Adora2b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Adora2b
Entrez Gene ID	29316
Full Name	adenosine A2B receptor
General protein information	Preferred Names adenosine A2B receptor Names adenosine receptor A2b
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q23
Summary	regulates renal medulla blood flow and sodium excretion; involved in angiogenesis and blood vessel remodeling after injury [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017161.1	NP_058857.1	adenosine receptor A2b

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Adora2b	NP_031439.2
Rattus norvegicus (Norway rat)	Adora2b	NP_058857.1
Homo sapiens (human)	ADORA2B	NP_000667.1
	ADORA2B	XP_001088484.2
Danio rerio (zebrafish)	adora2b	NP_001034902.1
Pan troglodytes (chimpanzee)	ADORA2B	XP_511779.2
Canis lupus familiaris (dog)	ADORA2B	NP_001002944.1
Gallus gallus (chicken)	ADORA2B	NP_990418.1
Bos taurus (cattle)	ADORA2B	NP_001069393.1
Xenopus tropicalis (tropical clawed frog)	adora2b	XP_002938969.1

Gene Ontology
Bibliography

Related articles in PubMed

Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia.
Densmore JC, Schaid TR, Jeziorczak PM, Medhora M, Audi S, Nayak S, Auchampach J, Dwinell MR, Geurts AM, Jacobs ER
Experimental lung research43(1)38-48(2017 Feb)

Adenosine A2A and A2B Receptor Substantially Attenuate Ischemia/Reperfusion Injury in Septic rat Hearts.
Busse H, Bitzinger D, H?cherl K, Seyfried T, Gruber M, Graf BM, Zausig YA
Cardiovascular drugs and therapy30(6)551-558(2016 Dec)

Adenosine Signaling Increases Proinflammatory and Profibrotic Mediators through Activation of a Functional Adenosine 2B Receptor in Renal Fibroblasts.
Wilkinson PF, Farrell FX, Morel D, Law W, Murphy S
Annals of clinical and laboratory science46(4)339-45(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Increased A2BAR and adenosine following unilateral lung ischemia as well as more ronchiolitis obliterans organizing pneumonia in A2BAR mutant rats implicate a protective role for A2BAR signaling in countering ischemic lung injury
Title: Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia.

Our results suggest for the first time that septic hearts are more or less cardioprotected, the adenosine receptors AdorA2a and AdorA2b play predominant role for a reduced morphological and functional I/R injury in the septic heart.
Title: Adenosine A2A and A2B Receptor Substantially Attenuate Ischemia/Reperfusion Injury in Septic rat Hearts.

renal fibroblasts express a functional AR1 receptor that inhibits cyclic AMP (cAMP) upon stimulation, leading to a functional AR2B receptor that increases cAMP upon stimulation.
Title: Adenosine Signaling Increases Proinflammatory and Profibrotic Mediators through Activation of a Functional Adenosine 2B Receptor in Renal Fibroblasts.

Our data indicate varying roles for A(2B)AR signaling in regulating blood pressure in SS rats
Title: Characterization of Dahl salt-sensitive rats with genetic disruption of the A2B adenosine receptor gene: implications for A2B adenosine receptor signaling during hypertension.

A2B receptors are downregulated during aging, leading to a reduced adenosine-mediated detrusor relaxation.
Title: Age-related decrease of adenosine-mediated relaxation in rat detrusor is a result of A2B receptor downregulation.

The following Adora2b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Adora2b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12539	NM_017161.1 Latest version!	Rattus norvegicus adenosine A2B receptor (Adora2b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Adora2b ( NM_017161.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058857.1 Rattus norvegicus adenosine A2B receptor (Adora2b), mRNA.

