Amhr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Amhr2
Entrez Gene ID	29530
Full Name	anti-Mullerian hormone receptor type 2
General protein information	Preferred Names anti-Mullerian hormone receptor type 2 Names anti-Muellerian hormone type-2 receptor AMH type II receptor C14 MIS type II receptor MISRII MRII anti-Muellerian hormone type II receptor anti-Mullerian hormone receptor type 11 SV1 anti-Mullerian hormone receptor, type II anti-Mullerian hormone type 2 receptor
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q36
Summary	receptor that binds Mullerian inhibiting substance; involved in testis and ovary function [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_030998.1	NP_112260.1	anti-Muellerian hormone type-2 receptor precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Amhr2	NP_653130.2
Xenopus tropicalis (tropical clawed frog)	LOC100498418	XP_002936675.1
	AMHR2	XP_001105261.1
Canis lupus familiaris (dog)	AMHR2	XP_543632.4
Rattus norvegicus (Norway rat)	Amhr2	NP_112260.1
Homo sapiens (human)	AMHR2	NP_065434.1
Pan troglodytes (chimpanzee)	AMHR2	XP_522405.2
Bos taurus (cattle)	AMHR2	NP_001192257.1

Gene Ontology
Bibliography

Related articles in PubMed

The type 2 anti-M?llerian hormone receptor has splice variants that are dominant-negative inhibitors.
Imhoff FM, Yang D, Mathew SF, Clarkson AN, Kawagishi Y, Tate WP, Koishi K, McLennan IS
FEBS letters587(12)1749-53(2013 Jun)

The expression of M?llerian inhibiting substance/anti-M?llerian hormone type II receptor protein and mRNA in benign, borderline and malignant ovarian neoplasia.
Song JY, Chen KY, Kim SY, Kim MR, Ryu KS, Cha JH, Kang CS, MacLaughlin DT, Kim JH
International journal of oncology34(6)1583-91(2009 Jun)

M?llerian inhibiting substance type II receptor (MISIIR): a novel, tissue-specific target expressed by gynecologic cancers.
Bakkum-Gamez JN, Aletti G, Lewis KA, Keeney GL, Thomas BM, Navarro-Teulon I, Cliby WA
Gynecologic oncology108(1)141-8(2008 Jan)

M?llerian inhibiting substance regulates its receptor/SMAD signaling and causes mesenchymal transition of the coelomic epithelial cells early in M?llerian duct regression.
Zhan Y, Fujino A, MacLaughlin DT, Manganaro TF, Szotek PP, Arango NA, Teixeira J, Donahoe PK
Development (Cambridge, England)133(12)2359-69(2006 Jun)

Detection of anti-Mullerian hormone receptor II protein in the postnatal rat testis from birth to sexual maturity.
Mendis-Handagama SM, Di Clementi N, Ariyaratne HB, Mrkonjich L
Histology and histopathology21(2)125-30(2006 02)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

physiological function(s) of type 2 anti-Mullerian hormone receptor
Title: The type 2 anti-M?llerian hormone receptor has splice variants that are dominant-negative inhibitors.

Data suggest that Mullerian inhibiting substance (MIS) initiates an epithelial-to-mesenchymal transition of MISRI receptor-expressing cells and specifies the components of the receptor/SMAD8 signaling pathway by regulating their expression.
Title: M?llerian inhibiting substance regulates its receptor/SMAD signaling and causes mesenchymal transition of the coelomic epithelial cells early in M?llerian duct regression.

examined the presence of AMH receptor type II (AMHR-II) in fetal Leydig cells (FLC) and cells in the adult Leydig cells lineage in the postnatal testis; presence of AMHR-II in postnatal FLC suggests a possible role by AMH on FLC
Title: Detection of anti-Mullerian hormone receptor II protein in the postnatal rat testis from birth to sexual maturity.

