Vav3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Vav3
Entrez Gene ID	295378
Full Name	vav guanine nucleotide exchange factor 3
Synonyms	RGD1565941
General protein information	Preferred Names vav guanine nucleotide exchange factor 3 Names guanine nucleotide exchange factor VAV3 vav 3 guanine nucleotide exchange factor vav 3 oncogene
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q41

mRNA and Protein(s)

mRNA	Protein	Name
NM_001191714.1	NP_001178643.1	guanine nucleotide exchange factor VAV3
XM_017590775.1	XP_017446264.1	guanine nucleotide exchange factor VAV3 isoform X1

Pathways from BioSystems

Homologies

	VAV3	XP_002801727.1
Mus musculus (house mouse)	Vav3	NP_065251.2
Canis lupus familiaris (dog)	VAV3	XP_537047.3
Bos taurus (cattle)	VAV3	XP_002686208.1
Gallus gallus (chicken)	VAV3	NP_996745.1
Homo sapiens (human)	VAV3	NP_006104.4
Rattus norvegicus (Norway rat)	Vav3	NP_001178643.1
Xenopus tropicalis (tropical clawed frog)	vav3	XP_002932225.2
Danio rerio (zebrafish)	vav3b	NP_001119865.1
Caenorhabditis elegans (roundworm)	vav-1	NP_001041222.1

Gene Ontology
Bibliography

Related articles in PubMed

Radixin regulates cell migration and cell-cell adhesion through Rac1.
Valderrama F, Thevapala S, Ridley AJ
Journal of cell science125(Pt 14)3310-9(2012 Jul)

P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses.
Lawson CD, Donald S, Anderson KE, Patton DT, Welch HC
Journal of immunology (Baltimore, Md. : 1950)186(3)1467-76(2011 Feb)

The Rho protein exchange factor Vav3 regulates vascular smooth muscle cell proliferation and migration.
Toumaniantz G, Ferland-McCollough D, Cario-Toumaniantz C, Pacaud P, Loirand G
Cardiovascular research86(1)131-40(2010 Apr)

ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia.
Joshi AD, Hegde GV, Dickinson JD, Mittal AK, Lynch JC, Eudy JD, Armitage JO, Bierman PJ, Bociek RG, Devetten MP, Vose JM, Joshi SS
Clinical cancer research : an official journal of the American Association for Cancer Research13(18 Pt 1)5295-304(2007 Sep)

Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells.
Aoki K, Nakamura T, Fujikawa K, Matsuda M
Molecular biology of the cell16(5)2207-17(2005 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The Rho GEF Vav3 controls vascular smooth muscle cell proliferation and migration through activation of Rac1/PAK signalling
Title: The Rho protein exchange factor Vav3 regulates vascular smooth muscle cell proliferation and migration.

The following Vav3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vav3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07460	NM_001191714.1 Latest version!	Rattus norvegicus vav guanine nucleotide exchange factor 3 (Vav3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
ORa59689	XM_017590775.1 Latest version!	Rattus norvegicus vav guanine nucleotide exchange factor 3 (Vav3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Vav3 ( NM_001191714.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001178643.1 Rattus norvegicus vav guanine nucleotide exchange factor 3 (Vav3), mRNA.

