Hap1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hap1
Entrez Gene ID	29430
Full Name	huntingtin-associated protein 1
Synonyms	HAP1-A,HAP1-B
General protein information	Preferred Names huntingtin-associated protein 1 Names huntingtin-associated protein 1 HAP-1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q31
Summary	Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that is homologous to the human huntingtin-associated protein 1. The human protein interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Two transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_024133.2	NP_077047.1	huntingtin-associated protein 1 isoform A
NM_177982.2	NP_817091.1	huntingtin-associated protein 1 isoform B
NM_024133.3	NP_077047.1	huntingtin-associated protein 1 isoform A
NM_177982.1	NP_817091.1	huntingtin-associated protein 1 isoform B

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	HAP1	XP_005624544.1
Pan troglodytes (chimpanzee)	HAP1	XP_001167911.1
Bos taurus (cattle)	HAP1	XP_003587493.1
Rattus norvegicus (Norway rat)	Hap1	NP_077047.1
Homo sapiens (human)	HAP1	NP_817084.2
Mus musculus (house mouse)	Hap1	NP_034534.1

Gene Ontology
Bibliography

Related articles in PubMed

Immunohistochemical analysis of huntingtin-associated protein 1 in adult rat spinal cord and its regional relationship with androgen receptor.
Islam MN, Takeshita Y, Yanai A, Imagawa A, Jahan MR, Wroblewski G, Nemoto J, Fujinaga R, Shinoda K
Neuroscience340201-217(2017 Jan)

Downregulation of GABA
Mele M, Aspromonte MC, Duarte CB
Molecular neurobiology54(1)45-57(2017 Jan)

HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic ? cells.
Wang Z, Peng T, Wu H, He J, Li H
Histochemistry and cell biology144(1)39-48(2015 Jul)

Molecular characterization of genes modifying the age at onset in Huntington's Disease in Uruguayan patients.
Vital M, Bidegain E, Raggio V, Esperon P
The International journal of neuroscience1-17(2015 May)

The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.
Wong YC, Holzbaur EL
The Journal of neuroscience : the official journal of the Society for Neuroscience34(4)1293-305(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study demonstrated that HAP1 is abundantly expressed in spinal neurons of the somatosensory, viscerosensory, and autonomic regions but absent in somatomotor neurons, suggesting that the spinal motoneurons are, due to lack of putative HAP1 protectivity, more vulnerable to stresses in neurodegenerative diseases than other HAP1-expressing neurons probably involved in spinal sensory and autonomic functions.
Title: Immunohistochemical analysis of huntingtin-associated protein 1 in adult rat spinal cord and its regional relationship with androgen receptor.

results provide real-time evidence in living cells that HAP1 may help regulate transport of insulin-containing secretory granules along cortical actin filaments
Title: HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic ? cells.

sortilin stabilizes the proBDNF.HAP1 complex
Title: Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing.

HAP1 is selectively expressed in beta-cells of rat pancreatic islets, suggesting the involvement of HAP1 in the regulation of cellular trafficking and secretion of insulin.
Title: Selective expression of Huntingtin-associated protein 1 in {beta}-cells of the rat pancreatic islets.

Data suggest that HAP1-KIF5-dependent GABA(A)R trafficking is a fundamental mechanism controlling the strength of synaptic inhibition in the brain.
Title: Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.

