Nedd4l cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nedd4l
Entrez Gene ID	291553
Full Name	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Synonyms	Nedd4-2
General protein information	Preferred Names neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase Names E3 ubiquitin-protein ligase NEDD4-like
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18q12.1
Summary	mouse homolog appears to be involved in binding and regulating the amiloride-sensitive epithelial sodium channel which plays a role in sodium homeostasis and control of blood volume and blood pressure [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001008300.2	NP_001008301.2	E3 ubiquitin-protein ligase NEDD4-like

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NEDD4L	XP_001140979.1
Canis lupus familiaris (dog)	NEDD4L	XP_005615425.1
Bos taurus (cattle)	NEDD4L	XP_005224408.1
Schizosaccharomyces pombe (fission yeast)	pub1	NP_594396.1
	NEDD4L	XP_001088661.2
Gallus gallus (chicken)	NEDD4L	XP_004949055.1
Eremothecium gossypii	AGOS_ADL055C	NP_984041.1
Neurospora crassa	NCU03947	XP_957586.2
Homo sapiens (human)	NEDD4L	NP_001138439.1
Drosophila melanogaster (fruit fly)	Nedd4	NP_730284.2
Xenopus tropicalis (tropical clawed frog)	nedd4l	NP_001006727.1
Caenorhabditis elegans (roundworm)	Y92H12A.2	NP_490865.3
Magnaporthe oryzae (rice blast fungus)	MGG_07255	XP_003715474.1
Mus musculus (house mouse)	Nedd4l	NP_001107858.1
Rattus norvegicus (Norway rat)	Nedd4l	NP_001008301.2
Danio rerio (zebrafish)	nedd4l	XP_005161145.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP000787	XP_311327.5
Saccharomyces cerevisiae (baker's yeast)	RSP5	NP_011051.3
Kluyveromyces lactis	KLLA0E13575g	XP_454562.1

Gene Ontology
Bibliography

Related articles in PubMed

Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).
Anta B, Mart?n-Rodr?guez C, Gomis-Perez C, Calvo L, L?pez-Benito S, Calder?n-Garc?a AA, Vicente-Garc?a C, Villarroel ?, Ar?valo JC
The Journal of biological chemistry291(36)19132-45(2016 09)

Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.
Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J, Tan SS
The Journal of biological chemistry290(11)7141-50(2015 Mar)

Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels.
Wilkars W, Wollberg J, Mohr E, Han M, Chetkovich DM, B?hring R, Bender RA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology28(5)2177-90(2014 May)

Hypoxia-induced inhibition of epithelial Na(+) channels in the lung. Role of Nedd4-2 and the ubiquitin-proteasome pathway.
Gille T, Randrianarison-Pellan N, Goolaerts A, Dard N, Uzunhan Y, Ferrary E, Hummler E, Clerici C, Plan?s C
American journal of respiratory cell and molecular biology50(3)526-37(2014 Mar)

SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation.
Yoo JC, Lim Ty, Park JS, Hah YS, Park N, Hong SG, Park JY, Yoon TJ
Journal of dermatological science72(3)246-51(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2-dependent Kv7.2/3 channel regulation.
Title: Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).

Nedd4-2 plays an important role in the regulation of HCN1 trafficking and may compete with TRIP8b(1a-4) in this process
Title: Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels.

Nedd4-2-mediated ubiquitination of beta-ENaC leading to endocytosis and degradation of apical Na(+) channels is a key feature of hypoxia-induced inhibition of transepithelial alveolar Na(+) transport.
Title: Hypoxia-induced inhibition of epithelial Na(+) channels in the lung. Role of Nedd4-2 and the ubiquitin-proteasome pathway.

SGK1,3 enhances the expression level of mature hERG channels by inhibiting Nedd4-2 as well as by promoting Rab11-mediated hERG recycling.
Title: The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11.

The results of this study indicated that Nedd4-2 is present in nociceptive neurons, is downregulated after peripheral nerve injury.
Title: Neuronal expression of the ubiquitin ligase Nedd4-2 in rat dorsal root ganglia: modulation in the spared nerve injury model of neuropathic pain.