Price & Availability↑

CloneID	ORa07460
Clone ID Related Accession (Same CDS sequence)	NM_001191714.1
Accession Version	NM_001191714.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2544bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Rattus norvegicus(Norway rat)
Product	guanine nucleotide exchange factor VAV3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07012868.1. On Jul 17, 2010 this sequence version replaced XM_227600.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCCGT GGAAGCAGTG CGCTCAGTGG CTCATCCACT GCAAAGTGCT GCCCGCCAAC 
CACCGGGTGA CCTGGGACTC GGCGCAGGTG TTCGACCTGG CGCAGACCCT CCGCGATGGA 
GTCCTGCTCT GCCAGCTGCT CAACAACCTG CGGCCACACT CCATCAATCT GAAGGAGATC 
AACCTGAGAC CCCAGATGTC CCAGTTTCTC TGTCTGAAGA ATATCCGGAC ATTTCTGGCC 
GCCTGCTGTG ACACGTTCGG AATGAAGAAA AGTGAGCTTT TTGAGGCATT TGACCTATTC 
GATGTTCGTG ACTTTGGAAA GGTTATAGAA ACATTATCTC GCCTATCCCG AACACCAATA 
GCATTGGCCA CAGGAATCAG GCCATTCCCC ACGGAAGAAA GTGTAAATGA TGAAGACATC 
TACAAAGGCC TTCCTGACCT GATAGATGAA ACCCGTGTGG AGGACGAAGA AGACCTCTAT 
GACTGTGTGT ACGGGGAGGA TGAAGGCGGA GAAGTCTATG AAGATTTGAT GAAGGCGGAG 
GAGGCTCACC AAGCTAAATC ACAAGAAAAT GATATACGGA GTTGTTGCCT AGCAGAAATT 
AGGCAGACAG AAGAAAAATA CACAGAAACT TTGGAGTCAA TAGAAAAATA TTTCATGGCA 
CCATTGAAAA GATTTCTGAC AGCGGCGGAA TTTGATTCAG TATTTATCAA CATTCCTGAC 
CTTGTAAAAG TTCATCGGAG CTTAATGCAA GAGATTCACG ATTCCATTGT AAATAAAGAT 
GACCATAACT TGTATCAAGT TTTTATTAAC TACAAGGAAA GATTGGTTAT TTATGGACAG 
TACTGCAGTG GAGTGGAGTC AGCCATCTCT AGCCTAGACT ACATCTCTAA GACAAAAGAA 
GATGTCAGAC TGAAACTAGA GGAATGTTCA AAGAGAGCCA ATAATGGGAA ATTTACTCTG 
CGTGATTTGC TGGTAGTTCC CATGCAGCGG GTGCTGAAAT ATCACCTCCT CCTTCAGGAG 
CTGGTTAAAC ACACCCATGA TCCCATGGAG AAGTCGAACC TGAAGCTGGC TCTGGATGCA 
ATGAAGGACT TGGCACAATA TGTGAATGAA GTAAAAAGAG ATAATGAGAC CCTTCGTGAA 
ATTAAGCAGT TTCAGCTATC TATAGAAAAT TTGAACCAGC CCGTTTTGCT CTTTGGGCGA 
CCGCAGGGAG ACGGTGAAAT CCGAATAACC ACACTGGACA AGCATACGAA ACAAGAAAGG 
CATATCTTCT TATTCGATCT GGCAGTGATT GTCTGTAAAA GGAAAGGGGA TAACTACGAG 
ATGAAGGAAA TAATAGATCT CCAGCAGTAC AAGATCGCCA ACAACCCTAC CACGGATAAA 
GAGAATAAAA AGTGGTCTTA TGGCTTCTAC CTCATCCATA CCCAAGGACA AAATGGGCTG 
GAATTTTATT GCAAAACAAA AGATTTAAAG AAAAAATGGC TGGAACAGTT TGAAATGGCT 