The following Hap1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hap1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa06791	NM_024133.3 Latest version!	Rattus norvegicus huntingtin-associated protein 1 (Hap1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$349.30 $499.00
ORa12449	NM_177982.2 Latest version!	Rattus norvegicus huntingtin-associated protein 1 (Hap1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
View Old Accession Versions >>
ORa06791	NM_024133.2	Rattus norvegicus huntingtin-associated protein 1 (Hap1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$349.30 $499.00
ORa12449	NM_177982.1	Rattus norvegicus huntingtin-associated protein 1 (Hap1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hap1 ( NM_024133.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_077047.1 Rattus norvegicus huntingtin-associated protein 1 (Hap1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa06791
Clone ID Related Accession (Same CDS sequence)	NM_024133.2 , NM_024133.3
Accession Version	NM_024133.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1800bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-12
Organism	Rattus norvegicus(Norway rat)
Product	huntingtin-associated protein 1 isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U38373.1. On Apr 23, 2003 this sequence version replaced NM_024133.1. Transcript Variant: This variant (1) encodes the shorter isoform (A). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U38373.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCCCGA AGGACCAGGT GCAGAGCAGT GCCGGGGACG GGACGGGGTC GGGGGACCCA 
GCAACAGGCA CCCCCACGAC CCAGCCTGCA GCGGATCCCG CTCCGGAGCC CTCGGCAGAG 
CCCAAACCTG CTCCGGCGCA GGGAACCGGG TCCGGACAGA AATCAGGATC CCGAACCAAG 
ACAGGAGGAA GCTTTTGTAG GTCCAGGATC CGTGGCGACT CGGACGCACC ATGGACCCGC 
TACATATTCC AGGGGCCTTA CGGTCCCCGG GCTACTGGCC TGGGCACTGG AAGGGCTGAG 
GGAATCTGGA AGACGCCAGC CGCGTACATC GGCCGAAGGC CCGGCGTGTC CGGCCCTGAG 
CGCGCGGCGT TTATTCGAGA GCTGCAGGAA GCGCTGTGTC CTAATCCACT GCCCAGGAAG 
AAGATCACCG AAGATGATAT CAAAGTGATG TTGTATTTGC TGGAAGAGAA AGAACGGGAC 
CTGAACACAG CCGCTCGCAT CGGCCAGTCC CTGGTGAAAC AGAATAGTGT TCTGATGGAG 
GAGAATAACA AGCTGGAAAC CATGCTGGGC TCAGCCAGAG AGGAGATTTT ACATCTCCGG 
AAGCAGGTGA ACCTGCGAGA TGATCTCCTT CAGCTCTACT CGGACTCCGA TGACGATGAG 
GAGGATGAAG AGGATGAGGA AGAGGAAGAG GGAGAAGAGG AGGAACGAGA AGGACAGAGG 
GACCAAGATC AGCAGCACGA CCATCCCTAT GGTGCCCCCA AGCCGCCCCC TAAGGCTGAG 
ACGCTGCACC ACTGCCCACA GCTGGAAGCC CTGAAGCAGA AGCTGAAACT GCTGGAAGAA 
GAGAACGACC ATCTTCGAGA GGAGGCCTCC CACCTTGACA ACCTGGAAGA CAAAGAACAG 
ATGCTCATTC TGGAGTGTGT GGAACAGTTT TCTGAAGCCA GCCAGCAGAT GGCAGAGCTA 
TCCGAGGTGT TGGTGCTGAG GCTGGAAGGC TATGAGAGGC AGCAGAAGGA GATCACTCAG 
CTGCAGGCCG AGATCACCAA GCTACAACAG CGTTGTCAGT CTTATGGGGC CCAGACGGAG 
AAACTGCAGC AGCAGCTGGC CTCAGAGAAG GGAGTCCACC CAGAGAGCCT GCGAGCTGGC 
TCCCACATGC AGGATTATGG AAGCAGGCCT CGTGAACGCC AGGAGGATGG GAAGAGCCAT 
CGTCAGCGTT CCTCAATGCC TGCAGGTTCT GTCACCCACT ATGGATACAG TGTGCCTCTG 
GATGCACTTC CAAGTTTCCC AGAGACACTG GCGGAGGAGC TCCGGACATC CCTGAGGAAG 
TTCATCACTG ACCCTGCGTA TTTCATGGAG AGATGTGACA CTCGCTGCAG AGAGGAACGA 
AAGAAGGAGC AGGGGACAAT GCCACCCCCA CCGGTGCAAG ATCTCAAGCC GCCTGAAGAT 
TTCGAGGCTC CAGAGGAGCT GGTTCCTGAG GAGGAGCTGG GGGCCATAGA AGAGGTGGGG 
ACAGCTGAGG ATGGGCCGGC AGAAGAGACA GAGCAGGCAT CTGAGGAGAC CGAGGCCTGG 
GAGGAGGTGG AACCGGAGGT GGACGAGGCC ACAAGGATGA ATGTGGTGGT CTCTGCCCTG 
GAGGCCAGCG GCCTGGGCCC TTCACACCTG GACATGAAGT ATGTCCTCCA GCAACTGTCC 
AACTGGCAGG ACGCCCATTC TAAGCGGCAG CAGAAGCAGA AGGTGGTCCC GAAAGGTGAG 
TGTTCCCGCA GAGGACACCC TCCTGCCAGT GGGACAAGCT ACCGATCATC AACCCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077047.1
CDS	25..1824
Translation	MRPKDQVQSSAGDGTGSGDPATGTPTTQPAADPAPEPSAEPKPAPAQGTGSGQKSGSRTKTGGSFCRSRIRGDSDAPWTRYIFQGPYGPRATGLGTGRAEGIWKTPAAYIGRRPGVSGPERAAFIRELQEALCPNPLPRKKITEDDIKVMLYLLEEKERDLNTAARIGQSLVKQNSVLMEENNKLETMLGSAREEILHLRKQVNLRDDLLQLYSDSDDDEEDEEDEEEEEGEEEEREGQRDQDQQHDHPYGAPKPPPKAETLHHCPQLEALKQKLKLLEEENDHLREEASHLDNLEDKEQMLILECVEQFSEASQQMAELSEVLVLRLEGYERQQKEITQLQAEITKLQQRCQSYGAQTEKLQQQLASEKGVHPESLRAGSHMQDYGSRPRERQEDGKSHRQRSSMPAGSVTHYGYSVPLDALPSFPETLAEELRTSLRKFITDPAYFMERCDTRCREERKKEQGTMPPPPVQDLKPPEDFEAPEELVPEEELGAIEEVGTAEDGPAEETEQASEETEAWEEVEPEVDEATRMNVVVSALEASGLGPSHLDMKYVLQQLSNWQDAHSKRQQKQKVVPKGECSRRGHPPASGTSYRSSTL

Target ORF information:

RefSeq Version	NM_024133.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus huntingtin-associated protein 1 (Hap1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024133.2

ORF Insert Sequence:

ATGCGCCCGA AGGACCAGGT GCAGAGCAGT GCCGGGGACG GGACGGGGTC GGGGGACCCA 
GCAACAGGCA CCCCCACGAC CCAGCCTGCA GCGGATCCCG CTCCGGAGCC CTCGGCAGAG 
CCCAAACCTG CTCCGGCGCA GGGAACCGGG TCCGGACAGA AATCAGGATC CCGAACCAAG 
ACAGGAGGAA GCTTTTGTAG GTCCAGGATC CGTGGCGACT CGGACGCACC ATGGACCCGC 
TACATATTCC AGGGGCCTTA CGGTCCCCGG GCTACTGGCC TGGGCACTGG AAGGGCTGAG 
GGAATCTGGA AGACGCCAGC CGCGTACATC GGCCGAAGGC CCGGCGTGTC CGGCCCTGAG 
CGCGCGGCGT TTATTCGAGA GCTGCAGGAA GCGCTGTGTC CTAATCCACT GCCCAGGAAG 
AAGATCACCG AAGATGATAT CAAAGTGATG TTGTATTTGC TGGAAGAGAA AGAACGGGAC 
CTGAACACAG CCGCTCGCAT CGGCCAGTCC CTGGTGAAAC AGAATAGTGT TCTGATGGAG 
GAGAATAACA AGCTGGAAAC CATGCTGGGC TCAGCCAGAG AGGAGATTTT ACATCTCCGG 
AAGCAGGTGA ACCTGCGAGA TGATCTCCTT CAGCTCTACT CGGACTCCGA TGACGATGAG 
GAGGATGAAG AGGATGAGGA AGAGGAAGAG GGAGAAGAGG AGGAACGAGA AGGACAGAGG 
GACCAAGATC AGCAGCACGA CCATCCCTAT GGTGCCCCCA AGCCGCCCCC TAAGGCTGAG 
ACGCTGCACC ACTGCCCACA GCTGGAAGCC CTGAAGCAGA AGCTGAAACT GCTGGAAGAA 
GAGAACGACC ATCTTCGAGA GGAGGCCTCC CACCTTGACA ACCTGGAAGA CAAAGAACAG 
ATGCTCATTC TGGAGTGTGT GGAACAGTTT TCTGAAGCCA GCCAGCAGAT GGCAGAGCTA 
TCCGAGGTGT TGGTGCTGAG GCTGGAAGGC TATGAGAGGC AGCAGAAGGA GATCACTCAG 
CTGCAGGCCG AGATCACCAA GCTACAACAG CGTTGTCAGT CTTATGGGGC CCAGACGGAG 
AAACTGCAGC AGCAGCTGGC CTCAGAGAAG GGAGTCCACC CAGAGAGCCT GCGAGCTGGC 
TCCCACATGC AGGATTATGG AAGCAGGCCT CGTGAACGCC AGGAGGATGG GAAGAGCCAT 
CGTCAGCGTT CCTCAATGCC TGCAGGTTCT GTCACCCACT ATGGATACAG TGTGCCTCTG 
GATGCACTTC CAAGTTTCCC AGAGACACTG GCGGAGGAGC TCCGGACATC CCTGAGGAAG 
TTCATCACTG ACCCTGCGTA TTTCATGGAG AGATGTGACA CTCGCTGCAG AGAGGAACGA 
AAGAAGGAGC AGGGGACAAT GCCACCCCCA CCGGTGCAAG ATCTCAAGCC GCCTGAAGAT 
TTCGAGGCTC CAGAGGAGCT GGTTCCTGAG GAGGAGCTGG GGGCCATAGA AGAGGTGGGG 
ACAGCTGAGG ATGGGCCGGC AGAAGAGACA GAGCAGGCAT CTGAGGAGAC CGAGGCCTGG 
GAGGAGGTGG AACCGGAGGT GGACGAGGCC ACAAGGATGA ATGTGGTGGT CTCTGCCCTG 
GAGGCCAGCG GCCTGGGCCC TTCACACCTG GACATGAAGT ATGTCCTCCA GCAACTGTCC 
AACTGGCAGG ACGCCCATTC TAAGCGGCAG CAGAAGCAGA AGGTGGTCCC GAAAGGTGAG 
TGTTCCCGCA GAGGACACCC TCCTGCCAGT GGGACAAGCT ACCGATCATC AACCCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hap1 ( NM_024133.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_077047.1 Rattus norvegicus huntingtin-associated protein 1 (Hap1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa06791
Clone ID Related Accession (Same CDS sequence)	NM_024133.2 , NM_024133.3
Accession Version	NM_024133.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1800bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Rattus norvegicus(Norway rat)
Product	huntingtin-associated protein 1 isoform A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U38373.2. On Aug 1, 2018 this sequence version replaced NM_024133.2. Transcript Variant: This variant (1) encodes the shorter isoform (A). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U38373.2 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCGCCCGA AGGACCAGGT GCAGAGCAGT GCCGGGGACG GGACGGGGTC GGGGGACCCA 
GCAACAGGCA CCCCCACGAC CCAGCCTGCA GCGGATCCCG CTCCGGAGCC CTCGGCAGAG 
CCCAAACCTG CTCCGGCGCA GGGAACCGGG TCCGGACAGA AATCAGGATC CCGAACCAAG 
ACAGGAGGAA GCTTTTGTAG GTCCAGGATC CGTGGCGACT CGGACGCACC ATGGACCCGC 
TACATATTCC AGGGGCCTTA CGGTCCCCGG GCTACTGGCC TGGGCACTGG AAGGGCTGAG 
GGAATCTGGA AGACGCCAGC CGCGTACATC GGCCGAAGGC CCGGCGTGTC CGGCCCTGAG 
CGCGCGGCGT TTATTCGAGA GCTGCAGGAA GCGCTGTGTC CTAATCCACT GCCCAGGAAG 
AAGATCACCG AAGATGATAT CAAAGTGATG TTGTATTTGC TGGAAGAGAA AGAACGGGAC 
CTGAACACAG CCGCTCGCAT CGGCCAGTCC CTGGTGAAAC AGAATAGTGT TCTGATGGAG 
GAGAATAACA AGCTGGAAAC CATGCTGGGC TCAGCCAGAG AGGAGATTTT ACATCTCCGG 
AAGCAGGTGA ACCTGCGAGA TGATCTCCTT CAGCTCTACT CGGACTCCGA TGACGATGAG 
GAGGATGAAG AGGATGAGGA AGAGGAAGAG GGAGAAGAGG AGGAACGAGA AGGACAGAGG 
GACCAAGATC AGCAGCACGA CCATCCCTAT GGTGCCCCCA AGCCGCCCCC TAAGGCTGAG 
ACGCTGCACC ACTGCCCACA GCTGGAAGCC CTGAAGCAGA AGCTGAAACT GCTGGAAGAA 
GAGAACGACC ATCTTCGAGA GGAGGCCTCC CACCTTGACA ACCTGGAAGA CAAAGAACAG 
ATGCTCATTC TGGAGTGTGT GGAACAGTTT TCTGAAGCCA GCCAGCAGAT GGCAGAGCTA 
TCCGAGGTGT TGGTGCTGAG GCTGGAAGGC TATGAGAGGC AGCAGAAGGA GATCACTCAG 
CTGCAGGCCG AGATCACCAA GCTACAACAG CGTTGTCAGT CTTATGGGGC CCAGACGGAG 
AAACTGCAGC AGCAGCTGGC CTCAGAGAAG GGAGTCCACC CAGAGAGCCT GCGAGCTGGC 
TCCCACATGC AGGATTATGG AAGCAGGCCT CGTGAACGCC AGGAGGATGG GAAGAGCCAT 
CGTCAGCGTT CCTCAATGCC TGCAGGTTCT GTCACCCACT ATGGATACAG TGTGCCTCTG 
GATGCACTTC CAAGTTTCCC AGAGACACTG GCGGAGGAGC TCCGGACATC CCTGAGGAAG 
TTCATCACTG ACCCTGCGTA TTTCATGGAG AGATGTGACA CTCGCTGCAG AGAGGAACGA 
AAGAAGGAGC AGGGGACAAT GCCACCCCCA CCGGTGCAAG ATCTCAAGCC GCCTGAAGAT 
TTCGAGGCTC CAGAGGAGCT GGTTCCTGAG GAGGAGCTGG GGGCCATAGA AGAGGTGGGG 
ACAGCTGAGG ATGGGCCGGC AGAAGAGACA GAGCAGGCAT CTGAGGAGAC CGAGGCCTGG 
GAGGAGGTGG AACCGGAGGT GGACGAGGCC ACAAGGATGA ATGTGGTGGT CTCTGCCCTG 
GAGGCCAGCG GCCTGGGCCC TTCACACCTG GACATGAAGT ATGTCCTCCA GCAACTGTCC 
AACTGGCAGG ACGCCCATTC TAAGCGGCAG CAGAAGCAGA AGGTGGTCCC GAAAGGTGAG 
TGTTCCCGCA GAGGACACCC TCCTGCCAGT GGGACAAGCT ACCGATCATC AACCCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077047.1
CDS	23..1822
Translation	MRPKDQVQSSAGDGTGSGDPATGTPTTQPAADPAPEPSAEPKPAPAQGTGSGQKSGSRTKTGGSFCRSRIRGDSDAPWTRYIFQGPYGPRATGLGTGRAEGIWKTPAAYIGRRPGVSGPERAAFIRELQEALCPNPLPRKKITEDDIKVMLYLLEEKERDLNTAARIGQSLVKQNSVLMEENNKLETMLGSAREEILHLRKQVNLRDDLLQLYSDSDDDEEDEEDEEEEEGEEEEREGQRDQDQQHDHPYGAPKPPPKAETLHHCPQLEALKQKLKLLEEENDHLREEASHLDNLEDKEQMLILECVEQFSEASQQMAELSEVLVLRLEGYERQQKEITQLQAEITKLQQRCQSYGAQTEKLQQQLASEKGVHPESLRAGSHMQDYGSRPRERQEDGKSHRQRSSMPAGSVTHYGYSVPLDALPSFPETLAEELRTSLRKFITDPAYFMERCDTRCREERKKEQGTMPPPPVQDLKPPEDFEAPEELVPEEELGAIEEVGTAEDGPAEETEQASEETEAWEEVEPEVDEATRMNVVVSALEASGLGPSHLDMKYVLQQLSNWQDAHSKRQQKQKVVPKGECSRRGHPPASGTSYRSSTL

