Prdx2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Prdx2
Entrez Gene ID	29338
Full Name	peroxiredoxin 2
Synonyms	Tdpx1
General protein information	Preferred Names peroxiredoxin 2 Names peroxiredoxin-2 TSA thiol-specific antioxidant protein thioredoxin peroxidase 1 thioredoxin-dependent peroxide reductase 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19q11
Summary	protective enzyme against oxidative damage by cellular reactive sulfur species [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017169.1	NP_058865.1	peroxiredoxin-2
XM_006255244.1	XP_006255306.1	peroxiredoxin-2 isoform X1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Prdx2	NP_035693.3
Anopheles gambiae (African malaria mosquito)	TPX2	XP_308081.2
Arabidopsis thaliana (thale cress)	AT3G11630	NP_187769.1
Arabidopsis thaliana (thale cress)	2-Cys Prx B	NP_568166.1
Saccharomyces cerevisiae (baker's yeast)	TSA1	NP_013684.1
Pan troglodytes (chimpanzee)	PRDX2	XP_003953433.1
Bos taurus (cattle)	PRDX2	NP_777188.1
Schizosaccharomyces pombe (fission yeast)	tpx1	NP_588430.1
Homo sapiens (human)	PRDX2	NP_005800.3
Canis lupus familiaris (dog)	PRDX2	XP_003639771.1
Rattus norvegicus (Norway rat)	Prdx2	NP_058865.1
Danio rerio (zebrafish)	prdx2	NP_001002468.1
Drosophila melanogaster (fruit fly)	Jafrac1	NP_477510.1
Caenorhabditis elegans (roundworm)	prdx-2	NP_001122604.1
Oryza sativa (rice)	Os02g0537700	NP_001047050.1
Xenopus tropicalis (tropical clawed frog)	prdx2	NP_989001.1
	PRDX2	XP_001109216.1

Gene Ontology
Bibliography

Related articles in PubMed

Alterations in NO/ROS ratio and expression of Trx1 and Prdx2 in isoproterenol-induced cardiac hypertrophy.
Su H, Pistolozzi M, Shi X, Sun X, Tan W
Acta biochimica et biophysica Sinica49(11)1022-1028(2017 Nov)

Role of peroxiredoxin?2 in H2O2?induced oxidative stress of primary Leydig cells.
Duan T, Fan K, Chen S, Yao Q, Zeng R, Hong Z, Peng L, Shao Y, Yao B
Molecular medicine reports13(6)4807-13(2016 Jun)

Expression of peroxiredoxin 1, 2, and 6 in the rat brain during perinatal development and in response to dexamethasone.
Shim SY, Kim HS, Kim EK, Choi JH
Free radical research46(3)231-9(2012 Mar)

Downregulation of the antioxidant protein peroxiredoxin 2 contributes to angiotensin II-mediated podocyte apoptosis.
Hsu HH, Hoffmann S, Di Marco GS, Endlich N, Peter-Katalini? J, Weide T, Pavenst?dt H
Kidney international80(9)959-69(2011 Nov)

CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs.
Li W, Febbraio M, Reddy SP, Yu DY, Yamamoto M, Silverstein RL
The Journal of clinical investigation120(11)3996-4006(2010 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Prdx2 may prevent H2O2 accumulation in Leydig cells, and may be important in oxidative stressinduced apoptosis and decreased testosterone production.
Title: Role of peroxiredoxin?2 in H2O2?induced oxidative stress of primary Leydig cells.

Prdx 2 expression in perinatal rat brain remained largely unchanged.
Title: Expression of peroxiredoxin 1, 2, and 6 in the rat brain during perinatal development and in response to dexamethasone.

Peroxiredoxin 2 is an important modulator of angiotensin II-induced podocyte injury.
Title: Downregulation of the antioxidant protein peroxiredoxin 2 contributes to angiotensin II-mediated podocyte apoptosis.

Prx2 is implied in the regulation of hydrogen peroxide production in the bone marrow during aging.
Title: Proteomic analysis of interstitial fluid in bone marrow identified that peroxiredoxin 2 regulates H(2)O(2) level of bone marrow during aging.

peroxiredoxin II may be a unique antioxidant in the cardiac system and may represent a potential target for cardiac protection from oxidative stress-induced injury.
Title: Protection of peroxiredoxin II on oxidative stress-induced cardiomyocyte death and apoptosis.