The following Amhr2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Amhr2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07313	NM_030998.1 Latest version!	Rattus norvegicus anti-Mullerian hormone receptor type 2 (Amhr2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Amhr2 ( NM_030998.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112260.1 Rattus norvegicus anti-Mullerian hormone receptor type 2 (Amhr2), mRNA.

Price & Availability↑

CloneID	ORa07313
Clone ID Related Accession (Same CDS sequence)	NM_030998.1
Accession Version	NM_030998.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1674bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	anti-Muellerian hormone type-2 receptor precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U42427.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U42427.1, X71916.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689601, SAMEA2689604 [ECO:0000348] ##Evidence-Data-END##

ATGCTGGGGA CACTGGGGCT TTGGACACTG CTTCCTGCAG CTGCACAAGT ATCCCCAAAC 
AGGAGGACCT GTGTGTTCTT TGAGGCTCCT GGAGTTCGGG GAAGCACAAA AACACTGGGG 
GAAGTGGTAG ATGCAGGACC AGGCCCCCCG AAGGGTATCC GCTGCCTCTA CAGCCATTGC 
TGCTTTGGGA TCTGGAATCT GACCCATGGC CGGGCACAAG TGGAGATGCA AGGATGCCTA 
GACAGTGATG AACCCGGCTG TGAGTCCCTC CACTGTGACC CCGTCCCCCG AGCGCACCCC 
AGCCCCAGCT CCACACTCTT CACATGCTCC TGCGGTACCG ACTTCTGCAA TGCCAACTAC 
AGCCATCTGC CTCCTTCAGG AAACCGAGGG GCTCCCGGCC CCCAGGAGCC TCAGGCTACC 
CCAGGTGGGC CCATCTGGAT GGCGCAGCTG CTGCTGGGAG TGTTCCTTGT GCTGCTGCTG 
AGTATCATCA TCTTGGCCCT GTTACAACGA AAAGCCTGTA GAGTGCAAGG TGGGTCAGAC 
CCGGAGCCGG AGCCAGGCTC AGGAGGAGAC TGCAGTGAGG AACTGCCCGA GTTGGCTGAG 
CTGCGCTTCT CCCAGGTAAT CCAGGAAGGA GGTCATGCAG TCGTCTGGGC TGGGAGGCTC 
CAGGGTGAGA TGGTAGCCAT CAAGGCCTTC CCCCCAAGGG CTGTGGCCCA GTTCCGAGCT 