Target ORF information:

RefSeq Version	NM_024133.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus huntingtin-associated protein 1 (Hap1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024133.3

ORF Insert Sequence:

ATGCGCCCGA AGGACCAGGT GCAGAGCAGT GCCGGGGACG GGACGGGGTC GGGGGACCCA 
GCAACAGGCA CCCCCACGAC CCAGCCTGCA GCGGATCCCG CTCCGGAGCC CTCGGCAGAG 
CCCAAACCTG CTCCGGCGCA GGGAACCGGG TCCGGACAGA AATCAGGATC CCGAACCAAG 
ACAGGAGGAA GCTTTTGTAG GTCCAGGATC CGTGGCGACT CGGACGCACC ATGGACCCGC 
TACATATTCC AGGGGCCTTA CGGTCCCCGG GCTACTGGCC TGGGCACTGG AAGGGCTGAG 
GGAATCTGGA AGACGCCAGC CGCGTACATC GGCCGAAGGC CCGGCGTGTC CGGCCCTGAG 
CGCGCGGCGT TTATTCGAGA GCTGCAGGAA GCGCTGTGTC CTAATCCACT GCCCAGGAAG 
AAGATCACCG AAGATGATAT CAAAGTGATG TTGTATTTGC TGGAAGAGAA AGAACGGGAC 
CTGAACACAG CCGCTCGCAT CGGCCAGTCC CTGGTGAAAC AGAATAGTGT TCTGATGGAG 
GAGAATAACA AGCTGGAAAC CATGCTGGGC TCAGCCAGAG AGGAGATTTT ACATCTCCGG 
AAGCAGGTGA ACCTGCGAGA TGATCTCCTT CAGCTCTACT CGGACTCCGA TGACGATGAG 
GAGGATGAAG AGGATGAGGA AGAGGAAGAG GGAGAAGAGG AGGAACGAGA AGGACAGAGG 
GACCAAGATC AGCAGCACGA CCATCCCTAT GGTGCCCCCA AGCCGCCCCC TAAGGCTGAG 
ACGCTGCACC ACTGCCCACA GCTGGAAGCC CTGAAGCAGA AGCTGAAACT GCTGGAAGAA 
GAGAACGACC ATCTTCGAGA GGAGGCCTCC CACCTTGACA ACCTGGAAGA CAAAGAACAG 
ATGCTCATTC TGGAGTGTGT GGAACAGTTT TCTGAAGCCA GCCAGCAGAT GGCAGAGCTA 
TCCGAGGTGT TGGTGCTGAG GCTGGAAGGC TATGAGAGGC AGCAGAAGGA GATCACTCAG 
CTGCAGGCCG AGATCACCAA GCTACAACAG CGTTGTCAGT CTTATGGGGC CCAGACGGAG 
AAACTGCAGC AGCAGCTGGC CTCAGAGAAG GGAGTCCACC CAGAGAGCCT GCGAGCTGGC 
TCCCACATGC AGGATTATGG AAGCAGGCCT CGTGAACGCC AGGAGGATGG GAAGAGCCAT 
CGTCAGCGTT CCTCAATGCC TGCAGGTTCT GTCACCCACT ATGGATACAG TGTGCCTCTG 
GATGCACTTC CAAGTTTCCC AGAGACACTG GCGGAGGAGC TCCGGACATC CCTGAGGAAG 
TTCATCACTG ACCCTGCGTA TTTCATGGAG AGATGTGACA CTCGCTGCAG AGAGGAACGA 
AAGAAGGAGC AGGGGACAAT GCCACCCCCA CCGGTGCAAG ATCTCAAGCC GCCTGAAGAT 
TTCGAGGCTC CAGAGGAGCT GGTTCCTGAG GAGGAGCTGG GGGCCATAGA AGAGGTGGGG 
ACAGCTGAGG ATGGGCCGGC AGAAGAGACA GAGCAGGCAT CTGAGGAGAC CGAGGCCTGG 
GAGGAGGTGG AACCGGAGGT GGACGAGGCC ACAAGGATGA ATGTGGTGGT CTCTGCCCTG 
GAGGCCAGCG GCCTGGGCCC TTCACACCTG GACATGAAGT ATGTCCTCCA GCAACTGTCC 
AACTGGCAGG ACGCCCATTC TAAGCGGCAG CAGAAGCAGA AGGTGGTCCC GAAAGGTGAG 
TGTTCCCGCA GAGGACACCC TCCTGCCAGT GGGACAAGCT ACCGATCATC AACCCTATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hap1 ( NM_177982.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_817091.1 Rattus norvegicus huntingtin-associated protein 1 (Hap1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa12449
Clone ID Related Accession (Same CDS sequence)	NM_177982.2 , NM_177982.1
Accession Version	NM_177982.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1890bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Rattus norvegicus(Norway rat)
Product	huntingtin-associated protein 1 isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U38370.2. On Aug 1, 2018 this sequence version replaced NM_177982.1. Transcript Variant: This variant (2) lacks a segment in the 3' coding region that causes a frameshift, and lacks a segment in the 3' UTR, compared to variant 1. The encoded protein (isoform B) is longer and has a distinct C-terminus, compared to isoform A. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U38370.2 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: PMID: 7477378 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGCCCGA AGGACCAGGT GCAGAGCAGT GCCGGGGACG GGACGGGGTC GGGGGACCCA 
