Col1a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Col1a1
Entrez Gene ID	29393
Full Name	collagen type I alpha 1 chain
Synonyms	COLIA1
General protein information	Preferred Names collagen type I alpha 1 chain Names collagen alpha-1(I) chain alpha-1 type I collagen collagen, type 1, alpha 1 collagen, type I, alpha 1 procollagen type I, alpha 1 procollagen, type 1, alpha 1 type I-alpha 1 collagen
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q26
Summary	extracellular matrix collagen protein [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053304.1	NP_445756.1	collagen alpha-1(I) chain precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	COL1A1	NP_001029211.1
Mus musculus (house mouse)	Col1a1	NP_031768.2
Danio rerio (zebrafish)	col1a1a	NP_954684.1
Pan troglodytes (chimpanzee)	COL1A1	XP_001169409.1
	COL1A1	XP_001096194.2
Canis lupus familiaris (dog)	COL1A1	NP_001003090.1
Rattus norvegicus (Norway rat)	Col1a1	NP_445756.1
Homo sapiens (human)	COL1A1	NP_000079.2
Xenopus tropicalis (tropical clawed frog)	LOC496414	NP_001011005.1

Gene Ontology
Bibliography

Related articles in PubMed

Pin1 facilitates isoproterenol?induced cardiac fibrosis and collagen deposition by promoting oxidative stress and activating the MEK1/2?ERK1/2 signal transduction pathway in rats.
Wu X, Li M, Chen SQ, Li S, Guo F
International journal of molecular medicine41(3)1573-1583(2018 Mar)

Periostin cross?reacts with the renin?angiotensin system during liver fibrosis development.
Takeda K, Noguchi R, Kitade M, Namisaki T, Moriya K, Kawaratani H, Okura Y, Kaji K, Aihara Y, Douhara A, Nishimura N, Sawada Y, Seki K, Yoshiji H
Molecular medicine reports16(5)5752-5758(2017 Nov)

miR?21 promotes ??SMA and collagen I expression in hepatic stellate cells via the Smad7 signaling pathway.
Fu RQ, Hu DP, Hu YB, Hong L, Sun QF, Ding JG
Molecular medicine reports16(4)4327-4333(2017 Oct)

Effects of lentiviral vector?mediated shRNA silencing of TGF?1 on the expression of Col1a1 in rat hepatic stellate cells.
Bai GP, Yan GH, Wang GJ, Wan P, Liu XF, Wang H, Zhang RH
Molecular medicine reports16(3)2785-2790(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the diagnostic value of urinary collagen degradation products in a proteinuria-driven fibrosis rat model, was investigated.
Title: Urinary collagen degradation products as early markers of progressive renal fibrosis.

myocyte-derived exosomes and myocyte-secreted IL-6 are responsible in unison for the biphasic activation of STAT-3 signaling in cardiac fibroblasts that culminates in excess collagen synthesis, leading to severely compromised cardiac function during cardiac hypertrophy.
Title: Myocyte-Derived Hsp90 Modulates Collagen Upregulation via Biphasic Activation of STAT-3 in Fibroblasts during Cardiac Hypertrophy.

treatment with LG ameliorated STZ-induced DN via the inhibition of oxidonitrosative stress as well as downregulation of KIM-1, NGAL, TGF-beta1, and collagen-1 mRNA expressions.
Title: Protective effect of L-glutamine against diabetes-induced nephropathy in experimental animal: Role of KIM-1, NGAL, TGF-?1, and collagen-1.

Liganded vitamin D receptor through its interacting repressor inhibits the expression of Col1a1.
Title: Liganded Vitamin D Receptor Through Its Interacting Repressor Inhibits the Expression of Type I Collagen ?1.

Brefeldin A induced a significant up-regulation of Col1a1 mRNA levels in CFSC-2G hepatic stellate cells that was time-dependent. The UPR correlated with enhanced mRNA and protein levels of collagen type I in these cells. Analysis of the 3 branches of UPR revealed the activation of IRE1alpha, PERK and ATF6 in response to BFA. An IRE1alpha-p38 MAPK-Smad pathway may be responsible for the fibrogenic action of BFA on HSC.
Title: Unfolded protein response induced by Brefeldin A increases collagen type I levels in hepatic stellate cells through an IRE1?, p38 MAPK and Smad-dependent pathway.

