Pts cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pts
Entrez Gene ID	29498
Full Name	6-pyruvoyl-tetrahydropterin synthase
General protein information	Preferred Names 6-pyruvoyl-tetrahydropterin synthase Names 6-pyruvoyl tetrahydrobiopterin synthase 6-pyruvoyltetrahydropterin synthase PTP synthase PTPS
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q23
Summary	catalyzes the formation of 6-pyruvoyltetrahydrobiopterin in tetrahydrobiopterin biosynthesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017220.1	NP_058916.1	6-pyruvoyl tetrahydrobiopterin synthase

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PTS	XP_854076.1
Rattus norvegicus (Norway rat)	Pts	NP_058916.1
Gallus gallus (chicken)	PTS	XP_004948194.1
Drosophila melanogaster (fruit fly)	pr	NP_724244.1
Xenopus tropicalis (tropical clawed frog)	LOC100487259	XP_002937697.1
Pan troglodytes (chimpanzee)	PTS	XP_001147929.1
	PTS	XP_001108264.1
Mus musculus (house mouse)	Pts	NP_035350.1
Bos taurus (cattle)	PTS	NP_001107009.1
Caenorhabditis elegans (roundworm)	ptps-1	NP_001040626.1
Danio rerio (zebrafish)	pts	NP_001092237.1
Homo sapiens (human)	PTS	NP_000308.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008730	XP_314842.3

Gene Ontology
Bibliography

Related articles in PubMed

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Next-generation sequencing to generate interactome datasets.
Yu H, Tardivo L, Tam S, Weiner E, Gebreab F, Fan C, Svrzikapa N, Hirozane-Kishikawa T, Rietman E, Yang X, Sahalie J, Salehi-Ashtiani K, Hao T, Cusick ME, Hill DE, Roth FP, Braun P, Vidal M
Nature methods8(6)478-80(2011 Jun)

A human protein-protein interaction network: a resource for annotating the proteome.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toks?z E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE
Cell122(6)957-68(2005 Sep)

Protein-protein interaction panel using mouse full-length cDNAs.
Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y
Genome research11(10)1758-65(2001 Oct)

Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase.
Ploom T, Th?ny B, Yim J, Lee S, Nar H, Leimbacher W, Richardson J, Huber R, Auerbach G
Journal of molecular biology286(3)851-60(1999 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Pts gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pts cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03282	NM_017220.1 Latest version!	Rattus norvegicus 6-pyruvoyl-tetrahydropterin synthase (Pts), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pts ( NM_017220.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058916.1 Rattus norvegicus 6-pyruvoyl-tetrahydropterin synthase (Pts), mRNA.

Price & Availability↑

CloneID	ORa03282
Clone ID Related Accession (Same CDS sequence)	NM_017220.1
Accession Version	NM_017220.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	6-pyruvoyl tetrahydrobiopterin synthase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M77850.1. ##Evidence-Data-START## Transcript exon combination :: M77850.1, BC059140.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAACGCGG CGGTTGGCCT TCGGCGCCGC GCGCGATTGT CGCGCCTCGT GTCCTTCAGC 
GCGAGCCACC GGCTGCACAG CCCATCTCTG AGTGCTGAGG AGAACTTGAA AGTGTTTGGG 
AAATGCAACA ATCCGAATGG CCATGGGCAC AACTATAAAG TTGTGGTGAC AATTCATGGA 
GAGATCGATC CGGTTACAGG AATGGTTATG AATTTGACTG ACCTCAAAGA ATACATGGAG 
GAGGCCATTA TGAAGCCCCT TGATCACAAG AACCTGGATC TGGATGTGCC ATACTTTGCA 
GATGTTGTAA GCACGACAGA AAATGTAGCT GTCTATATCT GGGAGAACCT GCAGAGACTT 
CTTCCAGTGG GAGCTCTCTA TAAAGTAAAA GTGTATGAAA CTGACAACAA CATTGTGGTC 
TACAAAGGAG AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058916.1
CDS	51..485
Translation	MNAAVGLRRRARLSRLVSFSASHRLHSPSLSAEENLKVFGKCNNPNGHGHNYKVVVTIHGEIDPVTGMVMNLTDLKEYMEEAIMKPLDHKNLDLDVPYFADVVSTTENVAVYIWENLQRLLPVGALYKVKVYETDNNIVVYKGE

Target ORF information:

RefSeq Version	NM_017220.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus 6-pyruvoyl-tetrahydropterin synthase (Pts), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017220.1

ORF Insert Sequence:

ATGAACGCGG CGGTTGGCCT TCGGCGCCGC GCGCGATTGT CGCGCCTCGT GTCCTTCAGC 
GCGAGCCACC GGCTGCACAG CCCATCTCTG AGTGCTGAGG AGAACTTGAA AGTGTTTGGG 
AAATGCAACA ATCCGAATGG CCATGGGCAC AACTATAAAG TTGTGGTGAC AATTCATGGA 
GAGATCGATC CGGTTACAGG AATGGTTATG AATTTGACTG ACCTCAAAGA ATACATGGAG 
GAGGCCATTA TGAAGCCCCT TGATCACAAG AACCTGGATC TGGATGTGCC ATACTTTGCA 
GATGTTGTAA GCACGACAGA AAATGTAGCT GTCTATATCT GGGAGAACCT GCAGAGACTT 
CTTCCAGTGG GAGCTCTCTA TAAAGTAAAA GTGTATGAAA CTGACAACAA CATTGTGGTC 
TACAAAGGAG AATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M

Next-generation sequencing to generate interactome datasets.
Nature methods8(6)478-80(2011 Jun)
Yu H,Tardivo L,Tam S,Weiner E,Gebreab F,Fan C,Svrzikapa N,Hirozane-Kishikawa T,Rietman E,Yang X,Sahalie J,Salehi-Ashtiani K,Hao T,Cusick ME,Hill DE,Roth FP,Braun P,Vidal M

A human protein-protein interaction network: a resource for annotating the proteome.
Cell122(6)957-68(2005 Sep)
Stelzl U,Worm U,Lalowski M,Haenig C,Brembeck FH,Goehler H,Stroedicke M,Zenkner M,Schoenherr A,Koeppen S,Timm J,Mintzlaff S,Abraham C,Bock N,Kietzmann S,Goedde A,Toks?z E,Droege A,Krobitsch S,Korn B,Birchmeier W,Lehrach H,Wanker EE

Protein-protein interaction panel using mouse full-length cDNAs.
Genome research11(10)1758-65(2001 Oct)
Suzuki H,Fukunishi Y,Kagawa I,Saito R,Oda H,Endo T,Kondo S,Bono H,Okazaki Y,Hayashizaki Y

Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase.
Journal of molecular biology286(3)851-60(1999 Feb)
Ploom T,Th?ny B,Yim J,Lee S,Nar H,Leimbacher W,Richardson J,Huber R,Auerbach G

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Pts cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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