Hras cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Hras
Entrez Gene ID	293621
Full Name	HRas proto-oncogene, GTPase
Synonyms	HRAS1,c-H-ras
General protein information	Preferred Names HRas proto-oncogene, GTPase Names GTPase HRas H-Ras-1 Harvey ras1 protein Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog Harvey rat sarcoma virus oncogene p21ras transforming protein p21
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q41
Summary	mutated in rats exposed to the carcinogen 2-amino-1-methyl-6phenylimidazo[4;5-b]pyridine (PhiP); may be involved in the pathogenesis of chemically induced mammary tumors [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017589007.1	XP_017444496.1	GTPase HRas isoform X1
XM_006230535.3	XP_006230597.3	GTPase HRas isoform X1
NM_001098241.1	NP_001091711.1	GTPase HRas precursor
XM_017589006.1	XP_017444495.1	GTPase HRas isoform X1
XM_017589008.1	XP_017444497.1	GTPase HRas isoform X2
NM_001130441.1	NP_001123913.1	GTPase HRas precursor

Pathways from BioSystems

Homologies

	HRAS	XP_001085804.1
Danio rerio (zebrafish)	hrasb	NP_001018465.1
Homo sapiens (human)	HRAS	NP_005334.1
Danio rerio (zebrafish)	hrasa	NP_001017623.1
Danio rerio (zebrafish)	LOC100151000	XP_001923439.1
Mus musculus (house mouse)	Hras	NP_001123915.1
Rattus norvegicus (Norway rat)	Hras	NP_001091711.1
Gallus gallus (chicken)	HRAS	NP_990623.1
Pan troglodytes (chimpanzee)	HRAS	XP_521702.2
Canis lupus familiaris (dog)	HRAS	XP_540523.3
Bos taurus (cattle)	HRAS	NP_001229275.1
Xenopus tropicalis (tropical clawed frog)	hras	NP_001017003.1

Gene Ontology
Bibliography

Related articles in PubMed

H-Ras Isoform Mediates Protection Against Pressure Overload-Induced Cardiac Dysfunction in Part Through Activation of AKT.
Matsuda T, Jeong JI, Ikeda S, Yamamoto T, Gao S, Babu GJ, Zhai P, Del Re DP
Circulation. Heart failure10(2)(2017 Feb)

PATZ1 is a target of miR-29b that is induced by Ha-Ras oncogene in rat thyroid cells.
Vitiello M, Valentino T, De Menna M, Crescenzi E, Francesca P, Rea D, Arra C, Fusco A, De Vita G, Cerchia L, Fedele M
Scientific reports625268(2016 04)

Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers.
Najumudeen AK, Posada IM, Lectez B, Zhou Y, Landor SK, Fallarero A, Vuorela P, Hancock J, Abankwa D
Biochemistry54(49)7212-21(2015 Dec)

An attenuated phenotype of Costello syndrome in three unrelated individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates with uncommon functional consequences.
Gripp KW, Sol-Church K, Smpokou P, Graham GE, Stevenson DA, Hanson H, Viskochil DH, Baker LC, Russo B, Gardner N, Stabley DL, Kolbe V, Rosenberger G
American journal of medical genetics. Part A167A(9)2085-97(2015 Sep)

[Antiapoptotic gene bcl-2 prevents cellular senescence program reactivation induced by histone deacetylase inhibitor sodium butyrate in E1A and cHa-ras transformed rat fibroblasts].
Gordeev SA, Bykova TV, Zubova SG, Aksenov ND, Pospelova TV
Tsitologiia57(2)135-43(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

H-ras isoform mediates protection against pressure overload-induced cardiac dysfunction in part through activation of AKT/PI3K signaling pathway.
Title: H-Ras Isoform Mediates Protection Against Pressure Overload-Induced Cardiac Dysfunction in Part Through Activation of AKT.

Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers.
Title: Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers.

Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases.
Title: Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases.