The following Col1a1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Col1a1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09221	NM_053304.1 Latest version!	Rattus norvegicus collagen type I alpha 1 chain (Col1a1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$727.30 $1039.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Col1a1 ( NM_053304.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445756.1 Rattus norvegicus collagen type I alpha 1 chain (Col1a1), mRNA.

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CloneID	ORa09221
Clone ID Related Accession (Same CDS sequence)	NM_053304.1
Accession Version	NM_053304.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4362bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Rattus norvegicus(Norway rat)
Product	collagen alpha-1(I) chain precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CB693258.1, BC133728.1, CB579389.1, CO397981.1 and BQ206338.1. On or before Oct 27, 2007 this sequence version replaced XM_213440.4, XM_001081230.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z78279.1, BC133728.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689596, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTCAGCT TTGTGGACCT CCGGCTCCTG CTCCTCTTAG GGGCCACTGC CCTCCTGACG 
CATGGCCAAG AAGACATCCC TGAAGTCAGC TGCATACACA ATGGCCTAAG GGTCCCTAAT 
GGTGAGACGT GGAAACCTGA TGTATGCTTG ATCTGTATCT GCCACAATGG CACGGCTGTG 
TGCGATGGCG TGCTATGCAA AGAAGACTTG GACTGTCCCA ACCCCCAAAA ACGGGAGGGC 
GAGTGCTGTC CTTTCTGCCC AGAAGAATAT GTATCACCAG ACGCAGAAGT CATAGGAGTC 
GAGGGACCCA AGGGAGACCC TGGCCCCCAA GGCCCACGGG GACCTGTTGG CCCCCCTGGA 
CAAGATGGCA TCCCTGGACA GCCTGGACTT CCTGGTCCTC CTGGTCCCCC CGGCCCCCCC 
GGACCCCCTG GTCTTGGAGG AAACTTTGCT TCCCAGATGT CCTATGGCTA TGATGAGAAA 
TCAGCTGGAG TTTCCGTGCC TGGCCCCATG GGTCCTTCTG GTCCTCGTGG TCTCCCTGGC 
CCCCCTGGTG CACCTGGTCC TCAAGGTTTC CAAGGCCCCC CTGGTGAACC TGGCGAGCCT 
GGCGCTTCAG GTCCAATGGG TCCCCGAGGT CCCCCTGGCC CTCCTGGCAA GAACGGAGAT 
GATGGGGAAG CTGGTAAGCC TGGCCGCCCT GGTGAGCGTG GACCTCCTGG ACCTCAGGGT 
GCTCGTGGAT TGCCTGGAAC AGCTGGCCTC CCCGGAATGA AGGGACACAG AGGTTTCAGT 
GGTTTGGATG GTGCCAAAGG AGATACTGGT CCTGCTGGTC CTAAGGGAGA GCCTGGCAGT 
CCTGGTGAAA ATGGAGCTCC CGGCCAGATG GGTCCCCGAG GTCTGCCTGG TGAGAGAGGT 
CGCCCTGGAC CCCCTGGCAG TGCTGGTGCT CGTGGTAACG ATGGTGCTGT CGGTGCAGCT 
GGGCCCCCCG GTCCCACCGG CCCTACTGGC CCTCCTGGCT TCCCTGGTGC AGCTGGTGCT 
AAGGGTGAAG CTGGTCCCCA GGGAGCCCGA GGCTCTGAAG GTCCCCAGGG TGTGCGTGGT 
GAGCCCGGAC CCCCTGGCCC TGCTGGTGCT GCTGGTCCTG CTGGAAACCC TGGTGCTGAT 
GGACAACCTG GTGCTAAAGG TGCCAATGGT GCTCCTGGTA TTGCTGGTGC TCCTGGCTTC 
