Gata6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Gata6
Entrez Gene ID	29300
Full Name	GATA binding protein 6
General protein information	Preferred Names GATA binding protein 6 Names transcription factor GATA-6 DNA-binding protein GATA-GT2 GATA-binding factor 6
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18p13
Summary	zinc-finger transcription factor that binds DNA at GATA regions; involved in gene regulation in the stomach [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019185.2	NP_062058.2	transcription factor GATA-6

Pathways from BioSystems

Homologies

	GATA6	XP_002800933.1
Canis lupus familiaris (dog)	GATA6	XP_005623196.1
Rattus norvegicus (Norway rat)	Gata6	NP_062058.1
Xenopus tropicalis (tropical clawed frog)	gata6	NP_989422.1
Homo sapiens (human)	GATA6	NP_005248.2
Pan troglodytes (chimpanzee)	GATA6	XP_003954430.1
Mus musculus (house mouse)	Gata6	NP_034388.2
Danio rerio (zebrafish)	gata6	NP_571632.1

Gene Ontology
Bibliography

Related articles in PubMed

Gain-of-function mutations in GATA6 lead to atrial fibrillation.
Tucker NR, Mahida S, Ye J, Abraham EJ, Mina JA, Parsons VA, McLellan MA, Shea MA, Hanley A, Benjamin EJ, Milan DJ, Lin H, Ellinor PT
Heart rhythm14(2)284-291(2017 Feb)

Elevated expression of steroidogenesis pathway genes; CYP17, GATA6 and StAR in prenatally androgenized rats.
Jahromi MS, Tehrani FR, Noroozzadeh M, Zarkesh M, Ghasemi A, Zadeh-Vakili A
Gene593(1)167-171(2016 Nov)

Role of GATA-6 and Bone Morphogenetic Protein-2 in Dexamethasone-Induced Cleft Palate Formation in Institute of Cancer Research Mice.
Lan SJ, Yang XG, Chen Z, Yang TY, Xiang CH, Zhang D, Li YX, Rong L
The Journal of craniofacial surgery27(6)1600-5(2016 Sep)

Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in ?-adrenergic signaling and enhances apoptosis.
Roca-Alonso L, Castellano L, Mills A, Dabrowska AF, Sikkel MB, Pellegrino L, Jacob J, Frampton AE, Krell J, Coombes RC, Harding SE, Lyon AR, Stebbing J
Cell death & disease6e1754(2015 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Elevated expression of steroidogenesis pathway genes; CYP17, GATA6 and StAR in prenatally androgenized rats.
Title: Elevated expression of steroidogenesis pathway genes; CYP17, GATA6 and StAR in prenatally androgenized rats.

Sulforaphane can inhibit transcription factors GATA4/6 as well as p-JNK1/2 and p-ERK1/2 MAPK signaling pathways in the cardiomyocytes.
Title: Sulforaphane suppresses cardiac hypertrophy by inhibiting GATA4/GATA6 expression and MAPK signaling pathways.

These results establish SHP as a novel antihypertrophic regulator that acts by interfering with GATA6 signaling.
Title: Small heterodimer partner blocks cardiac hypertrophy by interfering with GATA6 signaling.

In this study, they examined whether or not the JNK signaling pathway participates in the cAMP-dependent proteolysis of GATA-6 since a JNK inhibitor, SP600125, inhibited the proteolysis.
Title: cAMP-dependent proteolysis of GATA-6 is linked to JNK-signaling pathway.

Simvastatin restores down-regulated GATA-6 expression in pulmonary hypertensive rats.
Title: Simvastatin restores down-regulated GATA-6 expression in pulmonary hypertensive rats.

The following Gata6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Gata6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa43246	NM_019185.2 Latest version!	Rattus norvegicus GATA binding protein 6 (Gata6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Gata6 ( NM_019185.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062058.2 Rattus norvegicus GATA binding protein 6 (Gata6), mRNA.

