Stmn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Stmn1
Entrez Gene ID	29332
Full Name	stathmin 1
Synonyms	Lap18,OP18,PP17,PP19,PR22,SMN,prosolin
General protein information	Preferred Names stathmin 1 Names stathmin leukemia-associated cytosolic phosphoprotein stathmin leukemia-associated phosphoprotein p18 metablastin oncoprotein 18 phosphoprotein p19
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 5 Map Location: 5q36
Summary	may promote microtubule depolymerization; may act as a signaling relay phosphoprotein for second messenger signaling pathways involved in cell proliferation and differentiation [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006239123.3	XP_006239185.1	stathmin isoform X1
XM_017593202.1	XP_017448691.1	stathmin isoform X1
NM_017166.1	NP_058862.1	stathmin

Pathways from BioSystems

Homologies

Bos taurus (cattle)	STMN1	NP_001029962.1
Homo sapiens (human)	STMN1	NP_981944.1
	STMN1	XP_001114361.2
Mus musculus (house mouse)	Stmn1	NP_062615.1
Rattus norvegicus (Norway rat)	Stmn1	NP_058862.1
Danio rerio (zebrafish)	stmn1b	NP_001017850.1
Pan troglodytes (chimpanzee)	STMN1	XP_003949375.1
Canis lupus familiaris (dog)	STMN1	XP_866126.1
Gallus gallus (chicken)	STMN1	NP_001001858.1
Xenopus tropicalis (tropical clawed frog)	stmn1	NP_001007972.1
Danio rerio (zebrafish)	stmn1a	NP_001035465.1

Gene Ontology
Bibliography

Related articles in PubMed

Stathmin is enriched in the developing corticospinal tract.
Fuller HR, Slade R, Jovanov-Milo?evi? N, Babi? M, Sedmak G, ?imi? G, Fuszard MA, Shirran SL, Botting CH, Gates MA
Molecular and cellular neurosciences6912-21(2015 Nov)

Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis.
Menon MB, Sawada A, Chaturvedi A, Mishra P, Schuster-Gossler K, Galla M, Schambach A, Gossler A, F?rster R, Heuser M, Kotlyarov A, Kinoshita M, Gaestel M
PLoS genetics10(8)e1004558(2014 Aug)

Microtubule dynamics control HGF-induced lung endothelial barrier enhancement.
Tian X, Tian Y, Moldobaeva N, Sarich N, Birukova AA
PloS one9(9)e105912(2014)

cAMP-dependent protein kinase and c-Jun N-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress.
Yip YY, Yeap YY, Bogoyevitch MA, Ng DC
The Journal of biological chemistry289(4)2157-69(2014 Jan)

Stathmin mediates hepatocyte resistance to death from oxidative stress by down regulating JNK.
Zhao E, Amir M, Lin Y, Czaja MJ
PloS one9(10)e109750(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Stathmin is enriched in the developing corticospinal tract
Title: Stathmin is enriched in the developing corticospinal tract.

JNK- and PKA-mediated STMN Ser-38 and Ser-63 phosphorylation are required to preserve interphase microtubules in response to hyperosmotic stress.
Title: cAMP-dependent protein kinase and c-Jun N-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress.

Stathmin therefore mediates hepatocyte resistance to death from oxidative stress by down regulating JNK and maintaining mitochondrial integrity
Title: Stathmin mediates hepatocyte resistance to death from oxidative stress by down regulating JNK.

Stathmin 1 expression was decreased in the experimental animals from 1 to 14 days postseizure and then significantly increased at Days 30 and 60.
Title: Abnormal expression of stathmin 1 in brain tissue of patients with intractable temporal lobe epilepsy and a rat model.

role of stathmin 1 in FcRI-mediated activation of cells of mast cell lineage and might shed light on the diverse response of these cells to IgE or IgE plus antigen.
Title: A novel insight to the functional role of Stathmin 1 in IgE-mediated activation of RBL-2H3 cells.

