Sell cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Sell
Entrez Gene ID	29259
Full Name	selectin L
Synonyms	A.11,L-selectin,LECAM-1
General protein information	Preferred Names selectin L Names L-selectin CD62 antigen-like family member L LAM-1 LECAM1 leukocyte adhesion molecule 1 leukocyte-endothelial cell adhesion molecule 1 ly-22 lymph node homing receptor lymphocyte antigen 22 lymphocyte surface MEL-14 antigen selectin, lymphocyte
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q23
Summary	lymphocyte adhesion molecule that facilitates adhesion of lymphocytes to high endothelial venules [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_019177.3	NP_062050.3	L-selectin precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	SELL	NP_000646.2
	SELL	NP_001036228.1
Mus musculus (house mouse)	Sell	NP_035476.1
Pan troglodytes (chimpanzee)	SELL	NP_001009074.1
Canis lupus familiaris (dog)	SELL	XP_537201.2
Bos taurus (cattle)	SELL	NP_776607.1
Rattus norvegicus (Norway rat)	Sell	NP_062050.3
Xenopus tropicalis (tropical clawed frog)	sele	XP_002933828.2

Gene Ontology
Bibliography

Related articles in PubMed

Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force.
Mehta-D'souza P, Klopocki AG, Oganesyan V, Terzyan S, Mather T, Li Z, Panicker SR, Zhu C, McEver RP
The Journal of biological chemistry292(6)2510-2518(2017 02)

CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration.
Chiang YJ, Ho KC, Sun CT, Chiu JJ, Lee FJ, Liao F, Yang-Yen HF, Yen JJ
PloS one8(4)e61761(2013)

L-selectin and P-selectin are novel biomarkers of cervicovaginal inflammation for preclinical mucosal safety assessment of anti-HIV-1 microbicide.
Zhong M, He B, Yang J, Bao R, Zhang Y, Zhou D, Chen Y, Li L, Han C, Yang Y, Sun Y, Cao Y, Li Y, Shi W, Jiang S, Zhang X, Yan H
Antimicrobial agents and chemotherapy56(6)3121-32(2012 Jun)

Transcriptional changes in adhesion-related genes are site-specific during noise-induced cochlear pathogenesis.
Cai Q, Patel M, Coling D, Hu BH
Neurobiology of disease45(2)723-32(2012 Feb)

Investigation of P213S SELL gene polymorphism in type 2 diabetes mellitus and related end stage renal disease. A case-control study.
Stavarachi M, Panduru NM, Serafinceanu C, Mo?a E, Mo?a M, Cimponeriu D, Ion DA
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie52(3 Suppl)995-8(2011)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

L-selectin levels are not only down-regulated during T-cell activation but also routinely reduced while transmigrating within lymph nodes.
Title: Cyclical expression of L-selectin (CD62L) by recirculating T cells.

These results show that NO, produced at physiological levels, controls expression of constitutive adhesion molecules L-selectin and PECAM-1 in cell membranes by different mechanisms of action.
Title: In vivo blockade of Ca(+2)-dependent nitric oxide synthases impairs expressions of L-selectin and PECAM-1.

Data show that upon experimental and human renal ischemia/reperfusion, microvascular basement membrane (BM) heparan sulfate proteoglycans (collagen 18alpha1, agrin and perlecan) are modified to bind L-selectin and monocyte chemoattractant protein-1.
Title: Subendothelial heparan sulfate proteoglycans become major L-selectin and monocyte chemoattractant protein-1 ligands upon renal ischemia/reperfusion.

L-selectin-mediated neutrophil recruitment may be a critical early step in AAA formation.
Title: L-selectin-mediated neutrophil recruitment in experimental rodent aneurysm formation.

The following Sell gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sell cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa03947	NM_019177.3 Latest version!	Rattus norvegicus selectin L (Sell), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Sell ( NM_019177.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_062050.3 Rattus norvegicus selectin L (Sell), mRNA.

