Mc3r cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mc3r
Entrez Gene ID	29310
Full Name	melanocortin 3 receptor
General protein information	Preferred Names melanocortin 3 receptor Names melanocortin receptor 3 MC3-R
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q42
Summary	receptor for corticotropin (ACTH) and melanotropin (MSH) [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001025270.3	NP_001020441.3	melanocortin receptor 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	MC3R	NP_063941.3
Pan troglodytes (chimpanzee)	MC3R	XP_525362.1
Mus musculus (house mouse)	Mc3r	NP_032587.1
Rattus norvegicus (Norway rat)	Mc3r	NP_001020441.3
Gallus gallus (chicken)	LOC100857164	XP_004947293.1
Danio rerio (zebrafish)	mc3r	NP_851303.1
Xenopus tropicalis (tropical clawed frog)	mc3r	XP_002935436.1
Canis lupus familiaris (dog)	MC3R	NP_001128596.1
	LOC698439	XP_001091108.1
Bos taurus (cattle)	MC3R	XP_002692472.1

Gene Ontology
Bibliography

Related articles in PubMed

Effects of Melanocortin 3 and 4 Receptor Deficiency on Energy Homeostasis in Rats.
You P, Hu H, Chen Y, Zhao Y, Yang Y, Wang T, Xing R, Shao Y, Zhang W, Li D, Chen H, Liu M
Scientific reports634938(2016 Oct)

Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward.
Pandit R, Omrani A, Luijendijk MC, de Vrind VA, Van Rozen AJ, Ophuis RJ, Garner K, Kallo I, Ghanem A, Liposits Z, Conzelmann KK, Vanderschuren LJ, la Fleur SE, Adan RA
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology41(9)2241-51(2016 Aug)

[THE THYROID STATUS OF RATS IMMUNIZED WITH PEPTIDES DERIVED FROM THE EXTRACELLULAR REGIONS OF THE TYPES 3 AND 4 MELANOCORTIN RECEPTORS AND THE 1B-SUBTYPE 5-HYDROXYTRYPTAMINE RECEPTOR].
Derkach KV, Moyseuk IV, Shpakova EA, Sphakov AO
Zhurnal evoliutsionnoi biokhimii i fiziologii51(4)243-50(2015 Jul-Aug)

Aminoprocalcitonin-mediated suppression of feeding involves the hypothalamic melanocortin system.
Tavares E, Maldonado R, Mi?ano FJ
American journal of physiology. Endocrinology and metabolism304(12)E1251-62(2013 Jun)

Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure.
Li P, Cui BP, Zhang LL, Sun HJ, Liu TY, Zhu GQ
Experimental physiology98(2)435-43(2013 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study demonstrates an arcuate nucleus of the hypothalamus pro-opiomelanocortinergic projection onto ventral tegmental area dopaminergic neurons that modulates motivation for palatable food via activation of melanocortin 3 receptor signaling.
Title: Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward.

in rats immunized with M4R and M3R peptides the sensitivity of ACSS thyrocytes to TSH were decreased, whereas in rats iimunized with 5-HT1BR peptide the deficit of thyroid hormones was associated with decreased level of TSH
Title: [THE THYROID STATUS OF RATS IMMUNIZED WITH PEPTIDES DERIVED FROM THE EXTRACELLULAR REGIONS OF THE TYPES 3 AND 4 MELANOCORTIN RECEPTORS AND THE 1B-SUBTYPE 5-HYDROXYTRYPTAMINE RECEPTOR].

We showed that the melanocortin-3/4 receptor antagonist SHU 9119 attenuates the food intake-suppressive effect of aminoprocalcitonin.
Title: Aminoprocalcitonin-mediated suppression of feeding involves the hypothalamic melanocortin system.

Results indicate that activation of MC3/4Rs in the paraventricular nucleus increases the sympathetic outflow and blood pressure via the cAMP-protein kinase A pathway.
Title: Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure.

Compared with low-activity rats, high-activity rats show enhanced mRNA expression of MCRs in the brain, specifically of MC3R in the paraventricular nucleus.
Title: Region-specific differences in brain melanocortin receptors in rats of the lean phenotype.

The following Mc3r gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mc3r cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42640	NM_001025270.3 Latest version!	Rattus norvegicus melanocortin 3 receptor (Mc3r), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mc3r ( NM_001025270.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001020441.3 Rattus norvegicus melanocortin 3 receptor (Mc3r), mRNA.

Price & Availability↑

CloneID	ORa42640
Clone ID Related Accession (Same CDS sequence)	NM_001025270.3
Accession Version	NM_001025270.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-22
Organism	Rattus norvegicus(Norway rat)
Product	melanocortin receptor 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY671938.1. On May 26, 2007 this sequence version replaced NM_001025270.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AY671938.1 [ECO:0000345] ##Evidence-Data-END##

