptor FcRn large subunit p51 isoform X1
XM_008759343.2	XP_008757565.1	IgG receptor FcRn large subunit p51 isoform X1
NM_033351.2	NP_203502.1	IgG receptor FcRn large subunit p51 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	FCGRT	NP_001129491.1
Canis lupus familiaris (dog)	FCGRT	XP_533618.2
Mus musculus (house mouse)	Fcgrt	NP_034319.2
Pan troglodytes (chimpanzee)	FCGRT	XP_512822.4
	FCGRT	XP_001115305.1
Bos taurus (cattle)	FCGRT	NP_788830.1
Rattus norvegicus (Norway rat)	Fcgrt	NP_203502.1

Gene Ontology
Bibliography

Related articles in PubMed

Mechanism of increased clearance of glycated albumin by proximal tubule cells.
Wagner MC, Myslinski J, Pratap S, Flores B, Rhodes G, Campos-Bilderback SB, Sandoval RM, Kumar S, Patel M, Ashish, Molitoris BA
American journal of physiology. Renal physiology310(10)F1089-102(2016 May)

The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.
Abdiche YN, Yeung YA, Chaparro-Riggers J, Barman I, Strop P, Chin SM, Pham A, Bolton G, McDonough D, Lindquist K, Pons J, Rajpal A
mAbs7(2)331-43(2015)

Characterization and screening of IgG binding to the neonatal Fc receptor.
Neuber T, Frese K, Jaehrling J, J?ger S, Daubert D, Felderer K, Linnemann M, H?hne A, Kaden S, K?lln J, Tiller T, Brocks B, Ostendorp R, Pabst S
mAbs6(4)928-42(2014 Jul-Aug)

Contribution of FcRn binding to intestinal uptake of IgG in suckling rat pups and human FcRn-transgenic mice.
Kliwinski C, Cooper PR, Perkinson R, Mabus JR, Tam SH, Wilkinson TM, Giles-Komar J, Scallon B, Powers GD, Hornby PJ
American journal of physiology. Gastrointestinal and liver physiology304(3)G262-70(2013 Feb)

Embryo-fetal transfer of bevacizumab (Avastin) in the rat over the course of gestation and the impact of neonatal Fc receptor (FcRn) binding.
Thorn M, Piche-Nicholas N, Stedman D, Davenport SW, Zhang N, Collinge M, Bowman CJ
Birth defects research. Part B, Developmental and reproductive toxicology95(5)363-75(2012 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

significant structural changes occur to albumin with glycation, particularly in the FcRn-binding region, which could explain the reduced affinity to FcRn
Title: Mechanism of increased clearance of glycated albumin by proximal tubule cells.

The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.
Title: The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.

Characterization and screening of IgG binding to the neonatal Fc receptor.
Title: Characterization and screening of IgG binding to the neonatal Fc receptor.

The suckling rat pup intestine is a mechanistic model of FcRn-IgG-mediated transcytosis
Title: Contribution of FcRn binding to intestinal uptake of IgG in suckling rat pups and human FcRn-transgenic mice.

Fetal transfer of Avastins mutated in the portion of the antibody that binds the neonatal Fc receptor (FcRn) was tested in late gestation and was found to correlate with affinities of the mutant Avastin antibody to FcRn.
Title: Embryo-fetal transfer of bevacizumab (Avastin) in the rat over the course of gestation and the impact of neonatal Fc receptor (FcRn) binding.

The following Fcgrt gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fcgrt cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa09108	NM_033351.2 Latest version!	Rattus norvegicus Fc fragment of IgG receptor and transporter (Fcgrt), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
ORa09108	XM_006229043.2 Latest version!	Rattus norvegicus Fc fragment of IgG receptor and transporter (Fcgrt), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
ORa09108	XM_008759343.2 Latest version!	Rattus norvegicus Fc fragment of IgG receptor and transporter (Fcgrt), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
ORa56538	XM_017589060.1 Latest version!	Rattus norvegicus Fc fragment of IgG receptor and transporter (Fcgrt), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fcgrt ( NM_033351.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_203502.1 Rattus norvegicus Fc fragment of IgG receptor and transporter (Fcgrt), mRNA.

