Sf3b4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sf3b4
Entrez Gene ID	295270
Full Name	splicing factor 3b, subunit 4
General protein information	Preferred Names splicing factor 3b, subunit 4 Names splicing factor 3B subunit 4
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34

mRNA and Protein(s)

mRNA	Protein	Name
NM_001011951.1	NP_001011951.1	splicing factor 3B subunit 4

Pathways from BioSystems

Homologies

Homo sapiens (human)	SF3B4	NP_005841.1
Pan troglodytes (chimpanzee)	SF3B4	XP_513768.2
Mus musculus (house mouse)	Sf3b4	NP_694693.1
	SF3B4	XP_001097793.1
Bos taurus (cattle)	SF3B4	NP_001192513.1
Canis lupus familiaris (dog)	SF3B4	XP_540295.3
Rattus norvegicus (Norway rat)	Sf3b4	NP_001011951.1
Gallus gallus (chicken)	SF3B4	XP_423721.2
Danio rerio (zebrafish)	sf3b4	NP_705947.3

Gene Ontology
Bibliography

Related articles in PubMed

Structure of the human activated spliceosome in three conformational states.
Zhang X, Yan C, Zhan X, Li L, Lei J, Shi Y
Cell research(2018 Jan)

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Teng T, Tsai JH, Puyang X, Seiler M, Peng S, Prajapati S, Aird D, Buonamici S, Caleb B, Chan B, Corson L, Feala J, Fekkes P, Gerard B, Karr C, Korpal M, Liu X, T Lowe J, Mizui Y, Palacino J, Park E, Smith PG, Subramanian V, Wu ZJ, Zou J, Yu L, Chicas A, Warmuth M, Larsen N, Zhu P
Nature communications815522(2017 May)

Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.
Cretu C, Schmitzov? J, Ponce-Salvatierra A, Dybkov O, De Laurentiis EI, Sharma K, Will CL, Urlaub H, L?hrmann R, Pena V
Molecular cell64(2)307-319(2016 Oct)

A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing.
Zheng S, Damoiseaux R, Chen L, Black DL
Genome research23(6)998-1007(2013 Jun)

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Sf3b4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sf3b4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01704	NM_001011951.1 Latest version!	Rattus norvegicus splicing factor 3b, subunit 4 (Sf3b4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sf3b4 ( NM_001011951.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001011951.1 Rattus norvegicus splicing factor 3b, subunit 4 (Sf3b4), mRNA.

Price & Availability↑

CloneID	ORa01704
Clone ID Related Accession (Same CDS sequence)	NM_001011951.1
Accession Version	NM_001011951.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1275bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Rattus norvegicus(Norway rat)
Product	splicing factor 3B subunit 4
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC078997.1. On Feb 11, 2005 this sequence version replaced XM_238245.2. ##Evidence-Data-START## Transcript exon combination :: BC078997.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGCCG GACCGATCTC CGAACGGAAT CAGGATGCCA CGGTGTACGT GGGAGGTCTA 
GACGAGAAAG TGAGCGAGCC ACTGCTATGG GAGCTCTTTC TCCAGGCAGG GCCAGTGGTC 
AACACCCACA TGCCAAAGGA TAGAGTCACT GGCCAGCACC AAGGCTATGG CTTTGTTGAA 
TTCTTGAGTG AGGAAGATGC TGACTATGCC ATTAAGATTA TGAACATGAT CAAACTCTAT 
GGGAAGCCAA TACGGGTGAA CAAAGCCTCG GCTCACAACA AAAACCTGGA TGTAGGAGCC 
AACATTTTCA TTGGAAATCT GGACCCAGAA ATTGATGAGA AGTTGCTTTA CGATACTTTT 
AGCGCCTTTG GAGTCATCTT ACAGACCCCC AAGATTATGC GGGACCCTGA CACAGGCAAC 
TCCAAGGGTT ACGCCTTCAT TAATTTTGCT TCATTTGATG CTTCAGATGC AGCAATTGAG 
GCCATGAATG GGCAGTACCT GTGTAACCGC CCTATCACTG TGTCTTATGC CTTCAAGAAG 
GACTCTAAGG GTGAACGACA TGGCTCAGCA GCTGAACGAC TTCTGGCAGC CCAGAACCCG 
CTGTCTCAGG CTGACCGCCC TCATCAGCTG TTTGCCGATG CACCCCCTCC ACCCTCTGCC 
CCCAATCCTG TGGTTTCATC CCTGGGTTCT GGGCTTCCTC CACCAGGAAT GCCACCTCCT 
GGTTCGTTCC CACCTCCAGT GCCACCTCCT GGGGCCCTTC CTCCTGGGAT ACCCCCAGCA 
ATGCCCCCAC CACCTATGCC ACCTGGGGCT GGAGGACATG GTCCCCCAGC AGCAGGAACT 
CCAGGGGCTG GACATCCTGG TCATGGACAT TCACATCCTC ATCCATTCCC ACCAGGTGGG 
ATGCCCCATC CAGGGATGTC CCAGATGCAG CTGGCCCACC ATGGCCCCCA TGGCCTAGGA 
CACCCCCATG CTGGGCCTCC AGGCTCTGGA GGGCAGCCAC CACCCCGACC ACCCCCTGGA 
ATGCCTCATC CTGGACCACC TCCGATGGGC ATGCCTCCCC GAGGGCCTCC TTTTGGATCT 
CCCATGGGTC ACCCAGGTCC CATGCCTCCA CACGGTATGC GTGGGCCTCC TCCATTGATG 
CCCCCTCATG GATACACCGG TCCTCCGAGA CCCCCTCCCT ATGGCTACCA GCGGGGACCC 
CTCCCTCCAC CCAGACCCAC TCCACGGCCC CCAGTTCCTC CTCGTGGTCC ACTTCGGGGC 
CCACTTCCTC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001011951.1
CDS	238..1512
Translation	MAAGPISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGYGFVEFLSEEDADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANIFIGNLDPEIDEKLLYDTFSAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITVSYAFKKDSKGERHGSAAERLLAAQNPLSQADRPHQLFADAPPPPSAPNPVVSSLGSGLPPPGMPPPGSFPPPVPPPGALPPGIPPAMPPPPMPPGAGGHGPPAAGTPGAGHPGHGHSHPHPFPPGGMPHPGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMPHPGPPPMGMPPRGPPFGSPMGHPGPMPPHGMRGPPPLMPPHGYTGPPRPPPYGYQRGPLPPPRPTPRPPVPPRGPLRGPLPQ

