Prcp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Prcp
Entrez Gene ID	293118
Full Name	prolylcarboxypeptidase
General protein information	Preferred Names prolylcarboxypeptidase Names lysosomal Pro-X carboxypeptidase prolylcarboxypeptidase (angiotensinase C)
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q32

mRNA and Protein(s)

mRNA	Protein	Name
NM_001106281.2	NP_001099751.2	lysosomal Pro-X carboxypeptidase precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PRCP	XP_001175153.1
	PRCP	XP_001096750.1
Mus musculus (house mouse)	Prcp	NP_082519.1
Rattus norvegicus (Norway rat)	Prcp	NP_001099751.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000994	XP_309189.4
Oryza sativa (rice)	Os01g0767100	NP_001044360.1
Xenopus tropicalis (tropical clawed frog)	prcp	NP_001072639.1
Canis lupus familiaris (dog)	PRCP	XP_533994.2
Danio rerio (zebrafish)	prcp	NP_001002694.1
Homo sapiens (human)	PRCP	NP_005031.1
Bos taurus (cattle)	PRCP	NP_001033253.1
Gallus gallus (chicken)	PRCP	XP_425654.3
Drosophila melanogaster (fruit fly)	CG2493	NP_610037.1
Caenorhabditis elegans (roundworm)	pcp-5	NP_498718.1
Arabidopsis thaliana (thale cress)	AT5G65760	NP_201377.2

Gene Ontology
Bibliography

Related articles in PubMed

Angiotensinase C mRNA and Protein Downregulations Are Involved in Ethanol-Deteriorated Left Ventricular Systolic Dysfunction in Spontaneously Hypertensive Rats.
Liu J, Hakucho A, Fujimiya T
BioMed research international2015409350(2015)

Deficient prolylcarboxypeptidase gene and protein expression in left ventricles of spontaneously hypertensive rats (SHR).
Marangoni RA, Santos RA, Piccolo C
Peptides6169-74(2014 Nov)

Relationship of angiotensinase and vasopressinase activities between hypothalamus, heart, and plasma in L-NAME-treated WKY and SHR.
Villarejo AB, Prieto I, Segarra AB, Banegas I, Wangensteen R, Vives F, de Gasparo M, Ram?rez-S?nchez M
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme46(8)561-7(2014 Jul)

Prolylcarboxypeptidase promotes angiogenesis and vascular repair.
Adams GN, Stavrou EX, Fang C, Merkulova A, Alaiti MA, Nakajima K, Morooka T, Merkulov S, Larusch GA, Simon DI, Jain MK, Schmaier AH
Blood122(8)1522-31(2013 Aug)

Deletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesity.
Jeong JK, Szabo G, Raso GM, Meli R, Diano S
American journal of physiology. Endocrinology and metabolism302(12)E1502-10(2012 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

chronic ethanol regimen is sufficient to promote the enhanced RAS activity-induced decrease in the production of cardiac collagen via downregulated angiotensinase C, leading to the further deterioration of LV systolic dysfunction in SHRs
Title: Angiotensinase C mRNA and Protein Downregulations Are Involved in Ethanol-Deteriorated Left Ventricular Systolic Dysfunction in Spontaneously Hypertensive Rats.

it appears unlikely that PRCP function is regulated by the renin-angiotensin system or by afterload conditions.
Title: Deficient prolylcarboxypeptidase gene and protein expression in left ventricles of spontaneously hypertensive rats (SHR).

eNOS inhibition in spontaneously hypertensive rats induces or enhances an inverse reciprocal interaction between hypothalamus and left ventricle involving the renin-angiotensin system and vasopressin.
Title: Relationship of angiotensinase and vasopressinase activities between hypothalamus, heart, and plasma in L-NAME-treated WKY and SHR.

PRCP is an important component of melanocortin signaling and weight maintenance via control of active alpha-MSH1-13 levels.
Title: Prolylcarboxypeptidase regulates food intake by inactivating alpha-MSH in rodents.

Suggest that in renovascular hypertension the repression of increases in systolic blood pressure and reversal of mesenteric artery remodelling by rutaecarpine may be related to increased expression of PRCP.
Title: Involvement of prolylcarboxypeptidase in the effect of rutaecarpine on the regression of mesenteric artery hypertrophy in renovascular hypertensive rats.

The following Prcp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Prcp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04541	NM_001106281.2 Latest version!	Rattus norvegicus prolylcarboxypeptidase (Prcp), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Prcp ( NM_001106281.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099751.2 Rattus norvegicus prolylcarboxypeptidase (Prcp), mRNA.

