Gap43 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gap43
Entrez Gene ID	29423
Full Name	growth associated protein 43
Synonyms	Basp2
General protein information	Preferred Names growth associated protein 43 Names neuromodulin axonal membrane protein GAP-43 brain abundant, membrane attached signal protein 2 growth accentuating protein 43 protein F1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 11 Map Location: 11q21
Summary	may play a role in neurite outgrowth and nerve regeneration [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017195.3	NP_058891.1	neuromodulin

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Gap43	NP_032109.1
Xenopus tropicalis (tropical clawed frog)	gap43	NP_001072212.1
Canis lupus familiaris (dog)	GAP43	XP_535747.1
Pan troglodytes (chimpanzee)	GAP43	NP_001009816.1
Bos taurus (cattle)	GAP43	NP_976234.2
Gallus gallus (chicken)	GAP43	XP_425527.3
	GAP43	XP_001107759.2
Homo sapiens (human)	GAP43	NP_001123536.1
Rattus norvegicus (Norway rat)	Gap43	NP_058891.1

Gene Ontology
Bibliography

Related articles in PubMed

Possible role of miR-204 in optic nerve injury through the regulation of GAP-43.
Wang N, Yang W, Xiao T, Miao Z, Luo W, You Z, Li G
Molecular medicine reports(2017 Dec)

Axonal localization of neuritin/CPG15 mRNA is limited by competition for HuD binding.
Gomes C, Lee SJ, Gardiner AS, Smith T, Sahoo PK, Patel P, Thames E, Rodriguez R, Taylor R, Yoo S, Heise T, Kar AN, Perrone-Bizzozero N, Twiss JL
Journal of cell science130(21)3650-3662(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that growth-associated protein 43 (GAP43) gene-modified bone marrow-derived mesenchymal stem cells (BMSCs) transplantation can increase survival photoreceptor cells and delay retinal degeneration
Title: [Therapeutical effect of growth-associated protein 43 (GAP43) gene-modified bone marrow mesenchymal stem cell transplantation on rat retinal degenerative diseases].

Results show that repeated contingent, but not non-contingent, cocaine self-administration promotes an increase of nELAV expression immediately and 7 days after the last cocaine self-administration session, with a transient disappearance observed 24 h later. The evidence that the ubiquitous ELAV/HuR is not changed calls for a specific involvement of nELAV in these molecular mechanisms.
Title: Abstinence from cocaine-self-administration activates the nELAV/GAP -43 pathway in the hippocampus: A stress-related effect?

astrocytic GAP43 upregulation may serve to indicate beneficial astrogliosis after central nervous system injury
Title: Astrocytic GAP43 Induced by the TLR4/NF-?B/STAT3 Axis Attenuates Astrogliosis-Mediated Microglial Activation and Neurotoxicity.

Lentiviral-mediated GAP-43 modification of bone marrow mesenchymal stem cells improves traumatic optic neuropathy in rats.
Title: Lentiviral-mediated growth-associated protein-43 modification of bone marrow mesenchymal stem cells improves traumatic optic neuropathy in rats.

Data show that the paw skin and back skin revealed a significantly higher number of nerve fibres expressing growth-associated protein 43 (GAP-43) at both the acute and chronic stages of antigen-induced arthritis (AIA).
Title: Antigen-induced arthritis in rats is associated with increased growth-associated protein?43-positive intraepidermal nerve fibres remote from the joint.

The following Gap43 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gap43 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13357	NM_017195.3 Latest version!	Rattus norvegicus growth associated protein 43 (Gap43), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gap43 ( NM_017195.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058891.1 Rattus norvegicus growth associated protein 43 (Gap43), mRNA.

