Myog cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Myog
Entrez Gene ID	29148
Full Name	myogenin
General protein information	Preferred Names myogenin Names myogenin
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q13
Summary	This gene belongs to the myogenic factor subfamily of the basic helix-loop-helix (BHLH) family of transcription factors. The protein encoded by this gene is a muscle-specific skeletal myogenin, which acts in concert with other family members to regulate myogenesis. The protein plays an essential role in the conversion of undifferentiated cells to myoblasts and functional skeletal muscle. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_017115.2	NP_058811.2	myogenin

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Myog	NP_112466.1
Rattus norvegicus (Norway rat)	Myog	NP_058811.2
Homo sapiens (human)	MYOG	NP_002470.2
Xenopus tropicalis (tropical clawed frog)	myog	NP_001016725.1
Gallus gallus (chicken)	MYOG	NP_989515.1
Canis lupus familiaris (dog)	MYOG	XP_547345.2
Bos taurus (cattle)	MYOG	NP_001104795.1
Danio rerio (zebrafish)	myog	NP_571081.1
	MYOG	XP_001104569.2

Gene Ontology
Bibliography

Related articles in PubMed

Comparative effects of low-level laser therapy pre- and post-injury on mRNA expression of MyoD, myogenin, and IL-6 during the skeletal muscle repair.
Alves AN, Ribeiro BG, Fernandes KP, Souza NH, Rocha LA, Nunes FD, Bussadori SK, Mesquita-Ferrari RA
Lasers in medical science31(4)679-85(2016 May)

The regulatory mechanisms of myogenin expression in doxorubicin-treated rat cardiomyocytes.
Liu ST, Huang SM, Ho CL, Yen LC, Huang CJ, Lin WS, Chan JY
Oncotarget6(35)37443-57(2015 Nov)

Myogenin gene expression is not altered in the developing diaphragm of nitrofen-induced congenital diaphragmatic hernia.
Takahashi T, Friedmacher F, Takahashi H, Hofmann AD, Puri P
Pediatric surgery international30(9)901-6(2014 Sep)

Myomaker is essential for muscle regeneration.
Millay DP, Sutherland LB, Bassel-Duby R, Olson EN
Genes & development28(15)1641-6(2014 Aug)

The H19 long noncoding RNA gives rise to microRNAs miR-675-3p and miR-675-5p to promote skeletal muscle differentiation and regeneration.
Dey BK, Pfeifer K, Dutta A
Genes & development28(5)491-501(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

low-level laser therapy (LLLT) administered following muscle injury modulates the mRNA expression of MyoD and myogenin. Moreover, the both forms of LLLT administration were able to modulate the mRNA expression of IL-6 during the muscle repair process.
Title: Comparative effects of low-level laser therapy pre- and post-injury on mRNA expression of MyoD, myogenin, and IL-6 during the skeletal muscle repair.

Suggest that myogenin is the target for doxorubicin-induced cardio-toxicity.
Title: The regulatory mechanisms of myogenin expression in doxorubicin-treated rat cardiomyocytes.

Myogenin, which is expressed in MPCs, belongs to a family of basic helix-loop-helix transcription factors that activate skeletal muscle differentiation and thus plays a key role in fetal diaphragmatic development and muscularization.
Title: Myogenin gene expression is not altered in the developing diaphragm of nitrofen-induced congenital diaphragmatic hernia.

Myogenin, myostatin, and follistatin expression is lower and MRF4 levels higher in spontaneously hypertensive rats (SHR)
Title: Heart failure-induced skeletal myopathy in spontaneously hypertensive rats.

Sema3A is a crucial factor that is up-stream of the muscle-specific transcription factor, myogenin.
Title: Comparative analysis of semaphorin 3A in soleus and EDL muscle satellite cells in vitro toward understanding its role in modulating myogenin expression.

The following Myog gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Myog cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12682	NM_017115.2 Latest version!	Rattus norvegicus myogenin (Myog), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Myog ( NM_017115.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_058811.2 Rattus norvegicus myogenin (Myog), mRNA.

Price & Availability↑

CloneID	ORa12682
Clone ID Related Accession (Same CDS sequence)	NM_017115.2
Accession Version	NM_017115.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 675bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	myogenin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M24393.1. On May 22, 2002 this sequence version replaced NM_017115.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M24393.1, AF054894.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689600, SAMEA2689602 [ECO:0000348] ##Evidence-Data-END##