TTATCCAACA TAAGGCCGGA CTATGCAGAC TCCAATTTCC ATGACTTCAA GATGCACACA 
TTCACTCGGG TGACATCCTG TAGGGTCTGC CAAATGCTCC TGAGGGGGAC ATTTTATCAA 
GGCTACTTAT GTTTTAAGTG TGGAGCAAAA GCGCATAAAG AATGTTTGGG AAGAGTAGAC 
AATTGTGGCA GAGTTAATTC CGTTGAACAA GGGCCATTCA AACCACCGGA GAAGCGGACC 
AATGGACTTC GGAGAGCTTC CAGACAGGTG GATCCAGGCT TGCCGAAGAT GCGGGTCATT 
AGGAACTACA CTGGCACCCC GCCCCCAGCT CTTCACGAAG GACCACCGTT GCATATCCAG 
GCAGGGGACA CTGTTGAACT TCTGAGAGGA GAGGCACACA CTGTTTTCTG GCAGGGACGA 
AACTTAGCTT CAGGAGAGGT TGGATTTTTC CCAAGCGATG CTGTCAAGCC ATCTCCATGT 
GTACCTAAAC CAGTAGATTA TTCTTGCCAA CCCTGGTATG CTGGCCCAAT GGAAAGATTG 
CAGGCAGAAA CTGAACTTAT TAACAGGGTG AATAGCACTT ACCTTGTAAG GCTCAGGACC 
AAAGAGTCTG GAGAATATGC AATTAGCATT AAGTACAATA ATGAAGCAAA ACACATCAAG 
ATTTTAACAA GAGATGGCTT TTTTCACATT GCAGAAAATA GAAAATTTAA AAGCTTAATG 
GAACTTGTGG AGTACTACAA GCACCATTCT CTTAAAGAAG GGTTCAGGAC CTTAGATACG 
ACGCTACAGT TTCCATACAA GGAGCCTGAA CACGCATCTG GACAGAGGGG TAATAGAACA 
GGCAACAGCT TGCTAAGTCC CAAAGTTCTG GGCATTGCCA TCGCTCGGTA TGACTTCTGT 
GCAAGAGATA TGCGGGAGCT CTCCCTATTG AAAGGAGACA TGGTGAAGAT TTACACAAAG 
ATGAGTGCAA ATGGCTGGTG GAGAGGAGAA GTAAATGGCA GGGTGGGCTG GTTTCCATCC 
ACGTATGTGG AAGAAGACGA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001178643.1
CDS	1..2544
Translation	MEPWKQCAQWLIHCKVLPANHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRPHSINLKEINLRPQMSQFLCLKNIRTFLAACCDTFGMKKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEESVNDEDIYKGLPDLIDETRVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQAKSQENDIRSCCLAEIRQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPDLVKVHRSLMQEIHDSIVNKDDHNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVRLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTHDPMEKSNLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCRVCQMLLRGTFYQGYLCFKCGAKAHKECLGRVDNCGRVNSVEQGPFKPPEKRTNGLRRASRQVDPGLPKMRVIRNYTGTPPPALHEGPPLHIQAGDTVELLRGEAHTVFWQGRNLASGEVGFFPSDAVKPSPCVPKPVDYSCQPWYAGPMERLQAETELINRVNSTYLVRLRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHASGQRGNRTGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDMVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE

Target ORF information:

RefSeq Version	NM_001191714.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus vav guanine nucleotide exchange factor 3 (Vav3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001191714.1

ORF Insert Sequence:

ATGGAGCCGT GGAAGCAGTG CGCTCAGTGG CTCATCCACT GCAAAGTGCT GCCCGCCAAC 
CACCGGGTGA CCTGGGACTC GGCGCAGGTG TTCGACCTGG CGCAGACCCT CCGCGATGGA 
GTCCTGCTCT GCCAGCTGCT CAACAACCTG CGGCCACACT CCATCAATCT GAAGGAGATC 
AACCTGAGAC CCCAGATGTC CCAGTTTCTC TGTCTGAAGA ATATCCGGAC ATTTCTGGCC 
GCCTGCTGTG ACACGTTCGG AATGAAGAAA AGTGAGCTTT TTGAGGCATT TGACCTATTC 
GATGTTCGTG ACTTTGGAAA GGTTATAGAA ACATTATCTC GCCTATCCCG AACACCAATA 
GCATTGGCCA CAGGAATCAG GCCATTCCCC ACGGAAGAAA GTGTAAATGA TGAAGACATC 
TACAAAGGCC TTCCTGACCT GATAGATGAA ACCCGTGTGG AGGACGAAGA AGACCTCTAT 
GACTGTGTGT ACGGGGAGGA TGAAGGCGGA GAAGTCTATG AAGATTTGAT GAAGGCGGAG 
GAGGCTCACC AAGCTAAATC ACAAGAAAAT GATATACGGA GTTGTTGCCT AGCAGAAATT 
AGGCAGACAG AAGAAAAATA CACAGAAACT TTGGAGTCAA TAGAAAAATA TTTCATGGCA 
CCATTGAAAA GATTTCTGAC AGCGGCGGAA TTTGATTCAG TATTTATCAA CATTCCTGAC 
CTTGTAAAAG TTCATCGGAG CTTAATGCAA GAGATTCACG ATTCCATTGT AAATAAAGAT 
GACCATAACT TGTATCAAGT TTTTATTAAC TACAAGGAAA GATTGGTTAT TTATGGACAG 
TACTGCAGTG GAGTGGAGTC AGCCATCTCT AGCCTAGACT ACATCTCTAA GACAAAAGAA 
GATGTCAGAC TGAAACTAGA GGAATGTTCA AAGAGAGCCA ATAATGGGAA ATTTACTCTG 
CGTGATTTGC TGGTAGTTCC CATGCAGCGG GTGCTGAAAT ATCACCTCCT CCTTCAGGAG 
CTGGTTAAAC ACACCCATGA TCCCATGGAG AAGTCGAACC TGAAGCTGGC TCTGGATGCA 
ATGAAGGACT TGGCACAATA TGTGAATGAA GTAAAAAGAG ATAATGAGAC CCTTCGTGAA 
ATTAAGCAGT TTCAGCTATC TATAGAAAAT TTGAACCAGC CCGTTTTGCT CTTTGGGCGA 
CCGCAGGGAG ACGGTGAAAT CCGAATAACC ACACTGGACA AGCATACGAA ACAAGAAAGG 
CATATCTTCT TATTCGATCT GGCAGTGATT GTCTGTAAAA GGAAAGGGGA TAACTACGAG 
ATGAAGGAAA TAATAGATCT CCAGCAGTAC AAGATCGCCA ACAACCCTAC CACGGATAAA 
GAGAATAAAA AGTGGTCTTA TGGCTTCTAC CTCATCCATA CCCAAGGACA AAATGGGCTG 
GAATTTTATT GCAAAACAAA AGATTTAAAG AAAAAATGGC TGGAACAGTT TGAAATGGCT 
TTATCCAACA TAAGGCCGGA CTATGCAGAC TCCAATTTCC ATGACTTCAA GATGCACACA 
TTCACTCGGG TGACATCCTG TAGGGTCTGC CAAATGCTCC TGAGGGGGAC ATTTTATCAA 
GGCTACTTAT GTTTTAAGTG TGGAGCAAAA GCGCATAAAG AATGTTTGGG AAGAGTAGAC 
AATTGTGGCA GAGTTAATTC CGTTGAACAA GGGCCATTCA AACCACCGGA GAAGCGGACC 
AATGGACTTC GGAGAGCTTC CAGACAGGTG GATCCAGGCT TGCCGAAGAT GCGGGTCATT 
AGGAACTACA CTGGCACCCC GCCCCCAGCT CTTCACGAAG GACCACCGTT GCATATCCAG 
GCAGGGGACA CTGTTGAACT TCTGAGAGGA GAGGCACACA CTGTTTTCTG GCAGGGACGA 
AACTTAGCTT CAGGAGAGGT TGGATTTTTC CCAAGCGATG CTGTCAAGCC ATCTCCATGT 
GTACCTAAAC CAGTAGATTA TTCTTGCCAA CCCTGGTATG CTGGCCCAAT GGAAAGATTG 