The following Stmn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Stmn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa28729	XM_006239123.3 Latest version!	Rattus norvegicus stathmin 1 (Stmn1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa28729	XM_017593202.1 Latest version!	Rattus norvegicus stathmin 1 (Stmn1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa12655	NM_017166.1 Latest version!	Rattus norvegicus stathmin 1 (Stmn1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Stmn1 ( XM_006239123.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006239185.1 Rattus norvegicus stathmin 1 (Stmn1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa28729
Clone ID Related Accession (Same CDS sequence)	XM_006239123.3 , XM_017593202.1
Accession Version	XM_006239123.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 450bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	stathmin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006239123.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCATCTT CTGATATTCA GGTGAAAGAG CTGGAGAAGC GTGCTTCCGG CCAGGCTTTT 
GAGCTGATTC TCAGCCCTCG ATCAAAAGAA TCTGTCCCCG AGTTCCCCCT TTCCCCCCCA 
AAGAAGAAGG ATCTTTCCCT GGAGGAAATT CAGAAGAAAT TAGAAGCTGC AGAAGAAAGA 
CGCAAGTCTC ATGAAGCAGA AGTCTTGAAG CAGCTCGCTG AGAAGCGGGA GCATGAAAAA 
GAAGTGCTCC AGAAAGCCAT TGAGGAGAAC AACAACTTCA GCAAAATGGC AGAGGAGAAA 
CTGACCCACA AAATGGAGGC TAACAAAGAG AACCGGGAGG CGCAAATGGC TGCCAAGCTG 
GAGCGTTTGC GAGAGAAGGA CAAGCACGTT GAAGAGGTGC GGAAGAACAA AGAATCCAAA 
GACCCCGCGG ACGAGACCGA GGCTGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006239185.1
CDS	165..614
Translation	MASSDIQVKELEKRASGQAFELILSPRSKESVPEFPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKLERLREKDKHVEEVRKNKESKDPADETEAD

Target ORF information:

RefSeq Version	XM_006239123.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus stathmin 1 (Stmn1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006239123.3

ORF Insert Sequence:

ATGGCATCTT CTGATATTCA GGTGAAAGAG CTGGAGAAGC GTGCTTCCGG CCAGGCTTTT 
GAGCTGATTC TCAGCCCTCG ATCAAAAGAA TCTGTCCCCG AGTTCCCCCT TTCCCCCCCA 
AAGAAGAAGG ATCTTTCCCT GGAGGAAATT CAGAAGAAAT TAGAAGCTGC AGAAGAAAGA 
CGCAAGTCTC ATGAAGCAGA AGTCTTGAAG CAGCTCGCTG AGAAGCGGGA GCATGAAAAA 
GAAGTGCTCC AGAAAGCCAT TGAGGAGAAC AACAACTTCA GCAAAATGGC AGAGGAGAAA 
CTGACCCACA AAATGGAGGC TAACAAAGAG AACCGGGAGG CGCAAATGGC TGCCAAGCTG 
GAGCGTTTGC GAGAGAAGGA CAAGCACGTT GAAGAGGTGC GGAAGAACAA AGAATCCAAA 
GACCCCGCGG ACGAGACCGA GGCTGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Stmn1 ( XM_017593202.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017448691.1 Rattus norvegicus stathmin 1 (Stmn1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa28729
Clone ID Related Accession (Same CDS sequence)	XM_006239123.3 , XM_017593202.1
Accession Version	XM_017593202.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 450bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	stathmin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005104.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCATCTT CTGATATTCA GGTGAAAGAG CTGGAGAAGC GTGCTTCCGG CCAGGCTTTT 
GAGCTGATTC TCAGCCCTCG ATCAAAAGAA TCTGTCCCCG AGTTCCCCCT TTCCCCCCCA 
AAGAAGAAGG ATCTTTCCCT GGAGGAAATT CAGAAGAAAT TAGAAGCTGC AGAAGAAAGA 
CGCAAGTCTC ATGAAGCAGA AGTCTTGAAG CAGCTCGCTG AGAAGCGGGA GCATGAAAAA 
GAAGTGCTCC AGAAAGCCAT TGAGGAGAAC AACAACTTCA GCAAAATGGC AGAGGAGAAA 
CTGACCCACA AAATGGAGGC TAACAAAGAG AACCGGGAGG CGCAAATGGC TGCCAAGCTG 
GAGCGTTTGC GAGAGAAGGA CAAGCACGTT GAAGAGGTGC GGAAGAACAA AGAATCCAAA 
GACCCCGCGG ACGAGACCGA GGCTGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017448691.1
CDS	179..628
Translation	MASSDIQVKELEKRASGQAFELILSPRSKESVPEFPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKLERLREKDKHVEEVRKNKESKDPADETEAD

Target ORF information:

RefSeq Version	XM_017593202.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus stathmin 1 (Stmn1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017593202.1

ORF Insert Sequence:

ATGGCATCTT CTGATATTCA GGTGAAAGAG CTGGAGAAGC GTGCTTCCGG CCAGGCTTTT 
GAGCTGATTC TCAGCCCTCG ATCAAAAGAA TCTGTCCCCG AGTTCCCCCT TTCCCCCCCA 
AAGAAGAAGG ATCTTTCCCT GGAGGAAATT CAGAAGAAAT TAGAAGCTGC AGAAGAAAGA 
CGCAAGTCTC ATGAAGCAGA AGTCTTGAAG CAGCTCGCTG AGAAGCGGGA GCATGAAAAA 
GAAGTGCTCC AGAAAGCCAT TGAGGAGAAC AACAACTTCA GCAAAATGGC AGAGGAGAAA 
CTGACCCACA AAATGGAGGC TAACAAAGAG AACCGGGAGG CGCAAATGGC TGCCAAGCTG 
GAGCGTTTGC GAGAGAAGGA CAAGCACGTT GAAGAGGTGC GGAAGAACAA AGAATCCAAA 
GACCCCGCGG ACGAGACCGA GGCTGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Stmn1 ( NM_017166.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058862.1 Rattus norvegicus stathmin 1 (Stmn1), mRNA.

