Spint2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Spint2
Entrez Gene ID	292770
Full Name	serine peptidase inhibitor, Kunitz type, 2
Synonyms	HAI-2,Pb
General protein information	Preferred Names serine peptidase inhibitor, Kunitz type, 2 Names kunitz-type protease inhibitor 2 hepatocyte growth factor activator inhibitor type 2 placental bikunin serine protease inhibitor, Kunitz type 2
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 1 Map Location: 1q21

mRNA and Protein(s)

mRNA	Protein	Name
NM_001082549.1	NP_001076018.1	kunitz-type protease inhibitor 2 isoform a precursor
NM_199087.1	NP_954518.1	kunitz-type protease inhibitor 2 isoform b precursor

Pathways from BioSystems

Homologies

	SPINT2	XP_001106508.1
Mus musculus (house mouse)	Spint2	NP_035594.1
Xenopus tropicalis (tropical clawed frog)	spint2	NP_001039077.1
Bos taurus (cattle)	SPINT2	NP_001039436.1
Canis lupus familiaris (dog)	SPINT2	XP_853537.1
Rattus norvegicus (Norway rat)	Spint2	NP_001076018.1
Danio rerio (zebrafish)	spint2	NP_001070718.2
Homo sapiens (human)	SPINT2	NP_066925.1

Gene Ontology
Bibliography

Related articles in PubMed

Hepatocyte growth factor activator inhibitor-1 is induced by bone morphogenetic proteins and regulates proliferation and cell fate of neural progenitor cells.
Koivuniemi R, M?kel? J, Hokkanen ME, Bruelle C, Ho TH, Ola R, Korhonen L, Schr?der J, Kataoka H, Lindholm D
PloS one8(2)e56117(2013)

Persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affects liver fibrosis and differentiation.
Huang HP, Chang MH, Chen YT, Hsu HY, Chiang CL, Cheng TS, Wu YM, Wu MZ, Hsu YC, Shen CC, Lee CN, Chuang YH, Hong CL, Jeng YM, Chen PH, Chen HL, Lee MS
Hepatology (Baltimore, Md.)55(1)161-72(2012 Jan)

Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice.
Szabo R, Hobson JP, Christoph K, Kosa P, List K, Bugge TH
Development (Cambridge, England)136(15)2653-63(2009 Aug)

Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea.
Heinz-Erian P, M?ller T, Krabichler B, Schranz M, Becker C, R?schendorf F, N?rnberg P, Rossier B, Vujic M, Booth IW, Holmberg C, Wijmenga C, Grigelioniene G, Kneepkens CM, Rosipal S, Mistrik M, Kappler M, Michaud L, D?czy LC, Siu VM, Krantz M, Zoller H, Utermann G, Janecke AR
American journal of human genetics84(2)188-96(2009 Feb)

Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes.
Itoh H, Kataoka H, Yamauchi M, Naganuma S, Akiyama Y, Nuki Y, Shimomura T, Miyazawa K, Kitamura N, Koono M
Biochemical and biophysical research communications288(2)390-9(2001 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following Spint2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Spint2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04836	NM_199087.1 Latest version!	Rattus norvegicus serine peptidase inhibitor, Kunitz type, 2 (Spint2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
ORa10871	NM_001082549.1 Latest version!	Rattus norvegicus serine peptidase inhibitor, Kunitz type, 2 (Spint2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Spint2 ( NM_199087.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_954518.1 Rattus norvegicus serine peptidase inhibitor, Kunitz type, 2 (Spint2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa04836
Clone ID Related Accession (Same CDS sequence)	NM_199087.1
Accession Version	NM_199087.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 582bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Rattus norvegicus(Norway rat)
Product	kunitz-type protease inhibitor 2 isoform b precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC061768.1. On Jan 1, 2004 this sequence version replaced XM_214891.2. ##Evidence-Data-START## Transcript exon combination :: BC061768.1, EV776248.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCAGC TATGTGAGCC GCGGCGGGGC CGGGCGCTTC TCGCCCTGTT AGCCTCGCTG 
CTTCTCTCCG GGGCCCAGGC GGCCAGCAGA GACCTAGACG TCCACGAGAA CACCATTGAT 
GGTCTGGCCA GGAGCAGTGA TGGCGCTTCT GCCCTGAGCG TTCCCAGAAA GCAGGATTCT 
GCGGACCTCG CTGGTGAGAT CTTCAACTAT GAAGAATACT GTGTCCCAAA GGCGGTCACT 
GGGCCTTGCC GCGCAGCCTT CCCTCGCTGG TACTATGATG TTGAAAAGAA TTCCTGTAGC 
AGCTTCATCT ATGGCGGGTG CAGAGGCAAC AAGAACAGTT ACCTCTCCCA GGAAGCGTGC 
ATGCAGCACT GCTCTGGGAA GCAGATGTAT CCTTTCCTGA CCCCGGGCAC AAAAGCGGTG 
ATCCTGGTGG GGCTGTTCAT CATGGTCCTG ATCCTCCTCC TGGGATCCTC CATGGTGTTC 
CTGATCCGAA TGGTTCGCAG AAAGCAGGAG CGTGCTCTCC GCACTGTTTG GAGCACTGCG 
GATGACAAGG AGCAGCTGGT GAAGAATACC TGTGTCTTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_954518.1
CDS	286..867
Translation	MAQLCEPRRGRALLALLASLLLSGAQAASRDLDVHENTIDGLARSSDGASALSVPRKQDSADLAGEIFNYEEYCVPKAVTGPCRAAFPRWYYDVEKNSCSSFIYGGCRGNKNSYLSQEACMQHCSGKQMYPFLTPGTKAVILVGLFIMVLILLLGSSMVFLIRMVRRKQERALRTVWSTADDKEQLVKNTCVL