CCTGGTGCCC GAGGCCCCTC TGGACCTCAG GGCCCCAGCG GCGCTCCTGG TCCCAAAGGC 
AACAGTGGTG AACCTGGTGC CCCTGGCAAC AAAGGAGACA CTGGTGCCAA AGGAGAACCC 
GGCCCTGCTG GAGTTCAAGG TCCCCCTGGC CCTGCTGGAG AAGAAGGAAA ACGAGGAGCC 
CGTGGTGAGC CTGGACCTAG CGGCCTGCCC GGACCTCCTG GCGAGCGCGG TGGACCTGGT 
AGCCGTGGTT TCCCTGGTGC TGATGGTGTT GCTGGCCCCA AGGGTCCTGC TGGTGAACGT 
GGTTCTCCTG GCCCTGCTGG TCCCAAAGGT TCTCCTGGTG AAGCTGGTCG CCCTGGTGAA 
GCTGGTCTCC CTGGTGCCAA GGGTCTCACT GGCAGTCCTG GCAGCCCTGG TCCTGATGGC 
AAAACCGGCC CCCCTGGTCC CGCTGGTCAA GATGGTCGCC CTGGACCCGC AGGTCCTCCT 
GGAGCCCGTG GACAGGCTGG TGTGATGGGA TTCCCTGGAC CTAAGGGTAC TGCTGGAGAA 
CCTGGAAAGG CTGGAGAACG AGGTGTCCCC GGACCCCCTG GCGCTGTTGG TCCCGCTGGC 
AAAGATGGCG AAGCTGGAGC TCAAGGAGCC CCCGGCCCTG CTGGTCCTGC TGGTGAGAGA 
GGTGAACAAG GTCCCGCTGG CTCCCCTGGA TTCCAGGGTC TTCCTGGTCC CGCTGGTCCT 
CCTGGTGAAG CAGGCAAGCC TGGTGAACAG GGTGTTCCTG GAGACCTTGG TGCCCCTGGA 
CCCTCTGGCG CAAGAGGCGA GAGAGGTTTC CCTGGTGAAC GTGGTGTACA AGGTCCCCCA 
GGTCCTGCTG GTCCCCGAGG AAACAATGGT GCCCCCGGCA ACGATGGTGC CAAGGGTGAT 
ACTGGTGCCC CCGGAGCTCC TGGTAGCCAG GGTGCCCCCG GTCTTCAGGG AATGCCTGGT 
GAACGTGGTG CAGCTGGTCT TCCAGGTCCT AAGGGTGACA GAGGTGATGC TGGTCCCAAA 
GGTGCTGATG GTTCTCCTGG CAAAGATGGC GTCCGTGGTC TGACTGGTCC CATTGGTCCT 
CCTGGCCCTG CTGGTGCCCC TGGTGACAAG GGTGAAACTG GTCCCAGTGG TCCTGCTGGC 
CCCACCGGAG CCCGTGGTGC CCCCGGAGAC CGTGGTGAGC CTGGTCCCCC TGGTCCTGCT 
GGCTTCGCTG GCCCCCCTGG TGCTGATGGC CAACCTGGTG CGAAAGGTGA ACCTGGTGAT 
ACTGGTGTGA AAGGTGACGC TGGTCCTCCT GGCCCTGCTG GTCCCGCTGG ACCCCCTGGC 
CCCATTGGTA ACGTTGGTGC TCCTGGACCC AAAGGTTCTC GTGGTGCTGC TGGTCCCCCT 
GGTGCTACTG GTTTCCCTGG TGCTGCTGGT CGTGTTGGTC CCCCTGGTCC CTCTGGAAAT 
GCTGGACCCC CTGGCCCTCC CGGTCCCGTT GGCAAAGAAG GGGGCAAAGG TCCCCGTGGT 
GAGACTGGTC CCGCTGGACG TCCTGGTGAA GTTGGTCCCC CAGGTCCCCC TGGCCCTGCT 
GGTGAGAAAG GATCTCCTGG TGCTGATGGA CCTGCTGGCT CTCCTGGTAC CCCTGGACCT 
CAGGGTATTG CTGGACAGCG TGGTGTGGTC GGTCTTCCCG GTCAGAGAGG AGAAAGAGGC 
TTCCCTGGTC TTCCTGGACC CTCTGGTGAA CCCGGCAAAC AAGGTCCTTC TGGAGCAAGT 
GGTGAACGTG GTCCCCCTGG CCCTATGGGC CCCCCTGGAT TGGCTGGCCC CCCTGGTGAA 
TCTGGTCGTG AGGGATCCCC TGGTGCTGAA GGCTCCCCTG GAAGAGATGG TGCTCCTGGT 
GCCAAGGGTG ACCGTGGTGA GACTGGCCCT GCTGGCCCCC CTGGTGCTCC TGGTGCTCCT 
GGTGCTCCCG GCCCTGTTGG TCCTGCTGGC AAGAATGGCG ACCGTGGTGA GACTGGTCCT 
GCTGGTCCTG CTGGTCCCAT TGGCCCTGCT GGTGCCCGTG GTCCTGCTGG ACCCCAAGGC 
CCCCGTGGTG ACAAGGGTGA GACAGGCGAA CAAGGTGACA GAGGCATAAA GGGTCATCGT 
GGCTTCTCTG GTCTCCAGGG TCCTCCTGGC TCTCCTGGCT CTCCTGGTGA ACAAGGCCCC 
TCTGGAGCTT CTGGTCCTGC AGGTCCCCGG GGTCCCCCTG GCTCTGCTGG TTCTCCTGGC 
AAAGATGGAC TCAACGGTCT CCCTGGCCCC ATTGGTCCCC CTGGTCCTCG AGGTCGCACT 
