Lbp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lbp
Entrez Gene ID	29469
Full Name	lipopolysaccharide binding protein
Synonyms	Bpifd2
General protein information	Preferred Names lipopolysaccharide binding protein Names lipopolysaccharide-binding protein BPI fold containing family D, member 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q42
Summary	binds lipopolysaccharide on outer membrane of gram negative bacteria; involved in immune response [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017208.2	NP_058904.2	lipopolysaccharide-binding protein precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	LBP	NP_004130.2
Bos taurus (cattle)	LBP	NP_001033763.1
Mus musculus (house mouse)	Lbp	NP_032515.2
	LBP	XP_001094451.1
Rattus norvegicus (Norway rat)	Lbp	NP_058904.2
Canis lupus familiaris (dog)	LBP	XP_542993.3

Gene Ontology
Bibliography

Related articles in PubMed

Lipopolysaccharide-binding protein (LBP) blockade augments the protective effect of granulocyte colony-stimulating factor (G-CSF) in a rat sepsis model.
Liu A, Weiss S, Fang H, Claus RA, R?del J, Dirsch O, Dahmen U
Shock (Augusta, Ga.)43(5)497-503(2015 May)

The kinetic expression of lipopolysaccharide-binding protein and CD14 gene in obstructive jaundice.
Tsai CH, Yeh CH, Sheen-Chen SM, Huang CY, Liu YW, Huang CC, Shen SC, Tang RP
Journal of investigative surgery : the official journal of the Academy of Surgical Research28(1)18-23(2015 Feb)

The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane.
Tanimura N, Saitoh S, Ohto U, Akashi-Takamura S, Fujimoto Y, Fukase K, Shimizu T, Miyake K
International immunology26(6)307-14(2014 Jun)

The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity.
Eckert JK, Kim YJ, Kim JI, G?rtler K, Oh DY, Sur S, Lundvall L, Hamann L, van der Ploeg A, Pickkers P, Giamarellos-Bourboulis E, Kubarenko AV, Weber AN, Kabesch M, Kumpf O, An HJ, Lee JO, Schumann RR
Immunity39(4)647-60(2013 Oct)

Liver transplantation and inflammation: is lipopolysaccharide binding protein the link?
Fang H, Liu A, Dirsch O, Dahmen U
Cytokine64(1)71-8(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LBP has a role in augmentation of the host's response in a rat sepsis model via G-CSF
Title: Lipopolysaccharide-binding protein (LBP) blockade augments the protective effect of granulocyte colony-stimulating factor (G-CSF) in a rat sepsis model.

Hepatic LBP mRNA expression increased significantly at five days after bile duct ligation.
Title: The kinetic expression of lipopolysaccharide-binding protein and CD14 gene in obstructive jaundice.

these findings suggest that translocation of Lipopolysaccharide occurs after liver transplantation and that lipopolysaccharide binding protein is mediating the LPS-induced inflammatory response after liver transplantation.
Title: Liver transplantation and inflammation: is lipopolysaccharide binding protein the link?

G-CSF induced LBP expression could serve as a new model for investigation of LPS sensitization. We demonstrated the crucial role of LBP upregulation in pathogenesis of LPS induced SIRS.
Title: Granulocyte colony stimulating factor induces lipopolysaccharide (LPS) sensitization via upregulation of LPS binding protein in rat.

lipopolysaccharide disrupts the tight junction of a bile duct epithelial monolayer by a c-Src-, TLR4-, LBP-, and myosin light chain kinase-dependent mechanism.
Title: Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism.

The following Lbp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lbp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12910	NM_017208.2 Latest version!	Rattus norvegicus lipopolysaccharide binding protein (Lbp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lbp ( NM_017208.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058904.2 Rattus norvegicus lipopolysaccharide binding protein (Lbp), mRNA.

Price & Availability↑

CloneID	ORa12910
Clone ID Related Accession (Same CDS sequence)	NM_017208.2
Accession Version	NM_017208.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Rattus norvegicus(Norway rat)
Product	lipopolysaccharide-binding protein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC101906.1. On Apr 4, 2007 this sequence version replaced NM_017208.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC101906.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689598 [ECO:0000348] ##Evidence-Data-END##