Price & Availability↑

CloneID	ORa43246
Clone ID Related Accession (Same CDS sequence)	NM_019185.2
Accession Version	NM_019185.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1764bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-20
Organism	Rattus norvegicus(Norway rat)
Product	transcription factor GATA-6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07031164.1, AI712574.1 and L22760.1. On May 5, 2015 this sequence version replaced NM_019185.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2689596, SAMN01906347 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCTTGA CTGACGGCGG CTGGTGCCTG CCGAAGCGTT TCGGGGCTGC TGCTGCGGAC 
GCCGGCGACT CTGGGCCCTT TCCAGCGCGG GAGCCCTCCT CGCCGCTCTC CCCCATCTCG 
TCCTCTTCCT CCTCCTGCTC CCGGGGTGGG GATCGTGGTC CCTGCGGCGC CAGCAACTGC 
AGGACGCCGC AGCTCGACAC TGAGGCGGTG GCGGGACCTC CGGGCCGCTC GCTCTTGCTC 
AGCCCCTACA CTTCCCATCC CTTCGCCGCT GCTCACGGAG CCGCGGCGCC CGGGGTCGCT 
GGCCCCGGGA GCGCCCTGTC GACTTGGGAG GACCTGTTGC TCTTCACTGA CCTCGATCAG 
GCCGCGACCG CCAGCAAGCT GCTGTGGTCC AGCCGGGGCG CCAAGCTGAG TCCCTTCGCG 
GCCGAGCAGC CGGAGGAAAT GTACCAGACG CTCGCCGCTC TGTCCAGCCA GGGGCCCGCC 
GCTTACGACG GCGCGCCCGG CGGCTTCGTA CACTCCGCAG CTGCGGCGGC CGCGGCGGCC 
GCGGCAGCCA GCTCTCCGGT CTACGTGCCC ACCACACGCG TGGGCTCCAT GCTGCCCGGC 
CTGCCTTACC TGCAGGGGGC GGGCAGCGGG CCCAGCAATC ACGCGGGCGG CGCGGGCGCC 
CACCCGGGCT GGCCCCAGGC CTCCGCCGAC AGCCCCCCGT ATGGCGGGGG TGGTGCAGCG 
GGCGGCGGCG CGGCCGGACC CGGAGGTGCG GGATCAGCCA CAGCCCACGC CTCTGCACGC 
TTCCCCTACT CGCCCAGCCC GCCCATGGCC AACGGCGCCG CGCGGGACCC CGGGGGCTAC 
GTGGCTGCGG GCGGCGCGGG CGCGGGTAGC GTGAGTGGCG GTGGCGGCAG CCTGGCGGCC 