Price & Availability↑

CloneID	ORa09108
Clone ID Related Accession (Same CDS sequence)	XM_006229043.2 , XM_008759343.2 , NM_033351.2
Accession Version	NM_033351.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1101bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	IgG receptor FcRn large subunit p51 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M35495.1. On Aug 31, 2012 this sequence version replaced NM_033351.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M35495.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGGGATGT CCCAGCCCGG GGTCCTCCTC AGCCTCTTAT TGGTCCTCCT GCCTCAGACC 
TGGGGAGCGG AGCCCCGTCT CCCACTGATG TATCATCTTG CAGCTGTGTC TGACTTATCA 
ACGGGGCTTC CCTCTTTCTG GGCCACGGGC TGGCTGGGTG CTCAGCAATA TCTGACCTAC 
AACAACCTGC GGCAGGAGGC TGACCCCTGT GGGGCCTGGA TATGGGAAAA CCAGGTGTCT 
TGGTATTGGG AGAAGGAGAC CACGGATCTG AAAAGCAAAG AACAGCTCTT CTTGGAGGCC 
ATCAGGACCC TGGAGAACCA AATAAATGGG ACCTTCACAC TGCAGGGCCT GCTGGGCTGT 
GAACTGGCCC CTGATAATTC TTCATTGCCC ACGGCTGTGT TTGCCCTCAA TGGTGAGGAG 
TTCATGCGGT TCAACCCAAG AACGGGCAAC TGGAGTGGGG AGTGGCCGGA GACAGATATC 
GTTGGTAATC TGTGGATGAA GCAACCTGAG GCGGCCAGGA AGGAGAGCGA GTTCCTGCTA 
ACTTCTTGTC CTGAGCGGCT GCTAGGCCAC CTGGAGAGGG GCCGTCAGAA CCTGGAGTGG 
AAGGAGCCGC CATCTATGCG CCTGAAGGCC CGTCCTGGCA ACTCTGGCTC CTCAGTACTG 
ACCTGTGCTG CTTTCTCCTT CTACCCGCCG GAGCTCAAGT TTCGATTCCT GCGCAATGGG 
CTAGCCTCAG GCTCTGGGAA TTGCAGCACT GGTCCCAATG GTGATGGATC TTTCCATGCA 
TGGTCATTGC TAGAGGTCAA ACGTGGAGAT GAACACCATT ACCAATGTCA AGTGGAGCAT 
GAGGGGCTGG CCCAGCCTCT CACTGTGGAC CTAGATTCGC CCGCCAGATC TTCTGTGCCT 
GTGGTCGGAA TCATTCTTGG TTTATTGCTG GTGGTAGTGG CCATCGCAGG GGGTGTGCTG 
CTATGGAACA GGATGCGAAG TGGGCTGCCA GCCCCATGGC TTTCTCTCAG TGGTGATGAC 
TCTGGCGACC TATTGCCTGG TGGGAACTTG CCCCCGGAGG CTGAACCTCA AGGTGTAAAT 
GCCTTTCCGG CCACTTCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_203502.1
CDS	203..1303
Translation	MGMSQPGVLLSLLLVLLPQTWGAEPRLPLMYHLAAVSDLSTGLPSFWATGWLGAQQYLTYNNLRQEADPCGAWIWENQVSWYWEKETTDLKSKEQLFLEAIRTLENQINGTFTLQGLLGCELAPDNSSLPTAVFALNGEEFMRFNPRTGNWSGEWPETDIVGNLWMKQPEAARKESEFLLTSCPERLLGHLERGRQNLEWKEPPSMRLKARPGNSGSSVLTCAAFSFYPPELKFRFLRNGLASGSGNCSTGPNGDGSFHAWSLLEVKRGDEHHYQCQVEHEGLAQPLTVDLDSPARSSVPVVGIILGLLLVVVAIAGGVLLWNRMRSGLPAPWLSLSGDDSGDLLPGGNLPPEAEPQGVNAFPATS

Target ORF information:

RefSeq Version	NM_033351.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Fc fragment of IgG receptor and transporter (Fcgrt), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033351.2

ORF Insert Sequence:

ATGGGGATGT CCCAGCCCGG GGTCCTCCTC AGCCTCTTAT TGGTCCTCCT GCCTCAGACC 
TGGGGAGCGG AGCCCCGTCT CCCACTGATG TATCATCTTG CAGCTGTGTC TGACTTATCA 
ACGGGGCTTC CCTCTTTCTG GGCCACGGGC TGGCTGGGTG CTCAGCAATA TCTGACCTAC 
AACAACCTGC GGCAGGAGGC TGACCCCTGT GGGGCCTGGA TATGGGAAAA CCAGGTGTCT 
TGGTATTGGG AGAAGGAGAC CACGGATCTG AAAAGCAAAG AACAGCTCTT CTTGGAGGCC 
ATCAGGACCC TGGAGAACCA AATAAATGGG ACCTTCACAC TGCAGGGCCT GCTGGGCTGT 
GAACTGGCCC CTGATAATTC TTCATTGCCC ACGGCTGTGT TTGCCCTCAA TGGTGAGGAG 
TTCATGCGGT TCAACCCAAG AACGGGCAAC TGGAGTGGGG AGTGGCCGGA GACAGATATC 
GTTGGTAATC TGTGGATGAA GCAACCTGAG GCGGCCAGGA AGGAGAGCGA GTTCCTGCTA 
ACTTCTTGTC CTGAGCGGCT GCTAGGCCAC CTGGAGAGGG GCCGTCAGAA CCTGGAGTGG 
AAGGAGCCGC CATCTATGCG CCTGAAGGCC CGTCCTGGCA ACTCTGGCTC CTCAGTACTG 
ACCTGTGCTG CTTTCTCCTT CTACCCGCCG GAGCTCAAGT TTCGATTCCT GCGCAATGGG 
CTAGCCTCAG GCTCTGGGAA TTGCAGCACT GGTCCCAATG GTGATGGATC TTTCCATGCA 
TGGTCATTGC TAGAGGTCAA ACGTGGAGAT GAACACCATT ACCAATGTCA AGTGGAGCAT 
GAGGGGCTGG CCCAGCCTCT CACTGTGGAC CTAGATTCGC CCGCCAGATC TTCTGTGCCT 
GTGGTCGGAA TCATTCTTGG TTTATTGCTG GTGGTAGTGG CCATCGCAGG GGGTGTGCTG 
CTATGGAACA GGATGCGAAG TGGGCTGCCA GCCCCATGGC TTTCTCTCAG TGGTGATGAC 
TCTGGCGACC TATTGCCTGG TGGGAACTTG CCCCCGGAGG CTGAACCTCA AGGTGTAAAT 
GCCTTTCCGG CCACTTCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fcgrt ( XM_006229043.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006229105.1 Rattus norvegicus Fc fragment of IgG receptor and transporter (Fcgrt), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa09108
Clone ID Related Accession (Same CDS sequence)	XM_006229043.2 , XM_008759343.2 , NM_033351.2
Accession Version	XM_006229043.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1101bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	IgG receptor FcRn large subunit p51 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006229043.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGATGT CCCAGCCCGG GGTCCTCCTC AGCCTCTTAT TGGTCCTCCT GCCTCAGACC 
TGGGGAGCGG AGCCCCGTCT CCCACTGATG TATCATCTTG CAGCTGTGTC TGACTTATCA 
ACGGGGCTTC CCTCTTTCTG GGCCACGGGC TGGCTGGGTG CTCAGCAATA TCTGACCTAC 
AACAACCTGC GGCAGGAGGC TGACCCCTGT GGGGCCTGGA TATGGGAAAA CCAGGTGTCT 
TGGTATTGGG AGAAGGAGAC CACGGATCTG AAAAGCAAAG AACAGCTCTT CTTGGAGGCC 
ATCAGGACCC TGGAGAACCA AATAAATGGG ACCTTCACAC TGCAGGGCCT GCTGGGCTGT 
GAACTGGCCC CTGATAATTC TTCATTGCCC ACGGCTGTGT TTGCCCTCAA TGGTGAGGAG 
TTCATGCGGT TCAACCCAAG AACGGGCAAC TGGAGTGGGG AGTGGCCGGA GACAGATATC 
GTTGGTAATC TGTGGATGAA GCAACCTGAG GCGGCCAGGA AGGAGAGCGA GTTCCTGCTA 
ACTTCTTGTC CTGAGCGGCT GCTAGGCCAC CTGGAGAGGG GCCGTCAGAA CCTGGAGTGG 
AAGGAGCCGC CATCTATGCG CCTGAAGGCC CGTCCTGGCA ACTCTGGCTC CTCAGTACTG 
ACCTGTGCTG CTTTCTCCTT CTACCCGCCG GAGCTCAAGT TTCGATTCCT GCGCAATGGG 
CTAGCCTCAG GCTCTGGGAA TTGCAGCACT GGTCCCAATG GTGATGGATC TTTCCATGCA 
TGGTCATTGC TAGAGGTCAA ACGTGGAGAT GAACACCATT ACCAATGTCA AGTGGAGCAT 
GAGGGGCTGG CCCAGCCTCT CACTGTGGAC CTAGATTCGC CCGCCAGATC TTCTGTGCCT 
GTGGTCGGAA TCATTCTTGG TTTATTGCTG GTGGTAGTGG CCATCGCAGG GGGTGTGCTG 
CTATGGAACA GGATGCGAAG TGGGCTGCCA GCCCCATGGC TTTCTCTCAG TGGTGATGAC 
TCTGGCGACC TATTGCCTGG TGGGAACTTG CCCCCGGAGG CTGAACCTCA AGGTGTAAAT 
GCCTTTCCGG CCACTTCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006229105.1
CDS	313..1413
Translation	MGMSQPGVLLSLLLVLLPQTWGAEPRLPLMYHLAAVSDLSTGLPSFWATGWLGAQQYLTYNNLRQEADPCGAWIWENQVSWYWEKETTDLKSKEQLFLEAIRTLENQINGTFTLQGLLGCELAPDNSSLPTAVFALNGEEFMRFNPRTGNWSGEWPETDIVGNLWMKQPEAARKESEFLLTSCPERLLGHLERGRQNLEWKEPPSMRLKARPGNSGSSVLTCAAFSFYPPELKFRFLRNGLASGSGNCSTGPNGDGSFHAWSLLEVKRGDEHHYQCQVEHEGLAQPLTVDLDSPARSSVPVVGIILGLLLVVVAIAGGVLLWNRMRSGLPAPWLSLSGDDSGDLLPGGNLPPEAEPQGVNAFPATS