GCAACAGGCA CCCCCACGAC CCAGCCTGCA GCGGATCCCG CTCCGGAGCC CTCGGCAGAG 
CCCAAACCTG CTCCGGCGCA GGGAACCGGG TCCGGACAGA AATCAGGATC CCGAACCAAG 
ACAGGAGGAA GCTTTTGTAG GTCCAGGATC CGTGGCGACT CGGACGCACC ATGGACCCGC 
TACATATTCC AGGGGCCTTA CGGTCCCCGG GCTACTGGCC TGGGCACTGG AAGGGCTGAG 
GGAATCTGGA AGACGCCAGC CGCGTACATC GGCCGAAGGC CCGGCGTGTC CGGCCCTGAG 
CGCGCGGCGT TTATTCGAGA GCTGCAGGAA GCGCTGTGTC CTAATCCACT GCCCAGGAAG 
AAGATCACCG AAGATGATAT CAAAGTGATG TTGTATTTGC TGGAAGAGAA AGAACGGGAC 
CTGAACACAG CCGCTCGCAT CGGCCAGTCC CTGGTGAAAC AGAATAGTGT TCTGATGGAG 
GAGAATAACA AGCTGGAAAC CATGCTGGGC TCAGCCAGAG AGGAGATTTT ACATCTCCGG 
AAGCAGGTGA ACCTGCGAGA TGATCTCCTT CAGCTCTACT CGGACTCCGA TGACGATGAG 
GAGGATGAAG AGGATGAGGA AGAGGAAGAG GGAGAAGAGG AGGAACGAGA AGGACAGAGG 
GACCAAGATC AGCAGCACGA CCATCCCTAT GGTGCCCCCA AGCCGCCCCC TAAGGCTGAG 
ACGCTGCACC ACTGCCCACA GCTGGAAGCC CTGAAGCAGA AGCTGAAACT GCTGGAAGAA 
GAGAACGACC ATCTTCGAGA GGAGGCCTCC CACCTTGACA ACCTGGAAGA CAAAGAACAG 
ATGCTCATTC TGGAGTGTGT GGAACAGTTT TCTGAAGCCA GCCAGCAGAT GGCAGAGCTA 
TCCGAGGTGT TGGTGCTGAG GCTGGAAGGC TATGAGAGGC AGCAGAAGGA GATCACTCAG 
CTGCAGGCCG AGATCACCAA GCTACAACAG CGTTGTCAGT CTTATGGGGC CCAGACGGAG 
AAACTGCAGC AGCAGCTGGC CTCAGAGAAG GGAGTCCACC CAGAGAGCCT GCGAGCTGGC 
TCCCACATGC AGGATTATGG AAGCAGGCCT CGTGAACGCC AGGAGGATGG GAAGAGCCAT 
CGTCAGCGTT CCTCAATGCC TGCAGGTTCT GTCACCCACT ATGGATACAG TGTGCCTCTG 
GATGCACTTC CAAGTTTCCC AGAGACACTG GCGGAGGAGC TCCGGACATC CCTGAGGAAG 
TTCATCACTG ACCCTGCGTA TTTCATGGAG AGATGTGACA CTCGCTGCAG AGAGGAACGA 
AAGAAGGAGC AGGGGACAAT GCCACCCCCA CCGGTGCAAG ATCTCAAGCC GCCTGAAGAT 
TTCGAGGCTC CAGAGGAGCT GGTTCCTGAG GAGGAGCTGG GGGCCATAGA AGAGGTGGGG 
ACAGCTGAGG ATGGGCCGGC AGAAGAGACA GAGCAGGCAT CTGAGGAGAC CGAGGCCTGG 
GAGGAGGTGG AACCGGAGGT GGACGAGGCC ACAAGGATGA ATGTGGTGGT CTCTGCCCTG 
GAGGCCAGCG GCCTGGGCCC TTCACACCTG GACATGAAGT ATGTCCTCCA GCAACTGTCC 
AACTGGCAGG ACGCCCATTC TAAGCGGCAG CAGAAGCAGA AGGTGGTCCC GAAAGACTCC 
CCAGCCCCGC AGCAGCAAAC AAACATGGGG GGCGGGATCG TGGAGCAGCA GCCCATAGTG 
CCGACCCAGG ACTCTCAGAG GCTGGAGGAG GACAGGGCCA CTCACTCTCC CAGTGCCAGG 
GAGGAAGAGG GGCCTTCTGG GGCCACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_817091.1
CDS	23..1912
Translation	MRPKDQVQSSAGDGTGSGDPATGTPTTQPAADPAPEPSAEPKPAPAQGTGSGQKSGSRTKTGGSFCRSRIRGDSDAPWTRYIFQGPYGPRATGLGTGRAEGIWKTPAAYIGRRPGVSGPERAAFIRELQEALCPNPLPRKKITEDDIKVMLYLLEEKERDLNTAARIGQSLVKQNSVLMEENNKLETMLGSAREEILHLRKQVNLRDDLLQLYSDSDDDEEDEEDEEEEEGEEEEREGQRDQDQQHDHPYGAPKPPPKAETLHHCPQLEALKQKLKLLEEENDHLREEASHLDNLEDKEQMLILECVEQFSEASQQMAELSEVLVLRLEGYERQQKEITQLQAEITKLQQRCQSYGAQTEKLQQQLASEKGVHPESLRAGSHMQDYGSRPRERQEDGKSHRQRSSMPAGSVTHYGYSVPLDALPSFPETLAEELRTSLRKFITDPAYFMERCDTRCREERKKEQGTMPPPPVQDLKPPEDFEAPEELVPEEELGAIEEVGTAEDGPAEETEQASEETEAWEEVEPEVDEATRMNVVVSALEASGLGPSHLDMKYVLQQLSNWQDAHSKRQQKQKVVPKDSPAPQQQTNMGGGIVEQQPIVPTQDSQRLEEDRATHSPSAREEEGPSGAT

