Irs2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Irs2
Entrez Gene ID	29376
Full Name	insulin receptor substrate 2
Synonyms	4PS,IRS-2
General protein information	Preferred Names insulin receptor substrate 2 Names insulin receptor substrate 2 tyrosine kinase substrate
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16q12.5
Summary	plays a role in insulin-stimulated fetal liver growth [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001168633.1	NP_001162104.1	insulin receptor substrate 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	IRS2	XP_529580.4
Mus musculus (house mouse)	Irs2	NP_001074681.1
Danio rerio (zebrafish)	irs2	XP_700746.4
Rattus norvegicus (Norway rat)	Irs2	NP_001162104.1
Gallus gallus (chicken)	IRS2	XP_425588.4
Danio rerio (zebrafish)	zgc:56306	NP_956609.1
Canis lupus familiaris (dog)	IRS2	XP_542667.4
Xenopus tropicalis (tropical clawed frog)	LOC100498409	XP_004912043.1
Homo sapiens (human)	IRS2	NP_003740.2
	IRS2	XP_002800884.1
Bos taurus (cattle)	IRS2	XP_005228650.1

Gene Ontology
Bibliography

Related articles in PubMed

Altered expression of IRS2 and GRB2 in demyelination of peripheral neurons: Implications in diabetic neuropathy.
Manu MS, Rachana KS, Advirao GM
Neuropeptides6271-79(2017 Apr)

MiR-126 Suppresses the Glucose-Stimulated Proliferation via IRS-2 in INS-1 ? Cells.
Tao H, Wang MM, Zhang M, Zhang SP, Wang CH, Yuan WJ, Sun T, He LJ, Hu QK
PloS one11(2)e0149954(2016)

CDK4 is an essential insulin effector in adipocytes.
Lagarrigue S, Lopez-Mejia IC, Denechaud PD, Escot? X, Castillo-Armengol J, Jimenez V, Chavey C, Giralt A, Lai Q, Zhang L, Martinez-Carreres L, Delacuisine B, Annicotte JS, Blanchet E, Hur? S, Abella A, Tinahones FJ, Vendrell J, Dubus P, Bosch F, Kahn CR, Fajas L
The Journal of clinical investigation126(1)335-48(2016 Jan)

Periapical Lesions Decrease Insulin Signaling in Rat Skeletal Muscle.
Astolphi RD, Curbete MM, Chiba FY, Cintra LT, Ervolino E, da Mota MS, Antoniali C, Garbin CA, Sumida DH
Journal of endodontics41(8)1305-10(2015 Aug)

Insulin injection restored increased insulin receptor substrate (IRS)-2 protein during short-term protein restriction but did not affect reduced insulin-like growth factor (IGF)-I mRNA or increased triglyceride accumulation in the liver of rats.
Ozaki Y, Takeda T, Akanishi N, Hakuno F, Toyoshima Y, Takahashi S, Takenaka A
Bioscience, biotechnology, and biochemistry78(1)130-8(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IRS-2 was one of the targets of miR-126. MiR-126 inhibited the beta-cell proliferation through IRS-2 instead of IRS-1. MiR-126 may take part in the glucose homeostasis both through its target IRS-2 and IRS-1.
Title: MiR-126 Suppresses the Glucose-Stimulated Proliferation via IRS-2 in INS-1 ? Cells.

Chronic periapical lesions are associated with decreased insulin signaling - evaluated according to insulin receptor substrate (pp185-insulin receptor substrate 1 [IRS-1]/insulin receptor substrate 2 [IRS-2]) tyrosine phosphorylation status, IRS-1 serine phosphorylation status, and IRS-1 and IRS-2 content - in the skeletal muscle of rats
Title: Periapical Lesions Decrease Insulin Signaling in Rat Skeletal Muscle.

reduced insulin secretion during protein restriction directly increased hepatic IRS-2 as a rapid response on day 1, while additional mechanisms contributed to the upregulation of IRS-2 on day 7
Title: Insulin injection restored increased insulin receptor substrate (IRS)-2 protein during short-term protein restriction but did not affect reduced insulin-like growth factor (IGF)-I mRNA or increased triglyceride accumulation in the liver of rats.