Target ORF information:

RefSeq Version	NM_199087.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serine peptidase inhibitor, Kunitz type, 2 (Spint2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_199087.1

ORF Insert Sequence:

ATGGCGCAGC TATGTGAGCC GCGGCGGGGC CGGGCGCTTC TCGCCCTGTT AGCCTCGCTG 
CTTCTCTCCG GGGCCCAGGC GGCCAGCAGA GACCTAGACG TCCACGAGAA CACCATTGAT 
GGTCTGGCCA GGAGCAGTGA TGGCGCTTCT GCCCTGAGCG TTCCCAGAAA GCAGGATTCT 
GCGGACCTCG CTGGTGAGAT CTTCAACTAT GAAGAATACT GTGTCCCAAA GGCGGTCACT 
GGGCCTTGCC GCGCAGCCTT CCCTCGCTGG TACTATGATG TTGAAAAGAA TTCCTGTAGC 
AGCTTCATCT ATGGCGGGTG CAGAGGCAAC AAGAACAGTT ACCTCTCCCA GGAAGCGTGC 
ATGCAGCACT GCTCTGGGAA GCAGATGTAT CCTTTCCTGA CCCCGGGCAC AAAAGCGGTG 
ATCCTGGTGG GGCTGTTCAT CATGGTCCTG ATCCTCCTCC TGGGATCCTC CATGGTGTTC 
CTGATCCGAA TGGTTCGCAG AAAGCAGGAG CGTGCTCTCC GCACTGTTTG GAGCACTGCG 
GATGACAAGG AGCAGCTGGT GAAGAATACC TGTGTCTTGT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Spint2 ( NM_001082549.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001076018.1 Rattus norvegicus serine peptidase inhibitor, Kunitz type, 2 (Spint2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa10871
Clone ID Related Accession (Same CDS sequence)	NM_001082549.1
Accession Version	NM_001082549.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 753bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Rattus norvegicus(Norway rat)
Product	kunitz-type protease inhibitor 2 isoform a precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DN934634.1 and BC061768.1. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCAGC TATGTGAGCC GCGGCGGGGC CGGGCGCTTC TCGCCCTGTT AGCCTCGCTG 
CTTCTCTCCG GGGCCCAGGC GGCCAGCAGA GACCTAGACG TCCACGAGTC TTGTGGAGTT 
TCGAAGGTAG TGGGGAAATG CCGGGCTTCC ATCCCCAGGT GGTGGTACAA TGTCACTGAT 
GGGACCTGCC AGCCCTTTGT TTATGGAGGC TGTGAGGGAA ATGGTAACAA CTATCCAAGC 
AAGGAGGAGT GTCTTGACAA GTGTGCTGGT ATCACTGAGA ACACCATTGA TGGTCTGGCC 
AGGAGCAGTG ATGGCGCTTC TGCCCTGAGC GTTCCCAGAA AGCAGGATTC TGCGGACCTC 
GCTGGTGAGA TCTTCAACTA TGAAGAATAC TGTGTCCCAA AGGCGGTCAC TGGGCCTTGC 
CGCGCAGCCT TCCCTCGCTG GTACTATGAT GTTGAAAAGA ATTCCTGTAG CAGCTTCATC 
TATGGCGGGT GCAGAGGCAA CAAGAACAGT TACCTCTCCC AGGAAGCGTG CATGCAGCAC 
TGCTCTGGGA AGCAGATGTA TCCTTTCCTG ACCCCGGGCA CAAAAGCGGT GATCCTGGTG 
GGGCTGTTCA TCATGGTCCT GATCCTCCTC CTGGGATCCT CCATGGTGTT CCTGATCCGA 
ATGGTTCGCA GAAAGCAGGA GCGTGCTCTC CGCACTGTTT GGAGCACTGC GGATGACAAG 
GAGCAGCTGG TGAAGAATAC CTGTGTCTTG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001076018.1
CDS	286..1038
Translation	MAQLCEPRRGRALLALLASLLLSGAQAASRDLDVHESCGVSKVVGKCRASIPRWWYNVTDGTCQPFVYGGCEGNGNNYPSKEECLDKCAGITENTIDGLARSSDGASALSVPRKQDSADLAGEIFNYEEYCVPKAVTGPCRAAFPRWYYDVEKNSCSSFIYGGCRGNKNSYLSQEACMQHCSGKQMYPFLTPGTKAVILVGLFIMVLILLLGSSMVFLIRMVRRKQERALRTVWSTADDKEQLVKNTCVL