Target ORF information:

RefSeq Version	NM_177982.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus huntingtin-associated protein 1 (Hap1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177982.2

ORF Insert Sequence:

ATGCGCCCGA AGGACCAGGT GCAGAGCAGT GCCGGGGACG GGACGGGGTC GGGGGACCCA 
GCAACAGGCA CCCCCACGAC CCAGCCTGCA GCGGATCCCG CTCCGGAGCC CTCGGCAGAG 
CCCAAACCTG CTCCGGCGCA GGGAACCGGG TCCGGACAGA AATCAGGATC CCGAACCAAG 
ACAGGAGGAA GCTTTTGTAG GTCCAGGATC CGTGGCGACT CGGACGCACC ATGGACCCGC 
TACATATTCC AGGGGCCTTA CGGTCCCCGG GCTACTGGCC TGGGCACTGG AAGGGCTGAG 
GGAATCTGGA AGACGCCAGC CGCGTACATC GGCCGAAGGC CCGGCGTGTC CGGCCCTGAG 
CGCGCGGCGT TTATTCGAGA GCTGCAGGAA GCGCTGTGTC CTAATCCACT GCCCAGGAAG 
AAGATCACCG AAGATGATAT CAAAGTGATG TTGTATTTGC TGGAAGAGAA AGAACGGGAC 
CTGAACACAG CCGCTCGCAT CGGCCAGTCC CTGGTGAAAC AGAATAGTGT TCTGATGGAG 
GAGAATAACA AGCTGGAAAC CATGCTGGGC TCAGCCAGAG AGGAGATTTT ACATCTCCGG 
AAGCAGGTGA ACCTGCGAGA TGATCTCCTT CAGCTCTACT CGGACTCCGA TGACGATGAG 
GAGGATGAAG AGGATGAGGA AGAGGAAGAG GGAGAAGAGG AGGAACGAGA AGGACAGAGG 
GACCAAGATC AGCAGCACGA CCATCCCTAT GGTGCCCCCA AGCCGCCCCC TAAGGCTGAG 
ACGCTGCACC ACTGCCCACA GCTGGAAGCC CTGAAGCAGA AGCTGAAACT GCTGGAAGAA 
GAGAACGACC ATCTTCGAGA GGAGGCCTCC CACCTTGACA ACCTGGAAGA CAAAGAACAG 
ATGCTCATTC TGGAGTGTGT GGAACAGTTT TCTGAAGCCA GCCAGCAGAT GGCAGAGCTA 
TCCGAGGTGT TGGTGCTGAG GCTGGAAGGC TATGAGAGGC AGCAGAAGGA GATCACTCAG 
CTGCAGGCCG AGATCACCAA GCTACAACAG CGTTGTCAGT CTTATGGGGC CCAGACGGAG 
AAACTGCAGC AGCAGCTGGC CTCAGAGAAG GGAGTCCACC CAGAGAGCCT GCGAGCTGGC 
TCCCACATGC AGGATTATGG AAGCAGGCCT CGTGAACGCC AGGAGGATGG GAAGAGCCAT 
CGTCAGCGTT CCTCAATGCC TGCAGGTTCT GTCACCCACT ATGGATACAG TGTGCCTCTG 
GATGCACTTC CAAGTTTCCC AGAGACACTG GCGGAGGAGC TCCGGACATC CCTGAGGAAG 
TTCATCACTG ACCCTGCGTA TTTCATGGAG AGATGTGACA CTCGCTGCAG AGAGGAACGA 
AAGAAGGAGC AGGGGACAAT GCCACCCCCA CCGGTGCAAG ATCTCAAGCC GCCTGAAGAT 
TTCGAGGCTC CAGAGGAGCT GGTTCCTGAG GAGGAGCTGG GGGCCATAGA AGAGGTGGGG 
ACAGCTGAGG ATGGGCCGGC AGAAGAGACA GAGCAGGCAT CTGAGGAGAC CGAGGCCTGG 
GAGGAGGTGG AACCGGAGGT GGACGAGGCC ACAAGGATGA ATGTGGTGGT CTCTGCCCTG 
GAGGCCAGCG GCCTGGGCCC TTCACACCTG GACATGAAGT ATGTCCTCCA GCAACTGTCC 
AACTGGCAGG ACGCCCATTC TAAGCGGCAG CAGAAGCAGA AGGTGGTCCC GAAAGACTCC 
CCAGCCCCGC AGCAGCAAAC AAACATGGGG GGCGGGATCG TGGAGCAGCA GCCCATAGTG 
CCGACCCAGG ACTCTCAGAG GCTGGAGGAG GACAGGGCCA CTCACTCTCC CAGTGCCAGG 
GAGGAAGAGG GGCCTTCTGG GGCCACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hap1 ( NM_177982.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_817091.1 Rattus norvegicus huntingtin-associated protein 1 (Hap1), transcript variant 2, mRNA.

