Aoc3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Aoc3
Entrez Gene ID	29473
Full Name	amine oxidase, copper containing 3
Synonyms	SSAO
General protein information	Preferred Names amine oxidase, copper containing 3 Names membrane primary amine oxidase VAP-1 VP97 copper amine oxidase semicarbazide-sensitive amine oxidase vascular adhesion protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q31
Summary	localized to the adipocyte plasma membrane and to glucose transporter Glut4 containing vesicles [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031582.2	NP_113770.2	membrane primary amine oxidase

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	aoc2	NP_001013573.3
Neurospora crassa	NCU09406	XP_958749.1
Canis lupus familiaris (dog)	AOC3	XP_537632.1
Mus musculus (house mouse)	Aoc3	NP_033805.1
Homo sapiens (human)	AOC3	NP_003725.1
Pan troglodytes (chimpanzee)	AOC3	XP_511524.2
Magnaporthe oryzae (rice blast fungus)	MGG_13291	XP_003711686.1
Xenopus tropicalis (tropical clawed frog)	aoc3	NP_001025584.1
	AOC3	XP_001096495.2
Xenopus tropicalis (tropical clawed frog)	LOC100497523	XP_002932567.1
Bos taurus (cattle)	AOC3	NP_851345.1
Rattus norvegicus (Norway rat)	Aoc3	NP_113770.2
Gallus gallus (chicken)	AOC3	XP_004948681.1

Gene Ontology
Bibliography

Related articles in PubMed

Alteration of SSAO interactome reveals weakened cell adhesion and motor function of adipocytes in T2D.
Ke M, Zhang Y, Deng Y
Acta biochimica et biophysica Sinica49(9)845-847(2017 Sep)

Vascular adhesion protein-1 enhances neutrophil infiltration by generation of hydrogen peroxide in renal ischemia/reperfusion injury.
Tanaka S, Tanaka T, Kawakami T, Takano H, Sugahara M, Saito H, Higashijima Y, Yamaguchi J, Inagi R, Nangaku M
Kidney international92(1)154-164(2017 Jul)

Cellular localization and trafficking of vascular adhesion protein-1 as revealed by an N-terminal GFP fusion protein.
Weston CJ, Shepherd EL, Adams DH
Journal of neural transmission (Vienna, Austria : 1996)120(6)951-61(2013 Jun)

Functional modulation of vascular adhesion protein-1 by a novel splice variant.
Kaitaniemi S, Gr?n K, Elovaara H, Salmi M, Jalkanen S, Elima K
PloS one8(1)e54151(2013)

Preliminary kinetic characterization of a copper amine oxidase from rat liver mitochondria matrix.
Stevanato R, Cardillo S, Braga M, De Iuliis A, Battaglia V, Toninello A, Agostinelli E, Vianello F
Amino acids40(2)713-20(2011 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The changes of K(M) and k(c)/K(M) values of copper amine oxidase appear due to the presence of positively charged groups in the substrate molecules.
Title: Preliminary kinetic characterization of a copper amine oxidase from rat liver mitochondria matrix.

Provide evidence for a role for VAP-1 in the inflammatory outcome of diabetic retinopathy. Specifically, VAP-1 plays a central role in regulating leukocyte transmigration rate during chronic low-grade inflammation.
Title: Vascular adhesion protein-1 regulates leukocyte transmigration rate in the retina during diabetes.

evidence for an important role of VAP-1 in the recruitment of macrophages to choroidal neovascularization lesions, establishing a novel link between VAP-1 and angiogenesis
Title: Vascular adhesion protein-1 blockade suppresses choroidal neovascularization.

It was concluded that hydroxylamine exerts hypotension partly through conversion to nitric oxide and partly by a "hydralazine-like" mechanism involving SSAO inhibition
Title: Hypotensive effect of hydroxylamine, an endogenous nitric oxide donor and SSAO inhibitor.

BZA + V treatment did not reduce HbA(1C) levels,but it reduced the elevated serum SSAO activity, decreased advanced-glycation end products and increased nitric oxide in diabetic animals.
Title: Studies on the insulinomimetic effects of benzylamine, exogenous substrate of semicarbazide-sensitive amine oxidase enzyme in streptozotocin induced diabetic rats.

The following Aoc3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aoc3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08157	NM_031582.2 Latest version!	Rattus norvegicus amine oxidase, copper containing 3 (Aoc3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$447.30 $639.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Aoc3 ( NM_031582.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113770.2 Rattus norvegicus amine oxidase, copper containing 3 (Aoc3), mRNA.