ATGGGTGGCC GGGAGCACCA GTACAGCTCG CTGTCCGCAG CCAGGCCGCT GAACGGGACG 
TACCACCACC ACCATCATCA CCACCCGACC TACTCGCCCT ACATGGGCGC TCCTCTGACT 
CCCGCCTGGC CAGCGGGACC CTTCGAAACG CCGGTGCTCC ACAGTTTACA GAGCCGCGCG 
GGAGCTCCAC TCCCGGTGCC ACGAGGCCCC AGCGCAGACC TGTTGGAGGA CCTGTCGGAG 
AGCCGCGAGT GCGTGAACTG TGGCTCCATC CAGACGCCAC TGTGGAGACG AGATGGCACC 
GGTCATTACC TGTGCAACGC ATGCGGTCTC TACAGTAAGA TGAACGGCCT CAGCAGGCCC 
CTCATCAAGC CACAGAAGCG CGTGCCTTCA TCACGACGGC TTGGACTGTC CTGTGCCAAC 
TGTCACACCA CAACCACTAC CTTATGGCGT AGAAACGCTG AGGGTGAGCC CGTGTGCAAT 
GCTTGCGGGC TTTATATGAA ACTCCATGGG GTGCCTCGAC CACTTGCTAT GAAAAAAGAA 
GGAATTCAAA CCAGGAAACG AAAACCTAAA AATATAAATA AGTCGAAAGC TTGCTCCGGT 
AACAGCTCTG TTCCTATGAC TCCAACTTCC TCCTCCTCTA ATTCAGATGA CTGCACCAAA 
AATACTTCTC CTCCCACACA GTCGACTGCC TCAGGGGTGG GTGCATCAGT GATGTCTGCA 
GTGGGAGAAA GTGCCAACCC TGAGAACAGT GACCTCAAGT ATTCAGGTCA AGATGGCCTC 
TACATAGGTG TCAGTTTGTC CTCCCCTGCC GAAGTTACAT CCTCGGTGCG ACAGGATTCT 
TGGTGTGCTC TGGCCCTGGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062058.2
CDS	135..1898
Translation	MALTDGGWCLPKRFGAAAADAGDSGPFPAREPSSPLSPISSSSSSCSRGGDRGPCGASNCRTPQLDTEAVAGPPGRSLLLSPYTSHPFAAAHGAAAPGVAGPGSALSTWEDLLLFTDLDQAATASKLLWSSRGAKLSPFAAEQPEEMYQTLAALSSQGPAAYDGAPGGFVHSAAAAAAAAAAASSPVYVPTTRVGSMLPGLPYLQGAGSGPSNHAGGAGAHPGWPQASADSPPYGGGGAAGGGAAGPGGAGSATAHASARFPYSPSPPMANGAARDPGGYVAAGGAGAGSVSGGGGSLAAMGGREHQYSSLSAARPLNGTYHHHHHHHPTYSPYMGAPLTPAWPAGPFETPVLHSLQSRAGAPLPVPRGPSADLLEDLSESRECVNCGSIQTPLWRRDGTGHYLCNACGLYSKMNGLSRPLIKPQKRVPSSRRLGLSCANCHTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMKKEGIQTRKRKPKNINKSKACSGNSSVPMTPTSSSSNSDDCTKNTSPPTQSTASGVGASVMSAVGESANPENSDLKYSGQDGLYIGVSLSSPAEVTSSVRQDSWCALALA