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CloneID	ORa12449
Clone ID Related Accession (Same CDS sequence)	NM_177982.2 , NM_177982.1
Accession Version	NM_177982.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1890bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-12
Organism	Rattus norvegicus(Norway rat)
Product	huntingtin-associated protein 1 isoform B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U38370.1. Transcript Variant: This variant (2) lacks a segment in the 3' coding region that causes a frameshift, and lacks a segment in the 3' UTR, compared to variant 1. The encoded protein (isoform B) is longer and has a distinct C-terminus, compared to isoform A. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U38370.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: PMID: 7477378 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCGCCCGA AGGACCAGGT GCAGAGCAGT GCCGGGGACG GGACGGGGTC GGGGGACCCA 
GCAACAGGCA CCCCCACGAC CCAGCCTGCA GCGGATCCCG CTCCGGAGCC CTCGGCAGAG 
CCCAAACCTG CTCCGGCGCA GGGAACCGGG TCCGGACAGA AATCAGGATC CCGAACCAAG 
ACAGGAGGAA GCTTTTGTAG GTCCAGGATC CGTGGCGACT CGGACGCACC ATGGACCCGC 
TACATATTCC AGGGGCCTTA CGGTCCCCGG GCTACTGGCC TGGGCACTGG AAGGGCTGAG 
GGAATCTGGA AGACGCCAGC CGCGTACATC GGCCGAAGGC CCGGCGTGTC CGGCCCTGAG 
CGCGCGGCGT TTATTCGAGA GCTGCAGGAA GCGCTGTGTC CTAATCCACT GCCCAGGAAG 
AAGATCACCG AAGATGATAT CAAAGTGATG TTGTATTTGC TGGAAGAGAA AGAACGGGAC 
CTGAACACAG CCGCTCGCAT CGGCCAGTCC CTGGTGAAAC AGAATAGTGT TCTGATGGAG 
GAGAATAACA AGCTGGAAAC CATGCTGGGC TCAGCCAGAG AGGAGATTTT ACATCTCCGG 
AAGCAGGTGA ACCTGCGAGA TGATCTCCTT CAGCTCTACT CGGACTCCGA TGACGATGAG 
GAGGATGAAG AGGATGAGGA AGAGGAAGAG GGAGAAGAGG AGGAACGAGA AGGACAGAGG 
GACCAAGATC AGCAGCACGA CCATCCCTAT GGTGCCCCCA AGCCGCCCCC TAAGGCTGAG 
ACGCTGCACC ACTGCCCACA GCTGGAAGCC CTGAAGCAGA AGCTGAAACT GCTGGAAGAA 
GAGAACGACC ATCTTCGAGA GGAGGCCTCC CACCTTGACA ACCTGGAAGA CAAAGAACAG 
ATGCTCATTC TGGAGTGTGT GGAACAGTTT TCTGAAGCCA GCCAGCAGAT GGCAGAGCTA 
TCCGAGGTGT TGGTGCTGAG GCTGGAAGGC TATGAGAGGC AGCAGAAGGA GATCACTCAG 
CTGCAGGCCG AGATCACCAA GCTACAACAG CGTTGTCAGT CTTATGGGGC CCAGACGGAG 
AAACTGCAGC AGCAGCTGGC CTCAGAGAAG GGAGTCCACC CAGAGAGCCT GCGAGCTGGC 
TCCCACATGC AGGATTATGG AAGCAGGCCT CGTGAACGCC AGGAGGATGG GAAGAGCCAT 
CGTCAGCGTT CCTCAATGCC TGCAGGTTCT GTCACCCACT ATGGATACAG TGTGCCTCTG 
GATGCACTTC CAAGTTTCCC AGAGACACTG GCGGAGGAGC TCCGGACATC CCTGAGGAAG 
TTCATCACTG ACCCTGCGTA TTTCATGGAG AGATGTGACA CTCGCTGCAG AGAGGAACGA 
AAGAAGGAGC AGGGGACAAT GCCACCCCCA CCGGTGCAAG ATCTCAAGCC GCCTGAAGAT 
TTCGAGGCTC CAGAGGAGCT GGTTCCTGAG GAGGAGCTGG GGGCCATAGA AGAGGTGGGG 
ACAGCTGAGG ATGGGCCGGC AGAAGAGACA GAGCAGGCAT CTGAGGAGAC CGAGGCCTGG 
GAGGAGGTGG AACCGGAGGT GGACGAGGCC ACAAGGATGA ATGTGGTGGT CTCTGCCCTG 
GAGGCCAGCG GCCTGGGCCC TTCACACCTG GACATGAAGT ATGTCCTCCA GCAACTGTCC 
AACTGGCAGG ACGCCCATTC TAAGCGGCAG CAGAAGCAGA AGGTGGTCCC GAAAGACTCC 
CCAGCCCCGC AGCAGCAAAC AAACATGGGG GGCGGGATCG TGGAGCAGCA GCCCATAGTG 
CCGACCCAGG ACTCTCAGAG GCTGGAGGAG GACAGGGCCA CTCACTCTCC CAGTGCCAGG 
GAGGAAGAGG GGCCTTCTGG GGCCACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_817091.1
CDS	25..1914
Translation	MRPKDQVQSSAGDGTGSGDPATGTPTTQPAADPAPEPSAEPKPAPAQGTGSGQKSGSRTKTGGSFCRSRIRGDSDAPWTRYIFQGPYGPRATGLGTGRAEGIWKTPAAYIGRRPGVSGPERAAFIRELQEALCPNPLPRKKITEDDIKVMLYLLEEKERDLNTAARIGQSLVKQNSVLMEENNKLETMLGSAREEILHLRKQVNLRDDLLQLYSDSDDDEEDEEDEEEEEGEEEEREGQRDQDQQHDHPYGAPKPPPKAETLHHCPQLEALKQKLKLLEEENDHLREEASHLDNLEDKEQMLILECVEQFSEASQQMAELSEVLVLRLEGYERQQKEITQLQAEITKLQQRCQSYGAQTEKLQQQLASEKGVHPESLRAGSHMQDYGSRPRERQEDGKSHRQRSSMPAGSVTHYGYSVPLDALPSFPETLAEELRTSLRKFITDPAYFMERCDTRCREERKKEQGTMPPPPVQDLKPPEDFEAPEELVPEEELGAIEEVGTAEDGPAEETEQASEETEAWEEVEPEVDEATRMNVVVSALEASGLGPSHLDMKYVLQQLSNWQDAHSKRQQKQKVVPKDSPAPQQQTNMGGGIVEQQPIVPTQDSQRLEEDRATHSPSAREEEGPSGAT