Price & Availability↑

CloneID	ORa04541
Clone ID Related Accession (Same CDS sequence)	NM_001106281.2
Accession Version	NM_001106281.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-27
Organism	Rattus norvegicus(Norway rat)
Product	lysosomal Pro-X carboxypeptidase precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07004794.1 and AABR07004795.1. On Jan 24, 2008 this sequence version replaced NM_001106281.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCTGCT GGGCTCTCCT GCTCCTGCCT TTTCTATCAC TCGGGGCCGC CACAACCATC 
CGGCCTAGGC TAAAGACCCT CGGCAGCCCG CACTTGTCAA CTAACACACC CGACCCTGCT 
GTACCCAGTA GCTACTCAGT TCATTACTTC CAACAGAAGG TTGACCACTT TGGGTTTTCT 
GACACAAGAA CTTTTAAGCA GCGGTACCTA GTAGCTGATA AACACTGGCA GAGAAATGGT 
GGATCTATAC TTTTCTACAC TGGAAATGAA GGGGACATTG TCTGGTTTTG TAATAATACG 
GGGTTCATGT GGGATGTGGC CGAGGAGCTG AAAGCTATGC TGGTGTTTGC TGAGCATCGA 
TACTATGGGA AGTCCCTTCC CTTCGGTCGG GACTCCTTCA AGGATTCCCA ACATTTGAAT 
TTCCTGACAT CAGAACAGGC TCTGGCTGAT TTTGCAGAGT TAATCAGGCA CTTGAAAGAA 
ACAATCCCAG GAACTGAAGG TCAGCCTGTC ATCGCCATTG GGGGCTCTTA TGGTGGCATG 
CTCGCAGCCT GGTTCAGGAT GAAATATCCT CACATAGTTG TCGGAGCTCT GGCAGCTTCC 
GCCCCTATCT GGCAGCTTGA TGGTATGGCC CCCTGTGGAG AGTTTATGAA GATTGTAACT 
AAAGACTTCA GCCAAAGTGG TCCACATTGT TCAGAAAGTA TCCGTAGATC CTGGAGTGTC 
ATTAATCGAC TCTCAGATAC CGGCAGTGGT CTCCAGTGGC TCAGGGACAC TCTTCACCTG 
TGTAGTCCCT TGACTTCTGA GAAGATGCCA ACGTTGAAAG GATGGATAGC TGAAACCTGG 
GTGAACCTGG CCATGGTGAA CTACCCGTAT GCATGCAACT TTTTGCAGCC TTTGCCTGCT 
TGGCCCATCA AGGAGGTGTG CCGATACTTG AGGAATCCCA ATGTGTCCGA TACAGTGCTG 
CTGCAGAATA TTTTCCAGGC TCTGAATGTG TATTATAATT ATTCGGGCCA AACAAAATGC 
CTGAATATTT CACAAACAAC CACAAGCAGT CTGGGCTCTA CGGGCTGGAG CTTTCAGGCC 
TGCACAGAAA TGGTCATGCC CTTTTGTACT AATGGTATTG ATGACATGTT TGAACCCTAT 
CTGTGGGACT TGGAGACGTA TTCCAATGAC TGTTTTAACC AATGGGGAGT GAAACCACGG 
CCTCATTGGA TGACTACCAT GTATGGTGGC AAAAACATCA GTTCACACTC CAACATCATT 
TTCAGCAATG GTGACCTAGA CCCGTGGTCA GGAGGTGGAG TCACCAAAGA CATCACAGAC 
ACCCTGGTGG CTATCAACAT CCCTGAGGGG GCCCATCATT TAGATCTTCG AGCCCACAAT 
GCCTTCGATC CTTCCTCTGT GCTGTTATCT CGCTTATTGG AAGTTAAACA CATGAAGAAA 
TGGATTGCAG ATTTCTATAG CAATTCTACT TGGAAGTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099751.2
CDS	63..1544
Translation	MGCWALLLLPFLSLGAATTIRPRLKTLGSPHLSTNTPDPAVPSSYSVHYFQQKVDHFGFSDTRTFKQRYLVADKHWQRNGGSILFYTGNEGDIVWFCNNTGFMWDVAEELKAMLVFAEHRYYGKSLPFGRDSFKDSQHLNFLTSEQALADFAELIRHLKETIPGTEGQPVIAIGGSYGGMLAAWFRMKYPHIVVGALAASAPIWQLDGMAPCGEFMKIVTKDFSQSGPHCSESIRRSWSVINRLSDTGSGLQWLRDTLHLCSPLTSEKMPTLKGWIAETWVNLAMVNYPYACNFLQPLPAWPIKEVCRYLRNPNVSDTVLLQNIFQALNVYYNYSGQTKCLNISQTTTSSLGSTGWSFQACTEMVMPFCTNGIDDMFEPYLWDLETYSNDCFNQWGVKPRPHWMTTMYGGKNISSHSNIIFSNGDLDPWSGGGVTKDITDTLVAINIPEGAHHLDLRAHNAFDPSSVLLSRLLEVKHMKKWIADFYSNSTWKS

Target ORF information:

RefSeq Version	NM_001106281.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus prolylcarboxypeptidase (Prcp), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001106281.2

ORF Insert Sequence:

ATGGGCTGCT GGGCTCTCCT GCTCCTGCCT TTTCTATCAC TCGGGGCCGC CACAACCATC 
CGGCCTAGGC TAAAGACCCT CGGCAGCCCG CACTTGTCAA CTAACACACC CGACCCTGCT 
GTACCCAGTA GCTACTCAGT TCATTACTTC CAACAGAAGG TTGACCACTT TGGGTTTTCT 
GACACAAGAA CTTTTAAGCA GCGGTACCTA GTAGCTGATA AACACTGGCA GAGAAATGGT 
GGATCTATAC TTTTCTACAC TGGAAATGAA GGGGACATTG TCTGGTTTTG TAATAATACG 
GGGTTCATGT GGGATGTGGC CGAGGAGCTG AAAGCTATGC TGGTGTTTGC TGAGCATCGA 
TACTATGGGA AGTCCCTTCC CTTCGGTCGG GACTCCTTCA AGGATTCCCA ACATTTGAAT 
TTCCTGACAT CAGAACAGGC TCTGGCTGAT TTTGCAGAGT TAATCAGGCA CTTGAAAGAA 
ACAATCCCAG GAACTGAAGG TCAGCCTGTC ATCGCCATTG GGGGCTCTTA TGGTGGCATG 
CTCGCAGCCT GGTTCAGGAT GAAATATCCT CACATAGTTG TCGGAGCTCT GGCAGCTTCC 
GCCCCTATCT GGCAGCTTGA TGGTATGGCC CCCTGTGGAG AGTTTATGAA GATTGTAACT 
AAAGACTTCA GCCAAAGTGG TCCACATTGT TCAGAAAGTA TCCGTAGATC CTGGAGTGTC 
ATTAATCGAC TCTCAGATAC CGGCAGTGGT CTCCAGTGGC TCAGGGACAC TCTTCACCTG 
TGTAGTCCCT TGACTTCTGA GAAGATGCCA ACGTTGAAAG GATGGATAGC TGAAACCTGG 
GTGAACCTGG CCATGGTGAA CTACCCGTAT GCATGCAACT TTTTGCAGCC TTTGCCTGCT 
TGGCCCATCA AGGAGGTGTG CCGATACTTG AGGAATCCCA ATGTGTCCGA TACAGTGCTG 
CTGCAGAATA TTTTCCAGGC TCTGAATGTG TATTATAATT ATTCGGGCCA AACAAAATGC 
CTGAATATTT CACAAACAAC CACAAGCAGT CTGGGCTCTA CGGGCTGGAG CTTTCAGGCC 
TGCACAGAAA TGGTCATGCC CTTTTGTACT AATGGTATTG ATGACATGTT TGAACCCTAT 
CTGTGGGACT TGGAGACGTA TTCCAATGAC TGTTTTAACC AATGGGGAGT GAAACCACGG 
CCTCATTGGA TGACTACCAT GTATGGTGGC AAAAACATCA GTTCACACTC CAACATCATT 
TTCAGCAATG GTGACCTAGA CCCGTGGTCA GGAGGTGGAG TCACCAAAGA CATCACAGAC 
ACCCTGGTGG CTATCAACAT CCCTGAGGGG GCCCATCATT TAGATCTTCG AGCCCACAAT 
GCCTTCGATC CTTCCTCTGT GCTGTTATCT CGCTTATTGG AAGTTAAACA CATGAAGAAA 
TGGATTGCAG ATTTCTATAG CAATTCTACT TGGAAGTCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Angiotensinase C mRNA and Protein Downregulations Are Involved in Ethanol-Deteriorated Left Ventricular Systolic Dysfunction in Spontaneously Hypertensive Rats.
BioMed research international2015409350(2015)
Liu J,Hakucho A,Fujimiya T

Deficient prolylcarboxypeptidase gene and protein expression in left ventricles of spontaneously hypertensive rats (SHR).
Peptides6169-74(2014 Nov)
Marangoni RA,Santos RA,Piccolo C

Relationship of angiotensinase and vasopressinase activities between hypothalamus, heart, and plasma in L-NAME-treated WKY and SHR.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme46(8)561-7(2014 Jul)
Villarejo AB,Prieto I,Segarra AB,Banegas I,Wangensteen R,Vives F,de Gasparo M,Ram?rez-S?nchez M

Prolylcarboxypeptidase promotes angiogenesis and vascular repair.
Blood122(8)1522-31(2013 Aug)
Adams GN,Stavrou EX,Fang C,Merkulova A,Alaiti MA,Nakajima K,Morooka T,Merkulov S,Larusch GA,Simon DI,Jain MK,Schmaier AH

Deletion of prolyl carboxypeptidase attenuates the metabolic effects of diet-induced obesity.
American journal of physiology. Endocrinology and metabolism302(12)E1502-10(2012 Jun)
Jeong JK,Szabo G,Raso GM,Meli R,Diano S

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Prcp cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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