Data suggest P38/Mapk14 (mitogen activated protein kinase 14) is involved in glucolipotoxicity-induced apoptosis in pancreatic beta-cells via phosphorylation of Irs2; thus, P38/Irs2 play roles in beta-cell response to hyperglycemia/hyperlipidemia.
Title: P38 plays an important role in glucolipotoxicity-induced apoptosis in INS-1 cells.

The study identified the serine phosphorylation (p-Ser) sites induced by PKC-Beta activation or AngII, which inhibits insulin-induced p-Tyr sites on IRS2 and its signals in endothelial cells.
Title: Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells.

The following Irs2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Irs2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05984	NM_001168633.1 Latest version!	Rattus norvegicus insulin receptor substrate 2 (Irs2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$643.30 $919.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Irs2 ( NM_001168633.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001162104.1 Rattus norvegicus insulin receptor substrate 2 (Irs2), mRNA.

Price & Availability↑

CloneID	ORa05984
Clone ID Related Accession (Same CDS sequence)	NM_001168633.1
Accession Version	NM_001168633.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3984bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-31
Organism	Rattus norvegicus(Norway rat)
Product	insulin receptor substrate 2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AABR07026565.1. On Dec 12, 2009 this sequence version replaced XM_573948.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CO398387.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCTAGCG CGCCCCTGCC TGGGCCCCCC GCGTCGGCGG GCGGGGACGG CCCGAACCTC 
AATAACAACA ACAACAACAA CAACAACCAC AGCGTGCGCA AGTGCGGCTA CCTGCGCAAG 
CAGAAGCACG GCCACAAGCG CTTCTTCGTG CTGCGCGGCC CGGGCACCGG CGGCGAGGAG 
GCAGCCGCGG CTGGGGGGTC GCCGCCGCAG CCTCCGCGGC TGGAGTACTA TGAGAGCGAG 
AAGAAGTGGA AGAGCAAGGC GGGCGCGCCG AAGCGAGTGA TCGCGCTCGA CTGCTGTCTG 
AACATCAACA AGCGCGCGGA CGCCAAGCAC AAGTACCTGA TCGCCCTCTA CACCAAGGAC 
GAGTACTTCG CCGTAGCGGC GGAGAACGAG CAGGAGCAGG AGGGCTGGTA CCGCGCACTC 
ACCGACTTGG TCAGCGAAGG CCGCTCTGGC GATGGGGGCT CCGGCACCAC GGGCGGCTCT 
TGCAGCGCCT CTCTCCCGGG GGCCCTGGGC GGCTCGGCGG GCGCCGCTGG CTGCGATGAC 
AACTACGGGC TCGTGACGCC CGCCACGGCA GTCTACCGCG AGGTGTGGCA GGTGAACCTG 
AAGCCTAAGG GACTGGGCCA GAGCAAGAAC CTGACCGGTG TATACCGCCT ATGCCTGTCT 
GCGCGCACCA TCGGCTTCGT GAAGCTCAAT TGCGAACAGC CGTCGGTGAC GCTGCAGCTT 
ATGAACATTC GCCGCTGCGG CCACTCGGAC AGCTTCTTCT TCATCGAGGT GGGCCGTTCA 