Target ORF information:

RefSeq Version	NM_177982.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus huntingtin-associated protein 1 (Hap1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177982.1

ORF Insert Sequence:

ATGCGCCCGA AGGACCAGGT GCAGAGCAGT GCCGGGGACG GGACGGGGTC GGGGGACCCA 
GCAACAGGCA CCCCCACGAC CCAGCCTGCA GCGGATCCCG CTCCGGAGCC CTCGGCAGAG 
CCCAAACCTG CTCCGGCGCA GGGAACCGGG TCCGGACAGA AATCAGGATC CCGAACCAAG 
ACAGGAGGAA GCTTTTGTAG GTCCAGGATC CGTGGCGACT CGGACGCACC ATGGACCCGC 
TACATATTCC AGGGGCCTTA CGGTCCCCGG GCTACTGGCC TGGGCACTGG AAGGGCTGAG 
GGAATCTGGA AGACGCCAGC CGCGTACATC GGCCGAAGGC CCGGCGTGTC CGGCCCTGAG 
CGCGCGGCGT TTATTCGAGA GCTGCAGGAA GCGCTGTGTC CTAATCCACT GCCCAGGAAG 
AAGATCACCG AAGATGATAT CAAAGTGATG TTGTATTTGC TGGAAGAGAA AGAACGGGAC 
CTGAACACAG CCGCTCGCAT CGGCCAGTCC CTGGTGAAAC AGAATAGTGT TCTGATGGAG 
GAGAATAACA AGCTGGAAAC CATGCTGGGC TCAGCCAGAG AGGAGATTTT ACATCTCCGG 
AAGCAGGTGA ACCTGCGAGA TGATCTCCTT CAGCTCTACT CGGACTCCGA TGACGATGAG 
GAGGATGAAG AGGATGAGGA AGAGGAAGAG GGAGAAGAGG AGGAACGAGA AGGACAGAGG 
GACCAAGATC AGCAGCACGA CCATCCCTAT GGTGCCCCCA AGCCGCCCCC TAAGGCTGAG 
ACGCTGCACC ACTGCCCACA GCTGGAAGCC CTGAAGCAGA AGCTGAAACT GCTGGAAGAA 
GAGAACGACC ATCTTCGAGA GGAGGCCTCC CACCTTGACA ACCTGGAAGA CAAAGAACAG 
ATGCTCATTC TGGAGTGTGT GGAACAGTTT TCTGAAGCCA GCCAGCAGAT GGCAGAGCTA 
TCCGAGGTGT TGGTGCTGAG GCTGGAAGGC TATGAGAGGC AGCAGAAGGA GATCACTCAG 
CTGCAGGCCG AGATCACCAA GCTACAACAG CGTTGTCAGT CTTATGGGGC CCAGACGGAG 
AAACTGCAGC AGCAGCTGGC CTCAGAGAAG GGAGTCCACC CAGAGAGCCT GCGAGCTGGC 
TCCCACATGC AGGATTATGG AAGCAGGCCT CGTGAACGCC AGGAGGATGG GAAGAGCCAT 
CGTCAGCGTT CCTCAATGCC TGCAGGTTCT GTCACCCACT ATGGATACAG TGTGCCTCTG 
GATGCACTTC CAAGTTTCCC AGAGACACTG GCGGAGGAGC TCCGGACATC CCTGAGGAAG 
TTCATCACTG ACCCTGCGTA TTTCATGGAG AGATGTGACA CTCGCTGCAG AGAGGAACGA 
AAGAAGGAGC AGGGGACAAT GCCACCCCCA CCGGTGCAAG ATCTCAAGCC GCCTGAAGAT 
TTCGAGGCTC CAGAGGAGCT GGTTCCTGAG GAGGAGCTGG GGGCCATAGA AGAGGTGGGG 
ACAGCTGAGG ATGGGCCGGC AGAAGAGACA GAGCAGGCAT CTGAGGAGAC CGAGGCCTGG 
GAGGAGGTGG AACCGGAGGT GGACGAGGCC ACAAGGATGA ATGTGGTGGT CTCTGCCCTG 
GAGGCCAGCG GCCTGGGCCC TTCACACCTG GACATGAAGT ATGTCCTCCA GCAACTGTCC 
AACTGGCAGG ACGCCCATTC TAAGCGGCAG CAGAAGCAGA AGGTGGTCCC GAAAGACTCC 
CCAGCCCCGC AGCAGCAAAC AAACATGGGG GGCGGGATCG TGGAGCAGCA GCCCATAGTG 
CCGACCCAGG ACTCTCAGAG GCTGGAGGAG GACAGGGCCA CTCACTCTCC CAGTGCCAGG 
GAGGAAGAGG GGCCTTCTGG GGCCACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Immunohistochemical analysis of huntingtin-associated protein 1 in adult rat spinal cord and its regional relationship with androgen receptor.
Neuroscience340201-217(2017 Jan)
Islam MN,Takeshita Y,Yanai A,Imagawa A,Jahan MR,Wroblewski G,Nemoto J,Fujinaga R,Shinoda K

Downregulation of GABA
Molecular neurobiology54(1)45-57(2017 Jan)
Mele M,Aspromonte MC,Duarte CB

HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic ? cells.
Histochemistry and cell biology144(1)39-48(2015 Jul)
Wang Z,Peng T,Wu H,He J,Li H

Molecular characterization of genes modifying the age at onset in Huntington's Disease in Uruguayan patients.
The International journal of neuroscience1-17(2015 May)
Vital M,Bidegain E,Raggio V,Esperon P

The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.
The Journal of neuroscience : the official journal of the Society for Neuroscience34(4)1293-305(2014 Jan)
Wong YC,Holzbaur EL

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Hap1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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