CAGGCAGAAA CTGAACTTAT TAACAGGGTG AATAGCACTT ACCTTGTAAG GCTCAGGACC 
AAAGAGTCTG GAGAATATGC AATTAGCATT AAGTACAATA ATGAAGCAAA ACACATCAAG 
ATTTTAACAA GAGATGGCTT TTTTCACATT GCAGAAAATA GAAAATTTAA AAGCTTAATG 
GAACTTGTGG AGTACTACAA GCACCATTCT CTTAAAGAAG GGTTCAGGAC CTTAGATACG 
ACGCTACAGT TTCCATACAA GGAGCCTGAA CACGCATCTG GACAGAGGGG TAATAGAACA 
GGCAACAGCT TGCTAAGTCC CAAAGTTCTG GGCATTGCCA TCGCTCGGTA TGACTTCTGT 
GCAAGAGATA TGCGGGAGCT CTCCCTATTG AAAGGAGACA TGGTGAAGAT TTACACAAAG 
ATGAGTGCAA ATGGCTGGTG GAGAGGAGAA GTAAATGGCA GGGTGGGCTG GTTTCCATCC 
ACGTATGTGG AAGAAGACGA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Vav3 ( XM_017590775.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017446264.1 Rattus norvegicus vav guanine nucleotide exchange factor 3 (Vav3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa59689
Clone ID Related Accession (Same CDS sequence)	XM_017590775.1
Accession Version	XM_017590775.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2628bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	guanine nucleotide exchange factor VAV3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGAGCCGT GGAAGCAGTG CGCTCAGTGG CTCATCCACT GCAAAGTGCT GCCCGCCAAC 
CACCGGGTGA CCTGGGACTC GGCGCAGGTG TTCGACCTGG CGCAGACCCT CCGCGATGGA 
GTCCTGCTCT GCCAGCTGCT CAACAACCTG CGGCCACACT CCATCAATCT GAAGGAGATC 
AACCTGAGAC CCCAGATGTC CCAGTTTCTC TGTCTGAAGA ATATCCGGAC ATTTCTGGCC 
GCCTGCTGTG ACACGTTCGG AATGAAGAAA AGTGAGCTTT TTGAGGCATT TGACCTATTC 
GATGTTCGTG ACTTTGGAAA GGTTATAGAA ACATTATCTC GCCTATCCCG AACACCAATA 
GCATTGGCCA CAGGAATCAG GCCATTCCCC ACGGAAGAAA GTGTAAATGA TGAAGACATC 
TACAAAGGCC TTCCTGACCT GATAGATGAA ACCCGTGTGG AGGACGAAGA AGACCTCTAT 
GACTGTGTGT ACGGGGAGGA TGAAGGCGGA GAAGTCTATG AAGATTTGAT GAAGGCGGAG 
GAGGCTCACC AAGCTAAATC ACAAGAAAAT GATATACGGA GTTGTTGCCT AGCAGAAATT 
AGGCAGACAG AAGAAAAATA CACAGAAACT TTGGAGTCAA TAGAAAAATA TTTCATGGCA 
CCATTGAAAA GATTTCTGAC AGCGGCGGAA TTTGATTCAG TATTTATCAA CATTCCTGAC 
CTTGTAAAAG TTCATCGGAG CTTAATGCAA GAGATTCACG ATTCCATTGT AAATAAAGAT 
GACCATAACT TGTATCAAGT TTTTATTAAC TACAAGGAAA GATTGGTTAT TTATGGACAG 
TACTGCAGTG GAGTGGAGTC AGCCATCTCT AGCCTAGACT ACATCTCTAA GACAAAAGAA 
GATGTCAGAC TGAAACTAGA GGAATGTTCA AAGAGAGCCA ATAATGGGAA ATTTACTCTG 
CGTGATTTGC TGGTAGTTCC CATGCAGCGG GTGCTGAAAT ATCACCTCCT CCTTCAGGAG 
CTGGTTAAAC ACACCCATGA TCCCATGGAG AAGTCGAACC TGAAGCTGGC TCTGGATGCA 
ATGAAGGACT TGGCACAATA TGTGAATGAA GTAAAAAGAG ATAATGAGAC CCTTCGTGAA 
ATTAAGCAGT TTCAGCTATC TATAGAAAAT TTGAACCAGC CCGTTTTGCT CTTTGGGCGA 