The following Nedd4l gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nedd4l cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13185	NM_001008300.2 Latest version!	Rattus norvegicus NEDD4 like E3 ubiquitin protein ligase (Nedd4l), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nedd4l ( NM_001008300.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001008301.2 Rattus norvegicus NEDD4 like E3 ubiquitin protein ligase (Nedd4l), mRNA.

Price & Availability↑

CloneID	ORa13185
Clone ID Related Accession (Same CDS sequence)	NM_001008300.2
Accession Version	NM_001008300.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2892bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-12
Organism	Rattus norvegicus(Norway rat)
Product	E3 ubiquitin-protein ligase NEDD4-like
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473971.1. On Sep 4, 2008 this sequence version replaced NM_001008300.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGAGCAGG GAGAATCCCG TATTCTCAGA GTAAAAGTTG TTTCTGGGAT TGACCTCGCC 
AAAAAGGACA TATTTGGAGC CAGTGACCCA TACGTGAAGC TCTCGTTGTA CGTAGCTGAC 
GAGAACAGAG AACTCGCTCT GGTTCAGACT AAGACAATTA AAAAGACGCT GAACCCAAAG 
TGGAATGAAG AGTTTTATTT TAGAGTAAAT CCATCTAATC ACAGGCTCTT ATTTGAAGTA 
TTTGACGAGA ACAGATTGAC ACGAGACGAC TTTCTGGGCC AGGTGGACGT GCCTCTTAGT 
CACCTTCCGA CAGAAGATCC AACCATGGAG AGACCCTATA CATTTAAGGA TTTTCTCCTG 
CGACCTAGAA GTCATAAATC ACGCGTCAAG GGGTTTTTGA GGTTGAAAAT GGCCTACATG 
CCGAAAAACG GAGGTCAGGA TGAAGAAAAC AGCGAGCAGA GGGACGACAT GGAGCATGGA 
TGGGAAGTTG TTGACTCAAA CGACTCAGCT TCCCAGCACC AGGAGGAGCT CCCTCCTCCT 
CCCCTGCCAC CAGGATGGGA AGAGAAAGTG GACAATTTAG GCCGAACTTA CTATGTCAAC 
CACAACAACA GGAGTACGCA GTGGCACCGA CCTAGCTTGA TGGATGTATC GTCAGAGTCA 
GACAATAACA TCAGGCAGAT CAATCAGGAG GCCGCACACC GGCGTTTCCG CTCTCGGAGG 
CACATTAGTG AAGACTTGGA GCCTGAGGCC TCTGAAGGTG GTGGAGAAGG CCCTGAGCCT 
TGGGAGACCA TTTCAGAGGA AGTGAACATG GCGGGAGATT CTCTCAGCCT GGCTCTACCC 
CCACCTCCTG CCTCCCCAGT GTCAAGGACC AGCCCCCAGG AGCTGTCGGA AGAACTGAGC 
AGAAGGTTGC AGATCACTCC GGACTCCAAT GGGGAACAGT TCAGTGCTCT GATTCAGAGA 
GAGCCCTCGT CTAGGCTCCG GTCCTGCAGT GTTACCGACA CGGTTGCTGA ACAAGCTCAC 
CTTCCACCGC CCAGCACCCC AACTAGGCGA GCCCGTTCGT CAACTGTCAC GGGTGGTGAG 
GAATCAACGC CATCAGTGGC CTATGTACAT ACCACGCCGG GCCTACCTTC AGGCTGGGAA 
GAAAGAAAAG ATGCTAAGGG ACGCACATAC TATGTCAATC ATAACAATCG AACCACAACT 
TGGACTCGAC CAATCATGCA GCTTGCAGAA GACGGTGCCT CTGGATCAGC CACAAACAGT 
AACAACCACC TAGTCGAACC CCAGATCCGC CGGCCTCGTA GCCTCAGCTC GCCAACAGTA 
ACCTTATCTG CCCCACTGGA GGGTGCCAAG GATTCACCCA TACGCCGTGC TGTGAAAGAT 