GGCGATAGTG GTCCTGCTGG TCCCCCCGGA CCTCCTGGAC CCCCTGGCCC TCCCGGTCCT 
CCCAGCGGTG GTTATGACTT CAGCTTCCTG CCTCAGCCAC CTCAAGAGAA GTCTCAAGAT 
GGTGGCCGTT ACTACCGGGC CGATGATGCC AACGTGGTCC GTGACCGTGA CCTTGAGGTG 
GACACTACCC TCAAGAGCCT GAGCCAGCAG ATTGAGAACA TCCGCAGCCC TGAGGGCAGC 
CGCAAGAACC CCGCCCGCAC ATGCCGTGAC CTCAAGATGT GCCACTCTGA CTGGAAGAGC 
GGAGAGTACT GGATCGACCC TAACCAAGGC TGCAACCTGG ATGCCATCAA GGTCTACTGC 
AACATGGAGA CAGGTCAGAC CTGTGTGTTC CCCACTCAGC CCTCTGTGCC TCAGAAGAAC 
TGGTACATCA GCCCAAACCC CAAGGAGAAG AAGCATGTCT GGTTTGGAGA GAGCATGACC 
GATGGATTCC AGTTCGAGTA TGGAAGCGAA GGTTCCGATC CTGCCGATGT CGCTATCCAG 
CTGACCTTCC TGCGCCTGAT GTCCACCGAG GCCTCCCAGA ACATCACCTA TCACTGCAAG 
AACAGCGTAG CCTACATGGA CCAACAGACT GGCAACCTCA AGAAGTCCCT GCTCCTCCAG 
GGCTCCAACG AGATCGAGCT CAGGGGCGAA GGCAACAGTC GATTCACCTA CAGCACGCTT 
GTGGATGGCT GCACGAGTCA CACCGGAACT TGGGGCAAGA CAGTCATCGA ATACAAAACC 
ACCAAGACCT CCCGCCTGCC CATCATCGAT GTGGCTCCCT TGGACATTGG TGCCCCAGAC 
CAGGAATTCG GAATGGACAT TGGCCCTGCC TGCTTCGTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445756.1
CDS	112..4473
Translation	MFSFVDLRLLLLLGATALLTHGQEDIPEVSCIHNGLRVPNGETWKPDVCLICICHNGTAVCDGVLCKEDLDCPNPQKREGECCPFCPEEYVSPDAEVIGVEGPKGDPGPQGPRGPVGPPGQDGIPGQPGLPGPPGPPGPPGPPGLGGNFASQMSYGYDEKSAGVSVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDTGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGPPGSAGARGNDGAVGAAGPPGPTGPTGPPGFPGAAGAKGEAGPQGARGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPSGAPGPKGNSGEPGAPGNKGDTGAKGEPGPAGVQGPPGPAGEEGKRGARGEPGPSGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPAGPPGARGQAGVMGFPGPKGTAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGAPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGNNGAPGNDGAKGDTGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGETGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDTGVKGDAGPPGPAGPAGPPGPIGNVGAPGPKGSRGAAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPVGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGSPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREGSPGAEGSPGRDGAPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKNGDRGETGPAGPAGPIGPAGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGSPGSPGEQGPSGASGPAGPRGPPGSAGSPGKDGLNGLPGPIGPPGPRGRTGDSGPAGPPGPPGPPGPPGPPSGGYDFSFLPQPPQEKSQDGGRYYRADDANVVRDRDLEVDTTLKSLSQQIENIRSPEGSRKNPARTCRDLKMCHSDWKSGEYWIDPNQGCNLDAIKVYCNMETGQTCVFPTQPSVPQKNWYISPNPKEKKHVWFGESMTDGFQFEYGSEGSDPADVAIQLTFLRLMSTEASQNITYHCKNSVAYMDQQTGNLKKSLLLQGSNEIELRGEGNSRFTYSTLVDGCTSHTGTWGKTVIEYKTTKTSRLPIIDVAPLDIGAPDQEFGMDIGPACFV