GAGCGAGCTG TGTACCAGCT GCTAGGCCTA CAGCATAACC ACATTGTTCG CTTTATCACT 
GCTGGCCAGG GAGGTCCTGG CCCCTTGCCC TCTGGGCCTT TGCTGGTACT GGAACTGTAC 
CCTAAGGGCT CCTTATGCCA CTACTTGACT CAGTACACGA GCGACTGGGG CAGTTCCTTG 
AGGATGGCTC TGTCCCTGGC CGAGGGCCTG GCGTTTCTCC ACGGGGAGCG TTGGCAGGAT 
GGCCAGTACA AACCAGGTAT CGCTCACCGA GACCTGAGCA GCCAGAATGT GCTCATTCGG 
GAAGATAGGT CATGTGCCAT CGGAGACCTG GGCCTTGCCT TGGTACTCCC TGGCCTTGCT 
CAGCCCCCTG CCTTGGCCCC TACTCAACCC CGAGGCCCAG CTGCCATTTT GGAGGCTGGC 
ACCCAGAGGT ACATGGCTCC GGAGCTCTTG GACAAGACTC TAGACCTGCA GGACTGGGGC 
ACAGCTCTCC AGAGAGCGGA TGTTTACTCT CTGGCTCTAC TACTGTGGGA GATCCTGAGC 
CGCTGTTCCG ATTTGAGGCC TGACCACAGA CCACCACCTT TTCAATTGGC TTATGAGGCA 
GAACTGGGCA GCAATCCCAG TGCCTGTGAG CTCTGGGCCC TGGCGGTCGC GGAGAGGAAG 
CGCCCCAACA TCCCTTCCTC TTGGAGCTGC TCTGCCACAG ACCCTAGGGG GCTGAGGGAG 
CTCCTGGAAG ATTGCTGGGA CGCAGACCCA GAAGCAAGGC TGACAGCTGA GTGTGTGCAG 
CAGCGCCTGG CAGCCCTGGC TTATCCTCAG GTGGCTTCCT CCTTCCCAGA GAGCTGTCCA 
CAGGGCTGCC CAGAGAACTG CCCTGCAGCG CCTGCCTCTG CGGCTTTCCC CTGCAGGCCT 
CAGCAGAGTT CTTGTCTCCT CAGTGTTCAG CAAGGCTCTG GCTCTAAGTC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112260.1
CDS	76..1749
Translation	MLGTLGLWTLLPAAAQVSPNRRTCVFFEAPGVRGSTKTLGEVVDAGPGPPKGIRCLYSHCCFGIWNLTHGRAQVEMQGCLDSDEPGCESLHCDPVPRAHPSPSSTLFTCSCGTDFCNANYSHLPPSGNRGAPGPQEPQATPGGPIWMAQLLLGVFLVLLLSIIILALLQRKACRVQGGSDPEPEPGSGGDCSEELPELAELRFSQVIQEGGHAVVWAGRLQGEMVAIKAFPPRAVAQFRAERAVYQLLGLQHNHIVRFITAGQGGPGPLPSGPLLVLELYPKGSLCHYLTQYTSDWGSSLRMALSLAEGLAFLHGERWQDGQYKPGIAHRDLSSQNVLIREDRSCAIGDLGLALVLPGLAQPPALAPTQPRGPAAILEAGTQRYMAPELLDKTLDLQDWGTALQRADVYSLALLLWEILSRCSDLRPDHRPPPFQLAYEAELGSNPSACELWALAVAERKRPNIPSSWSCSATDPRGLRELLEDCWDADPEARLTAECVQQRLAALAYPQVASSFPESCPQGCPENCPAAPASAAFPCRPQQSSCLLSVQQGSGSKS