ACCCTTTCCA ATCCACAGTC CCCTCAGCCA TCACCTTACA ACTCCCCCAA ACCACAACAC 
AAAGTCACAC AGAGCTTCCT GCCACCAGGC TGGGAGATGA GGATAGCGCC AAACGGCCGA 
CCCTTCTTCA TTGACCATAA CACAAAGACG ACAACCTGGG AAGATCCACG GCTGAAATTT 
CCAGTACATA TGCGGTCAAA AGCATCTTTA AACCCCAATG ACCTGGGCCC TCTTCCTCCT 
GGCTGGGAAG AAAGGATCCA CCTGGACGGC CGCACATTTT ACATTGACCA TAATAGCAAA 
ATTACTCAGT GGGAAGATCC AAGACTACAG AATCCAGCCA TAACTGGTCC GGCTGTGCCG 
TACTCCAGAG AATTTAAGCA GAAATACGAC TACTTTAGGA AGAAATTAAA GAAACCTGCT 
GATATTCCAA ACAGGTTTGA AATGAAACTC CACAGAAACA ACATATTTGA AGAATCCTAT 
CGGAGGATCA TGTCTGTAAA GAGACCTGAC GTCCTAAAGG CTAGACTGTG GATCGAGTTT 
GAATCAGAGA AAGGCCTGGA CTATGGGGGC GTGGCCAGAG AGTGGTTCTT CTTACTGTCC 
AAAGAGATGT TCAATCCCTA CTATGGCCTC TTCGAGTACT CTGCCACGGA CAACTACACA 
CTTCAGATCA ATCCCAACTC AGGCCTGTGT AACGAAGATC ACTTATCCTA TTTCACTTTC 
ATTGGGAGAG TTGCTGGCCT GGCAGTGTTT CATGGGAAAC TCTTAGATGG ATTCTTCATT 
CGACCTTTCT ACAAGATGAT GCTGGGGAAG CAAATAACTC TGAATGACAT GGAGTCTGTG 
GACAGCGAGT ACTACAACTC TTTGAAGTGG ATCTTGGAAA ACGACCCCAC GGAACTTGAC 
CTCATGTTCT GCATAGATGA AGAGAACTTT GGGCAGACTT ACCAAGTGGA CCTGAAGCCC 
AATGGGTCAG AAATCATGGT AACCAATGAG AACAAGCGAG AATATATTGA CTTGGTCATC 
CAGTGGAGAT TTGTGAACAG GGTCCAGAAG CAAATGAATG CCTTCTTGGA GGGATTTACA 
GAACTTCTTC CAATCGACTT GATTAAAATT TTTGATGAAA ATGAGCTGGA GTTGCTGATG 
TGCGGCCTTG GTGATGTGGA CGTGAATGAT TGGAGACAGC ACTCCATTTA CAAGAACGGC 
TACTGCCCCA ACCACCCTGT CATCCAGTGG TTCTGGAAGG CCGTGCTGCT GATGGATGCT 
GAGAAGCGGA TCCGGTTACT ACAGTTTGTC ACAGGCACCT CCAGAGTACC CATGAATGGA 
TTTGCCGAAC TTTATGGTTC CAATGGTCCT CAGCTGTTTA CAATAGAGCA ATGGGGTAGT 
CCTGAAAAAC TGCCCAGAGC TCATACATGC TTTAACCGCC TTGATTTACC TCCGTATGAA 
ACCTTTGAAG ATCTACGGGA GAAGCTTCTC ATGGCCGTGG AGAATGCTCA AGGCTTCGAA 
GGTGTGGATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001008301.2
CDS	76..2967
Translation	MEQGESRILRVKVVSGIDLAKKDIFGASDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRVNPSNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRDDMEHGWEVVDSNDSASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRSTQWHRPSLMDVSSESDNNIRQINQEAAHRRFRSRRHISEDLEPEASEGGGEGPEPWETISEEVNMAGDSLSLALPPPPASPVSRTSPQELSEELSRRLQITPDSNGEQFSALIQREPSSRLRSCSVTDTVAEQAHLPPPSTPTRRARSSTVTGGEESTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRPIMQLAEDGASGSATNSNNHLVEPQIRRPRSLSSPTVTLSAPLEGAKDSPIRRAVKDTLSNPQSPQPSPYNSPKPQHKVTQSFLPPGWEMRIAPNGRPFFIDHNTKTTTWEDPRLKFPVHMRSKASLNPNDLGPLPPGWEERIHLDGRTFYIDHNSKITQWEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKKPADIPNRFEMKLHRNNIFEESYRRIMSVKRPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFEGVD

Target ORF information:

RefSeq Version	NM_001008300.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NEDD4 like E3 ubiquitin protein ligase (Nedd4l), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001008300.2

ORF Insert Sequence:

ATGGAGCAGG GAGAATCCCG TATTCTCAGA GTAAAAGTTG TTTCTGGGAT TGACCTCGCC 
AAAAAGGACA TATTTGGAGC CAGTGACCCA TACGTGAAGC TCTCGTTGTA CGTAGCTGAC 
GAGAACAGAG AACTCGCTCT GGTTCAGACT AAGACAATTA AAAAGACGCT GAACCCAAAG 
TGGAATGAAG AGTTTTATTT TAGAGTAAAT CCATCTAATC ACAGGCTCTT ATTTGAAGTA 
TTTGACGAGA ACAGATTGAC ACGAGACGAC TTTCTGGGCC AGGTGGACGT GCCTCTTAGT 
CACCTTCCGA CAGAAGATCC AACCATGGAG AGACCCTATA CATTTAAGGA TTTTCTCCTG 
CGACCTAGAA GTCATAAATC ACGCGTCAAG GGGTTTTTGA GGTTGAAAAT GGCCTACATG 
CCGAAAAACG GAGGTCAGGA TGAAGAAAAC AGCGAGCAGA GGGACGACAT GGAGCATGGA 
TGGGAAGTTG TTGACTCAAA CGACTCAGCT TCCCAGCACC AGGAGGAGCT CCCTCCTCCT 
CCCCTGCCAC CAGGATGGGA AGAGAAAGTG GACAATTTAG GCCGAACTTA CTATGTCAAC 
CACAACAACA GGAGTACGCA GTGGCACCGA CCTAGCTTGA TGGATGTATC GTCAGAGTCA 
GACAATAACA TCAGGCAGAT CAATCAGGAG GCCGCACACC GGCGTTTCCG CTCTCGGAGG 
CACATTAGTG AAGACTTGGA GCCTGAGGCC TCTGAAGGTG GTGGAGAAGG CCCTGAGCCT 
TGGGAGACCA TTTCAGAGGA AGTGAACATG GCGGGAGATT CTCTCAGCCT GGCTCTACCC 
CCACCTCCTG CCTCCCCAGT GTCAAGGACC AGCCCCCAGG AGCTGTCGGA AGAACTGAGC 
AGAAGGTTGC AGATCACTCC GGACTCCAAT GGGGAACAGT TCAGTGCTCT GATTCAGAGA 
GAGCCCTCGT CTAGGCTCCG GTCCTGCAGT GTTACCGACA CGGTTGCTGA ACAAGCTCAC 
CTTCCACCGC CCAGCACCCC AACTAGGCGA GCCCGTTCGT CAACTGTCAC GGGTGGTGAG 
GAATCAACGC CATCAGTGGC CTATGTACAT ACCACGCCGG GCCTACCTTC AGGCTGGGAA 
GAAAGAAAAG ATGCTAAGGG ACGCACATAC TATGTCAATC ATAACAATCG AACCACAACT 
TGGACTCGAC CAATCATGCA GCTTGCAGAA GACGGTGCCT CTGGATCAGC CACAAACAGT 
AACAACCACC TAGTCGAACC CCAGATCCGC CGGCCTCGTA GCCTCAGCTC GCCAACAGTA 
ACCTTATCTG CCCCACTGGA GGGTGCCAAG GATTCACCCA TACGCCGTGC TGTGAAAGAT 
ACCCTTTCCA ATCCACAGTC CCCTCAGCCA TCACCTTACA ACTCCCCCAA ACCACAACAC 
AAAGTCACAC AGAGCTTCCT GCCACCAGGC TGGGAGATGA GGATAGCGCC AAACGGCCGA 
CCCTTCTTCA TTGACCATAA CACAAAGACG ACAACCTGGG AAGATCCACG GCTGAAATTT 
CCAGTACATA TGCGGTCAAA AGCATCTTTA AACCCCAATG ACCTGGGCCC TCTTCCTCCT 
GGCTGGGAAG AAAGGATCCA CCTGGACGGC CGCACATTTT ACATTGACCA TAATAGCAAA 
ATTACTCAGT GGGAAGATCC AAGACTACAG AATCCAGCCA TAACTGGTCC GGCTGTGCCG 
TACTCCAGAG AATTTAAGCA GAAATACGAC TACTTTAGGA AGAAATTAAA GAAACCTGCT 
GATATTCCAA ACAGGTTTGA AATGAAACTC CACAGAAACA ACATATTTGA AGAATCCTAT 
