Mzb1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mzb1
Entrez Gene ID	291675
Full Name	marginal zone B and B1 cell-specific protein
Synonyms	Pacap,RGD1310251,pERp1
General protein information	Preferred Names marginal zone B and B1 cell-specific protein Names marginal zone B- and B1-cell-specific protein plasma cell-induced resident ER protein plasma cell-induced resident endoplasmic reticulum protein proapoptotic caspase adapter protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18p11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001024240.1	NP_001019411.1	marginal zone B- and B1-cell-specific protein precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	LOC100859189	XP_003642115.1
Mus musculus (house mouse)	Mzb1	NP_081498.2
Rattus norvegicus (Norway rat)	Mzb1	NP_001019411.1
Bos taurus (cattle)	MZB1	NP_001092400.1
Homo sapiens (human)	MZB1	NP_057543.2
Pan troglodytes (chimpanzee)	MZB1	XP_001172512.1
	MZB1	XP_001082403.1
Canis lupus familiaris (dog)	MZB1	XP_003433803.2

Gene Ontology
Bibliography

Related articles in PubMed

Novel hormone-regulated genes in visceral adipose tissue: cloning and identification of proinflammatory cytokine-like mouse and human MEDA-7: implications for obesity, insulin resistance and the metabolic syndrome.
Zhang H, Chen X, Sairam MR
Diabetologia54(9)2368-80(2011 Sep)

VIP, CRF, and PACAP act at distinct receptors to elicit different cAMP/PKA dynamics in the neocortex.
Hu E, Demmou L, Cauli B, Gallopin T, Geoffroy H, Harris-Warrick RM, Paupardin-Tritsch D, Lambolez B, Vincent P, Hepp R
Cerebral cortex (New York, N.Y. : 1991)21(3)708-18(2011 Mar)

Neuroprotective effect of PACAP against NMDA-induced retinal damage in the mouse.
Endo K, Nakamachi T, Seki T, Kagami N, Wada Y, Nakamura K, Kishimoto K, Hori M, Tsuchikawa D, Shinntani N, Hashimoto H, Baba A, Koide R, Shioda S
Journal of molecular neuroscience : MN43(1)22-9(2011 Jan)

Pituitary adenylate cyclase-activating polypeptide (PACAP) is an upstream regulator of prodynorphin mRNA expression in neurons.
Dong YX, Fukuchi M, Inoue M, Takasaki I, Tabuchi A, Wu CF, Tsuda M
Neuroscience letters484(3)174-7(2010 Nov)

Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells.
Flach H, Rosenbaum M, Duchniewicz M, Kim S, Zhang SL, Cahalan MD, Mittler G, Grosschedl R
Immunity33(5)723-35(2010 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

VIP and CRF, originating from interneurons, and PACAP, expressed mainly by pyramidal cells, finely tune the excitability and gene expression in the neocortical network
Title: VIP, CRF, and PACAP act at distinct receptors to elicit different cAMP/PKA dynamics in the neocortex.

Results indicate that lack of pancreatic PACAP did not aggravate, but rather ameliorated, cerulein-induced pancreatitis.
Title: Cerulein-induced acute pancreatitis in PACAP knockout mice.

Data suggest that exogenous PACAP is able to counteract NMDA-induced toxicity, and that endogenous PACAP exerts a neuroprotective effect in the retina.
Title: Neuroprotective effect of PACAP against NMDA-induced retinal damage in the mouse.

It is evident that PACAP-induced prodynorphin mRNA expression is mediated by the activation of the protein kinase A (PKA) pathway.
Title: Pituitary adenylate cyclase-activating polypeptide (PACAP) is an upstream regulator of prodynorphin mRNA expression in neurons.

Endogenous PACAP protects against noxious stimuli in the kidney and PACAP may act as a stress sensor in renal cells as seen in PACAP knockout mice.
Title: Mice deficient in neuropeptide PACAP demonstrate increased sensitivity to in vitro kidney hypoxia.

The following Mzb1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mzb1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa05845	NM_001024240.1 Latest version!	Rattus norvegicus marginal zone B and B1 cell-specific protein (Mzb1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mzb1 ( NM_001024240.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001019411.1 Rattus norvegicus marginal zone B and B1 cell-specific protein (Mzb1), mRNA.