CCGCAGGGAG ACGGTGAAAT CCGAATAACC ACACTGGACA AGCATACGAA ACAAGAAAGG 
CATATCTTCT TATTCGATCT GGCAGTGATT GTCTGTAAAA GGAAAGGGGA TAACTACGAG 
ATGAAGGAAA TAATAGATCT CCAGCAGTAC AAGATCGCCA ACAACCCTAC CACGGATAAA 
GAGAATAAAA AGTGGTCTTA TGGCTTCTAC CTCATCCATA CCCAAGGACA AAATGGGCTG 
GAATTTTATT GCAAAACAAA AGATTTAAAG AAAAAATGGC TGGAACAGTT TGAAATGGCT 
TTATCCAACA TAAGGCCGGA CTATGCAGAC TCCAATTTCC ATGACTTCAA GATGCACACA 
TTCACTCGGG TGACATCCTG TAGGGTCTGC CAAATGCTCC TGAGGGGGAC ATTTTATCAA 
GGCTACTTAT GTTTTAAGTG TGGAGCAAAA GCGCATAAAG AATGTTTGGG AAGAGTAGAC 
AATTGTGGCA GAGTTAATTC CGTTGAACAA GGGCCATTCA AACCACCGGA GAAGCGGACC 
AATGGACTTC GGAGAGCTTC CAGACAGGTG GATCCAGGCT TGCCGAAGAT GCGGGTCATT 
AGGAACTACA CTGGCACCCC GCCCCCAGCT CTTCACGAAG GACCACCGTT GCATATCCAG 
GCAGGGGACA CTGTTGAACT TCTGAGAGGA GAGGCACACA CTGTTTTCTG GCAGGGACGA 
AACTTAGCTT CAGGAGAGGT TGGATTTTTC CCAAGCGATG CTGTCAAGCC ATCTCCATGT 
GTACCTAAAC CAGTAGATTA TTCTTGCCAA CCCTGGTATG CTGGCCCAAT GGAAAGATTG 
CAGGCAGAAA CTGAACTTAT TAACAGGGTG AATAGCACTT ACCTTGTAAG GCTCAGGACC 
AAAGAGTCTG GAGAATATGC AATTAGCATT AAGTACAATA ATGAAGCAAA ACACATCAAG 
ATTTTAACAA GAGATGGCTT TTTTCACATT GCAGAAAATA GAAAATTTAA AAGCTTAATG 
GAACTTGTGG AGTACTACAA GCACCATTCT CTTAAAGAAG GGTTCAGGAC CTTAGATACG 
ACGCTACAGT TTCCATACAA GGAGCCTGAA CACGCATCTG GACAGAGGGG TAATAGAACA 
GGCAACAGCT CCCCTCCTCT GTTCTGTGGC TTTTCTTTTG TAACTCCTCC AGACTACAGC 
TTTGTCCCCC CTTCTTCCAC TCCTTTCTGG TCAGTGCTAA GTCCCAAAGT TCTGGGCATT 
GCCATCGCTC GGTATGACTT CTGTGCAAGA GATATGCGGG AGCTCTCCCT ATTGAAAGGA 
GACATGGTGA AGATTTACAC AAAGATGAGT GCAAATGGCT GGTGGAGAGG AGAAGTAAAT 
GGCAGGGTGG GCTGGTTTCC ATCCACGTAT GTGGAAGAAG ACGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017446264.1
CDS	391..3018
Translation	MEPWKQCAQWLIHCKVLPANHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRPHSINLKEINLRPQMSQFLCLKNIRTFLAACCDTFGMKKSELFEAFDLFDVRDFGKVIETLSRLSRTPIALATGIRPFPTEESVNDEDIYKGLPDLIDETRVEDEEDLYDCVYGEDEGGEVYEDLMKAEEAHQAKSQENDIRSCCLAEIRQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFINIPDLVKVHRSLMQEIHDSIVNKDDHNLYQVFINYKERLVIYGQYCSGVESAISSLDYISKTKEDVRLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTHDPMEKSNLKLALDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCRVCQMLLRGTFYQGYLCFKCGAKAHKECLGRVDNCGRVNSVEQGPFKPPEKRTNGLRRASRQVDPGLPKMRVIRNYTGTPPPALHEGPPLHIQAGDTVELLRGEAHTVFWQGRNLASGEVGFFPSDAVKPSPCVPKPVDYSCQPWYAGPMERLQAETELINRVNSTYLVRLRTKESGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKEPEHASGQRGNRTGNSSPPLFCGFSFVTPPDYSFVPPSSTPFWSVLSPKVLGIAIARYDFCARDMRELSLLKGDMVKIYTKMSANGWWRGEVNGRVGWFPSTYVEEDE