GCCGTCACCG GTCCCGGCGA GCTGTGGATG CAAGCCGATG ACTCGGTGGT GGCGCAGAAC 
ATCCATGAGA CCATCCTGGA GGCCATGAAG GCACTCAAGG AGCTCTTCGA GTTCCGGCCT 
CGCAGCAAGA GTCAGTCGTC TGGGTCGTCT GCCACGCACC CCATCAGCGT ACCGGGCGCG 
CGCCGCCACC ACCACCTAGT CAACCTACCC CCTAGCCAGA CGGGCCTGGT GCGCCGCTCT 
CGCACTGATA GCCTGGCGGC CACCCCGCCA GCAGCCAAGT GCACTTCGTG CCGGGTTCGT 
ACAGCCAGCG AGGGTGACGG CGGCGCGGCA GGCGGAGCCG GGACGGCAGG AGGCAGGCCG 
ATGTCGGTGG CAGGGAGCCC CCTGAGTCCC GGGCCGGTGC GCGCGCCCCT TAGCCGCTCG 
CACACCCTGA GCGCCGGCTG CGGAGGCCGC CCGAGCAAAG TGGCTCTGGC GCCGGCAGGG 
GGAGCCCTAC AACACAGCCG CTCCATGTCC ATGCCCGTGG CGCACTCGCC GCCTGCAGCC 
ACCAGCCCAG GCAGCCTGTC CTCCAGCAGT GGGCATGGCT CAGGCTCCTA CCCGCTGCCT 
CCTGGTTCCC ACCCGCACCT GCCTCATCCG CTCCATCACC CCCAATGCCA ACGTCCGTCC 
AGCGGAAGTG CCTCCGCCTC GGGCTCCCCC AGCGACCCGG GTTTCATGTC CCTTGACGAG 
TATGGCTCCA GCCCTGGTGA CCTGAGAGCC TTCAGTAGCC ACAGGAGCAA CACACCTGAG 
TCCATCGCGG AGACCCCGCC AGCCAGGGAC GGCAGTGGGG GCGAGCTCTA TGGGTATATG 
AGCATGGATA GGCCCCTGAG CCACTGTGGC CGCCCTTACC GTAGGGTCTC TGGGGATGGG 
GCCCAGGATC TGGACAGAGG ACTGAGGAAG AGGACTTACT CCCTAACCAC GCCTGCCCGG 
CAGCGGCAGG TTCCTCAGCC TTCCTCTGCC TCTCTAGACG AATACACTCT CATGCGGGCC 
ACCTTCTCTG GCAGTTCAGG TCGCCTCTGC CCATCCCTCC CTGCGTCCTC TCCCAAAGTG 
GCCTACAACC CTTACCCAGA GGACTATGGA GACATTGAGA TTGGTTCTCA CAAGAGTTCC 
AGCAGTAACC TGGGGGCAGA TGATGGCTAC ATGCCCATGA CCCCTGGGGC AGCCCTCAGG 
AGTGGTGGCC CCAATAGCTG CAAGAGCGAT GACTACATGC CCATGAGCCC CACCAGCGTG 
TCTGCCCCTA AGCAGATCCT GCAACCACGT TCGGCAGCGG CCTTGCCCCC CTCTGGAGCA 
GCCGTGCCAG CACCCCCTTC AGGGGCGGGC AGGACTTTCC CAGTGAACGG AGGCGGCTAC 
AAAGCCAGCT CCCCAGCGGA GAGCTCCCCA GAAGATAGCG GGTACATGCG AATGTGGTGT 
GGCTCCAAGC TGTCCATGGA GAACCCAGAC CCTAAGCTGC TCCCCAATGG GGACTACCTC 
AACATGTCCC CCAGTGAGGC AGGCACCGCA GGGACCCCAC CTGACTTCTT CTCAGCAGCT 
TTGCGTCCAG GCGGTGAGGC CCTCAAAGGC GTCCCTGGCC ACTGCTACAG CTCTTTGCCC 
CGCTCTTACA AGGCTCCCTG TACTTGCGGT GGTGGAGACA ACGACCAGTA CGTGCTCATG 
AGCTCCCCTG TGGGTCGGAT TTTGGAAGAG GAGAGACTGG AGCCCCAGGC CACCCCAGGG 
GCTGGCACAT TTGGGGCAGC TGGTGGTAGT CATACCCAGC CTCATCACTC AGCAGTGCCT 
TCCTCCATGA GACCAAGTGG CATCGTTGGC CGACCTGAGG GCTTCCTGGG CCAGCGCTGT 
CGGGCAGTGC GGCCCACACG CCTTTCGCTA GAGGGACTGC AGACCCTTCC CAGCATGCAA 
GAGTACCCTC TACCCACTGA GCCCAAGAGC CCTGGCGAGT ACATCAACAT TGACTTTGGT 
GAAGGGGGTA CCCGTCTGTC TCCGCCTGCT CCCCCACTAC TGGCATCAGC GGCCTCCTCC 
TCTTCACTGC TCTCAGCCAG TAGTCCTGCT TCATCCCTGG GTTCAGGTAC CCCAGGCACC 
AGCAGTGACA GCCGGCAGCG CTCTCCGCTC TCTGACTATA TGAACCTGGA CTTCAGTTCT 
CCCAAGTCCC CTAAGCCTAG CACCCGCAGT GGGGACACAG TGGGCTCCAT CGATGGCCTT 