Target ORF information:

RefSeq Version	XM_006229043.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Fc fragment of IgG receptor and transporter (Fcgrt), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006229043.2

ORF Insert Sequence:

ATGGGGATGT CCCAGCCCGG GGTCCTCCTC AGCCTCTTAT TGGTCCTCCT GCCTCAGACC 
TGGGGAGCGG AGCCCCGTCT CCCACTGATG TATCATCTTG CAGCTGTGTC TGACTTATCA 
ACGGGGCTTC CCTCTTTCTG GGCCACGGGC TGGCTGGGTG CTCAGCAATA TCTGACCTAC 
AACAACCTGC GGCAGGAGGC TGACCCCTGT GGGGCCTGGA TATGGGAAAA CCAGGTGTCT 
TGGTATTGGG AGAAGGAGAC CACGGATCTG AAAAGCAAAG AACAGCTCTT CTTGGAGGCC 
ATCAGGACCC TGGAGAACCA AATAAATGGG ACCTTCACAC TGCAGGGCCT GCTGGGCTGT 
GAACTGGCCC CTGATAATTC TTCATTGCCC ACGGCTGTGT TTGCCCTCAA TGGTGAGGAG 
TTCATGCGGT TCAACCCAAG AACGGGCAAC TGGAGTGGGG AGTGGCCGGA GACAGATATC 
GTTGGTAATC TGTGGATGAA GCAACCTGAG GCGGCCAGGA AGGAGAGCGA GTTCCTGCTA 
ACTTCTTGTC CTGAGCGGCT GCTAGGCCAC CTGGAGAGGG GCCGTCAGAA CCTGGAGTGG 
AAGGAGCCGC CATCTATGCG CCTGAAGGCC CGTCCTGGCA ACTCTGGCTC CTCAGTACTG 
ACCTGTGCTG CTTTCTCCTT CTACCCGCCG GAGCTCAAGT TTCGATTCCT GCGCAATGGG 
CTAGCCTCAG GCTCTGGGAA TTGCAGCACT GGTCCCAATG GTGATGGATC TTTCCATGCA 
TGGTCATTGC TAGAGGTCAA ACGTGGAGAT GAACACCATT ACCAATGTCA AGTGGAGCAT 
GAGGGGCTGG CCCAGCCTCT CACTGTGGAC CTAGATTCGC CCGCCAGATC TTCTGTGCCT 
GTGGTCGGAA TCATTCTTGG TTTATTGCTG GTGGTAGTGG CCATCGCAGG GGGTGTGCTG 
CTATGGAACA GGATGCGAAG TGGGCTGCCA GCCCCATGGC TTTCTCTCAG TGGTGATGAC 
TCTGGCGACC TATTGCCTGG TGGGAACTTG CCCCCGGAGG CTGAACCTCA AGGTGTAAAT 
GCCTTTCCGG CCACTTCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fcgrt ( XM_008759343.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008757565.1 Rattus norvegicus Fc fragment of IgG receptor and transporter (Fcgrt), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa09108
Clone ID Related Accession (Same CDS sequence)	XM_006229043.2 , XM_008759343.2 , NM_033351.2