Target ORF information:

RefSeq Version	XM_017590775.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus vav guanine nucleotide exchange factor 3 (Vav3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017590775.1

ORF Insert Sequence:

ATGGAGCCGT GGAAGCAGTG CGCTCAGTGG CTCATCCACT GCAAAGTGCT GCCCGCCAAC 
CACCGGGTGA CCTGGGACTC GGCGCAGGTG TTCGACCTGG CGCAGACCCT CCGCGATGGA 
GTCCTGCTCT GCCAGCTGCT CAACAACCTG CGGCCACACT CCATCAATCT GAAGGAGATC 
AACCTGAGAC CCCAGATGTC CCAGTTTCTC TGTCTGAAGA ATATCCGGAC ATTTCTGGCC 
GCCTGCTGTG ACACGTTCGG AATGAAGAAA AGTGAGCTTT TTGAGGCATT TGACCTATTC 
GATGTTCGTG ACTTTGGAAA GGTTATAGAA ACATTATCTC GCCTATCCCG AACACCAATA 
GCATTGGCCA CAGGAATCAG GCCATTCCCC ACGGAAGAAA GTGTAAATGA TGAAGACATC 
TACAAAGGCC TTCCTGACCT GATAGATGAA ACCCGTGTGG AGGACGAAGA AGACCTCTAT 
GACTGTGTGT ACGGGGAGGA TGAAGGCGGA GAAGTCTATG AAGATTTGAT GAAGGCGGAG 
GAGGCTCACC AAGCTAAATC ACAAGAAAAT GATATACGGA GTTGTTGCCT AGCAGAAATT 
AGGCAGACAG AAGAAAAATA CACAGAAACT TTGGAGTCAA TAGAAAAATA TTTCATGGCA 
CCATTGAAAA GATTTCTGAC AGCGGCGGAA TTTGATTCAG TATTTATCAA CATTCCTGAC 
CTTGTAAAAG TTCATCGGAG CTTAATGCAA GAGATTCACG ATTCCATTGT AAATAAAGAT 
GACCATAACT TGTATCAAGT TTTTATTAAC TACAAGGAAA GATTGGTTAT TTATGGACAG 
TACTGCAGTG GAGTGGAGTC AGCCATCTCT AGCCTAGACT ACATCTCTAA GACAAAAGAA 
GATGTCAGAC TGAAACTAGA GGAATGTTCA AAGAGAGCCA ATAATGGGAA ATTTACTCTG 
CGTGATTTGC TGGTAGTTCC CATGCAGCGG GTGCTGAAAT ATCACCTCCT CCTTCAGGAG 
CTGGTTAAAC ACACCCATGA TCCCATGGAG AAGTCGAACC TGAAGCTGGC TCTGGATGCA 
ATGAAGGACT TGGCACAATA TGTGAATGAA GTAAAAAGAG ATAATGAGAC CCTTCGTGAA 
ATTAAGCAGT TTCAGCTATC TATAGAAAAT TTGAACCAGC CCGTTTTGCT CTTTGGGCGA 
CCGCAGGGAG ACGGTGAAAT CCGAATAACC ACACTGGACA AGCATACGAA ACAAGAAAGG 
CATATCTTCT TATTCGATCT GGCAGTGATT GTCTGTAAAA GGAAAGGGGA TAACTACGAG 
ATGAAGGAAA TAATAGATCT CCAGCAGTAC AAGATCGCCA ACAACCCTAC CACGGATAAA 
GAGAATAAAA AGTGGTCTTA TGGCTTCTAC CTCATCCATA CCCAAGGACA AAATGGGCTG 
GAATTTTATT GCAAAACAAA AGATTTAAAG AAAAAATGGC TGGAACAGTT TGAAATGGCT 
TTATCCAACA TAAGGCCGGA CTATGCAGAC TCCAATTTCC ATGACTTCAA GATGCACACA 
TTCACTCGGG TGACATCCTG TAGGGTCTGC CAAATGCTCC TGAGGGGGAC ATTTTATCAA 