CTCTCTCCAG AAGCCTCATC CCCATACCCA CCGCTGCCCC CGCGTCCTTC TGCTTCCCCT 
TCCTCCTTAC AGCAGCCTCT GCCACCTGCC CCAGGAGACC TATACCGCCT GCCTCCAGCA 
ACAGCTGCCA CATCCCAGGG TCCCACTGCT GGCTCCTCAA TGTCCTCTGA GCCTGGGGAT 
AATGGTGACT ATACCGAGAT GGCCTTTGGT GTGGCTGCTA CCCCGCCACA ACCTATTGCG 
GCACCCCCGA AGCCAGAAGG TGCCCGAGTG ACCAGTCCCA CATCAGGCTT GAAGCGGCTA 
AGTCTCATGG ATCAGGTATC TGGGGTAGAG GCCTTCCTTC AAGTCAGCCA GCCCCCTGAT 
CCCCACCGGG GCGCTAAGGT CATCCGTGCA GACCCGCAGG GGGGACGTCG TCGCCACAGT 
TCAGAGACCT TCTCCTCTAC CACCACTGTC ACCCCAGTGT CCCCATCCTT TGCTCACAAT 
TCCAAGCGCC ACAATTCGGC CTCTGTGGAA AACGTCTCTC TCAGGAAAAG CAGTGAAGGC 
AACAGCATCC TGGGAGGAAG TGATGAGCCA TCCACATCCC CAGGACAGGC ACAGCCCTCG 
GCAGGTGTGC CCCCAGCGCC ACAGGCTAGG CCATGGAACC CCGGTCAGCC TGGAGCTTTG 
ATTGGCTGTC CTGGAGGCAG CAGTTCTCCC ATGCGCAGAG AGACCTCCGT GGGTTTCCAG 
AACGGCCTCA ACTATATCGC CATCGATGTG AGAGGTGAGC AGGGGTCCTT GGCGCAGTCT 
CAGCCTCAGC ATCCACAGCC AGGAGACAAG AACTCCTGGG GCCGGACCCG TAGCCTTGGG 
GGGCTCCTCG GTACCGTTGG AGGCTCTGGC ACCAGTGGAG TGTGTGGGGG TCCAGGCACT 
GGAGCCTTAC CCTCTGCCAG CACCTACGCA AGCATCGACT TCTTGTCCCA TCACTTGAAA 
GAAGCCACCG TGGTGAAAGA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001162104.1
CDS	1..3984
Translation	MASAPLPGPPASAGGDGPNLNNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGTGGEEAAAAGGSPPQPPRLEYYESEKKWKSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRSGDGGSGTTGGSCSASLPGALGGSAGAAGCDDNYGLVTPATAVYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCTSCRVRTASEGDGGAAGGAGTAGGRPMSVAGSPLSPGPVRAPLSRSHTLSAGCGGRPSKVALAPAGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPLPPGSHPHLPHPLHHPQCQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFSSHRSNTPESIAETPPARDGSGGELYGYMSMDRPLSHCGRPYRRVSGDGAQDLDRGLRKRTYSLTTPARQRQVPQPSSASLDEYTLMRATFSGSSGRLCPSLPASSPKVAYNPYPEDYGDIEIGSHKSSSSNLGADDGYMPMTPGAALRSGGPNSCKSDDYMPMSPTSVSAPKQILQPRSAAALPPSGAAVPAPPSGAGRTFPVNGGGYKASSPAESSPEDSGYMRMWCGSKLSMENPDPKLLPNGDYLNMSPSEAGTAGTPPDFFSAALRPGGEALKGVPGHCYSSLPRSYKAPCTCGGGDNDQYVLMSSPVGRILEEERLEPQATPGAGTFGAAGGSHTQPHHSAVPSSMRPSGIVGRPEGFLGQRCRAVRPTRLSLEGLQTLPSMQEYPLPTEPKSPGEYINIDFGEGGTRLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPSTRSGDTVGSIDGLLSPEASSPYPPLPPRPSASPSSLQQPLPPAPGDLYRLPPATAATSQGPTAGSSMSSEPGDNGDYTEMAFGVAATPPQPIAAPPKPEGARVTSPTSGLKRLSLMDQVSGVEAFLQVSQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHNSKRHNSASVENVSLRKSSEGNSILGGSDEPSTSPGQAQPSAGVPPAPQARPWNPGQPGALIGCPGGSSSPMRRETSVGFQNGLNYIAIDVRGEQGSLAQSQPQHPQPGDKNSWGRTRSLGGLLGTVGGSGTSGVCGGPGTGALPSASTYASIDFLSHHLKEATVVKE