ATGGAGCTGT ATGAAACATC CCCCTATTTC TACCAGGAGC CCCACTTCTA TGACGGGGAA 
AACTACCTTC CTGTCCACCT TCAGGGCTTC GAGCCCCCGG GCTATGAGCG GACCGAGCTC 
AGCTTAAGCC CGGAAGCCCG AGGGCCCCTA GAAGAGAAGG GACTGGGGAC CCCTGAGCAT 
TGTCCAGGCC AGTGCCTGCC CTGGGCGTGT AAGGTGTGTA AGAGGAAGTC TGTGTCTGTG 
GACCGGCGGA GGGCAGCCAC ACTGAGGGAG AAGCGCAGGC TCAAGAAAGT GAATGAGGCC 
TTCGAGGCTC TGAAGAGAAG CACCCTGCTC AACCCCAACC AGCGGCTGCC TAAGGTGGAG 
ATCCTGCGCA GTGCCATCCA GTACATTGAG CGCCTACAGG CCTTGCTCAG CTCCCTCAAC 
CAGGAGGAGC GCGATCTCCG CTACCGAGGC GGGGGCGGGC CCCAGCCGGT GGTACCCAGT 
GAATGCAACT CCCACAGCGC CTCCTGCAGT CCGGAGTGGG GCAATGCACT GGAGTTTGGT 
CCCAACCCAG GAGATCATTT GCTCGCAGCT GACCCTACAG GTGCCCACAA CCTGCACTCC 
CTTACGTCCA TCGTGGACAG CATCACGGTG GAGGATATGT CTGTCACCTT CCCAGATGAA 
ACCATGCCCA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_058811.2
CDS	35..709
Translation	MELYETSPYFYQEPHFYDGENYLPVHLQGFEPPGYERTELSLSPEARGPLEEKGLGTPEHCPGQCLPWACKVCKRKSVSVDRRRAATLREKRRLKKVNEAFEALKRSTLLNPNQRLPKVEILRSAIQYIERLQALLSSLNQEERDLRYRGGGGPQPVVPSECNSHSASCSPEWGNALEFGPNPGDHLLAADPTGAHNLHSLTSIVDSITVEDMSVTFPDETMPN

Target ORF information:

RefSeq Version	NM_017115.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus myogenin (Myog), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017115.2

ORF Insert Sequence:

ATGGAGCTGT ATGAAACATC CCCCTATTTC TACCAGGAGC CCCACTTCTA TGACGGGGAA 
AACTACCTTC CTGTCCACCT TCAGGGCTTC GAGCCCCCGG GCTATGAGCG GACCGAGCTC 
AGCTTAAGCC CGGAAGCCCG AGGGCCCCTA GAAGAGAAGG GACTGGGGAC CCCTGAGCAT 
TGTCCAGGCC AGTGCCTGCC CTGGGCGTGT AAGGTGTGTA AGAGGAAGTC TGTGTCTGTG 
GACCGGCGGA GGGCAGCCAC ACTGAGGGAG AAGCGCAGGC TCAAGAAAGT GAATGAGGCC 
TTCGAGGCTC TGAAGAGAAG CACCCTGCTC AACCCCAACC AGCGGCTGCC TAAGGTGGAG 
ATCCTGCGCA GTGCCATCCA GTACATTGAG CGCCTACAGG CCTTGCTCAG CTCCCTCAAC 
CAGGAGGAGC GCGATCTCCG CTACCGAGGC GGGGGCGGGC CCCAGCCGGT GGTACCCAGT 
GAATGCAACT CCCACAGCGC CTCCTGCAGT CCGGAGTGGG GCAATGCACT GGAGTTTGGT 
CCCAACCCAG GAGATCATTT GCTCGCAGCT GACCCTACAG GTGCCCACAA CCTGCACTCC 
CTTACGTCCA TCGTGGACAG CATCACGGTG GAGGATATGT CTGTCACCTT CCCAGATGAA 
ACCATGCCCA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Comparative effects of low-level laser therapy pre- and post-injury on mRNA expression of MyoD, myogenin, and IL-6 during the skeletal muscle repair.
Lasers in medical science31(4)679-85(2016 May)
Alves AN,Ribeiro BG,Fernandes KP,Souza NH,Rocha LA,Nunes FD,Bussadori SK,Mesquita-Ferrari RA

The regulatory mechanisms of myogenin expression in doxorubicin-treated rat cardiomyocytes.
Oncotarget6(35)37443-57(2015 Nov)
Liu ST,Huang SM,Ho CL,Yen LC,Huang CJ,Lin WS,Chan JY

Myogenin gene expression is not altered in the developing diaphragm of nitrofen-induced congenital diaphragmatic hernia.
Pediatric surgery international30(9)901-6(2014 Sep)
Takahashi T,Friedmacher F,Takahashi H,Hofmann AD,Puri P

Myomaker is essential for muscle regeneration.
Genes & development28(15)1641-6(2014 Aug)
Millay DP,Sutherland LB,Bassel-Duby R,Olson EN

The H19 long noncoding RNA gives rise to microRNAs miR-675-3p and miR-675-5p to promote skeletal muscle differentiation and regeneration.
Genes & development28(5)491-501(2014 Mar)
Dey BK,Pfeifer K,Dutta A

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Myog cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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