Target ORF information:

RefSeq Version	NM_053304.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus collagen type I alpha 1 chain (Col1a1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053304.1

ORF Insert Sequence:

ATGTTCAGCT TTGTGGACCT CCGGCTCCTG CTCCTCTTAG GGGCCACTGC CCTCCTGACG 
CATGGCCAAG AAGACATCCC TGAAGTCAGC TGCATACACA ATGGCCTAAG GGTCCCTAAT 
GGTGAGACGT GGAAACCTGA TGTATGCTTG ATCTGTATCT GCCACAATGG CACGGCTGTG 
TGCGATGGCG TGCTATGCAA AGAAGACTTG GACTGTCCCA ACCCCCAAAA ACGGGAGGGC 
GAGTGCTGTC CTTTCTGCCC AGAAGAATAT GTATCACCAG ACGCAGAAGT CATAGGAGTC 
GAGGGACCCA AGGGAGACCC TGGCCCCCAA GGCCCACGGG GACCTGTTGG CCCCCCTGGA 
CAAGATGGCA TCCCTGGACA GCCTGGACTT CCTGGTCCTC CTGGTCCCCC CGGCCCCCCC 
GGACCCCCTG GTCTTGGAGG AAACTTTGCT TCCCAGATGT CCTATGGCTA TGATGAGAAA 
TCAGCTGGAG TTTCCGTGCC TGGCCCCATG GGTCCTTCTG GTCCTCGTGG TCTCCCTGGC 
CCCCCTGGTG CACCTGGTCC TCAAGGTTTC CAAGGCCCCC CTGGTGAACC TGGCGAGCCT 
GGCGCTTCAG GTCCAATGGG TCCCCGAGGT CCCCCTGGCC CTCCTGGCAA GAACGGAGAT 
GATGGGGAAG CTGGTAAGCC TGGCCGCCCT GGTGAGCGTG GACCTCCTGG ACCTCAGGGT 
GCTCGTGGAT TGCCTGGAAC AGCTGGCCTC CCCGGAATGA AGGGACACAG AGGTTTCAGT 
GGTTTGGATG GTGCCAAAGG AGATACTGGT CCTGCTGGTC CTAAGGGAGA GCCTGGCAGT 
CCTGGTGAAA ATGGAGCTCC CGGCCAGATG GGTCCCCGAG GTCTGCCTGG TGAGAGAGGT 
CGCCCTGGAC CCCCTGGCAG TGCTGGTGCT CGTGGTAACG ATGGTGCTGT CGGTGCAGCT 
GGGCCCCCCG GTCCCACCGG CCCTACTGGC CCTCCTGGCT TCCCTGGTGC AGCTGGTGCT 
AAGGGTGAAG CTGGTCCCCA GGGAGCCCGA GGCTCTGAAG GTCCCCAGGG TGTGCGTGGT 
GAGCCCGGAC CCCCTGGCCC TGCTGGTGCT GCTGGTCCTG CTGGAAACCC TGGTGCTGAT 
GGACAACCTG GTGCTAAAGG TGCCAATGGT GCTCCTGGTA TTGCTGGTGC TCCTGGCTTC 
CCTGGTGCCC GAGGCCCCTC TGGACCTCAG GGCCCCAGCG GCGCTCCTGG TCCCAAAGGC 
AACAGTGGTG AACCTGGTGC CCCTGGCAAC AAAGGAGACA CTGGTGCCAA AGGAGAACCC 
GGCCCTGCTG GAGTTCAAGG TCCCCCTGGC CCTGCTGGAG AAGAAGGAAA ACGAGGAGCC 
CGTGGTGAGC CTGGACCTAG CGGCCTGCCC GGACCTCCTG GCGAGCGCGG TGGACCTGGT 
AGCCGTGGTT TCCCTGGTGC TGATGGTGTT GCTGGCCCCA AGGGTCCTGC TGGTGAACGT 
GGTTCTCCTG GCCCTGCTGG TCCCAAAGGT TCTCCTGGTG AAGCTGGTCG CCCTGGTGAA 
GCTGGTCTCC CTGGTGCCAA GGGTCTCACT GGCAGTCCTG GCAGCCCTGG TCCTGATGGC 
AAAACCGGCC CCCCTGGTCC CGCTGGTCAA GATGGTCGCC CTGGACCCGC AGGTCCTCCT 