Target ORF information:

RefSeq Version	NM_001168633.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus insulin receptor substrate 2 (Irs2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001168633.1

ORF Insert Sequence:

ATGGCTAGCG CGCCCCTGCC TGGGCCCCCC GCGTCGGCGG GCGGGGACGG CCCGAACCTC 
AATAACAACA ACAACAACAA CAACAACCAC AGCGTGCGCA AGTGCGGCTA CCTGCGCAAG 
CAGAAGCACG GCCACAAGCG CTTCTTCGTG CTGCGCGGCC CGGGCACCGG CGGCGAGGAG 
GCAGCCGCGG CTGGGGGGTC GCCGCCGCAG CCTCCGCGGC TGGAGTACTA TGAGAGCGAG 
AAGAAGTGGA AGAGCAAGGC GGGCGCGCCG AAGCGAGTGA TCGCGCTCGA CTGCTGTCTG 
AACATCAACA AGCGCGCGGA CGCCAAGCAC AAGTACCTGA TCGCCCTCTA CACCAAGGAC 
GAGTACTTCG CCGTAGCGGC GGAGAACGAG CAGGAGCAGG AGGGCTGGTA CCGCGCACTC 
ACCGACTTGG TCAGCGAAGG CCGCTCTGGC GATGGGGGCT CCGGCACCAC GGGCGGCTCT 
TGCAGCGCCT CTCTCCCGGG GGCCCTGGGC GGCTCGGCGG GCGCCGCTGG CTGCGATGAC 
AACTACGGGC TCGTGACGCC CGCCACGGCA GTCTACCGCG AGGTGTGGCA GGTGAACCTG 
AAGCCTAAGG GACTGGGCCA GAGCAAGAAC CTGACCGGTG TATACCGCCT ATGCCTGTCT 
GCGCGCACCA TCGGCTTCGT GAAGCTCAAT TGCGAACAGC CGTCGGTGAC GCTGCAGCTT 
ATGAACATTC GCCGCTGCGG CCACTCGGAC AGCTTCTTCT TCATCGAGGT GGGCCGTTCA 
GCCGTCACCG GTCCCGGCGA GCTGTGGATG CAAGCCGATG ACTCGGTGGT GGCGCAGAAC 
ATCCATGAGA CCATCCTGGA GGCCATGAAG GCACTCAAGG AGCTCTTCGA GTTCCGGCCT 
CGCAGCAAGA GTCAGTCGTC TGGGTCGTCT GCCACGCACC CCATCAGCGT ACCGGGCGCG 
CGCCGCCACC ACCACCTAGT CAACCTACCC CCTAGCCAGA CGGGCCTGGT GCGCCGCTCT 
CGCACTGATA GCCTGGCGGC CACCCCGCCA GCAGCCAAGT GCACTTCGTG CCGGGTTCGT 
ACAGCCAGCG AGGGTGACGG CGGCGCGGCA GGCGGAGCCG GGACGGCAGG AGGCAGGCCG 
ATGTCGGTGG CAGGGAGCCC CCTGAGTCCC GGGCCGGTGC GCGCGCCCCT TAGCCGCTCG 
CACACCCTGA GCGCCGGCTG CGGAGGCCGC CCGAGCAAAG TGGCTCTGGC GCCGGCAGGG 
GGAGCCCTAC AACACAGCCG CTCCATGTCC ATGCCCGTGG CGCACTCGCC GCCTGCAGCC 
ACCAGCCCAG GCAGCCTGTC CTCCAGCAGT GGGCATGGCT CAGGCTCCTA CCCGCTGCCT 
CCTGGTTCCC ACCCGCACCT GCCTCATCCG CTCCATCACC CCCAATGCCA ACGTCCGTCC 
AGCGGAAGTG CCTCCGCCTC GGGCTCCCCC AGCGACCCGG GTTTCATGTC CCTTGACGAG 
TATGGCTCCA GCCCTGGTGA CCTGAGAGCC TTCAGTAGCC ACAGGAGCAA CACACCTGAG 
TCCATCGCGG AGACCCCGCC AGCCAGGGAC GGCAGTGGGG GCGAGCTCTA TGGGTATATG 
AGCATGGATA GGCCCCTGAG CCACTGTGGC CGCCCTTACC GTAGGGTCTC TGGGGATGGG 
GCCCAGGATC TGGACAGAGG ACTGAGGAAG AGGACTTACT CCCTAACCAC GCCTGCCCGG 
CAGCGGCAGG TTCCTCAGCC TTCCTCTGCC TCTCTAGACG AATACACTCT CATGCGGGCC 
ACCTTCTCTG GCAGTTCAGG TCGCCTCTGC CCATCCCTCC CTGCGTCCTC TCCCAAAGTG 
GCCTACAACC CTTACCCAGA GGACTATGGA GACATTGAGA TTGGTTCTCA CAAGAGTTCC 
AGCAGTAACC TGGGGGCAGA TGATGGCTAC ATGCCCATGA CCCCTGGGGC AGCCCTCAGG 