Price & Availability↑

CloneID	ORa12655
Clone ID Related Accession (Same CDS sequence)	NM_017166.1
Accession Version	NM_017166.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 450bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	stathmin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from J04979.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J04979.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMEA2689605 [ECO:0000348] ##Evidence-Data-END##

ATGGCATCTT CTGATATTCA GGTGAAAGAG CTGGAGAAGC GAGCTTCCGG CCAGGCTTTT 
GAGCTGATTC TCAGCCCTCG ATCAAAAGAA TCTGTCCCCG AGTTCCCCCT TTCCCCCCCA 
AAGAAGAAGG ATCTTTCCCT GGAGGAAATT CAGAAGAAAT TAGAAGCTGC AGAAGAAAGA 
CGCAAGTCTC ATGAAGCAGA AGTCTTGAAG CAGCTCGCTG AGAAGCGGGA GCATGAAAAA 
GAAGTGCTCC AGAAAGCCAT TGAGGAGAAC AACAACTTCA GCAAAATGGC AGAGGAGAAA 
CTGACCCACA AAATGGAGGC TAACAAAGAG AACCGGGAGG CGCAAATGGC TGCCAAGCTG 
GAGCGTTTGC GAGAGAAGGA CAAGCACGTT GAAGAGGTGC GGAAGAACAA AGAATCCAAA 
GACCCCGCGG ACGAGACCGA GGCTGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058862.1
CDS	169..618
Translation	MASSDIQVKELEKRASGQAFELILSPRSKESVPEFPLSPPKKKDLSLEEIQKKLEAAEERRKSHEAEVLKQLAEKREHEKEVLQKAIEENNNFSKMAEEKLTHKMEANKENREAQMAAKLERLREKDKHVEEVRKNKESKDPADETEAD

Target ORF information:

RefSeq Version	NM_017166.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus stathmin 1 (Stmn1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017166.1

ORF Insert Sequence:

ATGGCATCTT CTGATATTCA GGTGAAAGAG CTGGAGAAGC GAGCTTCCGG CCAGGCTTTT 
GAGCTGATTC TCAGCCCTCG ATCAAAAGAA TCTGTCCCCG AGTTCCCCCT TTCCCCCCCA 
AAGAAGAAGG ATCTTTCCCT GGAGGAAATT CAGAAGAAAT TAGAAGCTGC AGAAGAAAGA 
CGCAAGTCTC ATGAAGCAGA AGTCTTGAAG CAGCTCGCTG AGAAGCGGGA GCATGAAAAA 
GAAGTGCTCC AGAAAGCCAT TGAGGAGAAC AACAACTTCA GCAAAATGGC AGAGGAGAAA 
CTGACCCACA AAATGGAGGC TAACAAAGAG AACCGGGAGG CGCAAATGGC TGCCAAGCTG 
GAGCGTTTGC GAGAGAAGGA CAAGCACGTT GAAGAGGTGC GGAAGAACAA AGAATCCAAA 
GACCCCGCGG ACGAGACCGA GGCTGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Stathmin is enriched in the developing corticospinal tract.
Molecular and cellular neurosciences6912-21(2015 Nov)
Fuller HR,Slade R,Jovanov-Milo?evi? N,Babi? M,Sedmak G,?imi? G,Fuszard MA,Shirran SL,Botting CH,Gates MA

Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis.
PLoS genetics10(8)e1004558(2014 Aug)
Menon MB,Sawada A,Chaturvedi A,Mishra P,Schuster-Gossler K,Galla M,Schambach A,Gossler A,F?rster R,Heuser M,Kotlyarov A,Kinoshita M,Gaestel M

Microtubule dynamics control HGF-induced lung endothelial barrier enhancement.
PloS one9(9)e105912(2014)
Tian X,Tian Y,Moldobaeva N,Sarich N,Birukova AA

cAMP-dependent protein kinase and c-Jun N-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress.
The Journal of biological chemistry289(4)2157-69(2014 Jan)
Yip YY,Yeap YY,Bogoyevitch MA,Ng DC

Stathmin mediates hepatocyte resistance to death from oxidative stress by down regulating JNK.
PloS one9(10)e109750(2014)
Zhao E,Amir M,Lin Y,Czaja MJ

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Stmn1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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