Price & Availability↑

CloneID	ORa13357
Clone ID Related Accession (Same CDS sequence)	NM_017195.3
Accession Version	NM_017195.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 681bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-15
Organism	Rattus norvegicus(Norway rat)
Product	neuromodulin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from X06338.1, BF560544.1 and BI304179.1. On Jan 25, 2008 this sequence version replaced NM_017195.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X06338.1, BC127502.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCTGTGCT GTATGAGAAG AACCAAACAG GTTGAAAAGA ATGATGAGGA CCAAAAGATT 
GAACAAGATG GTGTCAAACC GGAGGATAAG GCTCATAAGG CTGCAACCAA AATTCAGGCT 
AGCTTCCGTG GACACATAAC AAGGAAAAAG CTCAAAGACG AGAAGAAGGG TGATGCACCA 
GCTGCTGAGG CCGAGGCCAA GGAGAAGGAT GATGCTCCCG TTGCTGATGG TGTGGAGAAG 
AAGGAGGGAG ATGGCTCTGC TACTACCGAT GCAGCCCCAG CCACCAGCCC TAAGGCTGAG 
GAGCCCAGCA AGGCAGGAGA TGCACCTTCT GAGGAGAAGA AGGGCGAAGG GGATGCGGCC 
CCTTCAGAGG AAAAGGCCGG CTCAGCTGAG ACAGAAAGTG CTGCTAAAGC TACCACTGAT 
AACTCGCCGT CCTCCAAGGC CGAAGATGGC CCAGCCAAGG AGGAGCCTAA ACAAGCCGAT 
GTGCCTGCTG CTGTCACTGA TGCTGCTGCC ACCACCCCTG CTGCAGAGGA TGCTGCCAAG 
GCAGCGCAGC CTCCAACGGA GACTGCAGAA AGCAGCCAAG CTGAGGAGGA GAAAGAAGCT 
GTAGATGAAG CCAAACCTAA GGAAAGTGCC CGACAGGATG AGGGTAAAGA AGACCCCGAG 
GCTGACCAAG AACATGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058891.1
CDS	217..897
Translation	MLCCMRRTKQVEKNDEDQKIEQDGVKPEDKAHKAATKIQASFRGHITRKKLKDEKKGDAPAAEAEAKEKDDAPVADGVEKKEGDGSATTDAAPATSPKAEEPSKAGDAPSEEKKGEGDAAPSEEKAGSAETESAAKATTDNSPSSKAEDGPAKEEPKQADVPAAVTDAAATTPAAEDAAKAAQPPTETAESSQAEEEKEAVDEAKPKESARQDEGKEDPEADQEHA

Target ORF information:

RefSeq Version	NM_017195.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus growth associated protein 43 (Gap43), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017195.3

ORF Insert Sequence:

ATGCTGTGCT GTATGAGAAG AACCAAACAG GTTGAAAAGA ATGATGAGGA CCAAAAGATT 
GAACAAGATG GTGTCAAACC GGAGGATAAG GCTCATAAGG CTGCAACCAA AATTCAGGCT 
AGCTTCCGTG GACACATAAC AAGGAAAAAG CTCAAAGACG AGAAGAAGGG TGATGCACCA 
GCTGCTGAGG CCGAGGCCAA GGAGAAGGAT GATGCTCCCG TTGCTGATGG TGTGGAGAAG 
AAGGAGGGAG ATGGCTCTGC TACTACCGAT GCAGCCCCAG CCACCAGCCC TAAGGCTGAG 
GAGCCCAGCA AGGCAGGAGA TGCACCTTCT GAGGAGAAGA AGGGCGAAGG GGATGCGGCC 
CCTTCAGAGG AAAAGGCCGG CTCAGCTGAG ACAGAAAGTG CTGCTAAAGC TACCACTGAT 
AACTCGCCGT CCTCCAAGGC CGAAGATGGC CCAGCCAAGG AGGAGCCTAA ACAAGCCGAT 
GTGCCTGCTG CTGTCACTGA TGCTGCTGCC ACCACCCCTG CTGCAGAGGA TGCTGCCAAG 
GCAGCGCAGC CTCCAACGGA GACTGCAGAA AGCAGCCAAG CTGAGGAGGA GAAAGAAGCT 
GTAGATGAAG CCAAACCTAA GGAAAGTGCC CGACAGGATG AGGGTAAAGA AGACCCCGAG 
GCTGACCAAG AACATGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Possible role of miR-204 in optic nerve injury through the regulation of GAP-43.
Molecular medicine reports(2017 Dec)
Wang N,Yang W,Xiao T,Miao Z,Luo W,You Z,Li G

Axonal localization of neuritin/CPG15 mRNA is limited by competition for HuD binding.
Journal of cell science130(21)3650-3662(2017 Nov)
Gomes C,Lee SJ,Gardiner AS,Smith T,Sahoo PK,Patel P,Thames E,Rodriguez R,Taylor R,Yoo S,Heise T,Kar AN,Perrone-Bizzozero N,Twiss JL

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Gap43 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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