GGCTACTTAT GTTTTAAGTG TGGAGCAAAA GCGCATAAAG AATGTTTGGG AAGAGTAGAC 
AATTGTGGCA GAGTTAATTC CGTTGAACAA GGGCCATTCA AACCACCGGA GAAGCGGACC 
AATGGACTTC GGAGAGCTTC CAGACAGGTG GATCCAGGCT TGCCGAAGAT GCGGGTCATT 
AGGAACTACA CTGGCACCCC GCCCCCAGCT CTTCACGAAG GACCACCGTT GCATATCCAG 
GCAGGGGACA CTGTTGAACT TCTGAGAGGA GAGGCACACA CTGTTTTCTG GCAGGGACGA 
AACTTAGCTT CAGGAGAGGT TGGATTTTTC CCAAGCGATG CTGTCAAGCC ATCTCCATGT 
GTACCTAAAC CAGTAGATTA TTCTTGCCAA CCCTGGTATG CTGGCCCAAT GGAAAGATTG 
CAGGCAGAAA CTGAACTTAT TAACAGGGTG AATAGCACTT ACCTTGTAAG GCTCAGGACC 
AAAGAGTCTG GAGAATATGC AATTAGCATT AAGTACAATA ATGAAGCAAA ACACATCAAG 
ATTTTAACAA GAGATGGCTT TTTTCACATT GCAGAAAATA GAAAATTTAA AAGCTTAATG 
GAACTTGTGG AGTACTACAA GCACCATTCT CTTAAAGAAG GGTTCAGGAC CTTAGATACG 
ACGCTACAGT TTCCATACAA GGAGCCTGAA CACGCATCTG GACAGAGGGG TAATAGAACA 
GGCAACAGCT CCCCTCCTCT GTTCTGTGGC TTTTCTTTTG TAACTCCTCC AGACTACAGC 
TTTGTCCCCC CTTCTTCCAC TCCTTTCTGG TCAGTGCTAA GTCCCAAAGT TCTGGGCATT 
GCCATCGCTC GGTATGACTT CTGTGCAAGA GATATGCGGG AGCTCTCCCT ATTGAAAGGA 
GACATGGTGA AGATTTACAC AAAGATGAGT GCAAATGGCT GGTGGAGAGG AGAAGTAAAT 
GGCAGGGTGG GCTGGTTTCC ATCCACGTAT GTGGAAGAAG ACGAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Radixin regulates cell migration and cell-cell adhesion through Rac1.
Journal of cell science125(Pt 14)3310-9(2012 Jul)
Valderrama F,Thevapala S,Ridley AJ

P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses.
Journal of immunology (Baltimore, Md. : 1950)186(3)1467-76(2011 Feb)
Lawson CD,Donald S,Anderson KE,Patton DT,Welch HC

The Rho protein exchange factor Vav3 regulates vascular smooth muscle cell proliferation and migration.
Cardiovascular research86(1)131-40(2010 Apr)
Toumaniantz G,Ferland-McCollough D,Cario-Toumaniantz C,Pacaud P,Loirand G

ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research13(18 Pt 1)5295-304(2007 Sep)
Joshi AD,Hegde GV,Dickinson JD,Mittal AK,Lynch JC,Eudy JD,Armitage JO,Bierman PJ,Bociek RG,Devetten MP,Vose JM,Joshi SS

Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells.
Molecular biology of the cell16(5)2207-17(2005 May)
Aoki K,Nakamura T,Fujikawa K,Matsuda M