H-Ras mediates the inhibitory effect of epidermal growth factor on the epithelial Na+ channel
Title: H-Ras mediates the inhibitory effect of epidermal growth factor on the epithelial Na+ channel.

It has been found that NaBut reduces proliferation rate of ERasBcl (E1A, cHa-ras and bcl-2 ) cells significantly weaker than of ERas transformed cells
Title: [Antiapoptotic gene bcl-2 prevents cellular senescence program reactivation induced by histone deacetylase inhibitor sodium butyrate in E1A and cHa-ras transformed rat fibroblasts].

The following Hras gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hras cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa02296	NM_001130441.1 Latest version!	Rattus norvegicus HRas proto-oncogene, GTPase (Hras), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa02296	NM_001098241.1 Latest version!	Rattus norvegicus HRas proto-oncogene, GTPase (Hras), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa56508	XM_017589008.1 Latest version!	Rattus norvegicus Harvey rat sarcoma virus oncogene (Hras), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
ORa56507	XM_017589006.1 Latest version!	Rattus norvegicus Harvey rat sarcoma virus oncogene (Hras), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
ORa56507	XM_006230535.3 Latest version!	Rattus norvegicus Harvey rat sarcoma virus oncogene (Hras), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
ORa56507	XM_017589007.1 Latest version!	Rattus norvegicus Harvey rat sarcoma virus oncogene (Hras), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Hras ( NM_001098241.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001091711.1 Rattus norvegicus HRas proto-oncogene, GTPase (Hras), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa02296
Clone ID Related Accession (Same CDS sequence)	NM_001098241.1 , NM_001130441.1
Accession Version	NM_001098241.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	GTPase HRas precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC099130.1 and BC086608.1. On or before Jul 25, 2008 this sequence version replaced XM_001062236.1, XM_001061671.1. Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC086608.1, BC099130.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACAGAAT ACAAGCTTGT GGTGGTGGGC GCTGGAGGCG TGGGAAAGAG TGCCCTGACC 
ATCCAGCTGA TCCAGAACCA TTTTGTGGAC GAGTATGATC CCACTATAGA GGACTCCTAC 
CGGAAACAGG TAGTCATTGA TGGGGAGACG TGTTTACTGG ACATCTTAGA CACAGCAGGT 
CAAGAAGAGT ATAGTGCCAT GCGGGACCAG TACATGCGCA CAGGGGAGGG CTTCCTCTGT 
GTATTTGCCA TCAACAACAC CAAGTCCTTT GAAGACATCC ATCAGTACAG GGAGCAGATC 
AAGCGGGTGA AAGATTCAGA TGATGTGCCA ATGGTGCTGG TGGGCAACAA GTGTGACCTG 
GCCGCTCGCA CTGTTGAGTC TCGGCAGGCC CAGGACCTTG CTCGCAGCTA TGGCATCCCC 
TACATTGAAA CATCAGCCAA GACCCGGCAG GGTGTGGAGG ATGCCTTCTA CACACTAGTA 
CGTGAGATTC GGCAGCATAA ACTGCGGAAA CTGAACCCGC CTGATGAGAG TGGCCCTGGC 
TGCATGAGCT GCAAGTGTGT GCTGTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001091711.1
CDS	167..736
Translation	MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS

Target ORF information:

RefSeq Version	NM_001098241.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus HRas proto-oncogene, GTPase (Hras), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001098241.1

ORF Insert Sequence:

ATGACAGAAT ACAAGCTTGT GGTGGTGGGC GCTGGAGGCG TGGGAAAGAG TGCCCTGACC 
ATCCAGCTGA TCCAGAACCA TTTTGTGGAC GAGTATGATC CCACTATAGA GGACTCCTAC 
CGGAAACAGG TAGTCATTGA TGGGGAGACG TGTTTACTGG ACATCTTAGA CACAGCAGGT 
CAAGAAGAGT ATAGTGCCAT GCGGGACCAG TACATGCGCA CAGGGGAGGG CTTCCTCTGT 
GTATTTGCCA TCAACAACAC CAAGTCCTTT GAAGACATCC ATCAGTACAG GGAGCAGATC 
AAGCGGGTGA AAGATTCAGA TGATGTGCCA ATGGTGCTGG TGGGCAACAA GTGTGACCTG 
GCCGCTCGCA CTGTTGAGTC TCGGCAGGCC CAGGACCTTG CTCGCAGCTA TGGCATCCCC 
TACATTGAAA CATCAGCCAA GACCCGGCAG GGTGTGGAGG ATGCCTTCTA CACACTAGTA 
CGTGAGATTC GGCAGCATAA ACTGCGGAAA CTGAACCCGC CTGATGAGAG TGGCCCTGGC 
TGCATGAGCT GCAAGTGTGT GCTGTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hras ( NM_001130441.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001123913.1 Rattus norvegicus HRas proto-oncogene, GTPase (Hras), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa02296
Clone ID Related Accession (Same CDS sequence)	NM_001098241.1 , NM_001130441.1
Accession Version	NM_001130441.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	GTPase HRas precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CO567790.1 and BC086608.1. Transcript Variant: This variant (1) differs in the 3' UTR, compared to variant 2. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: CO567790.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACAGAAT ACAAGCTTGT GGTGGTGGGC GCTGGAGGCG TGGGAAAGAG TGCCCTGACC 
ATCCAGCTGA TCCAGAACCA TTTTGTGGAC GAGTATGATC CCACTATAGA GGACTCCTAC 
CGGAAACAGG TAGTCATTGA TGGGGAGACG TGTTTACTGG ACATCTTAGA CACAGCAGGT 
CAAGAAGAGT ATAGTGCCAT GCGGGACCAG TACATGCGCA CAGGGGAGGG CTTCCTCTGT 
GTATTTGCCA TCAACAACAC CAAGTCCTTT GAAGACATCC ATCAGTACAG GGAGCAGATC 
AAGCGGGTGA AAGATTCAGA TGATGTGCCA ATGGTGCTGG TGGGCAACAA GTGTGACCTG 
GCCGCTCGCA CTGTTGAGTC TCGGCAGGCC CAGGACCTTG CTCGCAGCTA TGGCATCCCC 
TACATTGAAA CATCAGCCAA GACCCGGCAG GGTGTGGAGG ATGCCTTCTA CACACTAGTA 
CGTGAGATTC GGCAGCATAA ACTGCGGAAA CTGAACCCGC CTGATGAGAG TGGCCCTGGC 
TGCATGAGCT GCAAGTGTGT GCTGTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001123913.1
CDS	167..736
Translation	MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS

Target ORF information:

RefSeq Version	NM_001130441.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus HRas proto-oncogene, GTPase (Hras), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001130441.1

ORF Insert Sequence:

ATGACAGAAT ACAAGCTTGT GGTGGTGGGC GCTGGAGGCG TGGGAAAGAG TGCCCTGACC 
ATCCAGCTGA TCCAGAACCA TTTTGTGGAC GAGTATGATC CCACTATAGA GGACTCCTAC 
CGGAAACAGG TAGTCATTGA TGGGGAGACG TGTTTACTGG ACATCTTAGA CACAGCAGGT 
CAAGAAGAGT ATAGTGCCAT GCGGGACCAG TACATGCGCA CAGGGGAGGG CTTCCTCTGT 
GTATTTGCCA TCAACAACAC CAAGTCCTTT GAAGACATCC ATCAGTACAG GGAGCAGATC 
AAGCGGGTGA AAGATTCAGA TGATGTGCCA ATGGTGCTGG TGGGCAACAA GTGTGACCTG 
GCCGCTCGCA CTGTTGAGTC TCGGCAGGCC CAGGACCTTG CTCGCAGCTA TGGCATCCCC 
TACATTGAAA CATCAGCCAA GACCCGGCAG GGTGTGGAGG ATGCCTTCTA CACACTAGTA 
CGTGAGATTC GGCAGCATAA ACTGCGGAAA CTGAACCCGC CTGATGAGAG TGGCCCTGGC 
TGCATGAGCT GCAAGTGTGT GCTGTCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hras ( XM_017589008.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444497.1 Rattus norvegicus Harvey rat sarcoma virus oncogene (Hras), transcript variant X4, mRNA.