Price & Availability↑

CloneID	ORa08157
Clone ID Related Accession (Same CDS sequence)	NM_031582.2
Accession Version	NM_031582.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2292bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	membrane primary amine oxidase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC100613.1. On Aug 7, 2005 this sequence version replaced NM_031582.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC100613.1, AB195675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACCCAGA AGACCACCCT AGTGCTCCTT GCCCTGGCTG TCATCACCAT CTTCGCTTTG 
GTTTGCGTCT TGCTAGCTGG CAGGAGCGGA GATGGGGGCA GACTGAGCCA ACCTCTTCAT 
TGCCCTTCCG TTCTTCCTAG CGTCCAGCCC CAGACACACC CTGGCCAGAG CCAGCCGTTT 
GCAGACCTGA GCCCTGAGGA GCTGACAGCT GTGATGAGCT TTCTGATCAA GCACCTGGGG 
CCAGGGCTGG TGGATGCAGC CCAGGCTCGA CCCTCGGACA ACTGTGTCTT CTCAGTAGAG 
TTGCAGCTGC CTGCCAAGGC TGCAGCCCTG GCCCACCTGG ACAGAGGGGG GCCCCCACCC 
GTGCGGGAGG CACTGGCCAT CATCTTCTTT GGTGGACAAC CCAAGCCTAA TGTGAGCGAG 
TTGGTGGTGG GGCCCCTGCC TCACCCCTCA TACATGCGGG ATGTGACTGT GGAGCGTCAT 
GGCGGCCCCC TGCCCTATTA CCGGCGTCCT GTGCTGACCA GAGAGTATCA GGATATCCAG 
GAGATGATCT TCCACAGAGA GCTGCCCCAA GCGTCTGGTC TCCTCCATCA CTGTTGCTTC 
TACAAACGCC AAGGACACAA CCTGCTAAAA ATGACTACAG CCCCCCGTGG TTTGCAATCA 
GGGGACCGGG CCACCTGGTT TGGCATATAT TACAATCTCT CAGGGGCTGG GTTTTACCCT 
CACCCCATTG GCTTAGAGCT TCTGGTAGAT CACAAGGCCC TGGATCCTGC CCTGTGGACC 
ATCCAGAAGG TATTCTACCA AGGCCGTTAC TATGAGAGTC TGACTCAGCT GGAGGACATG 
TTTGAGGCTG GCCTGGTGAA TGTGGTTTTG GTCCCAGACA ATGGCACAGG TGGGTCCTGG 
TCTCTGAAGT CTTCAGTGCC ACCAGGCCGA GCTCCTCCTC TGCAGTTCCA TCCTGAGGGA 
CCCCGTTTCA GCGTCCAGGG GAGTCAAGTG AGATCCTCCT TGTGGGCTTT TTCTTTTGGT 
CTTGGAGCTT TCAGTGGCCC AAGGATCTTT GATATCCGCT TTCAAGGGGA GAGGGTGGCC 
TATGAAATCA GTGTCCAGGA GGCCATAGCC CTCTATGGTG GTAATTCCCC GGCATCAATG 
TCGACCTGCT ATATGGACGG AAGCTTTGGC ATTGGCAAAT ACTCTACCCC GCTGACCCGA 
GGGGTAGACT GTCCATACCT TGCCACCTAT GTGGACTGGC ACTTCCTTCT GGAGTCTCAG 
ACCCCCAAGA CACTACGTGA TGCGTTTTGC GTGTTTGAAC AGAACCAGGG CCTCCCGCTC 