ATGAACTCTT CCTGCTGCCC GTCCTCCTCT TATCCGACGC TGCCTAACCT CTCCCAGCAC 
CCTGCAGCCC CCTCTGCCAG CAACCGGAGT GGCAGTGGGT TCTGCGAGCA GGTTTTCATC 
AAGCCAGAGG TCTTCCTGGC ACTGGGCATC GTCAGTCTGA TGGAAAACAT CCTGGTGATC 
CTGGCTGTGG TGAGGAACGG CAACCTGCAC TCCCCCATGT ACTTCTTCCT GTGCAGCCTG 
GCTGCGGCCG ACATGCTGGT GAGCCTGTCC AACTCCCTGG AGACCATCAT GATCGTGGTT 
ATCAACAGCG ACTCCCTGAC CTTGGAGGAC CAATTCATCC AGCACATGGA CAACATCTTC 
GACTCTATGA TCTGCATCTC CCTGGTGGCC TCCATCTGCA ACCTCCTGGC CATCGCCGTG 
GACAGGTACG TCACCATCTT CTATGCCCTC CGTTACCACA GCATCATGAC GGTTAGGAAA 
GCCCTCTCCT TGATCGTGGC CATCTGGGTC TGCTGCGGCA TCTGCGGCGT GATGTTCATC 
GTCTACTCCG AGAGCAAGAT GGTCATCGTG TGCCTCATCA CCATGTTCTT CGCCATGGTG 
CTGCTCATGG GCACCCTGTA CATCCACATG TTCCTCTTCG CCAGGCTGCA CGTCCAGCGC 
ATCGCGGCAC TGCCACCTGC TGATGGGGTA GCCCCGCAGC AGCACTCGTG CATGAAGGGG 
GCCGTCACCA TCACCATCCT GCTGGGGGTT TTCATCTTCT GCTGGGCGCC TTTCTTCCTC 
CACCTGGTCC TCATCATCAC CTGCCCCACC AACCCCTACT GCATCTGCTA CACGGCGCAC 
TTCAACACCT ACCTGGTTCT CATCATGTGC AACTCTGTCA TCGACCCCCT TATCTACGCC 
TTCCGCAGCC TGGAGCTGCG GAACACCTTC AAGGAGATTC TCTGCGGTTG CAATGGCATG 
AACGTGGGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001020441.3
CDS	101..1072
Translation	MNSSCCPSSSYPTLPNLSQHPAAPSASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVILAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIVVINSDSLTLEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALSLIVAIWVCCGICGVMFIVYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHVQRIAALPPADGVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNGMNVG

Target ORF information:

RefSeq Version	NM_001025270.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus melanocortin 3 receptor (Mc3r), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025270.3

ORF Insert Sequence:

ATGAACTCTT CCTGCTGCCC GTCCTCCTCT TATCCGACGC TGCCTAACCT CTCCCAGCAC 
CCTGCAGCCC CCTCTGCCAG CAACCGGAGT GGCAGTGGGT TCTGCGAGCA GGTTTTCATC 
AAGCCAGAGG TCTTCCTGGC ACTGGGCATC GTCAGTCTGA TGGAAAACAT CCTGGTGATC 
CTGGCTGTGG TGAGGAACGG CAACCTGCAC TCCCCCATGT ACTTCTTCCT GTGCAGCCTG 
GCTGCGGCCG ACATGCTGGT GAGCCTGTCC AACTCCCTGG AGACCATCAT GATCGTGGTT 
ATCAACAGCG ACTCCCTGAC CTTGGAGGAC CAATTCATCC AGCACATGGA CAACATCTTC 
GACTCTATGA TCTGCATCTC CCTGGTGGCC TCCATCTGCA ACCTCCTGGC CATCGCCGTG 
GACAGGTACG TCACCATCTT CTATGCCCTC CGTTACCACA GCATCATGAC GGTTAGGAAA 
GCCCTCTCCT TGATCGTGGC CATCTGGGTC TGCTGCGGCA TCTGCGGCGT GATGTTCATC 
GTCTACTCCG AGAGCAAGAT GGTCATCGTG TGCCTCATCA CCATGTTCTT CGCCATGGTG 
CTGCTCATGG GCACCCTGTA CATCCACATG TTCCTCTTCG CCAGGCTGCA CGTCCAGCGC 
ATCGCGGCAC TGCCACCTGC TGATGGGGTA GCCCCGCAGC AGCACTCGTG CATGAAGGGG 
GCCGTCACCA TCACCATCCT GCTGGGGGTT TTCATCTTCT GCTGGGCGCC TTTCTTCCTC 
CACCTGGTCC TCATCATCAC CTGCCCCACC AACCCCTACT GCATCTGCTA CACGGCGCAC 
TTCAACACCT ACCTGGTTCT CATCATGTGC AACTCTGTCA TCGACCCCCT TATCTACGCC 
TTCCGCAGCC TGGAGCTGCG GAACACCTTC AAGGAGATTC TCTGCGGTTG CAATGGCATG 
AACGTGGGCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effects of Melanocortin 3 and 4 Receptor Deficiency on Energy Homeostasis in Rats.
Scientific reports634938(2016 Oct)
You P,Hu H,Chen Y,Zhao Y,Yang Y,Wang T,Xing R,Shao Y,Zhang W,Li D,Chen H,Liu M

Melanocortin 3 Receptor Signaling in Midbrain Dopamine Neurons Increases the Motivation for Food Reward.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology41(9)2241-51(2016 Aug)
Pandit R,Omrani A,Luijendijk MC,de Vrind VA,Van Rozen AJ,Ophuis RJ,Garner K,Kallo I,Ghanem A,Liposits Z,Conzelmann KK,Vanderschuren LJ,la Fleur SE,Adan RA

[THE THYROID STATUS OF RATS IMMUNIZED WITH PEPTIDES DERIVED FROM THE EXTRACELLULAR REGIONS OF THE TYPES 3 AND 4 MELANOCORTIN RECEPTORS AND THE 1B-SUBTYPE 5-HYDROXYTRYPTAMINE RECEPTOR].
Zhurnal evoliutsionnoi biokhimii i fiziologii51(4)243-50(2015 Jul-Aug)
Derkach KV,Moyseuk IV,Shpakova EA,Sphakov AO

Aminoprocalcitonin-mediated suppression of feeding involves the hypothalamic melanocortin system.
American journal of physiology. Endocrinology and metabolism304(12)E1251-62(2013 Jun)
Tavares E,Maldonado R,Mi?ano FJ

Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure.
Experimental physiology98(2)435-43(2013 Feb)
Li P,Cui BP,Zhang LL,Sun HJ,Liu TY,Zhu GQ

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Mc3r cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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