Mgll cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mgll
Entrez Gene ID	29254
Full Name	monoglyceride lipase
Synonyms	MAGL
General protein information	Preferred Names monoglyceride lipase Names monoglyceride lipase MGL monoacylglycerol lipase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q34
Summary	serine hydrolase that converts monoglycerides to fatty acid and glycerol; may play a role in retrograde signaling at central synapses and other forms of short-range neuronal communication [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_138502.2	NP_612511.1	monoglyceride lipase
XM_008763053.2	XP_008761275.1	monoglyceride lipase isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	MGLL	XP_003310035.1
Canis lupus familiaris (dog)	MGLL	XP_533717.3
Oryza sativa (rice)	Os10g0135600	NP_001064121.2
Homo sapiens (human)	MGLL	NP_009214.1
Rattus norvegicus (Norway rat)	Mgll	NP_612511.1
Gallus gallus (chicken)	MGLL	NP_001264071.1
Danio rerio (zebrafish)	mgll	NP_956591.1
Xenopus tropicalis (tropical clawed frog)	mgll	NP_001106390.1
Bos taurus (cattle)	MGLL	NP_001193610.1
Mus musculus (house mouse)	Mgll	NP_001159723.1
Arabidopsis thaliana (thale cress)	AT5G16120	NP_001119234.1

Gene Ontology
Bibliography

Related articles in PubMed

Monoacylglycerol lipase inhibition alters social behavior in male and female rats after post-weaning social isolation.
Fontenot J, Loetz EC, Ishiki M, Bland ST
Behavioural brain research341146-153(2017 Dec)

Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat Islets.
Berdan CA, Erion KA, Burritt NE, Corkey BE, Deeney JT
PloS one11(2)e0149008(2016)

The distribution and time-dependent expression of MAGL during skeletal muscle wound healing in rats.
Jiang SK, Zhang M, Tian ZL, Wang LL, Zhao R, Li SS, Liu M, Wang M, Guan DW
Histology and histopathology30(10)1243-54(2015 Oct)

The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats.
Jiang SK, Zhang M, Tian ZL, Wang M, Zhao R, Wang LL, Li SS, Liu M, Li JY, Zhang MZ, Guan DW
European journal of pharmacology7611-10(2015 Aug)

Monoacylglycerol lipase promotes Fc? receptor-mediated phagocytosis in microglia but does not regulate LPS-induced upregulation of inflammatory cytokines.
Kouchi Z
Biochemical and biophysical research communications464(2)603-10(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MGL has an important role in insulin secretion
Title: Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat Islets.

expression of MAGL is distributed in certain cell types and time-dependently expressed in skeletal muscles after trauma, suggesting that MAGL may be involved in inflammatory response, fibrogenesis and regeneration during skeletal muscle wound healing
Title: The distribution and time-dependent expression of MAGL during skeletal muscle wound healing in rats.

MAGL inhibitor JZL184 is able to inhibit the inflammatory response and interfere with contused muscle healing.
Title: The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats.

results suggest that MAGL regulates phagocytosis, but not LPS-mediated cytokine induction in microglia
Title: Monoacylglycerol lipase promotes Fc? receptor-mediated phagocytosis in microglia but does not regulate LPS-induced upregulation of inflammatory cytokines.

the current findings support the therapeutic potential of FAAH and monoacylglycerol lipase inhibitors as a novel pharmacotherapy for pain
Title: Endocannabinoid modulation by FAAH and monoacylglycerol lipase within the analgesic circuitry of the periaqueductal grey.

The following Mgll gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mgll cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa01432	NM_138502.2 Latest version!	Rattus norvegicus monoglyceride lipase (Mgll), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00
ORa43239	XM_008763053.2 Latest version!	Rattus norvegicus monoglyceride lipase (Mgll), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mgll ( NM_138502.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_612511.1 Rattus norvegicus monoglyceride lipase (Mgll), mRNA.