Price & Availability↑

CloneID	ORa56508
Clone ID Related Accession (Same CDS sequence)	XM_017589008.1
Accession Version	XM_017589008.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 513bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	GTPase HRas isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACAGAAT ACAAGCTTGT GGTGGTGGGC GCTGGAGGCG TGGGAAAGAG TGCCCTGACC 
ATCCAGCTGA TCCAGAACCA TTTTGTGGAC GAGTATGATC CCACTATAGA GGACTCCTAC 
CGGAAACAGG TAGTCATTGA TGGGGAGACG TGTTTACTGG ACATCTTAGA CACAGCAGGT 
CAAGAAGAGT ATAGTGCCAT GCGGGACCAG TACATGCGCA CAGGGGAGGG CTTCCTCTGT 
GTATTTGCCA TCAACAACAC CAAGTCCTTT GAAGACATCC ATCAGTACAG GGAGCAGATC 
AAGCGGGTGA AAGATTCAGA TGATGTGCCA ATGGTGCTGG TGGGCAACAA GTGTGACCTG 
GCCGCTCGCA CTGTTGAGTC TCGGCAGGCC CAGGACCTTG CTCGCAGCTA TGGCATCCCC 
TACATTGAAA CATCAGCCAA GACCCGGCAG GGCAGCCGCT CTGGCTCTGG CTCCAGCTCC 
GGGACCCTCT GGGACCCCCC GGGACCCATG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444497.1
CDS	180..692
Translation	MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGSRSGSGSSSGTLWDPPGPM

Target ORF information:

RefSeq Version	XM_017589008.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Harvey rat sarcoma virus oncogene (Hras), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589008.1

ORF Insert Sequence:

ATGACAGAAT ACAAGCTTGT GGTGGTGGGC GCTGGAGGCG TGGGAAAGAG TGCCCTGACC 
ATCCAGCTGA TCCAGAACCA TTTTGTGGAC GAGTATGATC CCACTATAGA GGACTCCTAC 
CGGAAACAGG TAGTCATTGA TGGGGAGACG TGTTTACTGG ACATCTTAGA CACAGCAGGT 
CAAGAAGAGT ATAGTGCCAT GCGGGACCAG TACATGCGCA CAGGGGAGGG CTTCCTCTGT 
GTATTTGCCA TCAACAACAC CAAGTCCTTT GAAGACATCC ATCAGTACAG GGAGCAGATC 
AAGCGGGTGA AAGATTCAGA TGATGTGCCA ATGGTGCTGG TGGGCAACAA GTGTGACCTG 
GCCGCTCGCA CTGTTGAGTC TCGGCAGGCC CAGGACCTTG CTCGCAGCTA TGGCATCCCC 
TACATTGAAA CATCAGCCAA GACCCGGCAG GGCAGCCGCT CTGGCTCTGG CTCCAGCTCC 
GGGACCCTCT GGGACCCCCC GGGACCCATG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hras ( XM_017589007.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444496.1 Rattus norvegicus Harvey rat sarcoma virus oncogene (Hras), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa56507
Clone ID Related Accession (Same CDS sequence)	XM_017589007.1 , XM_006230535.3 , XM_017589006.1
Accession Version	XM_017589007.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	GTPase HRas isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGTTGCT CAGCCAATCA TAACAGGTGG CGGTGGGGCG GAGTTCGACC AATCATCGGC 
GGCCTCGAGT TGACGGACGG GCGCGGGGCG GAGCGGGGCG GGGCGAGCGC GGGCCCGGCC 
AAGTCCCCGC CGTCCGCGCC CGGCGCCCGC AGCCCGAGCC GCACCCGCCG CGGACGGAGC 
CCATGCGCGG GCCCAGTCGG CGCCCGTCCG CGCCCCCGCC CTGCCCCGGC CCCGGCCCCG 
GGGGCAGTCG CGCCAGCAAG CGGTGGGGCA GGAGCTCCTG GTTTGGCAGC CCCTGTAGAA 
GCGATGACAG AATACAAGCT TGTGGTGGTG GGCGCTGGAG GCGTGGGAAA GAGTGCCCTG 
ACCATCCAGC TGATCCAGAA CCATTTTGTG GACGAGTATG ATCCCACTAT AGAGGACTCC 
TACCGGAAAC AGGTAGTCAT TGATGGGGAG ACGTGTTTAC TGGACATCTT AGACACAGCA 
GGTCAAGAAG AGTATAGTGC CATGCGGGAC CAGTACATGC GCACAGGGGA GGGCTTCCTC 
TGTGTATTTG CCATCAACAA CACCAAGTCC TTTGAAGACA TCCATCAGTA CAGGGAGCAG 
ATCAAGCGGG TGAAAGATTC AGATGATGTG CCAATGGTGC TGGTGGGCAA CAAGTGTGAC 
CTGGCCGCTC GCACTGTTGA GTCTCGGCAG GCCCAGGACC TTGCTCGCAG CTATGGCATC 
CCCTACATTG AAACATCAGC CAAGACCCGG CAGGGTGTGG AGGATGCCTT CTACACACTA 
GTACGTGAGA TTCGGCAGCA TAAACTGCGG AAACTGAACC CGCCTGATGA GAGTGGCCCT 
GGCTGCATGA GCTGCAAGTG TGTGCTGTCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444496.1
CDS	19..891
Translation	MGCSANHNRWRWGGVRPIIGGLELTDGRGAERGGASAGPAKSPPSAPGARSPSRTRRGRSPCAGPVGARPRPRPAPAPAPGAVAPASGGAGAPGLAAPVEAMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS

Target ORF information:

RefSeq Version	XM_017589007.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Harvey rat sarcoma virus oncogene (Hras), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589007.1

ORF Insert Sequence:

ATGGGTTGCT CAGCCAATCA TAACAGGTGG CGGTGGGGCG GAGTTCGACC AATCATCGGC 
GGCCTCGAGT TGACGGACGG GCGCGGGGCG GAGCGGGGCG GGGCGAGCGC GGGCCCGGCC 
AAGTCCCCGC CGTCCGCGCC CGGCGCCCGC AGCCCGAGCC GCACCCGCCG CGGACGGAGC 
CCATGCGCGG GCCCAGTCGG CGCCCGTCCG CGCCCCCGCC CTGCCCCGGC CCCGGCCCCG 
GGGGCAGTCG CGCCAGCAAG CGGTGGGGCA GGAGCTCCTG GTTTGGCAGC CCCTGTAGAA 
GCGATGACAG AATACAAGCT TGTGGTGGTG GGCGCTGGAG GCGTGGGAAA GAGTGCCCTG 
ACCATCCAGC TGATCCAGAA CCATTTTGTG GACGAGTATG ATCCCACTAT AGAGGACTCC 
TACCGGAAAC AGGTAGTCAT TGATGGGGAG ACGTGTTTAC TGGACATCTT AGACACAGCA 
GGTCAAGAAG AGTATAGTGC CATGCGGGAC CAGTACATGC GCACAGGGGA GGGCTTCCTC 
TGTGTATTTG CCATCAACAA CACCAAGTCC TTTGAAGACA TCCATCAGTA CAGGGAGCAG 
ATCAAGCGGG TGAAAGATTC AGATGATGTG CCAATGGTGC TGGTGGGCAA CAAGTGTGAC 
CTGGCCGCTC GCACTGTTGA GTCTCGGCAG GCCCAGGACC TTGCTCGCAG CTATGGCATC 
CCCTACATTG AAACATCAGC CAAGACCCGG CAGGGTGTGG AGGATGCCTT CTACACACTA 
GTACGTGAGA TTCGGCAGCA TAAACTGCGG AAACTGAACC CGCCTGATGA GAGTGGCCCT 
GGCTGCATGA GCTGCAAGTG TGTGCTGTCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hras ( XM_006230535.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006230597.3 Rattus norvegicus Harvey rat sarcoma virus oncogene (Hras), transcript variant X3, mRNA.

