Fgf7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fgf7
Entrez Gene ID	29348
Full Name	fibroblast growth factor 7
Synonyms	KGF/FGF7,Kgf
General protein information	Preferred Names fibroblast growth factor 7 Names fibroblast growth factor 7 FGF-7 HBGF-7 Keratinocyte Growth Factor Fgf-7 heparin-binding growth factor 7
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q36
Summary	mediates glucocorticoid induction of fetal lung maturation; involved in regulation of surfactant synthesis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017591518.1	XP_017447007.1	fibroblast growth factor 7 isoform X1
XM_006234903.3	XP_006234965.1	fibroblast growth factor 7 isoform X1
NM_022182.1	NP_071518.1	fibroblast growth factor 7 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Fgf7	NP_071518.1
Danio rerio (zebrafish)	fgf7	NP_001007762.1
Xenopus tropicalis (tropical clawed frog)	fgf7	NP_001011366.1
	FGF7	XP_001113805.1
Canis lupus familiaris (dog)	FGF7	NP_001003237.1
Mus musculus (house mouse)	Fgf7	NP_032034.1
Pan troglodytes (chimpanzee)	FGF7	XP_001167319.1
Homo sapiens (human)	FGF7	NP_002000.1
Bos taurus (cattle)	FGF7	NP_001180060.1
Gallus gallus (chicken)	FGF7	NP_001012543.1

Gene Ontology
Bibliography

Related articles in PubMed

Biological roles of KGF, CTGF and TGF-? in cyclosporine-A- and phenytoin- induced gingival overgrowth: A comparative experimental animal study.
Al-Hamilly NS, Radwan LR, Abdul-Rahman M, Mourad MI, Grawish ME
Archives of oral biology6638-43(2016 Jun)

Mesenchymal stem cells ameliorate inflammatory?cytokine-induced impairment of AT-II?cells through a keratinocyte growth factor-dependent PI3K/Akt/mTOR signaling pathway.
Li J, Huang S, Zhang J, Feng C, Gao D, Yao B, Wu X, Fu X
Molecular medicine reports13(5)3755-62(2016 May)

Keratinocyte growth factor (KGF) gene therapy mediated by an attenuated form of Salmonella typhimurium ameliorates radiation induced pulmonary injury in rats.
Liu CJ, Ha XQ, Jiang JJ, Lv TD, Wu C
Journal of radiation research52(2)176-84(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The findings of the present study indicated that KGF, CTGF and TGF-beta have biological roles in progression of CsA- and PNT- induced GO. KGF plays a greater role in CsA- induced GO than in PNT- induced GO. Meanwhile, CTGF and TGF-beta play a role in PNT- induced GO greater than in CsA- induced GO.
Title: Biological roles of KGF, CTGF and TGF-? in cyclosporine-A- and phenytoin- induced gingival overgrowth: A comparative experimental animal study.

These data demonstrate that administration of MSCs to the inflammation-insulted AT-II cells may ameliorate the impairments through a KGF-dependent PI3K/AKT/mTOR signaling pathway.
Title: Mesenchymal stem cells ameliorate inflammatory?cytokine-induced impairment of AT-II?cells through a keratinocyte growth factor-dependent PI3K/Akt/mTOR signaling pathway.

The primary role of both KGF1 and FGF2 appeared to be in the proliferation and migration of keratinocytes
Title: Keratinocyte growth factor 1, fibroblast growth factor 2 and 10 in the healing tympanic membrane following perforation in rats.

KGF may have a role in ameliorating radiation-induced pulmonary injury in rats
Title: Keratinocyte growth factor (KGF) gene therapy mediated by an attenuated form of Salmonella typhimurium ameliorates radiation induced pulmonary injury in rats.

KGF promotes preadipocyte proliferation by an autocrine mechanism that involves activation of the PI3K/Akt signaling pathway
Title: Keratinocyte growth factor promotes preadipocyte proliferation via an autocrine mechanism.