Target ORF information:

RefSeq Version	NM_001011951.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus splicing factor 3b, subunit 4 (Sf3b4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001011951.1

ORF Insert Sequence:

ATGGCTGCCG GACCGATCTC CGAACGGAAT CAGGATGCCA CGGTGTACGT GGGAGGTCTA 
GACGAGAAAG TGAGCGAGCC ACTGCTATGG GAGCTCTTTC TCCAGGCAGG GCCAGTGGTC 
AACACCCACA TGCCAAAGGA TAGAGTCACT GGCCAGCACC AAGGCTATGG CTTTGTTGAA 
TTCTTGAGTG AGGAAGATGC TGACTATGCC ATTAAGATTA TGAACATGAT CAAACTCTAT 
GGGAAGCCAA TACGGGTGAA CAAAGCCTCG GCTCACAACA AAAACCTGGA TGTAGGAGCC 
AACATTTTCA TTGGAAATCT GGACCCAGAA ATTGATGAGA AGTTGCTTTA CGATACTTTT 
AGCGCCTTTG GAGTCATCTT ACAGACCCCC AAGATTATGC GGGACCCTGA CACAGGCAAC 
TCCAAGGGTT ACGCCTTCAT TAATTTTGCT TCATTTGATG CTTCAGATGC AGCAATTGAG 
GCCATGAATG GGCAGTACCT GTGTAACCGC CCTATCACTG TGTCTTATGC CTTCAAGAAG 
GACTCTAAGG GTGAACGACA TGGCTCAGCA GCTGAACGAC TTCTGGCAGC CCAGAACCCG 
CTGTCTCAGG CTGACCGCCC TCATCAGCTG TTTGCCGATG CACCCCCTCC ACCCTCTGCC 
CCCAATCCTG TGGTTTCATC CCTGGGTTCT GGGCTTCCTC CACCAGGAAT GCCACCTCCT 
GGTTCGTTCC CACCTCCAGT GCCACCTCCT GGGGCCCTTC CTCCTGGGAT ACCCCCAGCA 
ATGCCCCCAC CACCTATGCC ACCTGGGGCT GGAGGACATG GTCCCCCAGC AGCAGGAACT 
CCAGGGGCTG GACATCCTGG TCATGGACAT TCACATCCTC ATCCATTCCC ACCAGGTGGG 
ATGCCCCATC CAGGGATGTC CCAGATGCAG CTGGCCCACC ATGGCCCCCA TGGCCTAGGA 
CACCCCCATG CTGGGCCTCC AGGCTCTGGA GGGCAGCCAC CACCCCGACC ACCCCCTGGA 
ATGCCTCATC CTGGACCACC TCCGATGGGC ATGCCTCCCC GAGGGCCTCC TTTTGGATCT 
CCCATGGGTC ACCCAGGTCC CATGCCTCCA CACGGTATGC GTGGGCCTCC TCCATTGATG 
CCCCCTCATG GATACACCGG TCCTCCGAGA CCCCCTCCCT ATGGCTACCA GCGGGGACCC 
CTCCCTCCAC CCAGACCCAC TCCACGGCCC CCAGTTCCTC CTCGTGGTCC ACTTCGGGGC 
CCACTTCCTC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure of the human activated spliceosome in three conformational states.
Cell research(2018 Jan)
Zhang X,Yan C,Zhan X,Li L,Lei J,Shi Y

Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex.
Nature communications815522(2017 May)
Teng T,Tsai JH,Puyang X,Seiler M,Peng S,Prajapati S,Aird D,Buonamici S,Caleb B,Chan B,Corson L,Feala J,Fekkes P,Gerard B,Karr C,Korpal M,Liu X,T Lowe J,Mizui Y,Palacino J,Park E,Smith PG,Subramanian V,Wu ZJ,Zou J,Yu L,Chicas A,Warmuth M,Larsen N,Zhu P

Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.
Molecular cell64(2)307-319(2016 Oct)
Cretu C,Schmitzov? J,Ponce-Salvatierra A,Dybkov O,De Laurentiis EI,Sharma K,Will CL,Urlaub H,L?hrmann R,Pena V

A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing.
Genome research23(6)998-1007(2013 Jun)
Zheng S,Damoiseaux R,Chen L,Black DL

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Molecular cell46(5)674-90(2012 Jun)
Baltz AG,Munschauer M,Schwanh?usser B,Vasile A,Murakawa Y,Schueler M,Youngs N,Penfold-Brown D,Drew K,Milek M,Wyler E,Bonneau R,Selbach M,Dieterich C,Landthaler M

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Sf3b4 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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