ATGAAGTCTG CGACTGGGCC TCTGCTTCCT ACATTGCTGG GGCTACTGCT CCTGTCTATA 
CCAAGGACTC AGGGTGTCAA TCCCGCCATG GTGGTCAGGA TCACCGACAA GGGCCTGGAG 
TACGCGGCCA AGGAGGGGCT GTTGAGTCTG CAGAGAGAGC TGTACAAGAT CACACTGCCT 
GACTTCAGCG GGGACTTCAA GATCAAGGCT GTGGGCCGTG GGCAGTACGA GTTTCATAGC 
CTGGAGATCC AGAGCTGTCA GCTGCGTGGC TCGTCCCTGA AGCCGCTCCC AGGCCGAGGC 
CTGAGTCTCT CCATCTCTGA CTCTTCGATC AGCGTCCGGG GCAAATGGAA AGTGCGCAGA 
TCCTTCGTGA AACTTCACGG CTCCTTTGAC CTGGATGTCA AAGGTGTCAC TATTTCAGTG 
GACCTCCTCC TGGGCGTGGA TCCCTCAGGA CGGCCCACAG TCACCGCCTC TGGATGCAGC 
AACCGCATTC GTGATTTGGA ATTGCACGTA TCAGGAAATG TGGGGTGGCT GCTGAATCTT 
TTCCACAACC AGATCGAGTC CAAGCTCCAG AAAGTATTGG AGAGTAAGAT TTGTGAGATG 
ATCCAGAAGT CTGTGACCTC TGATCTGCAG CCTTATCTCC AAACTCTGCC AGTCACAGCG 
GATATCGACA CTATCCTGGG CATTGACTAC AGTTTGGTGG CGGCTCCCCA AGCAAAGGCC 
CAGACGCTGG ATGTGATGTT TAAGGGTGAA ATTTTTAATC GGAATCACCG CTCCCCAGTC 
ACTACCCCCA CCCCGACCAT GAGCCTACCT GAGGACAGTA AACAAATGGT CTACTTTGCC 
ATCTCAGATC AGGCCTTCAA CATAGCCACC CGGGTTTACC ACCAGGCCGG GTACCTGAAC 
TTTACCATCA CAGATGACAT GTTACCGCCT GACTCCAACA TCCGGCTGAA CACCAAGGCC 
TTCCGCCCCT TCACTCCTCT GATAACCAGA AAGTACCCCG ACATGAACTT GGAGCTTCTT 
GGAACAGTGG TCTCTGCCCC ACTTCTGAAT GTCAGTCCTG GGAATCTGTC CTTGGCCCCA 
CAGATGGAGA TTGAAGGCTT TGTGATCCTG CCCAGCTCCG CCCGCGAATC TGTCTTCCGG 
CTTGGCGTGG TCACGAATGT ATTCGTCTCA TTAACTTTTG ACAACAGCAA GGTCACCGGG 
ATGCTGCATC CAGAGAAGGC GCAAGTGAGA CTGATCGAAT CCAAAGTCGG CATGTTCAAT 
GTGAACCTGT TCCAGGCATT CCTCAACTAC TACCTTCTCA ACAGCCTCTA CCCTGATGTC 
AACGATGAGC TGGCCAAGGG CTTCCCCCTC CCTCTACCAA GGCGTATTAA GCTCCACGAC 
CTCGACTTCC AGATCCACAA GAACTTCCTA TACTTGGGTG CCAATGTCCA GTACATGAGA 
GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058904.2
CDS	22..1467
Translation	MKSATGPLLPTLLGLLLLSIPRTQGVNPAMVVRITDKGLEYAAKEGLLSLQRELYKITLPDFSGDFKIKAVGRGQYEFHSLEIQSCQLRGSSLKPLPGRGLSLSISDSSISVRGKWKVRRSFVKLHGSFDLDVKGVTISVDLLLGVDPSGRPTVTASGCSNRIRDLELHVSGNVGWLLNLFHNQIESKLQKVLESKICEMIQKSVTSDLQPYLQTLPVTADIDTILGIDYSLVAAPQAKAQTLDVMFKGEIFNRNHRSPVTTPTPTMSLPEDSKQMVYFAISDQAFNIATRVYHQAGYLNFTITDDMLPPDSNIRLNTKAFRPFTPLITRKYPDMNLELLGTVVSAPLLNVSPGNLSLAPQMEIEGFVILPSSARESVFRLGVVTNVFVSLTFDNSKVTGMLHPEKAQVRLIESKVGMFNVNLFQAFLNYYLLNSLYPDVNDELAKGFPLPLPRRIKLHDLDFQIHKNFLYLGANVQYMRV

Target ORF information:

RefSeq Version	NM_017208.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus lipopolysaccharide binding protein (Lbp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017208.2

ORF Insert Sequence:

ATGAAGTCTG CGACTGGGCC TCTGCTTCCT ACATTGCTGG GGCTACTGCT CCTGTCTATA 
CCAAGGACTC AGGGTGTCAA TCCCGCCATG GTGGTCAGGA TCACCGACAA GGGCCTGGAG 
TACGCGGCCA AGGAGGGGCT GTTGAGTCTG CAGAGAGAGC TGTACAAGAT CACACTGCCT 
GACTTCAGCG GGGACTTCAA GATCAAGGCT GTGGGCCGTG GGCAGTACGA GTTTCATAGC 
CTGGAGATCC AGAGCTGTCA GCTGCGTGGC TCGTCCCTGA AGCCGCTCCC AGGCCGAGGC 
CTGAGTCTCT CCATCTCTGA CTCTTCGATC AGCGTCCGGG GCAAATGGAA AGTGCGCAGA 
TCCTTCGTGA AACTTCACGG CTCCTTTGAC CTGGATGTCA AAGGTGTCAC TATTTCAGTG 
GACCTCCTCC TGGGCGTGGA TCCCTCAGGA CGGCCCACAG TCACCGCCTC TGGATGCAGC 
AACCGCATTC GTGATTTGGA ATTGCACGTA TCAGGAAATG TGGGGTGGCT GCTGAATCTT 
TTCCACAACC AGATCGAGTC CAAGCTCCAG AAAGTATTGG AGAGTAAGAT TTGTGAGATG 
ATCCAGAAGT CTGTGACCTC TGATCTGCAG CCTTATCTCC AAACTCTGCC AGTCACAGCG 
GATATCGACA CTATCCTGGG CATTGACTAC AGTTTGGTGG CGGCTCCCCA AGCAAAGGCC 
CAGACGCTGG ATGTGATGTT TAAGGGTGAA ATTTTTAATC GGAATCACCG CTCCCCAGTC 
ACTACCCCCA CCCCGACCAT GAGCCTACCT GAGGACAGTA AACAAATGGT CTACTTTGCC 
ATCTCAGATC AGGCCTTCAA CATAGCCACC CGGGTTTACC ACCAGGCCGG GTACCTGAAC 
TTTACCATCA CAGATGACAT GTTACCGCCT GACTCCAACA TCCGGCTGAA CACCAAGGCC 
TTCCGCCCCT TCACTCCTCT GATAACCAGA AAGTACCCCG ACATGAACTT GGAGCTTCTT 
GGAACAGTGG TCTCTGCCCC ACTTCTGAAT GTCAGTCCTG GGAATCTGTC CTTGGCCCCA 
CAGATGGAGA TTGAAGGCTT TGTGATCCTG CCCAGCTCCG CCCGCGAATC TGTCTTCCGG 
CTTGGCGTGG TCACGAATGT ATTCGTCTCA TTAACTTTTG ACAACAGCAA GGTCACCGGG 
ATGCTGCATC CAGAGAAGGC GCAAGTGAGA CTGATCGAAT CCAAAGTCGG CATGTTCAAT 
GTGAACCTGT TCCAGGCATT CCTCAACTAC TACCTTCTCA ACAGCCTCTA CCCTGATGTC 
AACGATGAGC TGGCCAAGGG CTTCCCCCTC CCTCTACCAA GGCGTATTAA GCTCCACGAC 
CTCGACTTCC AGATCCACAA GAACTTCCTA TACTTGGGTG CCAATGTCCA GTACATGAGA 
GTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lipopolysaccharide-binding protein (LBP) blockade augments the protective effect of granulocyte colony-stimulating factor (G-CSF) in a rat sepsis model.
Shock (Augusta, Ga.)43(5)497-503(2015 May)
Liu A,Weiss S,Fang H,Claus RA,R?del J,Dirsch O,Dahmen U

The kinetic expression of lipopolysaccharide-binding protein and CD14 gene in obstructive jaundice.
Journal of investigative surgery : the official journal of the Academy of Surgical Research28(1)18-23(2015 Feb)
Tsai CH,Yeh CH,Sheen-Chen SM,Huang CY,Liu YW,Huang CC,Shen SC,Tang RP

The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane.
International immunology26(6)307-14(2014 Jun)
Tanimura N,Saitoh S,Ohto U,Akashi-Takamura S,Fujimoto Y,Fukase K,Shimizu T,Miyake K

The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity.
Immunity39(4)647-60(2013 Oct)
Eckert JK,Kim YJ,Kim JI,G?rtler K,Oh DY,Sur S,Lundvall L,Hamann L,van der Ploeg A,Pickkers P,Giamarellos-Bourboulis E,Kubarenko AV,Weber AN,Kabesch M,Kumpf O,An HJ,Lee JO,Schumann RR

Liver transplantation and inflammation: is lipopolysaccharide binding protein the link?
Cytokine64(1)71-8(2013 Oct)
Fang H,Liu A,Dirsch O,Dahmen U

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Lbp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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