Price & Availability↑

CloneID	ORa01432
Clone ID Related Accession (Same CDS sequence)	NM_138502.2
Accession Version	NM_138502.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 912bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Rattus norvegicus(Norway rat)
Product	monoglyceride lipase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC107920.1. On Nov 18, 2005 this sequence version replaced NM_138502.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC107920.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCTGAGG CAAGTTCACC CAGGCGAACT CCACAGAACG TCCCCTACCA GGACCTTCCT 
CACCTGGTCA ATGCGGATGG ACAGTACCTC TTTTGTAGGT ACTGGAAGCC CAGTGGCACA 
CCCAAGGCCC TCATCTTCGT GTCCCATGGA GCTGGGGAAC ACTGTGGCCG TTATGACGAG 
CTGGCTCAGA TGTTGAAGAG GCTGGACATG CTGGTGTTTG CCCATGACCA TGTTGGCCAT 
GGGCAGAGCG AGGGAGAGAG GATGGTGGTA TCGGACTTCC AAGTTTTTGT CAGAGATTTG 
TTGCAGCACG TGAACACCGT CCAGAAGGAC TACCCCGAGG TCCCCGTCTT CCTCCTGGGC 
CACTCCATGG GCGGTGCCAT CTCCATCCTA GCAGCTGCAG AGAGACCAAC CCACTTTTCT 
GGCATGATCC TAATTTCACC TCTGATCCTT GCCAATCCGG AATCTGCATC GACTTTGAAG 
GTCCTTGCTG CCAAACTGCT CAATTTTGTC CTGCCAAACA TATCCTTGGG GCGCATCGAC 
TCCAGCGTGC TGTCTCGGAA CAAGTCGGAG GTTGACCTGT ACAACTCCGA CCCACTCATC 
TGCCACGCAG GGGTGAAGGT ATGCTTTGGC ATCCAGCTGC TGAACGCTGT CTCGAGGGTG 
GAGCGAGCAA TGCCCAGGCT GACACTGCCG TTCCTGCTGC TGCAGGGTTC TGCTGACCGG 
CTTTGCGACA GCAAAGGTGC CTACCTGCTC ATGGAATCAT CCCCGAGTCA GGACAAAACA 
CTCAAGATGT ATGAAGGTGC CTACCATGTT CTCCACAAGG AGCTTCCGGA AGTGACCAAC 
TCTGTCCTCC ATGAAATAAA TACGTGGGTG TCTCACAGGA TAGCAGTGGC AGGAGCTAGG 
TGTCTACCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_612511.1
CDS	118..1029
Translation	MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLGHSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRIDSSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGARCLP

Target ORF information:

RefSeq Version	NM_138502.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus monoglyceride lipase (Mgll), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138502.2

ORF Insert Sequence:

ATGCCTGAGG CAAGTTCACC CAGGCGAACT CCACAGAACG TCCCCTACCA GGACCTTCCT 
CACCTGGTCA ATGCGGATGG ACAGTACCTC TTTTGTAGGT ACTGGAAGCC CAGTGGCACA 
CCCAAGGCCC TCATCTTCGT GTCCCATGGA GCTGGGGAAC ACTGTGGCCG TTATGACGAG 
CTGGCTCAGA TGTTGAAGAG GCTGGACATG CTGGTGTTTG CCCATGACCA TGTTGGCCAT 
GGGCAGAGCG AGGGAGAGAG GATGGTGGTA TCGGACTTCC AAGTTTTTGT CAGAGATTTG 
TTGCAGCACG TGAACACCGT CCAGAAGGAC TACCCCGAGG TCCCCGTCTT CCTCCTGGGC 
CACTCCATGG GCGGTGCCAT CTCCATCCTA GCAGCTGCAG AGAGACCAAC CCACTTTTCT 
GGCATGATCC TAATTTCACC TCTGATCCTT GCCAATCCGG AATCTGCATC GACTTTGAAG 
GTCCTTGCTG CCAAACTGCT CAATTTTGTC CTGCCAAACA TATCCTTGGG GCGCATCGAC 
TCCAGCGTGC TGTCTCGGAA CAAGTCGGAG GTTGACCTGT ACAACTCCGA CCCACTCATC 
TGCCACGCAG GGGTGAAGGT ATGCTTTGGC ATCCAGCTGC TGAACGCTGT CTCGAGGGTG 
GAGCGAGCAA TGCCCAGGCT GACACTGCCG TTCCTGCTGC TGCAGGGTTC TGCTGACCGG 
CTTTGCGACA GCAAAGGTGC CTACCTGCTC ATGGAATCAT CCCCGAGTCA GGACAAAACA 
CTCAAGATGT ATGAAGGTGC CTACCATGTT CTCCACAAGG AGCTTCCGGA AGTGACCAAC 
TCTGTCCTCC ATGAAATAAA TACGTGGGTG TCTCACAGGA TAGCAGTGGC AGGAGCTAGG 
TGTCTACCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mgll ( XM_008763053.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_008761275.1 Rattus norvegicus monoglyceride lipase (Mgll), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa43239
Clone ID Related Accession (Same CDS sequence)	XM_008763053.2
Accession Version	XM_008763053.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 960bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	monoglyceride lipase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005103.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_008763053.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAAAAGC CAAGACTAAT GGAAACAGGG CCCAAAGACC CCTGCAGGAT GCCTGAGGCA 
AGTTCACCCA GGCGAACTCC ACAGAACGTC CCCTACCAGG ACCTTCCTCA CCTGGTCAAT 
GCGGATGGAC AGTACCTCTT TTGTAGGTAC TGGAAGCCCA GTGGCACACC CAAGGCCCTC 
ATCTTCGTGT CCCATGGAGC TGGGGAACAC TGTGGCCGTT ATGACGAGCT GGCTCAGATG 
TTGAAGAGGC TGGACATGCT GGTGTTTGCC CATGACCATG TTGGCCATGG GCAGAGCGAG 
GGAGAGAGGA TGGTGGTATC GGACTTCCAA GTTTTTGTCA GAGATTTGTT GCAGCACGTG 
AACACCGTCC AGAAGGACTA CCCCGAGGTC CCCGTCTTCC TCCTGGGCCA CTCCATGGGC 
GGTGCCATCT CCATCCTAGC AGCTGCAGAG AGACCAACCC ACTTTTCTGG CATGATCCTA 
ATTTCACCTC TGATCCTTGC CAATCCGGAA TCTGCATCGA CTTTGAAGGT CCTTGCTGCC 
AAACTGCTCA ATTTTGTCCT GCCAAACATA TCCTTGGGGC GCATCGACTC CAGCGTGCTG 
TCTCGGAACA AGTCGGAGGT TGACCTGTAC AACTCCGACC CACTCATCTG CCACGCAGGG 
GTGAAGGTAT GCTTTGGCAT CCAGCTGCTG AACGCTGTCT CGAGGGTGGA GCGAGCAATG 
CCCAGGCTGA CACTGCCGTT CCTGCTGCTG CAGGGTTCTG CTGACCGGCT TTGCGACAGC 
AAAGGTGCCT ACCTGCTCAT GGAATCATCC CCGAGTCAGG ACAAAACACT CAAGATGTAT 
GAAGGTGCCT ACCATGTTCT CCACAAGGAG CTTCCGGAAG TGACCAACTC TGTCCTCCAT 
GAAATAAATA CGTGGGTGTC TCACAGGATA GCAGTGGCAG GAGCTAGGTG TCTACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_008761275.1
CDS	730..1689
Translation	MQKPRLMETGPKDPCRMPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAQMLKRLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDLLQHVNTVQKDYPEVPVFLLGHSMGGAISILAAAERPTHFSGMILISPLILANPESASTLKVLAAKLLNFVLPNISLGRIDSSVLSRNKSEVDLYNSDPLICHAGVKVCFGIQLLNAVSRVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSPSQDKTLKMYEGAYHVLHKELPEVTNSVLHEINTWVSHRIAVAGARCLP