The following Fgf7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fgf7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa05373	NM_022182.1 Latest version!	Rattus norvegicus fibroblast growth factor 7 (Fgf7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa26308	XM_006234903.3 Latest version!	Rattus norvegicus fibroblast growth factor 7 (Fgf7), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa26308	XM_017591518.1 Latest version!	Rattus norvegicus fibroblast growth factor 7 (Fgf7), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fgf7 ( NM_022182.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_071518.1 Rattus norvegicus fibroblast growth factor 7 (Fgf7), mRNA.

Price & Availability↑

CloneID	ORa05373
Clone ID Related Accession (Same CDS sequence)	NM_022182.1
Accession Version	NM_022182.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	fibroblast growth factor 7 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X56551.1. On Jan 12, 2005 this sequence version replaced XM_346672.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X56551.1, AF295300.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689595, SAMEA2689596 [ECO:0000348] ##Evidence-Data-END##

ATGCGCAAAT GGATACTGAC ACGGATCCTG CCGACTCCGC TCTACAGACC GTGCTTCCAC 
CTCGTCTGTC TTGTGGGCAC CATATCTTTA GCTTGCAATG ACATGAGTCC AGAGCAGACG 
GCCACGAGCG TGAACTGTTC TAGCCCCGAG CGACACACGA GAAGTTATGA CTACATGGAA 
GGAGGGGATA TAAGGGTGAG GAGACTGTTC TGTCGCACCC AGTGGTACCT GAGGATTGAC 
AAACGAGGCA AAGTGAAAGG GACCCAGGAG ATGAGGAACA GCTACAACAT CATGGAAATC 
ATGACTGTGG CAGTTGGAAT TGTGGCAATC AAAGGGGTGG AAAGTGAATA CTATCTTGCC 
ATGAACAAAC AAGGGGAACT CTATGCAAAG AAAGAATGCA ATGAGGATTG CAACTTCAAA 
GAACTGATTC TGGAAAACCA TTACAACACC TCTGCATCAG CTAAATGGAC ACACAGCGGA 
GGGGAAATGT TCGTGGCCTT AAATCAAAAG GGGCTTCCTG TCAAAGGGAA GAAAACGAAG 
AAAGAACAAA AAACGGCCCA CTTTCTTCCT ATGGCAATAA CTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071518.1
CDS	109..693
Translation	MRKWILTRILPTPLYRPCFHLVCLVGTISLACNDMSPEQTATSVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMRNSYNIMEIMTVAVGIVAIKGVESEYYLAMNKQGELYAKKECNEDCNFKELILENHYNTSASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT

Target ORF information:

RefSeq Version	NM_022182.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fibroblast growth factor 7 (Fgf7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022182.1

ORF Insert Sequence:

ATGCGCAAAT GGATACTGAC ACGGATCCTG CCGACTCCGC TCTACAGACC GTGCTTCCAC 
CTCGTCTGTC TTGTGGGCAC CATATCTTTA GCTTGCAATG ACATGAGTCC AGAGCAGACG 
GCCACGAGCG TGAACTGTTC TAGCCCCGAG CGACACACGA GAAGTTATGA CTACATGGAA 
GGAGGGGATA TAAGGGTGAG GAGACTGTTC TGTCGCACCC AGTGGTACCT GAGGATTGAC 
AAACGAGGCA AAGTGAAAGG GACCCAGGAG ATGAGGAACA GCTACAACAT CATGGAAATC 
ATGACTGTGG CAGTTGGAAT TGTGGCAATC AAAGGGGTGG AAAGTGAATA CTATCTTGCC 
ATGAACAAAC AAGGGGAACT CTATGCAAAG AAAGAATGCA ATGAGGATTG CAACTTCAAA 
GAACTGATTC TGGAAAACCA TTACAACACC TCTGCATCAG CTAAATGGAC ACACAGCGGA 
GGGGAAATGT TCGTGGCCTT AAATCAAAAG GGGCTTCCTG TCAAAGGGAA GAAAACGAAG 
AAAGAACAAA AAACGGCCCA CTTTCTTCCT ATGGCAATAA CTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fgf7 ( XM_017591518.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017447007.1 Rattus norvegicus fibroblast growth factor 7 (Fgf7), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa26308
Clone ID Related Accession (Same CDS sequence)	XM_017591518.1 , XM_006234903.3
Accession Version	XM_017591518.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	fibroblast growth factor 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGCAAAT GGATACTGAC ACGGATCCTG CCGACTCCGC TCTACAGATC GTGCTTCCAC 
CTCGTCTGTC TTGTGGGCAC CATATCTTTA GCTTGCAATG ACATGAGTCC AGAGCAGACG 
GCCACGAGCG TGAACTGTTC TAGCCCCGAG CGACACACGA GAAGTTATGA CTACATGGAA 
GGAGGGGATA TAAGGGTGAG GAGACTGTTC TGTCGCACCC AGTGGTACCT GAGGATTGAC 
AAACGAGGCA AAGTGAAAGG GACCCAGGAG ATGAGGAACA GCTACAACAT CATGGAAATC 
AGGACTGTGG CAGTTGGAAT TGTGGCAATC AAAGGGGTGG AAAGTGAATA CTATCTTGCC 
ATGAACAAAG AAGGGAAACT CTATGCAAAG AAAGAATGCA ATGAGGATTG CAACTTCAAA 
GAACTGATTC TGGAAAACCA TTACAACACC TATGCATCAG CTAAATGGAC ACACAGCGGA 
GGGGAAATGT TCGTGGCCTT AAATCAAAAG GGGCTTCCTG TCAAAGGGAA GAAAACGAAG 
AAAGAACAAA AAACGGCCCA TTTTCTTCCC ATGGCAATAA CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017447007.1
CDS	1739..2323
Translation	MRKWILTRILPTPLYRSCFHLVCLVGTISLACNDMSPEQTATSVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMRNSYNIMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT

Target ORF information:

RefSeq Version	XM_017591518.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fibroblast growth factor 7 (Fgf7), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017591518.1

ORF Insert Sequence:

ATGCGCAAAT GGATACTGAC ACGGATCCTG CCGACTCCGC TCTACAGATC GTGCTTCCAC 
CTCGTCTGTC TTGTGGGCAC CATATCTTTA GCTTGCAATG ACATGAGTCC AGAGCAGACG 
GCCACGAGCG TGAACTGTTC TAGCCCCGAG CGACACACGA GAAGTTATGA CTACATGGAA 
GGAGGGGATA TAAGGGTGAG GAGACTGTTC TGTCGCACCC AGTGGTACCT GAGGATTGAC 
AAACGAGGCA AAGTGAAAGG GACCCAGGAG ATGAGGAACA GCTACAACAT CATGGAAATC 
AGGACTGTGG CAGTTGGAAT TGTGGCAATC AAAGGGGTGG AAAGTGAATA CTATCTTGCC 
ATGAACAAAG AAGGGAAACT CTATGCAAAG AAAGAATGCA ATGAGGATTG CAACTTCAAA 
GAACTGATTC TGGAAAACCA TTACAACACC TATGCATCAG CTAAATGGAC ACACAGCGGA 
GGGGAAATGT TCGTGGCCTT AAATCAAAAG GGGCTTCCTG TCAAAGGGAA GAAAACGAAG 
AAAGAACAAA AAACGGCCCA TTTTCTTCCC ATGGCAATAA CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Fgf7 ( XM_006234903.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006234965.1 Rattus norvegicus fibroblast growth factor 7 (Fgf7), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa26308
Clone ID Related Accession (Same CDS sequence)	XM_017591518.1 , XM_006234903.3
Accession Version	XM_006234903.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 585bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	fibroblast growth factor 7 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006234903.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCGCAAAT GGATACTGAC ACGGATCCTG CCGACTCCGC TCTACAGATC GTGCTTCCAC 
CTCGTCTGTC TTGTGGGCAC CATATCTTTA GCTTGCAATG ACATGAGTCC AGAGCAGACG 
GCCACGAGCG TGAACTGTTC TAGCCCCGAG CGACACACGA GAAGTTATGA CTACATGGAA 
GGAGGGGATA TAAGGGTGAG GAGACTGTTC TGTCGCACCC AGTGGTACCT GAGGATTGAC 
AAACGAGGCA AAGTGAAAGG GACCCAGGAG ATGAGGAACA GCTACAACAT CATGGAAATC 
AGGACTGTGG CAGTTGGAAT TGTGGCAATC AAAGGGGTGG AAAGTGAATA CTATCTTGCC 
ATGAACAAAG AAGGGAAACT CTATGCAAAG AAAGAATGCA ATGAGGATTG CAACTTCAAA 
GAACTGATTC TGGAAAACCA TTACAACACC TATGCATCAG CTAAATGGAC ACACAGCGGA 
GGGGAAATGT TCGTGGCCTT AAATCAAAAG GGGCTTCCTG TCAAAGGGAA GAAAACGAAG 
AAAGAACAAA AAACGGCCCA TTTTCTTCCC ATGGCAATAA CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006234965.1
CDS	1426..2010
Translation	MRKWILTRILPTPLYRSCFHLVCLVGTISLACNDMSPEQTATSVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMRNSYNIMEIRTVAVGIVAIKGVESEYYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMAIT

Target ORF information:

RefSeq Version	XM_006234903.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus fibroblast growth factor 7 (Fgf7), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006234903.3

ORF Insert Sequence:

ATGCGCAAAT GGATACTGAC ACGGATCCTG CCGACTCCGC TCTACAGATC GTGCTTCCAC 
CTCGTCTGTC TTGTGGGCAC CATATCTTTA GCTTGCAATG ACATGAGTCC AGAGCAGACG 
GCCACGAGCG TGAACTGTTC TAGCCCCGAG CGACACACGA GAAGTTATGA CTACATGGAA 
GGAGGGGATA TAAGGGTGAG GAGACTGTTC TGTCGCACCC AGTGGTACCT GAGGATTGAC 
AAACGAGGCA AAGTGAAAGG GACCCAGGAG ATGAGGAACA GCTACAACAT CATGGAAATC 
AGGACTGTGG CAGTTGGAAT TGTGGCAATC AAAGGGGTGG AAAGTGAATA CTATCTTGCC 
ATGAACAAAG AAGGGAAACT CTATGCAAAG AAAGAATGCA ATGAGGATTG CAACTTCAAA 
GAACTGATTC TGGAAAACCA TTACAACACC TATGCATCAG CTAAATGGAC ACACAGCGGA 
GGGGAAATGT TCGTGGCCTT AAATCAAAAG GGGCTTCCTG TCAAAGGGAA GAAAACGAAG 
AAAGAACAAA AAACGGCCCA TTTTCTTCCC ATGGCAATAA CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Biological roles of KGF, CTGF and TGF-? in cyclosporine-A- and phenytoin- induced gingival overgrowth: A comparative experimental animal study.
Archives of oral biology6638-43(2016 Jun)
Al-Hamilly NS,Radwan LR,Abdul-Rahman M,Mourad MI,Grawish ME

Mesenchymal stem cells ameliorate inflammatory?cytokine-induced impairment of AT-II?cells through a keratinocyte growth factor-dependent PI3K/Akt/mTOR signaling pathway.
Molecular medicine reports13(5)3755-62(2016 May)
Li J,Huang S,Zhang J,Feng C,Gao D,Yao B,Wu X,Fu X

Keratinocyte growth factor (KGF) gene therapy mediated by an attenuated form of Salmonella typhimurium ameliorates radiation induced pulmonary injury in rats.
Journal of radiation research52(2)176-84(2011)
Liu CJ,Ha XQ,Jiang JJ,Lv TD,Wu C