GGAGCCCGTG GACAGGCTGG TGTGATGGGA TTCCCTGGAC CTAAGGGTAC TGCTGGAGAA 
CCTGGAAAGG CTGGAGAACG AGGTGTCCCC GGACCCCCTG GCGCTGTTGG TCCCGCTGGC 
AAAGATGGCG AAGCTGGAGC TCAAGGAGCC CCCGGCCCTG CTGGTCCTGC TGGTGAGAGA 
GGTGAACAAG GTCCCGCTGG CTCCCCTGGA TTCCAGGGTC TTCCTGGTCC CGCTGGTCCT 
CCTGGTGAAG CAGGCAAGCC TGGTGAACAG GGTGTTCCTG GAGACCTTGG TGCCCCTGGA 
CCCTCTGGCG CAAGAGGCGA GAGAGGTTTC CCTGGTGAAC GTGGTGTACA AGGTCCCCCA 
GGTCCTGCTG GTCCCCGAGG AAACAATGGT GCCCCCGGCA ACGATGGTGC CAAGGGTGAT 
ACTGGTGCCC CCGGAGCTCC TGGTAGCCAG GGTGCCCCCG GTCTTCAGGG AATGCCTGGT 
GAACGTGGTG CAGCTGGTCT TCCAGGTCCT AAGGGTGACA GAGGTGATGC TGGTCCCAAA 
GGTGCTGATG GTTCTCCTGG CAAAGATGGC GTCCGTGGTC TGACTGGTCC CATTGGTCCT 
CCTGGCCCTG CTGGTGCCCC TGGTGACAAG GGTGAAACTG GTCCCAGTGG TCCTGCTGGC 
CCCACCGGAG CCCGTGGTGC CCCCGGAGAC CGTGGTGAGC CTGGTCCCCC TGGTCCTGCT 
GGCTTCGCTG GCCCCCCTGG TGCTGATGGC CAACCTGGTG CGAAAGGTGA ACCTGGTGAT 
ACTGGTGTGA AAGGTGACGC TGGTCCTCCT GGCCCTGCTG GTCCCGCTGG ACCCCCTGGC 
CCCATTGGTA ACGTTGGTGC TCCTGGACCC AAAGGTTCTC GTGGTGCTGC TGGTCCCCCT 
GGTGCTACTG GTTTCCCTGG TGCTGCTGGT CGTGTTGGTC CCCCTGGTCC CTCTGGAAAT 
GCTGGACCCC CTGGCCCTCC CGGTCCCGTT GGCAAAGAAG GGGGCAAAGG TCCCCGTGGT 
GAGACTGGTC CCGCTGGACG TCCTGGTGAA GTTGGTCCCC CAGGTCCCCC TGGCCCTGCT 
GGTGAGAAAG GATCTCCTGG TGCTGATGGA CCTGCTGGCT CTCCTGGTAC CCCTGGACCT 
CAGGGTATTG CTGGACAGCG TGGTGTGGTC GGTCTTCCCG GTCAGAGAGG AGAAAGAGGC 
TTCCCTGGTC TTCCTGGACC CTCTGGTGAA CCCGGCAAAC AAGGTCCTTC TGGAGCAAGT 
GGTGAACGTG GTCCCCCTGG CCCTATGGGC CCCCCTGGAT TGGCTGGCCC CCCTGGTGAA 
TCTGGTCGTG AGGGATCCCC TGGTGCTGAA GGCTCCCCTG GAAGAGATGG TGCTCCTGGT 
GCCAAGGGTG ACCGTGGTGA GACTGGCCCT GCTGGCCCCC CTGGTGCTCC TGGTGCTCCT 
GGTGCTCCCG GCCCTGTTGG TCCTGCTGGC AAGAATGGCG ACCGTGGTGA GACTGGTCCT 
GCTGGTCCTG CTGGTCCCAT TGGCCCTGCT GGTGCCCGTG GTCCTGCTGG ACCCCAAGGC 
CCCCGTGGTG ACAAGGGTGA GACAGGCGAA CAAGGTGACA GAGGCATAAA GGGTCATCGT 
GGCTTCTCTG GTCTCCAGGG TCCTCCTGGC TCTCCTGGCT CTCCTGGTGA ACAAGGCCCC 
TCTGGAGCTT CTGGTCCTGC AGGTCCCCGG GGTCCCCCTG GCTCTGCTGG TTCTCCTGGC 
AAAGATGGAC TCAACGGTCT CCCTGGCCCC ATTGGTCCCC CTGGTCCTCG AGGTCGCACT 
GGCGATAGTG GTCCTGCTGG TCCCCCCGGA CCTCCTGGAC CCCCTGGCCC TCCCGGTCCT 