Accession Version	XM_008759343.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1101bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	IgG receptor FcRn large subunit p51 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008759343.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGGATGT CCCAGCCCGG GGTCCTCCTC AGCCTCTTAT TGGTCCTCCT GCCTCAGACC 
TGGGGAGCGG AGCCCCGTCT CCCACTGATG TATCATCTTG CAGCTGTGTC TGACTTATCA 
ACGGGGCTTC CCTCTTTCTG GGCCACGGGC TGGCTGGGTG CTCAGCAATA TCTGACCTAC 
AACAACCTGC GGCAGGAGGC TGACCCCTGT GGGGCCTGGA TATGGGAAAA CCAGGTGTCT 
TGGTATTGGG AGAAGGAGAC CACGGATCTG AAAAGCAAAG AACAGCTCTT CTTGGAGGCC 
ATCAGGACCC TGGAGAACCA AATAAATGGG ACCTTCACAC TGCAGGGCCT GCTGGGCTGT 
GAACTGGCCC CTGATAATTC TTCATTGCCC ACGGCTGTGT TTGCCCTCAA TGGTGAGGAG 
TTCATGCGGT TCAACCCAAG AACGGGCAAC TGGAGTGGGG AGTGGCCGGA GACAGATATC 
GTTGGTAATC TGTGGATGAA GCAACCTGAG GCGGCCAGGA AGGAGAGCGA GTTCCTGCTA 
ACTTCTTGTC CTGAGCGGCT GCTAGGCCAC CTGGAGAGGG GCCGTCAGAA CCTGGAGTGG 
AAGGAGCCGC CATCTATGCG CCTGAAGGCC CGTCCTGGCA ACTCTGGCTC CTCAGTACTG 
ACCTGTGCTG CTTTCTCCTT CTACCCGCCG GAGCTCAAGT TTCGATTCCT GCGCAATGGG 
CTAGCCTCAG GCTCTGGGAA TTGCAGCACT GGTCCCAATG GTGATGGATC TTTCCATGCA 
TGGTCATTGC TAGAGGTCAA ACGTGGAGAT GAACACCATT ACCAATGTCA AGTGGAGCAT 
GAGGGGCTGG CCCAGCCTCT CACTGTGGAC CTAGATTCGC CCGCCAGATC TTCTGTGCCT 
GTGGTCGGAA TCATTCTTGG TTTATTGCTG GTGGTAGTGG CCATCGCAGG GGGTGTGCTG 
CTATGGAACA GGATGCGAAG TGGGCTGCCA GCCCCATGGC TTTCTCTCAG TGGTGATGAC 
TCTGGCGACC TATTGCCTGG TGGGAACTTG CCCCCGGAGG CTGAACCTCA AGGTGTAAAT 
GCCTTTCCGG CCACTTCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008757565.1
CDS	214..1314
Translation	MGMSQPGVLLSLLLVLLPQTWGAEPRLPLMYHLAAVSDLSTGLPSFWATGWLGAQQYLTYNNLRQEADPCGAWIWENQVSWYWEKETTDLKSKEQLFLEAIRTLENQINGTFTLQGLLGCELAPDNSSLPTAVFALNGEEFMRFNPRTGNWSGEWPETDIVGNLWMKQPEAARKESEFLLTSCPERLLGHLERGRQNLEWKEPPSMRLKARPGNSGSSVLTCAAFSFYPPELKFRFLRNGLASGSGNCSTGPNGDGSFHAWSLLEVKRGDEHHYQCQVEHEGLAQPLTVDLDSPARSSVPVVGIILGLLLVVVAIAGGVLLWNRMRSGLPAPWLSLSGDDSGDLLPGGNLPPEAEPQGVNAFPATS