Price & Availability↑

CloneID	ORa05845
Clone ID Related Accession (Same CDS sequence)	NM_001024240.1
Accession Version	NM_001024240.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	marginal zone B- and B1-cell-specific protein precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC093397.1. On May 27, 2005 this sequence version replaced XM_214585.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC093397.1, CV076226.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGAGACTAC CCCTGCCGCT GTTGCTACTG TTCGGGTGCA GGGCTATCCT GGGGAGCTTC 
GGGGATAGGG TTTCCCTCTC AGCTACAGCT CCTACACTGG ATGATGAAGA GAAGTACGCA 
TCCCATATGC CGACTCACCT GCGCTGCGAT GCCTGCCGGG CTGTGGCCTA CCAGATGGGC 
CAACATCTGG CGAAAGCAGA GGCTAAATCT CACACTCCAG ACTCCAGTGG ATCGCAGGAG 
CTGAGTGAAT CCACGTACAC AGATGTGCTG GACCGGACCT GCTCTCAGAA CTGGCAGTCC 
TATGGAGTCC AAGAAGTGAA CCAGATGAAG CGTCTCATGG GCCCGGGACT TAGCAAGGGG 
CCAGAGCCCA GCATCAGCGT GATGATTACT GGGGGTCCCT GGCCCAATAG GCTCTCCATG 
ACGTGTTTCC ACTACCTGGG AGAGTTTGGA GAGGACCAGA TCTATGAAGC CTACCGCCAA 
GGCCACGAGA CTCTGGAGGC GCTACTCTGT GGGGGCACCC ACGGGTCCTG CTCACAGGAG 
ATCCCGGCTC AGAGAGAAGA GCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001019411.1
CDS	2..568
Translation	MRLPLPLLLLFGCRAILGSFGDRVSLSATAPTLDDEEKYASHMPTHLRCDACRAVAYQMGQHLAKAEAKSHTPDSSGSQELSESTYTDVLDRTCSQNWQSYGVQEVNQMKRLMGPGLSKGPEPSISVMITGGPWPNRLSMTCFHYLGEFGEDQIYEAYRQGHETLEALLCGGTHGSCSQEIPAQREEL

Target ORF information:

RefSeq Version	NM_001024240.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus marginal zone B and B1 cell-specific protein (Mzb1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001024240.1

ORF Insert Sequence:

ATGAGACTAC CCCTGCCGCT GTTGCTACTG TTCGGGTGCA GGGCTATCCT GGGGAGCTTC 
GGGGATAGGG TTTCCCTCTC AGCTACAGCT CCTACACTGG ATGATGAAGA GAAGTACGCA 
TCCCATATGC CGACTCACCT GCGCTGCGAT GCCTGCCGGG CTGTGGCCTA CCAGATGGGC 
CAACATCTGG CGAAAGCAGA GGCTAAATCT CACACTCCAG ACTCCAGTGG ATCGCAGGAG 
CTGAGTGAAT CCACGTACAC AGATGTGCTG GACCGGACCT GCTCTCAGAA CTGGCAGTCC 
TATGGAGTCC AAGAAGTGAA CCAGATGAAG CGTCTCATGG GCCCGGGACT TAGCAAGGGG 
CCAGAGCCCA GCATCAGCGT GATGATTACT GGGGGTCCCT GGCCCAATAG GCTCTCCATG 
ACGTGTTTCC ACTACCTGGG AGAGTTTGGA GAGGACCAGA TCTATGAAGC CTACCGCCAA 
GGCCACGAGA CTCTGGAGGC GCTACTCTGT GGGGGCACCC ACGGGTCCTG CTCACAGGAG 
ATCCCGGCTC AGAGAGAAGA GCTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Novel hormone-regulated genes in visceral adipose tissue: cloning and identification of proinflammatory cytokine-like mouse and human MEDA-7: implications for obesity, insulin resistance and the metabolic syndrome.
Diabetologia54(9)2368-80(2011 Sep)
Zhang H,Chen X,Sairam MR

VIP, CRF, and PACAP act at distinct receptors to elicit different cAMP/PKA dynamics in the neocortex.
Cerebral cortex (New York, N.Y. : 1991)21(3)708-18(2011 Mar)
Hu E,Demmou L,Cauli B,Gallopin T,Geoffroy H,Harris-Warrick RM,Paupardin-Tritsch D,Lambolez B,Vincent P,Hepp R

Neuroprotective effect of PACAP against NMDA-induced retinal damage in the mouse.
Journal of molecular neuroscience : MN43(1)22-9(2011 Jan)
Endo K,Nakamachi T,Seki T,Kagami N,Wada Y,Nakamura K,Kishimoto K,Hori M,Tsuchikawa D,Shinntani N,Hashimoto H,Baba A,Koide R,Shioda S

Pituitary adenylate cyclase-activating polypeptide (PACAP) is an upstream regulator of prodynorphin mRNA expression in neurons.
Neuroscience letters484(3)174-7(2010 Nov)
Dong YX,Fukuchi M,Inoue M,Takasaki I,Tabuchi A,Wu CF,Tsuda M

Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells.
Immunity33(5)723-35(2010 Nov)
Flach H,Rosenbaum M,Duchniewicz M,Kim S,Zhang SL,Cahalan MD,Mittler G,Grosschedl R

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Mzb1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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