Target ORF information:

RefSeq Version	NM_001082549.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus serine peptidase inhibitor, Kunitz type, 2 (Spint2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001082549.1

ORF Insert Sequence:

ATGGCGCAGC TATGTGAGCC GCGGCGGGGC CGGGCGCTTC TCGCCCTGTT AGCCTCGCTG 
CTTCTCTCCG GGGCCCAGGC GGCCAGCAGA GACCTAGACG TCCACGAGTC TTGTGGAGTT 
TCGAAGGTAG TGGGGAAATG CCGGGCTTCC ATCCCCAGGT GGTGGTACAA TGTCACTGAT 
GGGACCTGCC AGCCCTTTGT TTATGGAGGC TGTGAGGGAA ATGGTAACAA CTATCCAAGC 
AAGGAGGAGT GTCTTGACAA GTGTGCTGGT ATCACTGAGA ACACCATTGA TGGTCTGGCC 
AGGAGCAGTG ATGGCGCTTC TGCCCTGAGC GTTCCCAGAA AGCAGGATTC TGCGGACCTC 
GCTGGTGAGA TCTTCAACTA TGAAGAATAC TGTGTCCCAA AGGCGGTCAC TGGGCCTTGC 
CGCGCAGCCT TCCCTCGCTG GTACTATGAT GTTGAAAAGA ATTCCTGTAG CAGCTTCATC 
TATGGCGGGT GCAGAGGCAA CAAGAACAGT TACCTCTCCC AGGAAGCGTG CATGCAGCAC 
TGCTCTGGGA AGCAGATGTA TCCTTTCCTG ACCCCGGGCA CAAAAGCGGT GATCCTGGTG 
GGGCTGTTCA TCATGGTCCT GATCCTCCTC CTGGGATCCT CCATGGTGTT CCTGATCCGA 
ATGGTTCGCA GAAAGCAGGA GCGTGCTCTC CGCACTGTTT GGAGCACTGC GGATGACAAG 
GAGCAGCTGG TGAAGAATAC CTGTGTCTTG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Hepatocyte growth factor activator inhibitor-1 is induced by bone morphogenetic proteins and regulates proliferation and cell fate of neural progenitor cells.
PloS one8(2)e56117(2013)
Koivuniemi R,M?kel? J,Hokkanen ME,Bruelle C,Ho TH,Ola R,Korhonen L,Schr?der J,Kataoka H,Lindholm D

Persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affects liver fibrosis and differentiation.
Hepatology (Baltimore, Md.)55(1)161-72(2012 Jan)
Huang HP,Chang MH,Chen YT,Hsu HY,Chiang CL,Cheng TS,Wu YM,Wu MZ,Hsu YC,Shen CC,Lee CN,Chuang YH,Hong CL,Jeng YM,Chen PH,Chen HL,Lee MS

Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice.
Development (Cambridge, England)136(15)2653-63(2009 Aug)
Szabo R,Hobson JP,Christoph K,Kosa P,List K,Bugge TH

Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea.
American journal of human genetics84(2)188-96(2009 Feb)
Heinz-Erian P,M?ller T,Krabichler B,Schranz M,Becker C,R?schendorf F,N?rnberg P,Rossier B,Vujic M,Booth IW,Holmberg C,Wijmenga C,Grigelioniene G,Kneepkens CM,Rosipal S,Mistrik M,Kappler M,Michaud L,D?czy LC,Siu VM,Krantz M,Zoller H,Utermann G,Janecke AR

Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes.
Biochemical and biophysical research communications288(2)390-9(2001 Oct)
Itoh H,Kataoka H,Yamauchi M,Naganuma S,Akiyama Y,Nuki Y,Shimomura T,Miyazawa K,Kitamura N,Koono M

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Spint2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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