CGGAGGATCA TGTCTGTAAA GAGACCTGAC GTCCTAAAGG CTAGACTGTG GATCGAGTTT 
GAATCAGAGA AAGGCCTGGA CTATGGGGGC GTGGCCAGAG AGTGGTTCTT CTTACTGTCC 
AAAGAGATGT TCAATCCCTA CTATGGCCTC TTCGAGTACT CTGCCACGGA CAACTACACA 
CTTCAGATCA ATCCCAACTC AGGCCTGTGT AACGAAGATC ACTTATCCTA TTTCACTTTC 
ATTGGGAGAG TTGCTGGCCT GGCAGTGTTT CATGGGAAAC TCTTAGATGG ATTCTTCATT 
CGACCTTTCT ACAAGATGAT GCTGGGGAAG CAAATAACTC TGAATGACAT GGAGTCTGTG 
GACAGCGAGT ACTACAACTC TTTGAAGTGG ATCTTGGAAA ACGACCCCAC GGAACTTGAC 
CTCATGTTCT GCATAGATGA AGAGAACTTT GGGCAGACTT ACCAAGTGGA CCTGAAGCCC 
AATGGGTCAG AAATCATGGT AACCAATGAG AACAAGCGAG AATATATTGA CTTGGTCATC 
CAGTGGAGAT TTGTGAACAG GGTCCAGAAG CAAATGAATG CCTTCTTGGA GGGATTTACA 
GAACTTCTTC CAATCGACTT GATTAAAATT TTTGATGAAA ATGAGCTGGA GTTGCTGATG 
TGCGGCCTTG GTGATGTGGA CGTGAATGAT TGGAGACAGC ACTCCATTTA CAAGAACGGC 
TACTGCCCCA ACCACCCTGT CATCCAGTGG TTCTGGAAGG CCGTGCTGCT GATGGATGCT 
GAGAAGCGGA TCCGGTTACT ACAGTTTGTC ACAGGCACCT CCAGAGTACC CATGAATGGA 
TTTGCCGAAC TTTATGGTTC CAATGGTCCT CAGCTGTTTA CAATAGAGCA ATGGGGTAGT 
CCTGAAAAAC TGCCCAGAGC TCATACATGC TTTAACCGCC TTGATTTACC TCCGTATGAA 
ACCTTTGAAG ATCTACGGGA GAAGCTTCTC ATGGCCGTGG AGAATGCTCA AGGCTTCGAA 
GGTGTGGATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).
The Journal of biological chemistry291(36)19132-45(2016 09)
Anta B,Mart?n-Rodr?guez C,Gomis-Perez C,Calvo L,L?pez-Benito S,Calder?n-Garc?a AA,Vicente-Garc?a C,Villarroel ?,Ar?valo JC

Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.
The Journal of biological chemistry290(11)7141-50(2015 Mar)
Low LH,Chow YL,Li Y,Goh CP,Putz U,Silke J,Ouchi T,Howitt J,Tan SS

Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology28(5)2177-90(2014 May)
Wilkars W,Wollberg J,Mohr E,Han M,Chetkovich DM,B?hring R,Bender RA

Hypoxia-induced inhibition of epithelial Na(+) channels in the lung. Role of Nedd4-2 and the ubiquitin-proteasome pathway.
American journal of respiratory cell and molecular biology50(3)526-37(2014 Mar)
Gille T,Randrianarison-Pellan N,Goolaerts A,Dard N,Uzunhan Y,Ferrary E,Hummler E,Clerici C,Plan?s C

SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation.
Journal of dermatological science72(3)246-51(2013 Dec)
Yoo JC,Lim Ty,Park JS,Hah YS,Park N,Hong SG,Park JY,Yoon TJ

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Nedd4l cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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