Target ORF information:

RefSeq Version	XM_008759343.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Fc fragment of IgG receptor and transporter (Fcgrt), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008759343.2

ORF Insert Sequence:

ATGGGGATGT CCCAGCCCGG GGTCCTCCTC AGCCTCTTAT TGGTCCTCCT GCCTCAGACC 
TGGGGAGCGG AGCCCCGTCT CCCACTGATG TATCATCTTG CAGCTGTGTC TGACTTATCA 
ACGGGGCTTC CCTCTTTCTG GGCCACGGGC TGGCTGGGTG CTCAGCAATA TCTGACCTAC 
AACAACCTGC GGCAGGAGGC TGACCCCTGT GGGGCCTGGA TATGGGAAAA CCAGGTGTCT 
TGGTATTGGG AGAAGGAGAC CACGGATCTG AAAAGCAAAG AACAGCTCTT CTTGGAGGCC 
ATCAGGACCC TGGAGAACCA AATAAATGGG ACCTTCACAC TGCAGGGCCT GCTGGGCTGT 
GAACTGGCCC CTGATAATTC TTCATTGCCC ACGGCTGTGT TTGCCCTCAA TGGTGAGGAG 
TTCATGCGGT TCAACCCAAG AACGGGCAAC TGGAGTGGGG AGTGGCCGGA GACAGATATC 
GTTGGTAATC TGTGGATGAA GCAACCTGAG GCGGCCAGGA AGGAGAGCGA GTTCCTGCTA 
ACTTCTTGTC CTGAGCGGCT GCTAGGCCAC CTGGAGAGGG GCCGTCAGAA CCTGGAGTGG 
AAGGAGCCGC CATCTATGCG CCTGAAGGCC CGTCCTGGCA ACTCTGGCTC CTCAGTACTG 
ACCTGTGCTG CTTTCTCCTT CTACCCGCCG GAGCTCAAGT TTCGATTCCT GCGCAATGGG 
CTAGCCTCAG GCTCTGGGAA TTGCAGCACT GGTCCCAATG GTGATGGATC TTTCCATGCA 
TGGTCATTGC TAGAGGTCAA ACGTGGAGAT GAACACCATT ACCAATGTCA AGTGGAGCAT 
GAGGGGCTGG CCCAGCCTCT CACTGTGGAC CTAGATTCGC CCGCCAGATC TTCTGTGCCT 
GTGGTCGGAA TCATTCTTGG TTTATTGCTG GTGGTAGTGG CCATCGCAGG GGGTGTGCTG 
CTATGGAACA GGATGCGAAG TGGGCTGCCA GCCCCATGGC TTTCTCTCAG TGGTGATGAC 
TCTGGCGACC TATTGCCTGG TGGGAACTTG CCCCCGGAGG CTGAACCTCA AGGTGTAAAT 
GCCTTTCCGG CCACTTCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fcgrt ( XM_017589060.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444549.1 Rattus norvegicus Fc fragment of IgG receptor and transporter (Fcgrt), transcript variant X3, mRNA.