CGGCGACACC ACTCAGATTT CTACTCCCAC TATTTTGGGG GCGTTGTGGA GACAGTGCTT 
GTGGTCAGAT CCGTGGCTAC CTTGCTCAAT TATGACTATG TGTGGGACAT GGTTTTCCAC 
TCCAATGGGG CCATAGAAGT CAAATTCCAC GCCACGGGCT ATATCACCTC GGCTTTCTTC 
TTCGGTGCTG GCGAGAAGTT TGGGAACCGA GTTGCCGAGC ACACACTGGG CACTGTACAC 
ACCCACAACG CTCACTTCAA AGTGGACTTG GATGTGGCAG GGTTGAAGAA CTGGGCCTGG 
GCAGAGGATT TGGCTTTTGT CCCTATGAAT GTACCTTGGC AACCGGAGTT CCAGATGCAG 
AGGCTGCAGG TGACTCGGAA GCTGCTGGAG ACAGAAGAGG AGGCTGCCTT CCCACTGGGA 
AATGCCACCC CACGCTACCT GTACCTGGCC AGTAACCACA GCAACAAGTG GGGTCACAGG 
CGAGGCTACC GCATCCAGAT ACTCAGCTTT GCTGGGAAGC CACTGCCCCA GGAAAGCCCC 
ATAGAGAAAG CCTTCACCTG GGGCAGGTAT CACTTGGCTG TGACCCAGAG GAAGGAGGAG 
GAGCCCAGCA GTTCTAGCAT CTACAACCAG AATGACCCGT GGACCCCCAC TGTGGACTTC 
ACTGACTTTA TCAGCAATGA GACCATTGCT GGCGAGGACT TGGTAGCCTG GGTGACAGCT 
GGCTTTTTGC ACATCCCACA TGCGGAAGAC ATTCCCAACA CGGTGACCGT AGGGAACGGG 
GTGGGTTTCT TCCTCCGGCC GTATAACTTC TTTGATGAGG ACCCCTCCTT CTACTCACCC 
GACTCCATCT ATTTCCGGAA GGACCAGGAT GTCACAGACT GTGAGGTCAA CTCCCTGGCT 
TGCCTGTCTC AGACTGCCAA CTGTGTCCCC GACCTCCCTG CCTTCTCCCA TGGGGGCTTT 
ACTTATAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113770.2
CDS	81..2372
Translation	MTQKTTLVLLALAVITIFALVCVLLAGRSGDGGRLSQPLHCPSVLPSVQPQTHPGQSQPFADLSPEELTAVMSFLIKHLGPGLVDAAQARPSDNCVFSVELQLPAKAAALAHLDRGGPPPVREALAIIFFGGQPKPNVSELVVGPLPHPSYMRDVTVERHGGPLPYYRRPVLTREYQDIQEMIFHRELPQASGLLHHCCFYKRQGHNLLKMTTAPRGLQSGDRATWFGIYYNLSGAGFYPHPIGLELLVDHKALDPALWTIQKVFYQGRYYESLTQLEDMFEAGLVNVVLVPDNGTGGSWSLKSSVPPGRAPPLQFHPEGPRFSVQGSQVRSSLWAFSFGLGAFSGPRIFDIRFQGERVAYEISVQEAIALYGGNSPASMSTCYMDGSFGIGKYSTPLTRGVDCPYLATYVDWHFLLESQTPKTLRDAFCVFEQNQGLPLRRHHSDFYSHYFGGVVETVLVVRSVATLLNYDYVWDMVFHSNGAIEVKFHATGYITSAFFFGAGEKFGNRVAEHTLGTVHTHNAHFKVDLDVAGLKNWAWAEDLAFVPMNVPWQPEFQMQRLQVTRKLLETEEEAAFPLGNATPRYLYLASNHSNKWGHRRGYRIQILSFAGKPLPQESPIEKAFTWGRYHLAVTQRKEEEPSSSSIYNQNDPWTPTVDFTDFISNETIAGEDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSPDSIYFRKDQDVTDCEVNSLACLSQTANCVPDLPAFSHGGFTYK