AGTGGTGGCC CCAATAGCTG CAAGAGCGAT GACTACATGC CCATGAGCCC CACCAGCGTG 
TCTGCCCCTA AGCAGATCCT GCAACCACGT TCGGCAGCGG CCTTGCCCCC CTCTGGAGCA 
GCCGTGCCAG CACCCCCTTC AGGGGCGGGC AGGACTTTCC CAGTGAACGG AGGCGGCTAC 
AAAGCCAGCT CCCCAGCGGA GAGCTCCCCA GAAGATAGCG GGTACATGCG AATGTGGTGT 
GGCTCCAAGC TGTCCATGGA GAACCCAGAC CCTAAGCTGC TCCCCAATGG GGACTACCTC 
AACATGTCCC CCAGTGAGGC AGGCACCGCA GGGACCCCAC CTGACTTCTT CTCAGCAGCT 
TTGCGTCCAG GCGGTGAGGC CCTCAAAGGC GTCCCTGGCC ACTGCTACAG CTCTTTGCCC 
CGCTCTTACA AGGCTCCCTG TACTTGCGGT GGTGGAGACA ACGACCAGTA CGTGCTCATG 
AGCTCCCCTG TGGGTCGGAT TTTGGAAGAG GAGAGACTGG AGCCCCAGGC CACCCCAGGG 
GCTGGCACAT TTGGGGCAGC TGGTGGTAGT CATACCCAGC CTCATCACTC AGCAGTGCCT 
TCCTCCATGA GACCAAGTGG CATCGTTGGC CGACCTGAGG GCTTCCTGGG CCAGCGCTGT 
CGGGCAGTGC GGCCCACACG CCTTTCGCTA GAGGGACTGC AGACCCTTCC CAGCATGCAA 
GAGTACCCTC TACCCACTGA GCCCAAGAGC CCTGGCGAGT ACATCAACAT TGACTTTGGT 
GAAGGGGGTA CCCGTCTGTC TCCGCCTGCT CCCCCACTAC TGGCATCAGC GGCCTCCTCC 
TCTTCACTGC TCTCAGCCAG TAGTCCTGCT TCATCCCTGG GTTCAGGTAC CCCAGGCACC 
AGCAGTGACA GCCGGCAGCG CTCTCCGCTC TCTGACTATA TGAACCTGGA CTTCAGTTCT 
CCCAAGTCCC CTAAGCCTAG CACCCGCAGT GGGGACACAG TGGGCTCCAT CGATGGCCTT 
CTCTCTCCAG AAGCCTCATC CCCATACCCA CCGCTGCCCC CGCGTCCTTC TGCTTCCCCT 
TCCTCCTTAC AGCAGCCTCT GCCACCTGCC CCAGGAGACC TATACCGCCT GCCTCCAGCA 
ACAGCTGCCA CATCCCAGGG TCCCACTGCT GGCTCCTCAA TGTCCTCTGA GCCTGGGGAT 
AATGGTGACT ATACCGAGAT GGCCTTTGGT GTGGCTGCTA CCCCGCCACA ACCTATTGCG 
GCACCCCCGA AGCCAGAAGG TGCCCGAGTG ACCAGTCCCA CATCAGGCTT GAAGCGGCTA 
AGTCTCATGG ATCAGGTATC TGGGGTAGAG GCCTTCCTTC AAGTCAGCCA GCCCCCTGAT 
CCCCACCGGG GCGCTAAGGT CATCCGTGCA GACCCGCAGG GGGGACGTCG TCGCCACAGT 
TCAGAGACCT TCTCCTCTAC CACCACTGTC ACCCCAGTGT CCCCATCCTT TGCTCACAAT 
TCCAAGCGCC ACAATTCGGC CTCTGTGGAA AACGTCTCTC TCAGGAAAAG CAGTGAAGGC 
AACAGCATCC TGGGAGGAAG TGATGAGCCA TCCACATCCC CAGGACAGGC ACAGCCCTCG 
GCAGGTGTGC CCCCAGCGCC ACAGGCTAGG CCATGGAACC CCGGTCAGCC TGGAGCTTTG 
ATTGGCTGTC CTGGAGGCAG CAGTTCTCCC ATGCGCAGAG AGACCTCCGT GGGTTTCCAG 
AACGGCCTCA ACTATATCGC CATCGATGTG AGAGGTGAGC AGGGGTCCTT GGCGCAGTCT 
CAGCCTCAGC ATCCACAGCC AGGAGACAAG AACTCCTGGG GCCGGACCCG TAGCCTTGGG 
GGGCTCCTCG GTACCGTTGG AGGCTCTGGC ACCAGTGGAG TGTGTGGGGG TCCAGGCACT 
GGAGCCTTAC CCTCTGCCAG CACCTACGCA AGCATCGACT TCTTGTCCCA TCACTTGAAA 
GAAGCCACCG TGGTGAAAGA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Altered expression of IRS2 and GRB2 in demyelination of peripheral neurons: Implications in diabetic neuropathy.
Neuropeptides6271-79(2017 Apr)
Manu MS,Rachana KS,Advirao GM