Price & Availability↑

CloneID	ORa03947
Clone ID Related Accession (Same CDS sequence)	NM_019177.3
Accession Version	NM_019177.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-21
Organism	Rattus norvegicus(Norway rat)
Product	L-selectin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from S79523.1. On Apr 28, 2006 this sequence version replaced NM_019177.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: S79523.1, D10831.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGGTGTTTC CATGGAGATG TCAGAGTGCT CAGCGGGGCT CCTGGAGCTT CCTGAAGCTG 
TGGATCTGGA CACTGCTGTG TTGTGATCTC CTGCCACACC ATGGAACTCA CTGTTGGACT 
TACCATTATT CTGAAAGATC CATGAACTGG GAAAATGCTA GAAAGTTCTG CAAGCACAAT 
TACACAGATT TAGTTGCTAT ACAAAATAAG AGAGAAATTG AGTATTTGGA AAAGACATTA 
CCCAAAAACC CTACCTACTA CTGGATAGGA ATCAGGAAAA TCGGGAAAAC GTGGACATGG 
GTGGGAACCA ACAAAACCCT CACCAAAGAA GCAGAGAACT GGGGTACTGG GGAGCCCAAC 
AACAAGAAGT CTAAGGAAGA CTGCGTGGAG ATCTATATCA AGAGGGAACG AGACTCTGGG 
AAGTGGAATG ACGATGCCTG CCACAAACGA AAGGCAGCTC TCTGCTACAC AGCCTCCTGC 
CAACCAGAAT CTTGCAACCG CCATGGAGAA TGTGTGGAAA CTATCAACAA TAACACCTGC 
ATCTGTGACC CAGGGTATTA TGGGCCCCAG TGTCAGTATG TGATCCAATG TGAGCCTTTG 
AAGGCCCCTG AGCTGGGTAC CATGAACTGT ATTCACCCCT TGGGAGACTT CAGCTTCCAG 
TCACAGTGTG CTTTCAACTG TTCTGAGGGA AGCGAGCTAC TTGGGAATGC AAAAACAGAG 
TGTGGAGCAT CTGGAAACTG GACATATCTA GAGCCAATCT GTCAAGTGAT TCAGTGCATG 
CCTCTAGCAG CACCGGATCT GGGCACTATG GAATGCAGTC ACCCCCTCGC CAACTTCAGT 
TTTACTTCTG CTTGTACCTT CACCTGCTCA GAAGAAACTG ACTTAATTGG GGAGAGAAAA 
ACTGTCTGCA GATCATCTGG CTCCTGGTCT AGTCCTAGTC CAATATGTCA AAAGACAAAG 
AGAAGTTTCT CAAAGATCAA GGAAGGCGAC TATAACCCCC TCTTCATTCC AGTAGCTGTC 
ATGGTCACTG CATTCTCAGG GCTGGCATTT ATCATTTGGC TGGCAAGGCG GCTAAAAAAA 
GGCAAGAAAT CGCAGGAAAG GATGGATGAT CCTTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062050.3
CDS	106..1224
Translation	MVFPWRCQSAQRGSWSFLKLWIWTLLCCDLLPHHGTHCWTYHYSERSMNWENARKFCKHNYTDLVAIQNKREIEYLEKTLPKNPTYYWIGIRKIGKTWTWVGTNKTLTKEAENWGTGEPNNKKSKEDCVEIYIKRERDSGKWNDDACHKRKAALCYTASCQPESCNRHGECVETINNNTCICDPGYYGPQCQYVIQCEPLKAPELGTMNCIHPLGDFSFQSQCAFNCSEGSELLGNAKTECGASGNWTYLEPICQVIQCMPLAAPDLGTMECSHPLANFSFTSACTFTCSEETDLIGERKTVCRSSGSWSSPSPICQKTKRSFSKIKEGDYNPLFIPVAVMVTAFSGLAFIIWLARRLKKGKKSQERMDDPY

Target ORF information:

RefSeq Version	NM_019177.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus selectin L (Sell), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019177.3

ORF Insert Sequence:

ATGGTGTTTC CATGGAGATG TCAGAGTGCT CAGCGGGGCT CCTGGAGCTT CCTGAAGCTG 
TGGATCTGGA CACTGCTGTG TTGTGATCTC CTGCCACACC ATGGAACTCA CTGTTGGACT 
TACCATTATT CTGAAAGATC CATGAACTGG GAAAATGCTA GAAAGTTCTG CAAGCACAAT 
TACACAGATT TAGTTGCTAT ACAAAATAAG AGAGAAATTG AGTATTTGGA AAAGACATTA 
CCCAAAAACC CTACCTACTA CTGGATAGGA ATCAGGAAAA TCGGGAAAAC GTGGACATGG 
GTGGGAACCA ACAAAACCCT CACCAAAGAA GCAGAGAACT GGGGTACTGG GGAGCCCAAC 
AACAAGAAGT CTAAGGAAGA CTGCGTGGAG ATCTATATCA AGAGGGAACG AGACTCTGGG 
AAGTGGAATG ACGATGCCTG CCACAAACGA AAGGCAGCTC TCTGCTACAC AGCCTCCTGC 
CAACCAGAAT CTTGCAACCG CCATGGAGAA TGTGTGGAAA CTATCAACAA TAACACCTGC 
ATCTGTGACC CAGGGTATTA TGGGCCCCAG TGTCAGTATG TGATCCAATG TGAGCCTTTG 
AAGGCCCCTG AGCTGGGTAC CATGAACTGT ATTCACCCCT TGGGAGACTT CAGCTTCCAG 
TCACAGTGTG CTTTCAACTG TTCTGAGGGA AGCGAGCTAC TTGGGAATGC AAAAACAGAG 
TGTGGAGCAT CTGGAAACTG GACATATCTA GAGCCAATCT GTCAAGTGAT TCAGTGCATG 
CCTCTAGCAG CACCGGATCT GGGCACTATG GAATGCAGTC ACCCCCTCGC CAACTTCAGT 
TTTACTTCTG CTTGTACCTT CACCTGCTCA GAAGAAACTG ACTTAATTGG GGAGAGAAAA 
ACTGTCTGCA GATCATCTGG CTCCTGGTCT AGTCCTAGTC CAATATGTCA AAAGACAAAG 
AGAAGTTTCT CAAAGATCAA GGAAGGCGAC TATAACCCCC TCTTCATTCC AGTAGCTGTC 
ATGGTCACTG CATTCTCAGG GCTGGCATTT ATCATTTGGC TGGCAAGGCG GCTAAAAAAA 
GGCAAGAAAT CGCAGGAAAG GATGGATGAT CCTTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force.
The Journal of biological chemistry292(6)2510-2518(2017 02)
Mehta-D'souza P,Klopocki AG,Oganesyan V,Terzyan S,Mather T,Li Z,Panicker SR,Zhu C,McEver RP

CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration.
PloS one8(4)e61761(2013)
Chiang YJ,Ho KC,Sun CT,Chiu JJ,Lee FJ,Liao F,Yang-Yen HF,Yen JJ

L-selectin and P-selectin are novel biomarkers of cervicovaginal inflammation for preclinical mucosal safety assessment of anti-HIV-1 microbicide.
Antimicrobial agents and chemotherapy56(6)3121-32(2012 Jun)
Zhong M,He B,Yang J,Bao R,Zhang Y,Zhou D,Chen Y,Li L,Han C,Yang Y,Sun Y,Cao Y,Li Y,Shi W,Jiang S,Zhang X,Yan H

Transcriptional changes in adhesion-related genes are site-specific during noise-induced cochlear pathogenesis.
Neurobiology of disease45(2)723-32(2012 Feb)
Cai Q,Patel M,Coling D,Hu BH

Investigation of P213S SELL gene polymorphism in type 2 diabetes mellitus and related end stage renal disease. A case-control study.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie52(3 Suppl)995-8(2011)
Stavarachi M,Panduru NM,Serafinceanu C,Mo?a E,Mo?a M,Cimponeriu D,Ion DA

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Sell cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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