Target ORF information:

RefSeq Version	NM_031582.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus amine oxidase, copper containing 3 (Aoc3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031582.2

ORF Insert Sequence:

ATGACCCAGA AGACCACCCT AGTGCTCCTT GCCCTGGCTG TCATCACCAT CTTCGCTTTG 
GTTTGCGTCT TGCTAGCTGG CAGGAGCGGA GATGGGGGCA GACTGAGCCA ACCTCTTCAT 
TGCCCTTCCG TTCTTCCTAG CGTCCAGCCC CAGACACACC CTGGCCAGAG CCAGCCGTTT 
GCAGACCTGA GCCCTGAGGA GCTGACAGCT GTGATGAGCT TTCTGATCAA GCACCTGGGG 
CCAGGGCTGG TGGATGCAGC CCAGGCTCGA CCCTCGGACA ACTGTGTCTT CTCAGTAGAG 
TTGCAGCTGC CTGCCAAGGC TGCAGCCCTG GCCCACCTGG ACAGAGGGGG GCCCCCACCC 
GTGCGGGAGG CACTGGCCAT CATCTTCTTT GGTGGACAAC CCAAGCCTAA TGTGAGCGAG 
TTGGTGGTGG GGCCCCTGCC TCACCCCTCA TACATGCGGG ATGTGACTGT GGAGCGTCAT 
GGCGGCCCCC TGCCCTATTA CCGGCGTCCT GTGCTGACCA GAGAGTATCA GGATATCCAG 
GAGATGATCT TCCACAGAGA GCTGCCCCAA GCGTCTGGTC TCCTCCATCA CTGTTGCTTC 
TACAAACGCC AAGGACACAA CCTGCTAAAA ATGACTACAG CCCCCCGTGG TTTGCAATCA 
GGGGACCGGG CCACCTGGTT TGGCATATAT TACAATCTCT CAGGGGCTGG GTTTTACCCT 
CACCCCATTG GCTTAGAGCT TCTGGTAGAT CACAAGGCCC TGGATCCTGC CCTGTGGACC 
ATCCAGAAGG TATTCTACCA AGGCCGTTAC TATGAGAGTC TGACTCAGCT GGAGGACATG 
TTTGAGGCTG GCCTGGTGAA TGTGGTTTTG GTCCCAGACA ATGGCACAGG TGGGTCCTGG 
TCTCTGAAGT CTTCAGTGCC ACCAGGCCGA GCTCCTCCTC TGCAGTTCCA TCCTGAGGGA 
CCCCGTTTCA GCGTCCAGGG GAGTCAAGTG AGATCCTCCT TGTGGGCTTT TTCTTTTGGT 
CTTGGAGCTT TCAGTGGCCC AAGGATCTTT GATATCCGCT TTCAAGGGGA GAGGGTGGCC 
TATGAAATCA GTGTCCAGGA GGCCATAGCC CTCTATGGTG GTAATTCCCC GGCATCAATG 
TCGACCTGCT ATATGGACGG AAGCTTTGGC ATTGGCAAAT ACTCTACCCC GCTGACCCGA 
GGGGTAGACT GTCCATACCT TGCCACCTAT GTGGACTGGC ACTTCCTTCT GGAGTCTCAG 
ACCCCCAAGA CACTACGTGA TGCGTTTTGC GTGTTTGAAC AGAACCAGGG CCTCCCGCTC 
CGGCGACACC ACTCAGATTT CTACTCCCAC TATTTTGGGG GCGTTGTGGA GACAGTGCTT 
GTGGTCAGAT CCGTGGCTAC CTTGCTCAAT TATGACTATG TGTGGGACAT GGTTTTCCAC 
TCCAATGGGG CCATAGAAGT CAAATTCCAC GCCACGGGCT ATATCACCTC GGCTTTCTTC 
TTCGGTGCTG GCGAGAAGTT TGGGAACCGA GTTGCCGAGC ACACACTGGG CACTGTACAC 
ACCCACAACG CTCACTTCAA AGTGGACTTG GATGTGGCAG GGTTGAAGAA CTGGGCCTGG 
GCAGAGGATT TGGCTTTTGT CCCTATGAAT GTACCTTGGC AACCGGAGTT CCAGATGCAG 
AGGCTGCAGG TGACTCGGAA GCTGCTGGAG ACAGAAGAGG AGGCTGCCTT CCCACTGGGA 
AATGCCACCC CACGCTACCT GTACCTGGCC AGTAACCACA GCAACAAGTG GGGTCACAGG 
CGAGGCTACC GCATCCAGAT ACTCAGCTTT GCTGGGAAGC CACTGCCCCA GGAAAGCCCC 
ATAGAGAAAG CCTTCACCTG GGGCAGGTAT CACTTGGCTG TGACCCAGAG GAAGGAGGAG 
GAGCCCAGCA GTTCTAGCAT CTACAACCAG AATGACCCGT GGACCCCCAC TGTGGACTTC 
ACTGACTTTA TCAGCAATGA GACCATTGCT GGCGAGGACT TGGTAGCCTG GGTGACAGCT 
GGCTTTTTGC ACATCCCACA TGCGGAAGAC ATTCCCAACA CGGTGACCGT AGGGAACGGG 
GTGGGTTTCT TCCTCCGGCC GTATAACTTC TTTGATGAGG ACCCCTCCTT CTACTCACCC 
GACTCCATCT ATTTCCGGAA GGACCAGGAT GTCACAGACT GTGAGGTCAA CTCCCTGGCT 
TGCCTGTCTC AGACTGCCAA CTGTGTCCCC GACCTCCCTG CCTTCTCCCA TGGGGGCTTT 
ACTTATAAAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Alteration of SSAO interactome reveals weakened cell adhesion and motor function of adipocytes in T2D.
Acta biochimica et biophysica Sinica49(9)845-847(2017 Sep)
Ke M,Zhang Y,Deng Y

Vascular adhesion protein-1 enhances neutrophil infiltration by generation of hydrogen peroxide in renal ischemia/reperfusion injury.
Kidney international92(1)154-164(2017 Jul)
Tanaka S,Tanaka T,Kawakami T,Takano H,Sugahara M,Saito H,Higashijima Y,Yamaguchi J,Inagi R,Nangaku M

Cellular localization and trafficking of vascular adhesion protein-1 as revealed by an N-terminal GFP fusion protein.
Journal of neural transmission (Vienna, Austria : 1996)120(6)951-61(2013 Jun)
Weston CJ,Shepherd EL,Adams DH

Functional modulation of vascular adhesion protein-1 by a novel splice variant.
PloS one8(1)e54151(2013)
Kaitaniemi S,Gr?n K,Elovaara H,Salmi M,Jalkanen S,Elima K

Preliminary kinetic characterization of a copper amine oxidase from rat liver mitochondria matrix.
Amino acids40(2)713-20(2011 Feb)
Stevanato R,Cardillo S,Braga M,De Iuliis A,Battaglia V,Toninello A,Agostinelli E,Vianello F

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Aoc3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報