The following Prdx2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prdx2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa38695	XM_006255244.1 Latest version!	Rattus norvegicus peroxiredoxin 2 (Prdx2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa12457	NM_017169.1 Latest version!	Rattus norvegicus peroxiredoxin 2 (Prdx2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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1 Clone	30% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Prdx2 ( XM_006255244.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006255306.1 Rattus norvegicus peroxiredoxin 2 (Prdx2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa38695
Clone ID Related Accession (Same CDS sequence)	XM_006255244.1
Accession Version	XM_006255244.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	peroxiredoxin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTCCG GCAACGCGCA CATCGGAAAG CCTGCCCCTG ACTTCACGGC CACCGCCGTG 
GTGGATGGTG CCTTTAAGGA AATCAAGCTT TCAGACTACA GAGGGAAGTA CGTGGTCCTC 
TTTTTCTATC CACTGGACTT CACTTTTGTT TGCCCCACGG AGATCATCGC TTTTAGCGAC 
CACGCTGAGG ACTTCCGAAA GCTAGGCTGC GAGGTGCTGG GAGTGTCTGT GGACTCTCAG 
TTCACCCACC TGGCCTGGAT CAATACCCCA CGGAAGGAGG GAGGCTTGGG CCCACTGAAT 
ATCCCTCTGC TTGCTGATGT GACTAAAAGC TTGTCCCAGA ATTACGGCGT GTTGAAAAAT 
GATGAGGGCA TCGCTTACAG GGGCCTCTTT ATCATCGATG CCAAGGGTGT CCTTCGCCAG 
ATCACAGTCA ACGACCTACC TGTGGGACGC TCTGTAGATG AGGCTCTCCG CCTCGTCCAG 
GCCTTTCAGT ATACAGATGA GCATGGGGAA GTCTGTCCTG CTGGCTGGAA GCCCGGCAGT 
GACACCATCA AACCCAATGT GGATGACAGC AAGGAATACT TCTCCAAACA CAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006255306.1
CDS	231..827
Translation	MASGNAHIGKPAPDFTATAVVDGAFKEIKLSDYRGKYVVLFFYPLDFTFVCPTEIIAFSDHAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTKSLSQNYGVLKNDEGIAYRGLFIIDAKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN

Target ORF information:

RefSeq Version	XM_006255244.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus peroxiredoxin 2 (Prdx2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006255244.1

ORF Insert Sequence:

ATGGCCTCCG GCAACGCGCA CATCGGAAAG CCTGCCCCTG ACTTCACGGC CACCGCCGTG 
GTGGATGGTG CCTTTAAGGA AATCAAGCTT TCAGACTACA GAGGGAAGTA CGTGGTCCTC 
TTTTTCTATC CACTGGACTT CACTTTTGTT TGCCCCACGG AGATCATCGC TTTTAGCGAC 
CACGCTGAGG ACTTCCGAAA GCTAGGCTGC GAGGTGCTGG GAGTGTCTGT GGACTCTCAG 
TTCACCCACC TGGCCTGGAT CAATACCCCA CGGAAGGAGG GAGGCTTGGG CCCACTGAAT 
ATCCCTCTGC TTGCTGATGT GACTAAAAGC TTGTCCCAGA ATTACGGCGT GTTGAAAAAT 
GATGAGGGCA TCGCTTACAG GGGCCTCTTT ATCATCGATG CCAAGGGTGT CCTTCGCCAG 
ATCACAGTCA ACGACCTACC TGTGGGACGC TCTGTAGATG AGGCTCTCCG CCTCGTCCAG 
GCCTTTCAGT ATACAGATGA GCATGGGGAA GTCTGTCCTG CTGGCTGGAA GCCCGGCAGT 
GACACCATCA AACCCAATGT GGATGACAGC AAGGAATACT TCTCCAAACA CAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Prdx2 ( NM_017169.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058865.1 Rattus norvegicus peroxiredoxin 2 (Prdx2), mRNA.