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CloneID	ORa56507
Clone ID Related Accession (Same CDS sequence)	XM_017589007.1 , XM_006230535.3 , XM_017589006.1
Accession Version	XM_006230535.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	GTPase HRas isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006230535.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGTTGCT CAGCCAATCA TAACAGGTGG CGGTGGGGCG GAGTTCGACC AATCATCGGC 
GGCCTCGAGT TGACGGACGG GCGCGGGGCG GAGCGGGGCG GGGCGAGCGC GGGCCCGGCC 
AAGTCCCCGC CGTCCGCGCC CGGCGCCCGC AGCCCGAGCC GCACCCGCCG CGGACGGAGC 
CCATGCGCGG GCCCAGTCGG CGCCCGTCCG CGCCCCCGCC CTGCCCCGGC CCCGGCCCCG 
GGGGCAGTCG CGCCAGCAAG CGGTGGGGCA GGAGCTCCTG GTTTGGCAGC CCCTGTAGAA 
GCGATGACAG AATACAAGCT TGTGGTGGTG GGCGCTGGAG GCGTGGGAAA GAGTGCCCTG 
ACCATCCAGC TGATCCAGAA CCATTTTGTG GACGAGTATG ATCCCACTAT AGAGGACTCC 
TACCGGAAAC AGGTAGTCAT TGATGGGGAG ACGTGTTTAC TGGACATCTT AGACACAGCA 
GGTCAAGAAG AGTATAGTGC CATGCGGGAC CAGTACATGC GCACAGGGGA GGGCTTCCTC 
TGTGTATTTG CCATCAACAA CACCAAGTCC TTTGAAGACA TCCATCAGTA CAGGGAGCAG 
ATCAAGCGGG TGAAAGATTC AGATGATGTG CCAATGGTGC TGGTGGGCAA CAAGTGTGAC 
CTGGCCGCTC GCACTGTTGA GTCTCGGCAG GCCCAGGACC TTGCTCGCAG CTATGGCATC 
CCCTACATTG AAACATCAGC CAAGACCCGG CAGGGTGTGG AGGATGCCTT CTACACACTA 
GTACGTGAGA TTCGGCAGCA TAAACTGCGG AAACTGAACC CGCCTGATGA GAGTGGCCCT 
GGCTGCATGA GCTGCAAGTG TGTGCTGTCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006230597.3
CDS	19..891
Translation	MGCSANHNRWRWGGVRPIIGGLELTDGRGAERGGASAGPAKSPPSAPGARSPSRTRRGRSPCAGPVGARPRPRPAPAPAPGAVAPASGGAGAPGLAAPVEAMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS

Target ORF information:

RefSeq Version	XM_006230535.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Harvey rat sarcoma virus oncogene (Hras), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006230535.3

ORF Insert Sequence:

ATGGGTTGCT CAGCCAATCA TAACAGGTGG CGGTGGGGCG GAGTTCGACC AATCATCGGC 
GGCCTCGAGT TGACGGACGG GCGCGGGGCG GAGCGGGGCG GGGCGAGCGC GGGCCCGGCC 
AAGTCCCCGC CGTCCGCGCC CGGCGCCCGC AGCCCGAGCC GCACCCGCCG CGGACGGAGC 
CCATGCGCGG GCCCAGTCGG CGCCCGTCCG CGCCCCCGCC CTGCCCCGGC CCCGGCCCCG 
GGGGCAGTCG CGCCAGCAAG CGGTGGGGCA GGAGCTCCTG GTTTGGCAGC CCCTGTAGAA 
GCGATGACAG AATACAAGCT TGTGGTGGTG GGCGCTGGAG GCGTGGGAAA GAGTGCCCTG 
ACCATCCAGC TGATCCAGAA CCATTTTGTG GACGAGTATG ATCCCACTAT AGAGGACTCC 
TACCGGAAAC AGGTAGTCAT TGATGGGGAG ACGTGTTTAC TGGACATCTT AGACACAGCA 
GGTCAAGAAG AGTATAGTGC CATGCGGGAC CAGTACATGC GCACAGGGGA GGGCTTCCTC 
TGTGTATTTG CCATCAACAA CACCAAGTCC TTTGAAGACA TCCATCAGTA CAGGGAGCAG 
ATCAAGCGGG TGAAAGATTC AGATGATGTG CCAATGGTGC TGGTGGGCAA CAAGTGTGAC 
CTGGCCGCTC GCACTGTTGA GTCTCGGCAG GCCCAGGACC TTGCTCGCAG CTATGGCATC 
CCCTACATTG AAACATCAGC CAAGACCCGG CAGGGTGTGG AGGATGCCTT CTACACACTA 
GTACGTGAGA TTCGGCAGCA TAAACTGCGG AAACTGAACC CGCCTGATGA GAGTGGCCCT 
GGCTGCATGA GCTGCAAGTG TGTGCTGTCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Hras ( XM_017589006.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017444495.1 Rattus norvegicus Harvey rat sarcoma virus oncogene (Hras), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa56507
Clone ID Related Accession (Same CDS sequence)	XM_017589007.1 , XM_006230535.3 , XM_017589006.1
Accession Version	XM_017589006.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 873bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	GTPase HRas isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGTTGCT CAGCCAATCA TAACAGGTGG CGGTGGGGCG GAGTTCGACC AATCATCGGC 
GGCCTCGAGT TGACGGACGG GCGCGGGGCG GAGCGGGGCG GGGCGAGCGC GGGCCCGGCC 
AAGTCCCCGC CGTCCGCGCC CGGCGCCCGC AGCCCGAGCC GCACCCGCCG CGGACGGAGC 
CCATGCGCGG GCCCAGTCGG CGCCCGTCCG CGCCCCCGCC CTGCCCCGGC CCCGGCCCCG 
GGGGCAGTCG CGCCAGCAAG CGGTGGGGCA GGAGCTCCTG GTTTGGCAGC CCCTGTAGAA 
GCGATGACAG AATACAAGCT TGTGGTGGTG GGCGCTGGAG GCGTGGGAAA GAGTGCCCTG 
ACCATCCAGC TGATCCAGAA CCATTTTGTG GACGAGTATG ATCCCACTAT AGAGGACTCC 
TACCGGAAAC AGGTAGTCAT TGATGGGGAG ACGTGTTTAC TGGACATCTT AGACACAGCA 
GGTCAAGAAG AGTATAGTGC CATGCGGGAC CAGTACATGC GCACAGGGGA GGGCTTCCTC 
TGTGTATTTG CCATCAACAA CACCAAGTCC TTTGAAGACA TCCATCAGTA CAGGGAGCAG 
ATCAAGCGGG TGAAAGATTC AGATGATGTG CCAATGGTGC TGGTGGGCAA CAAGTGTGAC 
CTGGCCGCTC GCACTGTTGA GTCTCGGCAG GCCCAGGACC TTGCTCGCAG CTATGGCATC 
CCCTACATTG AAACATCAGC CAAGACCCGG CAGGGTGTGG AGGATGCCTT CTACACACTA 
GTACGTGAGA TTCGGCAGCA TAAACTGCGG AAACTGAACC CGCCTGATGA GAGTGGCCCT 
GGCTGCATGA GCTGCAAGTG TGTGCTGTCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017444495.1
CDS	19..891
Translation	MGCSANHNRWRWGGVRPIIGGLELTDGRGAERGGASAGPAKSPPSAPGARSPSRTRRGRSPCAGPVGARPRPRPAPAPAPGAVAPASGGAGAPGLAAPVEAMTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDLAARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPGCMSCKCVLS

Target ORF information:

RefSeq Version	XM_017589006.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus Harvey rat sarcoma virus oncogene (Hras), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017589006.1

ORF Insert Sequence:

ATGGGTTGCT CAGCCAATCA TAACAGGTGG CGGTGGGGCG GAGTTCGACC AATCATCGGC 
GGCCTCGAGT TGACGGACGG GCGCGGGGCG GAGCGGGGCG GGGCGAGCGC GGGCCCGGCC 
AAGTCCCCGC CGTCCGCGCC CGGCGCCCGC AGCCCGAGCC GCACCCGCCG CGGACGGAGC 
CCATGCGCGG GCCCAGTCGG CGCCCGTCCG CGCCCCCGCC CTGCCCCGGC CCCGGCCCCG 
GGGGCAGTCG CGCCAGCAAG CGGTGGGGCA GGAGCTCCTG GTTTGGCAGC CCCTGTAGAA 
GCGATGACAG AATACAAGCT TGTGGTGGTG GGCGCTGGAG GCGTGGGAAA GAGTGCCCTG 
ACCATCCAGC TGATCCAGAA CCATTTTGTG GACGAGTATG ATCCCACTAT AGAGGACTCC 
TACCGGAAAC AGGTAGTCAT TGATGGGGAG ACGTGTTTAC TGGACATCTT AGACACAGCA 
GGTCAAGAAG AGTATAGTGC CATGCGGGAC CAGTACATGC GCACAGGGGA GGGCTTCCTC 
TGTGTATTTG CCATCAACAA CACCAAGTCC TTTGAAGACA TCCATCAGTA CAGGGAGCAG 
ATCAAGCGGG TGAAAGATTC AGATGATGTG CCAATGGTGC TGGTGGGCAA CAAGTGTGAC 
CTGGCCGCTC GCACTGTTGA GTCTCGGCAG GCCCAGGACC TTGCTCGCAG CTATGGCATC 
CCCTACATTG AAACATCAGC CAAGACCCGG CAGGGTGTGG AGGATGCCTT CTACACACTA 
GTACGTGAGA TTCGGCAGCA TAAACTGCGG AAACTGAACC CGCCTGATGA GAGTGGCCCT 
GGCTGCATGA GCTGCAAGTG TGTGCTGTCC TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

H-Ras Isoform Mediates Protection Against Pressure Overload-Induced Cardiac Dysfunction in Part Through Activation of AKT.
Circulation. Heart failure10(2)(2017 Feb)
Matsuda T,Jeong JI,Ikeda S,Yamamoto T,Gao S,Babu GJ,Zhai P,Del Re DP

PATZ1 is a target of miR-29b that is induced by Ha-Ras oncogene in rat thyroid cells.
Scientific reports625268(2016 04)
Vitiello M,Valentino T,De Menna M,Crescenzi E,Francesca P,Rea D,Arra C,Fusco A,De Vita G,Cerchia L,Fedele M

Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers.
Biochemistry54(49)7212-21(2015 Dec)
Najumudeen AK,Posada IM,Lectez B,Zhou Y,Landor SK,Fallarero A,Vuorela P,Hancock J,Abankwa D

An attenuated phenotype of Costello syndrome in three unrelated individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates with uncommon functional consequences.
American journal of medical genetics. Part A167A(9)2085-97(2015 Sep)
Gripp KW,Sol-Church K,Smpokou P,Graham GE,Stevenson DA,Hanson H,Viskochil DH,Baker LC,Russo B,Gardner N,Stabley DL,Kolbe V,Rosenberger G

[Antiapoptotic gene bcl-2 prevents cellular senescence program reactivation induced by histone deacetylase inhibitor sodium butyrate in E1A and cHa-ras transformed rat fibroblasts].
Tsitologiia57(2)135-43(2015)
Gordeev SA,Bykova TV,Zubova SG,Aksenov ND,Pospelova TV

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Hras cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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