Target ORF information:

RefSeq Version	NM_030998.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus anti-Mullerian hormone receptor type 2 (Amhr2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030998.1

ORF Insert Sequence:

ATGCTGGGGA CACTGGGGCT TTGGACACTG CTTCCTGCAG CTGCACAAGT ATCCCCAAAC 
AGGAGGACCT GTGTGTTCTT TGAGGCTCCT GGAGTTCGGG GAAGCACAAA AACACTGGGG 
GAAGTGGTAG ATGCAGGACC AGGCCCCCCG AAGGGTATCC GCTGCCTCTA CAGCCATTGC 
TGCTTTGGGA TCTGGAATCT GACCCATGGC CGGGCACAAG TGGAGATGCA AGGATGCCTA 
GACAGTGATG AACCCGGCTG TGAGTCCCTC CACTGTGACC CCGTCCCCCG AGCGCACCCC 
AGCCCCAGCT CCACACTCTT CACATGCTCC TGCGGTACCG ACTTCTGCAA TGCCAACTAC 
AGCCATCTGC CTCCTTCAGG AAACCGAGGG GCTCCCGGCC CCCAGGAGCC TCAGGCTACC 
CCAGGTGGGC CCATCTGGAT GGCGCAGCTG CTGCTGGGAG TGTTCCTTGT GCTGCTGCTG 
AGTATCATCA TCTTGGCCCT GTTACAACGA AAAGCCTGTA GAGTGCAAGG TGGGTCAGAC 
CCGGAGCCGG AGCCAGGCTC AGGAGGAGAC TGCAGTGAGG AACTGCCCGA GTTGGCTGAG 
CTGCGCTTCT CCCAGGTAAT CCAGGAAGGA GGTCATGCAG TCGTCTGGGC TGGGAGGCTC 
CAGGGTGAGA TGGTAGCCAT CAAGGCCTTC CCCCCAAGGG CTGTGGCCCA GTTCCGAGCT 
GAGCGAGCTG TGTACCAGCT GCTAGGCCTA CAGCATAACC ACATTGTTCG CTTTATCACT 
GCTGGCCAGG GAGGTCCTGG CCCCTTGCCC TCTGGGCCTT TGCTGGTACT GGAACTGTAC 
CCTAAGGGCT CCTTATGCCA CTACTTGACT CAGTACACGA GCGACTGGGG CAGTTCCTTG 
AGGATGGCTC TGTCCCTGGC CGAGGGCCTG GCGTTTCTCC ACGGGGAGCG TTGGCAGGAT 
GGCCAGTACA AACCAGGTAT CGCTCACCGA GACCTGAGCA GCCAGAATGT GCTCATTCGG 
GAAGATAGGT CATGTGCCAT CGGAGACCTG GGCCTTGCCT TGGTACTCCC TGGCCTTGCT 
CAGCCCCCTG CCTTGGCCCC TACTCAACCC CGAGGCCCAG CTGCCATTTT GGAGGCTGGC 
ACCCAGAGGT ACATGGCTCC GGAGCTCTTG GACAAGACTC TAGACCTGCA GGACTGGGGC 
ACAGCTCTCC AGAGAGCGGA TGTTTACTCT CTGGCTCTAC TACTGTGGGA GATCCTGAGC 
CGCTGTTCCG ATTTGAGGCC TGACCACAGA CCACCACCTT TTCAATTGGC TTATGAGGCA 
GAACTGGGCA GCAATCCCAG TGCCTGTGAG CTCTGGGCCC TGGCGGTCGC GGAGAGGAAG 
CGCCCCAACA TCCCTTCCTC TTGGAGCTGC TCTGCCACAG ACCCTAGGGG GCTGAGGGAG 
CTCCTGGAAG ATTGCTGGGA CGCAGACCCA GAAGCAAGGC TGACAGCTGA GTGTGTGCAG 
CAGCGCCTGG CAGCCCTGGC TTATCCTCAG GTGGCTTCCT CCTTCCCAGA GAGCTGTCCA 
CAGGGCTGCC CAGAGAACTG CCCTGCAGCG CCTGCCTCTG CGGCTTTCCC CTGCAGGCCT 
CAGCAGAGTT CTTGTCTCCT CAGTGTTCAG CAAGGCTCTG GCTCTAAGTC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The type 2 anti-M?llerian hormone receptor has splice variants that are dominant-negative inhibitors.
FEBS letters587(12)1749-53(2013 Jun)
Imhoff FM,Yang D,Mathew SF,Clarkson AN,Kawagishi Y,Tate WP,Koishi K,McLennan IS

The expression of M?llerian inhibiting substance/anti-M?llerian hormone type II receptor protein and mRNA in benign, borderline and malignant ovarian neoplasia.
International journal of oncology34(6)1583-91(2009 Jun)
Song JY,Chen KY,Kim SY,Kim MR,Ryu KS,Cha JH,Kang CS,MacLaughlin DT,Kim JH

M?llerian inhibiting substance type II receptor (MISIIR): a novel, tissue-specific target expressed by gynecologic cancers.
Gynecologic oncology108(1)141-8(2008 Jan)
Bakkum-Gamez JN,Aletti G,Lewis KA,Keeney GL,Thomas BM,Navarro-Teulon I,Cliby WA

M?llerian inhibiting substance regulates its receptor/SMAD signaling and causes mesenchymal transition of the coelomic epithelial cells early in M?llerian duct regression.
Development (Cambridge, England)133(12)2359-69(2006 Jun)
Zhan Y,Fujino A,MacLaughlin DT,Manganaro TF,Szotek PP,Arango NA,Teixeira J,Donahoe PK

Detection of anti-Mullerian hormone receptor II protein in the postnatal rat testis from birth to sexual maturity.
Histology and histopathology21(2)125-30(2006 02)
Mendis-Handagama SM,Di Clementi N,Ariyaratne HB,Mrkonjich L

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Amhr2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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