MiR-126 Suppresses the Glucose-Stimulated Proliferation via IRS-2 in INS-1 ? Cells.
PloS one11(2)e0149954(2016)
Tao H,Wang MM,Zhang M,Zhang SP,Wang CH,Yuan WJ,Sun T,He LJ,Hu QK

CDK4 is an essential insulin effector in adipocytes.
The Journal of clinical investigation126(1)335-48(2016 Jan)
Lagarrigue S,Lopez-Mejia IC,Denechaud PD,Escot? X,Castillo-Armengol J,Jimenez V,Chavey C,Giralt A,Lai Q,Zhang L,Martinez-Carreres L,Delacuisine B,Annicotte JS,Blanchet E,Hur? S,Abella A,Tinahones FJ,Vendrell J,Dubus P,Bosch F,Kahn CR,Fajas L

Periapical Lesions Decrease Insulin Signaling in Rat Skeletal Muscle.
Journal of endodontics41(8)1305-10(2015 Aug)
Astolphi RD,Curbete MM,Chiba FY,Cintra LT,Ervolino E,da Mota MS,Antoniali C,Garbin CA,Sumida DH

Insulin injection restored increased insulin receptor substrate (IRS)-2 protein during short-term protein restriction but did not affect reduced insulin-like growth factor (IGF)-I mRNA or increased triglyceride accumulation in the liver of rats.
Bioscience, biotechnology, and biochemistry78(1)130-8(2014)
Ozaki Y,Takeda T,Akanishi N,Hakuno F,Toyoshima Y,Takahashi S,Takenaka A

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Irs2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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