CCCAGCGGTG GTTATGACTT CAGCTTCCTG CCTCAGCCAC CTCAAGAGAA GTCTCAAGAT 
GGTGGCCGTT ACTACCGGGC CGATGATGCC AACGTGGTCC GTGACCGTGA CCTTGAGGTG 
GACACTACCC TCAAGAGCCT GAGCCAGCAG ATTGAGAACA TCCGCAGCCC TGAGGGCAGC 
CGCAAGAACC CCGCCCGCAC ATGCCGTGAC CTCAAGATGT GCCACTCTGA CTGGAAGAGC 
GGAGAGTACT GGATCGACCC TAACCAAGGC TGCAACCTGG ATGCCATCAA GGTCTACTGC 
AACATGGAGA CAGGTCAGAC CTGTGTGTTC CCCACTCAGC CCTCTGTGCC TCAGAAGAAC 
TGGTACATCA GCCCAAACCC CAAGGAGAAG AAGCATGTCT GGTTTGGAGA GAGCATGACC 
GATGGATTCC AGTTCGAGTA TGGAAGCGAA GGTTCCGATC CTGCCGATGT CGCTATCCAG 
CTGACCTTCC TGCGCCTGAT GTCCACCGAG GCCTCCCAGA ACATCACCTA TCACTGCAAG 
AACAGCGTAG CCTACATGGA CCAACAGACT GGCAACCTCA AGAAGTCCCT GCTCCTCCAG 
GGCTCCAACG AGATCGAGCT CAGGGGCGAA GGCAACAGTC GATTCACCTA CAGCACGCTT 
GTGGATGGCT GCACGAGTCA CACCGGAACT TGGGGCAAGA CAGTCATCGA ATACAAAACC 
ACCAAGACCT CCCGCCTGCC CATCATCGAT GTGGCTCCCT TGGACATTGG TGCCCCAGAC 
CAGGAATTCG GAATGGACAT TGGCCCTGCC TGCTTCGTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pin1 facilitates isoproterenol?induced cardiac fibrosis and collagen deposition by promoting oxidative stress and activating the MEK1/2?ERK1/2 signal transduction pathway in rats.
International journal of molecular medicine41(3)1573-1583(2018 Mar)
Wu X,Li M,Chen SQ,Li S,Guo F

Periostin cross?reacts with the renin?angiotensin system during liver fibrosis development.
Molecular medicine reports16(5)5752-5758(2017 Nov)
Takeda K,Noguchi R,Kitade M,Namisaki T,Moriya K,Kawaratani H,Okura Y,Kaji K,Aihara Y,Douhara A,Nishimura N,Sawada Y,Seki K,Yoshiji H

miR?21 promotes ??SMA and collagen I expression in hepatic stellate cells via the Smad7 signaling pathway.
Molecular medicine reports16(4)4327-4333(2017 Oct)
Fu RQ,Hu DP,Hu YB,Hong L,Sun QF,Ding JG

Effects of lentiviral vector?mediated shRNA silencing of TGF?1 on the expression of Col1a1 in rat hepatic stellate cells.
Molecular medicine reports16(3)2785-2790(2017 Sep)
Bai GP,Yan GH,Wang GJ,Wan P,Liu XF,Wang H,Zhang RH

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Col1a1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

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