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CloneID	ORa56538
Clone ID Related Accession (Same CDS sequence)	XM_017589060.1
Accession Version	XM_017589060.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	IgG receptor FcRn large subunit p51 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTATCATC TTGCAGCTGT GTCTGACTTA TCAACGGGGC TTCCCTCTTT CTGGGCCACG 
GGCTGGCTGG GTGCTCAGCA ATATCTGACC TACAACAACC TGCGGCAGGA GGCTGACCCC 
TGTGGGGCCT GGATATGGGA AAACCAGGTG TCTTGGTATT GGGAGAAGGA GACCACGGAT 
CTGAAAAGCA AAGAACAGCT CTTCTTGGAG GCCATCAGGA CCCTGGAGAA CCAAATAAAT 
GGGACCTTCA CACTGCAGGG CCTGCTGGGC TGTGAACTGG CCCCTGATAA TTCTTCATTG 
CCCACGGCTG TGTTTGCCCT CAATGGTGAG GAGTTCATGC GGTTCAACCC AAGAACGGGC 
AACTGGAGTG GGGAGTGGCC GGAGACAGAT ATCGTTGGTA ATCTGTGGAT GAAGCAACCT 
GAGGCGGCCA GGAAGGAGAG CGAGTTCCTG CTAACTTCTT GTCCTGAGCG GCTGCTAGGC 
CACCTGGAGA GGGGCCGTCA GAACCTGGAG TGGAAGGAGC CGCCATCTAT GCGCCTGAAG 
GCCCGTCCTG GCAACTCTGG CTCCTCAGTA CTGACCTGTG CTGCTTTCTC CTTCTACCCG 
CCGGAGCTCA AGTTTCGATT CCTGCGCAAT GGGCTAGCCT CAGGCTCTGG GAATTGCAGC 
ACTGGTCCCA ATGGTGATGG ATCTTTCCAT GCATGGTCAT TGCTAGAGGT CAAACGTGGA 
GATGAACACC ATTACCAATG TCAAGTGGAG CATGAGGGGC TGGCCCAGCC TCTCACTGTG 
GACCTAGATT CGCCCGCCAG ATCTTCTGTG CCTGTGGTCG GAATCATTCT TGGTTTATTG 
CTGGTGGTAG TGGCCATCGC AGGGGGTGTG CTGCTATGGA ACAGGATGCG AAGTGGGCTG 
CCAGCCCCAT GGCTTTCTCT CAGTGGTGAT GACTCTGGCG ACCTATTGCC TGGTGGGAAC 
TTGCCCCCGG AGGCTGAACC TCAAGGTGTA AATGCCTTTC CGGCCACTTC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444549.1
CDS	130..1143
Translation	MYHLAAVSDLSTGLPSFWATGWLGAQQYLTYNNLRQEADPCGAWIWENQVSWYWEKETTDLKSKEQLFLEAIRTLENQINGTFTLQGLLGCELAPDNSSLPTAVFALNGEEFMRFNPRTGNWSGEWPETDIVGNLWMKQPEAARKESEFLLTSCPERLLGHLERGRQNLEWKEPPSMRLKARPGNSGSSVLTCAAFSFYPPELKFRFLRNGLASGSGNCSTGPNGDGSFHAWSLLEVKRGDEHHYQCQVEHEGLAQPLTVDLDSPARSSVPVVGIILGLLLVVVAIAGGVLLWNRMRSGLPAPWLSLSGDDSGDLLPGGNLPPEAEPQGVNAFPATS

Target ORF information:

RefSeq Version	XM_017589060.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Fc fragment of IgG receptor and transporter (Fcgrt), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589060.1

ORF Insert Sequence:

ATGTATCATC TTGCAGCTGT GTCTGACTTA TCAACGGGGC TTCCCTCTTT CTGGGCCACG 
GGCTGGCTGG GTGCTCAGCA ATATCTGACC TACAACAACC TGCGGCAGGA GGCTGACCCC 
TGTGGGGCCT GGATATGGGA AAACCAGGTG TCTTGGTATT GGGAGAAGGA GACCACGGAT 
CTGAAAAGCA AAGAACAGCT CTTCTTGGAG GCCATCAGGA CCCTGGAGAA CCAAATAAAT 
GGGACCTTCA CACTGCAGGG CCTGCTGGGC TGTGAACTGG CCCCTGATAA TTCTTCATTG 
CCCACGGCTG TGTTTGCCCT CAATGGTGAG GAGTTCATGC GGTTCAACCC AAGAACGGGC 
AACTGGAGTG GGGAGTGGCC GGAGACAGAT ATCGTTGGTA ATCTGTGGAT GAAGCAACCT 
GAGGCGGCCA GGAAGGAGAG CGAGTTCCTG CTAACTTCTT GTCCTGAGCG GCTGCTAGGC 
CACCTGGAGA GGGGCCGTCA GAACCTGGAG TGGAAGGAGC CGCCATCTAT GCGCCTGAAG 
GCCCGTCCTG GCAACTCTGG CTCCTCAGTA CTGACCTGTG CTGCTTTCTC CTTCTACCCG 
CCGGAGCTCA AGTTTCGATT CCTGCGCAAT GGGCTAGCCT CAGGCTCTGG GAATTGCAGC 
ACTGGTCCCA ATGGTGATGG ATCTTTCCAT GCATGGTCAT TGCTAGAGGT CAAACGTGGA 
GATGAACACC ATTACCAATG TCAAGTGGAG CATGAGGGGC TGGCCCAGCC TCTCACTGTG 
GACCTAGATT CGCCCGCCAG ATCTTCTGTG CCTGTGGTCG GAATCATTCT TGGTTTATTG 
CTGGTGGTAG TGGCCATCGC AGGGGGTGTG CTGCTATGGA ACAGGATGCG AAGTGGGCTG 
CCAGCCCCAT GGCTTTCTCT CAGTGGTGAT GACTCTGGCG ACCTATTGCC TGGTGGGAAC 
TTGCCCCCGG AGGCTGAACC TCAAGGTGTA AATGCCTTTC CGGCCACTTC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mechanism of increased clearance of glycated albumin by proximal tubule cells.
American journal of physiology. Renal physiology310(10)F1089-102(2016 May)
Wagner MC,Myslinski J,Pratap S,Flores B,Rhodes G,Campos-Bilderback SB,Sandoval RM,Kumar S,Patel M,Ashish,Molitoris BA

The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity.
mAbs7(2)331-43(2015)
Abdiche YN,Yeung YA,Chaparro-Riggers J,Barman I,Strop P,Chin SM,Pham A,Bolton G,McDonough D,Lindquist K,Pons J,Rajpal A

Characterization and screening of IgG binding to the neonatal Fc receptor.
mAbs6(4)928-42(2014 Jul-Aug)
Neuber T,Frese K,Jaehrling J,J?ger S,Daubert D,Felderer K,Linnemann M,H?hne A,Kaden S,K?lln J,Tiller T,Brocks B,Ostendorp R,Pabst S

Contribution of FcRn binding to intestinal uptake of IgG in suckling rat pups and human FcRn-transgenic mice.
American journal of physiology. Gastrointestinal and liver physiology304(3)G262-70(2013 Feb)
Kliwinski C,Cooper PR,Perkinson R,Mabus JR,Tam SH,Wilkinson TM,Giles-Komar J,Scallon B,Powers GD,Hornby PJ

Embryo-fetal transfer of bevacizumab (Avastin) in the rat over the course of gestation and the impact of neonatal Fc receptor (FcRn) binding.
Birth defects research. Part B, Developmental and reproductive toxicology95(5)363-75(2012 Oct)
Thorn M,Piche-Nicholas N,Stedman D,Davenport SW,Zhang N,Collinge M,Bowman CJ

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Fcgrt cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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