Target ORF information:

RefSeq Version	XM_008763053.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus monoglyceride lipase (Mgll), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_008763053.2

ORF Insert Sequence:

ATGCAAAAGC CAAGACTAAT GGAAACAGGG CCCAAAGACC CCTGCAGGAT GCCTGAGGCA 
AGTTCACCCA GGCGAACTCC ACAGAACGTC CCCTACCAGG ACCTTCCTCA CCTGGTCAAT 
GCGGATGGAC AGTACCTCTT TTGTAGGTAC TGGAAGCCCA GTGGCACACC CAAGGCCCTC 
ATCTTCGTGT CCCATGGAGC TGGGGAACAC TGTGGCCGTT ATGACGAGCT GGCTCAGATG 
TTGAAGAGGC TGGACATGCT GGTGTTTGCC CATGACCATG TTGGCCATGG GCAGAGCGAG 
GGAGAGAGGA TGGTGGTATC GGACTTCCAA GTTTTTGTCA GAGATTTGTT GCAGCACGTG 
AACACCGTCC AGAAGGACTA CCCCGAGGTC CCCGTCTTCC TCCTGGGCCA CTCCATGGGC 
GGTGCCATCT CCATCCTAGC AGCTGCAGAG AGACCAACCC ACTTTTCTGG CATGATCCTA 
ATTTCACCTC TGATCCTTGC CAATCCGGAA TCTGCATCGA CTTTGAAGGT CCTTGCTGCC 
AAACTGCTCA ATTTTGTCCT GCCAAACATA TCCTTGGGGC GCATCGACTC CAGCGTGCTG 
TCTCGGAACA AGTCGGAGGT TGACCTGTAC AACTCCGACC CACTCATCTG CCACGCAGGG 
GTGAAGGTAT GCTTTGGCAT CCAGCTGCTG AACGCTGTCT CGAGGGTGGA GCGAGCAATG 
CCCAGGCTGA CACTGCCGTT CCTGCTGCTG CAGGGTTCTG CTGACCGGCT TTGCGACAGC 
AAAGGTGCCT ACCTGCTCAT GGAATCATCC CCGAGTCAGG ACAAAACACT CAAGATGTAT 
GAAGGTGCCT ACCATGTTCT CCACAAGGAG CTTCCGGAAG TGACCAACTC TGTCCTCCAT 
GAAATAAATA CGTGGGTGTC TCACAGGATA GCAGTGGCAG GAGCTAGGTG TCTACCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Monoacylglycerol lipase inhibition alters social behavior in male and female rats after post-weaning social isolation.
Behavioural brain research341146-153(2017 Dec)
Fontenot J,Loetz EC,Ishiki M,Bland ST

Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat Islets.
PloS one11(2)e0149008(2016)
Berdan CA,Erion KA,Burritt NE,Corkey BE,Deeney JT

The distribution and time-dependent expression of MAGL during skeletal muscle wound healing in rats.
Histology and histopathology30(10)1243-54(2015 Oct)
Jiang SK,Zhang M,Tian ZL,Wang LL,Zhao R,Li SS,Liu M,Wang M,Guan DW

The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats.
European journal of pharmacology7611-10(2015 Aug)
Jiang SK,Zhang M,Tian ZL,Wang M,Zhao R,Wang LL,Li SS,Liu M,Li JY,Zhang MZ,Guan DW

Monoacylglycerol lipase promotes Fc? receptor-mediated phagocytosis in microglia but does not regulate LPS-induced upregulation of inflammatory cytokines.
Biochemical and biophysical research communications464(2)603-10(2015 Aug)
Kouchi Z

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Mgll cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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