Price & Availability↑

CloneID	ORa12457
Clone ID Related Accession (Same CDS sequence)	NM_017169.1
Accession Version	NM_017169.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	peroxiredoxin-2
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U06099.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U06099.1, BC058481.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGCCTCCG GCAACGCGCA CATCGGAAAG CCTGCCCCTG ACTTCACGGG CACCGCCGTG 
GTGGATGGTG CCTTTAAGGA AATCAAGCTT TCAGACTACA GAGGGAAGTA CGTGGTCCTC 
TTTTTCTATC CACTGGACTT CACTTTTGTT TGCCCCACGG AGATCATCGC TTTTAGCGAC 
CACGCTGAGG ACTTCCGAAA GCTAGGCTGC GAGGTGCTGG GAGTGTCTGT GGACTCTCAG 
TTCACCCACC TGGCCTGGAT CAATACCCCA CGGAAGGAGG GAGGCTTGGG CCCACTGAAT 
ATCCCTCTGC TTGCTGATGT GACTAAAAGC TTGTCCCAGA ATTACGGCGT GTTGAAAAAT 
GATGAGGGCA TCGCTTACAG GGGCCTCTTT ATCATCGATG CCAAGGGTGT CCTTCGCCAG 
ATCACAGTCA ACGACCTACC TGTGGGACGC TCTGTAGATG AGGCTCTCCG CCTCGTCCAG 
GCCTTTCAGT ATACAGATGA GCATGGGGAA GTCTGTCCTG CTGGCTGGAA GCCCGGCAGT 
GACACCATCA AACCCAATGT GGATGACAGC AAGGAATACT TCTCCAAACA CAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058865.1
CDS	50..646
Translation	MASGNAHIGKPAPDFTGTAVVDGAFKEIKLSDYRGKYVVLFFYPLDFTFVCPTEIIAFSDHAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTKSLSQNYGVLKNDEGIAYRGLFIIDAKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN

Target ORF information:

RefSeq Version	NM_017169.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus peroxiredoxin 2 (Prdx2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017169.1

ORF Insert Sequence:

ATGGCCTCCG GCAACGCGCA CATCGGAAAG CCTGCCCCTG ACTTCACGGG CACCGCCGTG 
GTGGATGGTG CCTTTAAGGA AATCAAGCTT TCAGACTACA GAGGGAAGTA CGTGGTCCTC 
TTTTTCTATC CACTGGACTT CACTTTTGTT TGCCCCACGG AGATCATCGC TTTTAGCGAC 
CACGCTGAGG ACTTCCGAAA GCTAGGCTGC GAGGTGCTGG GAGTGTCTGT GGACTCTCAG 
TTCACCCACC TGGCCTGGAT CAATACCCCA CGGAAGGAGG GAGGCTTGGG CCCACTGAAT 
ATCCCTCTGC TTGCTGATGT GACTAAAAGC TTGTCCCAGA ATTACGGCGT GTTGAAAAAT 
GATGAGGGCA TCGCTTACAG GGGCCTCTTT ATCATCGATG CCAAGGGTGT CCTTCGCCAG 
ATCACAGTCA ACGACCTACC TGTGGGACGC TCTGTAGATG AGGCTCTCCG CCTCGTCCAG 
GCCTTTCAGT ATACAGATGA GCATGGGGAA GTCTGTCCTG CTGGCTGGAA GCCCGGCAGT 
GACACCATCA AACCCAATGT GGATGACAGC AAGGAATACT TCTCCAAACA CAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Alterations in NO/ROS ratio and expression of Trx1 and Prdx2 in isoproterenol-induced cardiac hypertrophy.
Acta biochimica et biophysica Sinica49(11)1022-1028(2017 Nov)
Su H,Pistolozzi M,Shi X,Sun X,Tan W

Role of peroxiredoxin?2 in H2O2?induced oxidative stress of primary Leydig cells.
Molecular medicine reports13(6)4807-13(2016 Jun)
Duan T,Fan K,Chen S,Yao Q,Zeng R,Hong Z,Peng L,Shao Y,Yao B

Expression of peroxiredoxin 1, 2, and 6 in the rat brain during perinatal development and in response to dexamethasone.
Free radical research46(3)231-9(2012 Mar)
Shim SY,Kim HS,Kim EK,Choi JH

Downregulation of the antioxidant protein peroxiredoxin 2 contributes to angiotensin II-mediated podocyte apoptosis.
Kidney international80(9)959-69(2011 Nov)
Hsu HH,Hoffmann S,Di Marco GS,Endlich N,Peter-Katalini? J,Weide T,Pavenst?dt H

CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs.
The Journal of clinical investigation120(11)3996-4006(2010 Nov)
Li W,Febbraio M,Reddy SP,Yu DY,Yamamoto M,Silverstein RL