Price & Availability↑

CloneID	ORa12539
Clone ID Related Accession (Same CDS sequence)	NM_017161.1
Accession Version	NM_017161.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	adenosine receptor A2b
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M91466.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M91466.1, EV762265.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCAGCTAG AGACGCAGGA CGCGCTGTAC GTGGCGCTGG AGCTGGTTAT CGCCGCGCTG 
GCAGTGGCGG GCAACGTGCT GGTGTGCGCT GCGGTGGGAG CCTCGAGTGC TTTACAGACC 
CCCACCAACT ACTTTCTGGT GTCCCTGGCG ACGGCGGACG TGGCTGTGGG ACTCTTCGCC 
ATCCCCTTTG CCATCACCAT CAGCCTGGGC TTCTGCACGG ACTTTCACAG CTGCCTCTTC 
CTCGCCTGCT TCGTGCTGGT GCTCACACAG AGCTCCATCT TTAGCCTCTT GGCGGTGGCT 
GTCGACCGGT ATCTGGCCAT TCGCGTCCCG CTCAGGTATA AAGGTTTGGT CACTGGAACA 
CGAGCAAGAG GGATCATCGC TGTCCTCTGG GTCCTTGCCT TTGGCATTGG ACTGACTCCT 
TTCCTGGGTT GGAACAGTAA AGACCGTGCC ACCAGCAACT GCACAGAACC TGGGGATGGC 
ATCACGAATA AGAGCTGCTG CCCTGTGAAG TGTCTCTTTG AGAACGTAGT TCCCATGAGC 
TACATGGTTT ATTTCAACTT CTTTGGGTGT GTCCTTCCTC CACTGCTCAT CATGATGGTG 
ATCTACATCA AAATCTTCAT GGTGGCCTGC AAGCAGCTTC AGCACATGGA ACTGATGGAG 
CACTCCAGGA CCACGCTGCA GCGGGAGATC CACGCGGCCA AGTCACTGGC TATGATTGTG 
GGCATCTTTG CTCTGTGTTG GCTCCCCGTG CATGCCATCA ACTGCATCAC CCTCTTCCAT 
CCAGCCCTGG CCAAGGACAA GCCCAAATGG GTGATGAATG TGGCCATCCT CCTGTCACAC 
GCCAATTCAG TTGTCAATCC CATTGTCTAT GCCTACAGGA ACCGGGACTT CCGCTACAGT 
TTCCACAGGA TCATCTCCAG ATACGTTCTC TGCCAGACGG ACACCAAGGG TGGGAGCGGG 
CAGGCCGGGG GACAGTCAAC TTTCAGTCTG AGCTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058857.1
CDS	108..1106
Translation	MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAITISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGTRARGIIAVLWVLAFGIGLTPFLGWNSKDRATSNCTEPGDGITNKSCCPVKCLFENVVPMSYMVYFNFFGCVLPPLLIMMVIYIKIFMVACKQLQHMELMEHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAINCITLFHPALAKDKPKWVMNVAILLSHANSVVNPIVYAYRNRDFRYSFHRIISRYVLCQTDTKGGSGQAGGQSTFSLSL

Target ORF information:

RefSeq Version	NM_017161.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus adenosine A2B receptor (Adora2b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017161.1

ORF Insert Sequence:

ATGCAGCTAG AGACGCAGGA CGCGCTGTAC GTGGCGCTGG AGCTGGTTAT CGCCGCGCTG 
GCAGTGGCGG GCAACGTGCT GGTGTGCGCT GCGGTGGGAG CCTCGAGTGC TTTACAGACC 
CCCACCAACT ACTTTCTGGT GTCCCTGGCG ACGGCGGACG TGGCTGTGGG ACTCTTCGCC 
ATCCCCTTTG CCATCACCAT CAGCCTGGGC TTCTGCACGG ACTTTCACAG CTGCCTCTTC 
CTCGCCTGCT TCGTGCTGGT GCTCACACAG AGCTCCATCT TTAGCCTCTT GGCGGTGGCT 
GTCGACCGGT ATCTGGCCAT TCGCGTCCCG CTCAGGTATA AAGGTTTGGT CACTGGAACA 
CGAGCAAGAG GGATCATCGC TGTCCTCTGG GTCCTTGCCT TTGGCATTGG ACTGACTCCT 
TTCCTGGGTT GGAACAGTAA AGACCGTGCC ACCAGCAACT GCACAGAACC TGGGGATGGC 
ATCACGAATA AGAGCTGCTG CCCTGTGAAG TGTCTCTTTG AGAACGTAGT TCCCATGAGC 
TACATGGTTT ATTTCAACTT CTTTGGGTGT GTCCTTCCTC CACTGCTCAT CATGATGGTG 
ATCTACATCA AAATCTTCAT GGTGGCCTGC AAGCAGCTTC AGCACATGGA ACTGATGGAG 
CACTCCAGGA CCACGCTGCA GCGGGAGATC CACGCGGCCA AGTCACTGGC TATGATTGTG 
GGCATCTTTG CTCTGTGTTG GCTCCCCGTG CATGCCATCA ACTGCATCAC CCTCTTCCAT 
CCAGCCCTGG CCAAGGACAA GCCCAAATGG GTGATGAATG TGGCCATCCT CCTGTCACAC 
GCCAATTCAG TTGTCAATCC CATTGTCTAT GCCTACAGGA ACCGGGACTT CCGCTACAGT 
TTCCACAGGA TCATCTCCAG ATACGTTCTC TGCCAGACGG ACACCAAGGG TGGGAGCGGG 
CAGGCCGGGG GACAGTCAAC TTTCAGTCTG AGCTTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia.
Experimental lung research43(1)38-48(2017 Feb)
Densmore JC,Schaid TR,Jeziorczak PM,Medhora M,Audi S,Nayak S,Auchampach J,Dwinell MR,Geurts AM,Jacobs ER

Adenosine A2A and A2B Receptor Substantially Attenuate Ischemia/Reperfusion Injury in Septic rat Hearts.
Cardiovascular drugs and therapy30(6)551-558(2016 Dec)
Busse H,Bitzinger D,H?cherl K,Seyfried T,Gruber M,Graf BM,Zausig YA

Adenosine Signaling Increases Proinflammatory and Profibrotic Mediators through Activation of a Functional Adenosine 2B Receptor in Renal Fibroblasts.
Annals of clinical and laboratory science46(4)339-45(2016 Jul)
Wilkinson PF,Farrell FX,Morel D,Law W,Murphy S

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Adora2b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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