Target ORF information:

RefSeq Version	NM_019185.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus GATA binding protein 6 (Gata6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019185.2

ORF Insert Sequence:

ATGGCCTTGA CTGACGGCGG CTGGTGCCTG CCGAAGCGTT TCGGGGCTGC TGCTGCGGAC 
GCCGGCGACT CTGGGCCCTT TCCAGCGCGG GAGCCCTCCT CGCCGCTCTC CCCCATCTCG 
TCCTCTTCCT CCTCCTGCTC CCGGGGTGGG GATCGTGGTC CCTGCGGCGC CAGCAACTGC 
AGGACGCCGC AGCTCGACAC TGAGGCGGTG GCGGGACCTC CGGGCCGCTC GCTCTTGCTC 
AGCCCCTACA CTTCCCATCC CTTCGCCGCT GCTCACGGAG CCGCGGCGCC CGGGGTCGCT 
GGCCCCGGGA GCGCCCTGTC GACTTGGGAG GACCTGTTGC TCTTCACTGA CCTCGATCAG 
GCCGCGACCG CCAGCAAGCT GCTGTGGTCC AGCCGGGGCG CCAAGCTGAG TCCCTTCGCG 
GCCGAGCAGC CGGAGGAAAT GTACCAGACG CTCGCCGCTC TGTCCAGCCA GGGGCCCGCC 
GCTTACGACG GCGCGCCCGG CGGCTTCGTA CACTCCGCAG CTGCGGCGGC CGCGGCGGCC 
GCGGCAGCCA GCTCTCCGGT CTACGTGCCC ACCACACGCG TGGGCTCCAT GCTGCCCGGC 
CTGCCTTACC TGCAGGGGGC GGGCAGCGGG CCCAGCAATC ACGCGGGCGG CGCGGGCGCC 
CACCCGGGCT GGCCCCAGGC CTCCGCCGAC AGCCCCCCGT ATGGCGGGGG TGGTGCAGCG 
GGCGGCGGCG CGGCCGGACC CGGAGGTGCG GGATCAGCCA CAGCCCACGC CTCTGCACGC 
TTCCCCTACT CGCCCAGCCC GCCCATGGCC AACGGCGCCG CGCGGGACCC CGGGGGCTAC 
GTGGCTGCGG GCGGCGCGGG CGCGGGTAGC GTGAGTGGCG GTGGCGGCAG CCTGGCGGCC 
ATGGGTGGCC GGGAGCACCA GTACAGCTCG CTGTCCGCAG CCAGGCCGCT GAACGGGACG 
TACCACCACC ACCATCATCA CCACCCGACC TACTCGCCCT ACATGGGCGC TCCTCTGACT 
CCCGCCTGGC CAGCGGGACC CTTCGAAACG CCGGTGCTCC ACAGTTTACA GAGCCGCGCG 
GGAGCTCCAC TCCCGGTGCC ACGAGGCCCC AGCGCAGACC TGTTGGAGGA CCTGTCGGAG 
AGCCGCGAGT GCGTGAACTG TGGCTCCATC CAGACGCCAC TGTGGAGACG AGATGGCACC 
GGTCATTACC TGTGCAACGC ATGCGGTCTC TACAGTAAGA TGAACGGCCT CAGCAGGCCC 
CTCATCAAGC CACAGAAGCG CGTGCCTTCA TCACGACGGC TTGGACTGTC CTGTGCCAAC 
TGTCACACCA CAACCACTAC CTTATGGCGT AGAAACGCTG AGGGTGAGCC CGTGTGCAAT 
GCTTGCGGGC TTTATATGAA ACTCCATGGG GTGCCTCGAC CACTTGCTAT GAAAAAAGAA 
GGAATTCAAA CCAGGAAACG AAAACCTAAA AATATAAATA AGTCGAAAGC TTGCTCCGGT 
AACAGCTCTG TTCCTATGAC TCCAACTTCC TCCTCCTCTA ATTCAGATGA CTGCACCAAA 
AATACTTCTC CTCCCACACA GTCGACTGCC TCAGGGGTGG GTGCATCAGT GATGTCTGCA 
GTGGGAGAAA GTGCCAACCC TGAGAACAGT GACCTCAAGT ATTCAGGTCA AGATGGCCTC 
TACATAGGTG TCAGTTTGTC CTCCCCTGCC GAAGTTACAT CCTCGGTGCG ACAGGATTCT 
TGGTGTGCTC TGGCCCTGGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gain-of-function mutations in GATA6 lead to atrial fibrillation.
Heart rhythm14(2)284-291(2017 Feb)
Tucker NR,Mahida S,Ye J,Abraham EJ,Mina JA,Parsons VA,McLellan MA,Shea MA,Hanley A,Benjamin EJ,Milan DJ,Lin H,Ellinor PT

Elevated expression of steroidogenesis pathway genes; CYP17, GATA6 and StAR in prenatally androgenized rats.
Gene593(1)167-171(2016 Nov)
Jahromi MS,Tehrani FR,Noroozzadeh M,Zarkesh M,Ghasemi A,Zadeh-Vakili A

Role of GATA-6 and Bone Morphogenetic Protein-2 in Dexamethasone-Induced Cleft Palate Formation in Institute of Cancer Research Mice.
The Journal of craniofacial surgery27(6)1600-5(2016 Sep)
Lan SJ,Yang XG,Chen Z,Yang TY,Xiang CH,Zhang D,Li YX,Rong L

Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in ?-adrenergic signaling and enhances apoptosis.
Cell death & disease6e1754(2015 May)
Roca-Alonso L,Castellano L,Mills A,Dabrowska AF,Sikkel MB,Pellegrino L,Jacob J,Frampton AE,Krell J,Coombes RC,Harding SE,Lyon AR,Stebbing J

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Gata6 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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